Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IEQ6_LEIDO

TriTrypDb:

LdBPK_280790.1 , LdCL_280012500 , LDHU3_28.0960

Length:

394

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IEQ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEQ6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	187	191	PF00656	0.630
CLV_C14_Caspase3-7	296	300	PF00656	0.616
CLV_NRD_NRD_1	209	211	PF00675	0.586
CLV_NRD_NRD_1	354	356	PF00675	0.510
CLV_NRD_NRD_1	37	39	PF00675	0.566
CLV_NRD_NRD_1	392	394	PF00675	0.693
CLV_PCSK_KEX2_1	208	210	PF00082	0.564
CLV_PCSK_KEX2_1	354	356	PF00082	0.510
CLV_PCSK_KEX2_1	392	394	PF00082	0.693
CLV_PCSK_PC7_1	204	210	PF00082	0.682
CLV_PCSK_SKI1_1	108	112	PF00082	0.633
CLV_PCSK_SKI1_1	237	241	PF00082	0.629
CLV_PCSK_SKI1_1	274	278	PF00082	0.524
CLV_PCSK_SKI1_1	309	313	PF00082	0.671
CLV_PCSK_SKI1_1	334	338	PF00082	0.497
DEG_Nend_UBRbox_2	1	3	PF02207	0.547
DEG_SCF_FBW7_1	148	155	PF00400	0.529
DOC_CYCLIN_RxL_1	105	115	PF00134	0.648
DOC_MAPK_JIP1_4	106	112	PF00069	0.694
DOC_PP2B_LxvP_1	381	384	PF13499	0.654
DOC_USP7_MATH_1	152	156	PF00917	0.599
DOC_USP7_UBL2_3	330	334	PF12436	0.558
DOC_WW_Pin1_4	148	153	PF00397	0.647
DOC_WW_Pin1_4	285	290	PF00397	0.452
DOC_WW_Pin1_4	361	366	PF00397	0.566
LIG_14-3-3_CanoR_1	108	113	PF00244	0.651
LIG_14-3-3_CanoR_1	163	172	PF00244	0.522
LIG_14-3-3_CanoR_1	212	218	PF00244	0.653
LIG_14-3-3_CanoR_1	219	224	PF00244	0.634
LIG_14-3-3_CanoR_1	229	233	PF00244	0.637
LIG_14-3-3_CanoR_1	281	289	PF00244	0.541
LIG_FHA_1	11	17	PF00498	0.565
LIG_FHA_1	275	281	PF00498	0.524
LIG_FHA_1	376	382	PF00498	0.719
LIG_FHA_2	120	126	PF00498	0.429
LIG_FHA_2	163	169	PF00498	0.537
LIG_FHA_2	229	235	PF00498	0.712
LIG_FHA_2	254	260	PF00498	0.552
LIG_FHA_2	294	300	PF00498	0.619
LIG_FHA_2	302	308	PF00498	0.632
LIG_FHA_2	362	368	PF00498	0.620
LIG_LIR_Apic_2	349	353	PF02991	0.631
LIG_LIR_Apic_2	374	380	PF02991	0.705
LIG_LIR_Gen_1	166	177	PF02991	0.519
LIG_LIR_Gen_1	197	207	PF02991	0.545
LIG_LIR_Gen_1	53	64	PF02991	0.560
LIG_LIR_Nem_3	166	172	PF02991	0.657
LIG_LIR_Nem_3	197	202	PF02991	0.546
LIG_LIR_Nem_3	211	217	PF02991	0.584
LIG_LIR_Nem_3	53	59	PF02991	0.569
LIG_Pex14_1	310	314	PF04695	0.547
LIG_PTB_Apo_2	279	286	PF02174	0.643
LIG_PTB_Phospho_1	279	285	PF10480	0.641
LIG_SH2_CRK	56	60	PF00017	0.569
LIG_SH2_GRB2like	56	59	PF00017	0.578
LIG_SH2_NCK_1	199	203	PF00017	0.558
LIG_SH2_NCK_1	263	267	PF00017	0.588
LIG_SH2_NCK_1	363	367	PF00017	0.635
LIG_SH2_NCK_1	56	60	PF00017	0.525
LIG_SH2_STAP1	373	377	PF00017	0.664
LIG_SH2_STAT3	30	33	PF00017	0.651
LIG_SH2_STAT5	169	172	PF00017	0.508
LIG_SH2_STAT5	193	196	PF00017	0.643
LIG_SH2_STAT5	344	347	PF00017	0.507
LIG_SH2_STAT5	363	366	PF00017	0.494
LIG_SH2_STAT5	373	376	PF00017	0.551
LIG_SH2_STAT5	377	380	PF00017	0.525
LIG_SH2_STAT5	56	59	PF00017	0.575
LIG_SH3_3	15	21	PF00018	0.600
LIG_SH3_3	38	44	PF00018	0.544
LIG_TRAF2_1	289	292	PF00917	0.553
LIG_TRFH_1	285	289	PF08558	0.439
LIG_TYR_ITIM	54	59	PF00017	0.530
LIG_WW_3	16	20	PF00397	0.599
MOD_CK2_1	227	233	PF00069	0.684
MOD_CK2_1	253	259	PF00069	0.608
MOD_CK2_1	361	367	PF00069	0.627
MOD_GlcNHglycan	154	157	PF01048	0.672
MOD_GlcNHglycan	176	180	PF01048	0.541
MOD_GlcNHglycan	247	250	PF01048	0.537
MOD_GlcNHglycan	314	317	PF01048	0.599
MOD_GlcNHglycan	320	324	PF01048	0.593
MOD_GlcNHglycan	6	9	PF01048	0.605
MOD_GSK3_1	108	115	PF00069	0.568
MOD_GSK3_1	148	155	PF00069	0.582
MOD_GSK3_1	219	226	PF00069	0.667
MOD_GSK3_1	228	235	PF00069	0.606
MOD_GSK3_1	371	378	PF00069	0.710
MOD_GSK3_1	383	390	PF00069	0.682
MOD_GSK3_1	46	53	PF00069	0.613
MOD_N-GLC_1	75	80	PF02516	0.591
MOD_NEK2_1	112	117	PF00069	0.561
MOD_NEK2_1	232	237	PF00069	0.578
MOD_NEK2_1	253	258	PF00069	0.644
MOD_NEK2_1	280	285	PF00069	0.656
MOD_NEK2_1	293	298	PF00069	0.482
MOD_NEK2_1	4	9	PF00069	0.577
MOD_NEK2_1	54	59	PF00069	0.590
MOD_NEK2_1	75	80	PF00069	0.574
MOD_NEK2_1	93	98	PF00069	0.531
MOD_PIKK_1	101	107	PF00454	0.607
MOD_PIKK_1	223	229	PF00454	0.514
MOD_PIKK_1	293	299	PF00454	0.495
MOD_PIKK_1	75	81	PF00454	0.570
MOD_PIKK_1	93	99	PF00454	0.581
MOD_PKA_2	162	168	PF00069	0.485
MOD_PKA_2	228	234	PF00069	0.633
MOD_PKA_2	280	286	PF00069	0.625
MOD_PKB_1	208	216	PF00069	0.674
MOD_Plk_1	210	216	PF00069	0.670
MOD_Plk_1	223	229	PF00069	0.648
MOD_Plk_1	274	280	PF00069	0.591
MOD_Plk_1	45	51	PF00069	0.563
MOD_Plk_1	75	81	PF00069	0.592
MOD_Plk_4	372	378	PF00069	0.735
MOD_Plk_4	383	389	PF00069	0.726
MOD_ProDKin_1	148	154	PF00069	0.651
MOD_ProDKin_1	285	291	PF00069	0.446
MOD_ProDKin_1	361	367	PF00069	0.562
MOD_SUMO_for_1	141	144	PF00179	0.520
TRG_AP2beta_CARGO_1	211	221	PF09066	0.578
TRG_ENDOCYTIC_2	169	172	PF00928	0.525
TRG_ENDOCYTIC_2	199	202	PF00928	0.552
TRG_ENDOCYTIC_2	373	376	PF00928	0.602
TRG_ENDOCYTIC_2	56	59	PF00928	0.528
TRG_ER_diArg_1	207	210	PF00400	0.596
TRG_ER_diArg_1	353	355	PF00400	0.498
TRG_Pf-PMV_PEXEL_1	108	113	PF00026	0.694

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDT5	Leptomonas seymouri	69%	92%
A0A0S4JAK0	Bodo saltans	28%	100%
A0A1X0NYG9	Trypanosomatidae	47%	93%
A0A3R7KQJ1	Trypanosoma rangeli	48%	92%
A4HGB5	Leishmania braziliensis	84%	99%
A4I3E9	Leishmania infantum	99%	100%
D0A7Z8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	94%
E9AZN6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q8J5	Leishmania major	95%	100%
V5BQC0	Trypanosoma cruzi	47%	91%