Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IER1_LEIDO

TriTrypDb:

LdBPK_330690.1 , LdCL_330012400 , LDHU3_33.0980

Length:

117

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IER1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IER1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	4
GO:0005509	calcium ion binding	5	4
GO:0043167	ion binding	2	4
GO:0043169	cation binding	3	4
GO:0046872	metal ion binding	4	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	88	92	PF00656	0.510
DOC_MAPK_DCC_7	37	47	PF00069	0.638
DOC_PP1_RVXF_1	35	42	PF00149	0.667
DOC_WW_Pin1_4	20	25	PF00397	0.626
LIG_14-3-3_CanoR_1	32	39	PF00244	0.692
LIG_FHA_1	1	7	PF00498	0.771
LIG_LIR_Gen_1	109	115	PF02991	0.645
LIG_LIR_Gen_1	91	100	PF02991	0.662
LIG_LIR_Nem_3	109	113	PF02991	0.509
LIG_SH2_STAT5	68	71	PF00017	0.644
LIG_SUMO_SIM_anti_2	49	56	PF11976	0.656
LIG_TRAF2_1	86	89	PF00917	0.664
MOD_CK2_1	83	89	PF00069	0.629
MOD_GlcNHglycan	33	36	PF01048	0.738
MOD_GSK3_1	19	26	PF00069	0.687
MOD_NEK2_1	19	24	PF00069	0.502
MOD_NEK2_1	2	7	PF00069	0.759
MOD_PKA_2	31	37	PF00069	0.650
MOD_Plk_1	50	56	PF00069	0.666
MOD_Plk_4	50	56	PF00069	0.567
MOD_ProDKin_1	20	26	PF00069	0.626
TRG_DiLeu_BaEn_1	50	55	PF01217	0.650
TRG_DiLeu_BaEn_4	50	56	PF01217	0.654
TRG_ENDOCYTIC_2	107	110	PF00928	0.650

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HLA4	Leishmania braziliensis	74%	100%
A4I8T0	Leishmania infantum	100%	100%
Q4Q4E1	Leishmania major	94%	100%