Ras-like small GTPase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ras-like small GTPases, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IER9_LEIDO

TriTrypDb:

LdBPK_310890.1 , LdCL_310014900 , LDHU3_31.1400

Length:

609

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IER9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IER9

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0003924	GTPase activity	7	7
GO:0005488	binding	1	7
GO:0005525	GTP binding	5	7
GO:0016462	pyrophosphatase activity	5	7
GO:0016787	hydrolase activity	2	7
GO:0016817	hydrolase activity, acting on acid anhydrides	3	7
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	7
GO:0017076	purine nucleotide binding	4	7
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	7
GO:0019001	guanyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032561	guanyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	220	224	PF00656	0.364
CLV_C14_Caspase3-7	285	289	PF00656	0.532
CLV_C14_Caspase3-7	413	417	PF00656	0.690
CLV_C14_Caspase3-7	78	82	PF00656	0.621
CLV_NRD_NRD_1	198	200	PF00675	0.310
CLV_NRD_NRD_1	243	245	PF00675	0.388
CLV_NRD_NRD_1	465	467	PF00675	0.536
CLV_NRD_NRD_1	483	485	PF00675	0.650
CLV_NRD_NRD_1	67	69	PF00675	0.534
CLV_PCSK_KEX2_1	200	202	PF00082	0.312
CLV_PCSK_KEX2_1	54	56	PF00082	0.371
CLV_PCSK_KEX2_1	67	69	PF00082	0.591
CLV_PCSK_PC1ET2_1	200	202	PF00082	0.291
CLV_PCSK_PC1ET2_1	54	56	PF00082	0.371
CLV_PCSK_PC7_1	196	202	PF00082	0.312
CLV_PCSK_SKI1_1	271	275	PF00082	0.291
CLV_PCSK_SKI1_1	385	389	PF00082	0.675
CLV_PCSK_SKI1_1	475	479	PF00082	0.681
CLV_PCSK_SKI1_1	54	58	PF00082	0.364
CLV_PCSK_SKI1_1	592	596	PF00082	0.491
DEG_APCC_DBOX_1	270	278	PF00400	0.291
DOC_CKS1_1	426	431	PF01111	0.705
DOC_CYCLIN_RxL_1	49	60	PF00134	0.401
DOC_MAPK_MEF2A_6	508	517	PF00069	0.611
DOC_PP2B_LxvP_1	102	105	PF13499	0.388
DOC_PP2B_LxvP_1	352	355	PF13499	0.652
DOC_PP4_FxxP_1	326	329	PF00568	0.703
DOC_USP7_MATH_1	109	113	PF00917	0.312
DOC_USP7_MATH_1	186	190	PF00917	0.359
DOC_USP7_MATH_1	194	198	PF00917	0.335
DOC_USP7_MATH_1	260	264	PF00917	0.289
DOC_USP7_MATH_1	315	319	PF00917	0.556
DOC_USP7_MATH_1	363	367	PF00917	0.775
DOC_USP7_MATH_1	391	395	PF00917	0.782
DOC_USP7_MATH_1	531	535	PF00917	0.643
DOC_USP7_UBL2_3	460	464	PF12436	0.610
DOC_USP7_UBL2_3	592	596	PF12436	0.613
DOC_USP7_UBL2_3	597	601	PF12436	0.687
DOC_WW_Pin1_4	222	227	PF00397	0.485
DOC_WW_Pin1_4	334	339	PF00397	0.628
DOC_WW_Pin1_4	343	348	PF00397	0.633
DOC_WW_Pin1_4	356	361	PF00397	0.712
DOC_WW_Pin1_4	386	391	PF00397	0.603
DOC_WW_Pin1_4	414	419	PF00397	0.781
DOC_WW_Pin1_4	425	430	PF00397	0.605
DOC_WW_Pin1_4	62	67	PF00397	0.518
DOC_WW_Pin1_4	89	94	PF00397	0.388
LIG_14-3-3_CanoR_1	135	140	PF00244	0.312
LIG_14-3-3_CanoR_1	283	287	PF00244	0.537
LIG_Actin_WH2_2	181	198	PF00022	0.291
LIG_Actin_WH2_2	267	285	PF00022	0.388
LIG_APCC_ABBA_1	251	256	PF00400	0.312
LIG_BIR_II_1	1	5	PF00653	0.611
LIG_BIR_III_4	438	442	PF00653	0.631
LIG_BRCT_BRCA1_1	300	304	PF00533	0.583
LIG_FHA_1	118	124	PF00498	0.312
LIG_FHA_1	323	329	PF00498	0.647
LIG_FHA_1	347	353	PF00498	0.672
LIG_FHA_1	48	54	PF00498	0.361
LIG_FHA_1	493	499	PF00498	0.551
LIG_FHA_1	90	96	PF00498	0.388
LIG_FHA_2	101	107	PF00498	0.255
LIG_FHA_2	15	21	PF00498	0.522
LIG_FHA_2	188	194	PF00498	0.315
LIG_FHA_2	228	234	PF00498	0.320
LIG_FHA_2	371	377	PF00498	0.585
LIG_FHA_2	453	459	PF00498	0.618
LIG_Integrin_RGD_1	430	432	PF01839	0.605
LIG_IRF3_LxIS_1	53	60	PF10401	0.266
LIG_LIR_Apic_2	325	329	PF02991	0.677
LIG_LIR_Gen_1	248	259	PF02991	0.315
LIG_LIR_Gen_1	571	580	PF02991	0.474
LIG_LIR_Nem_3	248	254	PF02991	0.315
LIG_LIR_Nem_3	256	262	PF02991	0.308
LIG_LIR_Nem_3	34	40	PF02991	0.368
LIG_LIR_Nem_3	571	576	PF02991	0.480
LIG_LIR_Nem_3	97	102	PF02991	0.312
LIG_MYND_1	329	333	PF01753	0.661
LIG_PCNA_yPIPBox_3	464	478	PF02747	0.586
LIG_PTB_Apo_2	133	140	PF02174	0.312
LIG_SH2_CRK	279	283	PF00017	0.436
LIG_SH2_NCK_1	259	263	PF00017	0.312
LIG_SH2_SRC	259	262	PF00017	0.285
LIG_SH2_STAP1	100	104	PF00017	0.312
LIG_SH2_STAP1	126	130	PF00017	0.312
LIG_SH2_STAT5	16	19	PF00017	0.504
LIG_SH2_STAT5	35	38	PF00017	0.421
LIG_SH3_1	357	363	PF00018	0.646
LIG_SH3_3	143	149	PF00018	0.340
LIG_SH3_3	24	30	PF00018	0.584
LIG_SH3_3	305	311	PF00018	0.609
LIG_SH3_3	357	363	PF00018	0.654
LIG_SH3_3	384	390	PF00018	0.587
LIG_SH3_CIN85_PxpxPR_1	339	344	PF14604	0.671
LIG_SUMO_SIM_anti_2	173	179	PF11976	0.324
LIG_SUMO_SIM_par_1	209	216	PF11976	0.340
LIG_SUMO_SIM_par_1	38	44	PF11976	0.346
LIG_SUMO_SIM_par_1	55	60	PF11976	0.387
LIG_TRFH_1	375	379	PF08558	0.637
LIG_TYR_ITIM	257	262	PF00017	0.312
LIG_TYR_ITIM	277	282	PF00017	0.259
LIG_WW_3	354	358	PF00397	0.691
MOD_CAAXbox	606	609	PF01239	0.538
MOD_CDC14_SPxK_1	65	68	PF00782	0.542
MOD_CDK_SPK_2	425	430	PF00069	0.663
MOD_CDK_SPK_2	62	67	PF00069	0.539
MOD_CDK_SPxK_1	62	68	PF00069	0.511
MOD_CK1_1	129	135	PF00069	0.493
MOD_CK1_1	151	157	PF00069	0.348
MOD_CK1_1	189	195	PF00069	0.453
MOD_CK1_1	218	224	PF00069	0.434
MOD_CK1_1	263	269	PF00069	0.313
MOD_CK1_1	322	328	PF00069	0.678
MOD_CK1_1	346	352	PF00069	0.779
MOD_CK1_1	366	372	PF00069	0.712
MOD_CK1_1	62	68	PF00069	0.620
MOD_CK2_1	14	20	PF00069	0.527
MOD_CK2_1	187	193	PF00069	0.325
MOD_CK2_1	227	233	PF00069	0.320
MOD_CK2_1	386	392	PF00069	0.650
MOD_Cter_Amidation	482	485	PF01082	0.597
MOD_GlcNHglycan	196	199	PF01048	0.387
MOD_GlcNHglycan	230	233	PF01048	0.314
MOD_GlcNHglycan	261	265	PF01048	0.314
MOD_GlcNHglycan	312	315	PF01048	0.634
MOD_GlcNHglycan	321	324	PF01048	0.740
MOD_GlcNHglycan	400	403	PF01048	0.762
MOD_GlcNHglycan	404	408	PF01048	0.712
MOD_GlcNHglycan	412	415	PF01048	0.630
MOD_GlcNHglycan	524	527	PF01048	0.756
MOD_GlcNHglycan	59	62	PF01048	0.401
MOD_GSK3_1	126	133	PF00069	0.471
MOD_GSK3_1	144	151	PF00069	0.237
MOD_GSK3_1	218	225	PF00069	0.337
MOD_GSK3_1	315	322	PF00069	0.599
MOD_GSK3_1	366	373	PF00069	0.644
MOD_GSK3_1	377	384	PF00069	0.642
MOD_GSK3_1	410	417	PF00069	0.700
MOD_GSK3_1	421	428	PF00069	0.801
MOD_GSK3_1	43	50	PF00069	0.372
MOD_GSK3_1	444	451	PF00069	0.683
MOD_GSK3_1	531	538	PF00069	0.657
MOD_GSK3_1	55	62	PF00069	0.411
MOD_GSK3_1	75	82	PF00069	0.435
MOD_GSK3_1	87	94	PF00069	0.276
MOD_N-GLC_1	135	140	PF02516	0.312
MOD_N-GLC_1	221	226	PF02516	0.279
MOD_N-GLC_2	605	607	PF02516	0.558
MOD_NEK2_1	144	149	PF00069	0.305
MOD_NEK2_1	282	287	PF00069	0.496
MOD_NEK2_1	304	309	PF00069	0.547
MOD_NEK2_1	444	449	PF00069	0.672
MOD_NEK2_1	57	62	PF00069	0.331
MOD_NEK2_1	75	80	PF00069	0.641
MOD_NEK2_1	87	92	PF00069	0.452
MOD_NEK2_2	109	114	PF00069	0.312
MOD_NEK2_2	130	135	PF00069	0.291
MOD_PK_1	158	164	PF00069	0.302
MOD_PK_1	55	61	PF00069	0.475
MOD_PKA_1	595	601	PF00069	0.558
MOD_PKA_2	282	288	PF00069	0.539
MOD_PKA_2	553	559	PF00069	0.756
MOD_Plk_1	130	136	PF00069	0.307
MOD_Plk_1	14	20	PF00069	0.527
MOD_Plk_1	215	221	PF00069	0.361
MOD_Plk_1	370	376	PF00069	0.618
MOD_Plk_1	43	49	PF00069	0.373
MOD_Plk_1	75	81	PF00069	0.598
MOD_Plk_2-3	14	20	PF00069	0.527
MOD_Plk_2-3	215	221	PF00069	0.364
MOD_Plk_2-3	371	377	PF00069	0.651
MOD_Plk_2-3	70	76	PF00069	0.622
MOD_Plk_4	135	141	PF00069	0.311
MOD_Plk_4	151	157	PF00069	0.381
MOD_Plk_4	158	164	PF00069	0.465
MOD_Plk_4	304	310	PF00069	0.549
MOD_Plk_4	48	54	PF00069	0.361
MOD_Plk_4	531	537	PF00069	0.627
MOD_ProDKin_1	222	228	PF00069	0.485
MOD_ProDKin_1	334	340	PF00069	0.631
MOD_ProDKin_1	343	349	PF00069	0.635
MOD_ProDKin_1	356	362	PF00069	0.709
MOD_ProDKin_1	386	392	PF00069	0.606
MOD_ProDKin_1	414	420	PF00069	0.784
MOD_ProDKin_1	425	431	PF00069	0.603
MOD_ProDKin_1	62	68	PF00069	0.527
MOD_ProDKin_1	89	95	PF00069	0.388
MOD_SUMO_rev_2	458	465	PF00179	0.657
MOD_SUMO_rev_2	468	477	PF00179	0.492
TRG_DiLeu_BaLyEn_6	52	57	PF01217	0.393
TRG_ENDOCYTIC_2	259	262	PF00928	0.312
TRG_ENDOCYTIC_2	279	282	PF00928	0.264
TRG_ER_diArg_1	201	204	PF00400	0.385
TRG_ER_diArg_1	66	68	PF00400	0.528
TRG_NLS_MonoExtC_3	198	203	PF00514	0.340
TRG_NLS_MonoExtC_3	591	596	PF00514	0.494
TRG_NLS_MonoExtN_4	196	203	PF00514	0.291
TRG_NLS_MonoExtN_4	590	596	PF00514	0.496

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTB6	Leptomonas seymouri	47%	97%
A4HJ62	Leishmania braziliensis	64%	99%
A4I6I0	Leishmania infantum	99%	100%
E9B1N7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q6H7	Leishmania major	90%	100%