Bystin, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Bystin, putative

Gene product:

bystin, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IER2_LEIDO

TriTrypDb:

LdBPK_300490.1 , LdCL_300010000 , LDHU3_30.0670

Length:

469

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0043226	organelle	2	12
GO:0043229	intracellular organelle	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0030684	preribosome	3	1
GO:0030688	preribosome, small subunit precursor	4	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0032991	protein-containing complex	1	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:1990904	ribonucleoprotein complex	2	1
GO:0016020	membrane	2	1

Expansion

Sequence features

A0A3Q8IER2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IER2

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0030515	snoRNA binding	5	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	206	210	PF00656	0.506
CLV_C14_Caspase3-7	38	42	PF00656	0.554
CLV_C14_Caspase3-7	85	89	PF00656	0.648
CLV_C14_Caspase3-7	93	97	PF00656	0.624
CLV_NRD_NRD_1	186	188	PF00675	0.161
CLV_NRD_NRD_1	307	309	PF00675	0.215
CLV_NRD_NRD_1	34	36	PF00675	0.630
CLV_NRD_NRD_1	452	454	PF00675	0.209
CLV_PCSK_KEX2_1	186	188	PF00082	0.128
CLV_PCSK_KEX2_1	224	226	PF00082	0.299
CLV_PCSK_KEX2_1	34	36	PF00082	0.551
CLV_PCSK_KEX2_1	452	454	PF00082	0.209
CLV_PCSK_KEX2_1	55	57	PF00082	0.523
CLV_PCSK_PC1ET2_1	224	226	PF00082	0.299
CLV_PCSK_PC1ET2_1	55	57	PF00082	0.559
CLV_PCSK_SKI1_1	187	191	PF00082	0.168
CLV_PCSK_SKI1_1	233	237	PF00082	0.209
CLV_PCSK_SKI1_1	308	312	PF00082	0.218
CLV_PCSK_SKI1_1	319	323	PF00082	0.209
CLV_PCSK_SKI1_1	334	338	PF00082	0.154
CLV_PCSK_SKI1_1	380	384	PF00082	0.237
CLV_PCSK_SKI1_1	55	59	PF00082	0.443
DEG_APCC_DBOX_1	344	352	PF00400	0.420
DOC_CKS1_1	446	451	PF01111	0.409
DOC_CYCLIN_yCln2_LP_2	311	317	PF00134	0.409
DOC_MAPK_DCC_7	319	327	PF00069	0.478
DOC_MAPK_MEF2A_6	279	288	PF00069	0.409
DOC_MAPK_MEF2A_6	297	305	PF00069	0.409
DOC_MAPK_MEF2A_6	319	327	PF00069	0.478
DOC_MAPK_MEF2A_6	368	377	PF00069	0.437
DOC_MAPK_RevD_3	282	298	PF00069	0.476
DOC_PP1_RVXF_1	311	318	PF00149	0.409
DOC_PP4_FxxP_1	321	324	PF00568	0.409
DOC_USP7_MATH_1	191	195	PF00917	0.490
DOC_USP7_UBL2_3	177	181	PF12436	0.476
DOC_USP7_UBL2_3	309	313	PF12436	0.409
DOC_USP7_UBL2_3	4	8	PF12436	0.717
DOC_WW_Pin1_4	139	144	PF00397	0.566
DOC_WW_Pin1_4	187	192	PF00397	0.494
DOC_WW_Pin1_4	254	259	PF00397	0.409
DOC_WW_Pin1_4	445	450	PF00397	0.420
LIG_14-3-3_CanoR_1	214	223	PF00244	0.409
LIG_14-3-3_CanoR_1	225	232	PF00244	0.409
LIG_14-3-3_CanoR_1	368	372	PF00244	0.478
LIG_14-3-3_CanoR_1	56	65	PF00244	0.425
LIG_Actin_WH2_2	320	336	PF00022	0.478
LIG_EVH1_1	348	352	PF00568	0.409
LIG_FHA_1	446	452	PF00498	0.409
LIG_FHA_1	52	58	PF00498	0.462
LIG_FHA_2	249	255	PF00498	0.509
LIG_FHA_2	330	336	PF00498	0.412
LIG_FHA_2	401	407	PF00498	0.497
LIG_FHA_2	71	77	PF00498	0.630
LIG_HCF-1_HBM_1	106	109	PF13415	0.669
LIG_LIR_Gen_1	370	377	PF02991	0.452
LIG_LIR_LC3C_4	335	339	PF02991	0.434
LIG_LIR_Nem_3	370	375	PF02991	0.452
LIG_Pex14_2	317	321	PF04695	0.409
LIG_PTB_Apo_2	437	444	PF02174	0.509
LIG_REV1ctd_RIR_1	315	323	PF16727	0.434
LIG_SH2_CRK	216	220	PF00017	0.409
LIG_SH2_CRK	281	285	PF00017	0.409
LIG_SH2_CRK	304	308	PF00017	0.420
LIG_SH2_NCK_1	216	220	PF00017	0.409
LIG_SH2_SRC	47	50	PF00017	0.626
LIG_SH2_STAP1	109	113	PF00017	0.709
LIG_SH2_STAP1	281	285	PF00017	0.409
LIG_SH2_STAT5	216	219	PF00017	0.414
LIG_SH2_STAT5	226	229	PF00017	0.400
LIG_SH2_STAT5	394	397	PF00017	0.409
LIG_SH2_STAT5	47	50	PF00017	0.626
LIG_SH3_3	133	139	PF00018	0.490
LIG_SH3_3	281	287	PF00018	0.409
LIG_SH3_3	346	352	PF00018	0.411
LIG_SUMO_SIM_par_1	132	140	PF11976	0.649
LIG_SUMO_SIM_par_1	245	251	PF11976	0.409
LIG_TRAF2_1	403	406	PF00917	0.460
LIG_TRAF2_1	73	76	PF00917	0.459
LIG_TRAF2_2	384	389	PF00917	0.409
LIG_TYR_ITIM	383	388	PF00017	0.509
LIG_UBA3_1	174	181	PF00899	0.452
LIG_UBA3_1	416	424	PF00899	0.489
LIG_WRC_WIRS_1	416	421	PF05994	0.409
MOD_CDK_SPxxK_3	445	452	PF00069	0.409
MOD_CK1_1	129	135	PF00069	0.464
MOD_CK1_1	28	34	PF00069	0.693
MOD_CK2_1	329	335	PF00069	0.414
MOD_CK2_1	400	406	PF00069	0.435
MOD_CK2_1	70	76	PF00069	0.460
MOD_GlcNHglycan	227	230	PF01048	0.215
MOD_GlcNHglycan	27	30	PF01048	0.542
MOD_GlcNHglycan	365	368	PF01048	0.209
MOD_GSK3_1	160	167	PF00069	0.452
MOD_GSK3_1	187	194	PF00069	0.398
MOD_GSK3_1	214	221	PF00069	0.411
MOD_GSK3_1	254	261	PF00069	0.420
MOD_GSK3_1	363	370	PF00069	0.420
MOD_N-GLC_1	126	131	PF02516	0.612
MOD_N-GLC_1	272	277	PF02516	0.291
MOD_N-GLC_1	50	55	PF02516	0.568
MOD_N-GLC_1	76	81	PF02516	0.645
MOD_N-GLC_2	437	439	PF02516	0.278
MOD_NEK2_1	11	16	PF00069	0.681
MOD_NEK2_1	248	253	PF00069	0.420
MOD_NEK2_1	272	277	PF00069	0.509
MOD_NEK2_1	398	403	PF00069	0.409
MOD_NEK2_2	367	372	PF00069	0.478
MOD_PKA_1	224	230	PF00069	0.509
MOD_PKA_2	224	230	PF00069	0.499
MOD_PKA_2	367	373	PF00069	0.478
MOD_Plk_1	126	132	PF00069	0.617
MOD_Plk_1	272	278	PF00069	0.491
MOD_Plk_1	329	335	PF00069	0.409
MOD_Plk_1	76	82	PF00069	0.586
MOD_Plk_2-3	201	207	PF00069	0.487
MOD_Plk_2-3	329	335	PF00069	0.409
MOD_Plk_4	218	224	PF00069	0.409
MOD_Plk_4	272	278	PF00069	0.509
MOD_Plk_4	338	344	PF00069	0.410
MOD_Plk_4	353	359	PF00069	0.413
MOD_Plk_4	367	373	PF00069	0.420
MOD_Plk_4	412	418	PF00069	0.409
MOD_ProDKin_1	139	145	PF00069	0.565
MOD_ProDKin_1	187	193	PF00069	0.494
MOD_ProDKin_1	254	260	PF00069	0.409
MOD_ProDKin_1	445	451	PF00069	0.420
MOD_SUMO_for_1	7	10	PF00179	0.673
MOD_SUMO_rev_2	201	208	PF00179	0.480
MOD_SUMO_rev_2	291	299	PF00179	0.456
TRG_DiLeu_BaEn_1	151	156	PF01217	0.409
TRG_DiLeu_BaEn_4	151	157	PF01217	0.429
TRG_DiLeu_BaLyEn_6	289	294	PF01217	0.509
TRG_DiLeu_LyEn_5	151	156	PF01217	0.418
TRG_ENDOCYTIC_2	216	219	PF00928	0.428
TRG_ENDOCYTIC_2	281	284	PF00928	0.409
TRG_ENDOCYTIC_2	304	307	PF00928	0.409
TRG_ENDOCYTIC_2	385	388	PF00928	0.420
TRG_ER_diArg_1	451	453	PF00400	0.409
TRG_NES_CRM1_1	450	463	PF08389	0.509
TRG_Pf-PMV_PEXEL_1	168	172	PF00026	0.209
TRG_Pf-PMV_PEXEL_1	292	296	PF00026	0.276
TRG_Pf-PMV_PEXEL_1	374	378	PF00026	0.209

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7F4	Leptomonas seymouri	82%	100%
A0A0S4IHQ3	Bodo saltans	59%	100%
A0A1X0P256	Trypanosomatidae	61%	99%
A0A422N4Z5	Trypanosoma rangeli	65%	100%
A4HHZ9	Leishmania braziliensis	90%	100%
A4I576	Leishmania infantum	99%	100%
A9UNU6	Monosiga brevicollis	44%	100%
C9ZQK2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	99%
E9B0H3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
O60071	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	40%	100%
P38333	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	38%	97%
P51406	Drosophila melanogaster	43%	100%
Q13895	Homo sapiens	39%	100%
Q20932	Caenorhabditis elegans	37%	100%
Q4Q7R0	Leishmania major	96%	100%
Q54IS0	Dictyostelium discoideum	42%	99%
Q5E9N0	Bos taurus	39%	100%
V5BGU1	Trypanosoma cruzi	64%	72%