Deoxyhypusine synthase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

deoxyhypusine synthase-like

Species:

Leishmania donovani

UniProt:

A0A3Q8IEQ5_LEIDO

TriTrypDb:

LdBPK_200270.1 , LdCL_200007500 , LDHU3_20.0290

Length:

379

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IEQ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEQ5

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0008612	peptidyl-lysine modification to peptidyl-hypusine	3	12
GO:0009058	biosynthetic process	2	12
GO:0018193	peptidyl-amino acid modification	5	12
GO:0018205	peptidyl-lysine modification	6	12
GO:0019538	protein metabolic process	3	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044238	primary metabolic process	2	12
GO:0051604	protein maturation	4	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0016740	transferase activity	2	6
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	3	6
GO:0034038	deoxyhypusine synthase activity	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	170	172	PF00675	0.330
CLV_NRD_NRD_1	19	21	PF00675	0.770
CLV_NRD_NRD_1	284	286	PF00675	0.406
CLV_NRD_NRD_1	93	95	PF00675	0.306
CLV_PCSK_FUR_1	91	95	PF00082	0.277
CLV_PCSK_KEX2_1	169	171	PF00082	0.366
CLV_PCSK_KEX2_1	19	21	PF00082	0.773
CLV_PCSK_KEX2_1	93	95	PF00082	0.304
CLV_PCSK_PC7_1	166	172	PF00082	0.428
CLV_PCSK_SKI1_1	108	112	PF00082	0.393
CLV_PCSK_SKI1_1	9	13	PF00082	0.762
DEG_Nend_Nbox_1	1	3	PF02207	0.691
DOC_CKS1_1	192	197	PF01111	0.455
DOC_CYCLIN_yClb5_NLxxxL_5	292	300	PF00134	0.373
DOC_MAPK_gen_1	292	300	PF00069	0.324
DOC_MAPK_MEF2A_6	292	300	PF00069	0.338
DOC_MAPK_RevD_3	273	286	PF00069	0.455
DOC_PP2B_LxvP_1	179	182	PF13499	0.308
DOC_PP4_FxxP_1	192	195	PF00568	0.323
DOC_USP7_MATH_1	112	116	PF00917	0.323
DOC_USP7_MATH_1	23	27	PF00917	0.690
DOC_USP7_MATH_1	37	41	PF00917	0.696
DOC_USP7_MATH_1	48	52	PF00917	0.596
DOC_USP7_MATH_1	74	78	PF00917	0.436
DOC_USP7_UBL2_3	21	25	PF12436	0.671
DOC_WW_Pin1_4	101	106	PF00397	0.455
DOC_WW_Pin1_4	191	196	PF00397	0.455
DOC_WW_Pin1_4	248	253	PF00397	0.323
DOC_WW_Pin1_4	44	49	PF00397	0.706
LIG_14-3-3_CanoR_1	208	215	PF00244	0.340
LIG_14-3-3_CanoR_1	244	250	PF00244	0.455
LIG_14-3-3_CanoR_1	311	316	PF00244	0.424
LIG_Actin_WH2_2	297	313	PF00022	0.428
LIG_Actin_WH2_2	57	75	PF00022	0.483
LIG_AP2alpha_1	189	193	PF02296	0.342
LIG_BRCT_BRCA1_1	250	254	PF00533	0.393
LIG_CaM_IQ_9	197	212	PF13499	0.338
LIG_FHA_1	192	198	PF00498	0.464
LIG_FHA_1	233	239	PF00498	0.399
LIG_FHA_1	320	326	PF00498	0.393
LIG_FHA_1	347	353	PF00498	0.455
LIG_FHA_1	79	85	PF00498	0.455
LIG_FHA_2	321	327	PF00498	0.342
LIG_FHA_2	65	71	PF00498	0.529
LIG_GBD_Chelix_1	296	304	PF00786	0.455
LIG_LIR_Apic_2	190	195	PF02991	0.308
LIG_LIR_Gen_1	124	134	PF02991	0.323
LIG_LIR_Gen_1	184	193	PF02991	0.323
LIG_LIR_Gen_1	59	66	PF02991	0.443
LIG_LIR_Nem_3	107	113	PF02991	0.322
LIG_LIR_Nem_3	124	129	PF02991	0.248
LIG_LIR_Nem_3	184	189	PF02991	0.308
LIG_LIR_Nem_3	190	196	PF02991	0.308
LIG_LIR_Nem_3	237	243	PF02991	0.308
LIG_LIR_Nem_3	59	63	PF02991	0.426
LIG_PCNA_yPIPBox_3	306	319	PF02747	0.455
LIG_Pex14_1	188	192	PF04695	0.428
LIG_Pex14_2	189	193	PF04695	0.308
LIG_Pex14_2	250	254	PF04695	0.393
LIG_PTB_Apo_2	180	187	PF02174	0.308
LIG_PTB_Phospho_1	180	186	PF10480	0.308
LIG_RPA_C_Fungi	88	100	PF08784	0.365
LIG_SH2_STAP1	113	117	PF00017	0.308
LIG_SH2_STAT5	113	116	PF00017	0.308
LIG_SH2_STAT5	128	131	PF00017	0.308
LIG_SH2_STAT5	186	189	PF00017	0.323
LIG_SH2_STAT5	264	267	PF00017	0.310
LIG_SH3_3	2	8	PF00018	0.680
LIG_SH3_3	246	252	PF00018	0.336
LIG_SH3_3	271	277	PF00018	0.323
LIG_SH3_3	357	363	PF00018	0.455
LIG_SUMO_SIM_par_1	316	323	PF11976	0.394
LIG_SUMO_SIM_par_1	362	370	PF11976	0.355
LIG_TRAF2_1	199	202	PF00917	0.338
LIG_TRAF2_1	66	69	PF00917	0.541
MOD_CDK_SPK_2	44	49	PF00069	0.514
MOD_CDK_SPxxK_3	101	108	PF00069	0.455
MOD_CK1_1	15	21	PF00069	0.760
MOD_CK1_1	24	30	PF00069	0.772
MOD_CK1_1	248	254	PF00069	0.461
MOD_CK1_1	78	84	PF00069	0.428
MOD_CK2_1	196	202	PF00069	0.391
MOD_CK2_1	320	326	PF00069	0.365
MOD_CK2_1	64	70	PF00069	0.536
MOD_GlcNHglycan	14	17	PF01048	0.746
MOD_GlcNHglycan	140	143	PF01048	0.393
MOD_GlcNHglycan	21	24	PF01048	0.752
MOD_GlcNHglycan	332	335	PF01048	0.404
MOD_GlcNHglycan	35	38	PF01048	0.685
MOD_GlcNHglycan	39	42	PF01048	0.630
MOD_GSK3_1	112	119	PF00069	0.299
MOD_GSK3_1	15	22	PF00069	0.766
MOD_GSK3_1	204	211	PF00069	0.323
MOD_GSK3_1	230	237	PF00069	0.361
MOD_GSK3_1	248	255	PF00069	0.180
MOD_GSK3_1	33	40	PF00069	0.575
MOD_GSK3_1	44	51	PF00069	0.618
MOD_GSK3_1	64	71	PF00069	0.394
MOD_GSK3_1	74	81	PF00069	0.432
MOD_N-GLC_1	266	271	PF02516	0.308
MOD_N-GLC_1	311	316	PF02516	0.455
MOD_N-GLC_2	185	187	PF02516	0.323
MOD_NEK2_1	1	6	PF00069	0.686
MOD_NEK2_1	111	116	PF00069	0.295
MOD_NEK2_1	122	127	PF00069	0.291
MOD_NEK2_1	138	143	PF00069	0.267
MOD_NEK2_1	287	292	PF00069	0.337
MOD_NEK2_1	320	325	PF00069	0.422
MOD_NEK2_1	84	89	PF00069	0.374
MOD_PIKK_1	64	70	PF00454	0.538
MOD_PIKK_1	84	90	PF00454	0.428
MOD_PKA_1	12	18	PF00069	0.756
MOD_PKA_1	19	25	PF00069	0.755
MOD_PKA_2	122	128	PF00069	0.308
MOD_PKA_2	19	25	PF00069	0.761
MOD_PKA_2	204	210	PF00069	0.308
MOD_PKA_2	37	43	PF00069	0.405
MOD_Plk_1	311	317	PF00069	0.455
MOD_Plk_1	356	362	PF00069	0.308
MOD_Plk_1	68	74	PF00069	0.562
MOD_Plk_4	153	159	PF00069	0.308
MOD_Plk_4	234	240	PF00069	0.296
MOD_Plk_4	356	362	PF00069	0.314
MOD_Plk_4	59	65	PF00069	0.549
MOD_ProDKin_1	101	107	PF00069	0.455
MOD_ProDKin_1	191	197	PF00069	0.455
MOD_ProDKin_1	248	254	PF00069	0.323
MOD_ProDKin_1	44	50	PF00069	0.705
TRG_AP2beta_CARGO_1	124	133	PF09066	0.342
TRG_DiLeu_BaEn_2	105	111	PF01217	0.471
TRG_ENDOCYTIC_2	186	189	PF00928	0.308
TRG_ER_diArg_1	168	171	PF00400	0.365
TRG_ER_diArg_1	282	285	PF00400	0.314
TRG_ER_diArg_1	91	94	PF00400	0.310
TRG_Pf-PMV_PEXEL_1	93	97	PF00026	0.308

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4N5	Leptomonas seymouri	81%	100%
A0A0S4JCE9	Bodo saltans	51%	100%
A0A0S4KFM4	Bodo saltans	27%	97%
A0A1X0NWI9	Trypanosomatidae	61%	100%
A0A422NEH6	Trypanosoma rangeli	60%	100%
A3MVC9	Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1)	30%	100%
A4HYL6	Leishmania infantum	99%	100%
A4YHK6	Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)	27%	100%
A4ZZ93	Leishmania donovani	97%	100%
A6URC0	Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)	37%	100%
A8AA61	Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)	28%	100%
A9KDQ8	Coxiella burnetii (strain Dugway 5J108-111)	21%	100%
A9NCJ8	Coxiella burnetii (strain RSA 331 / Henzerling II)	21%	100%
B0R5L2	Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)	30%	100%
B2IZP9	Nostoc punctiforme (strain ATCC 29133 / PCC 73102)	23%	97%
B2KER6	Elusimicrobium minutum (strain Pei191)	22%	100%
B3QLU4	Chlorobaculum parvum (strain DSM 263 / NCIMB 8327)	26%	100%
B6YVB1	Thermococcus onnurineus (strain NA1)	37%	100%
B8HNE7	Cyanothece sp. (strain PCC 7425 / ATCC 29141)	23%	95%
C3MPN8	Sulfolobus islandicus (strain L.S.2.15 / Lassen #1)	25%	100%
C3MYN2	Sulfolobus islandicus (strain M.14.25 / Kamchatka #1)	25%	100%
C3N5B4	Sulfolobus islandicus (strain M.16.27)	25%	100%
C3NDW8	Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1)	25%	100%
C3NHT5	Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2)	25%	100%
C4KGY0	Sulfolobus islandicus (strain M.16.4 / Kamchatka #3)	25%	100%
C5A5L0	Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)	38%	100%
C9ZHW4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9AI79	Leishmania braziliensis	87%	100%
E9AUG5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O26230	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	25%	100%
O27984	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	22%	100%
O28088	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	24%	100%
O50105	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	37%	100%
O94337	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	100%
P38791	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	98%
P49365	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	37%	100%
P49366	Homo sapiens	39%	100%
P59650	Coxiella burnetii (strain RSA 493 / Nine Mile phase I)	21%	100%
P60038	Senecio vernalis	37%	100%
Q3TXU5	Mus musculus	40%	100%
Q4GZD1	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	58%	100%
Q4J978	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	26%	100%
Q4QD19	Leishmania major	96%	100%
Q54MQ7	Dictyostelium discoideum	38%	100%
Q58224	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	38%	100%
Q5JEY0	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	37%	100%
Q6AY53	Rattus norvegicus	40%	100%
Q6BJH5	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	34%	100%
Q6CG56	Yarrowia lipolytica (strain CLIB 122 / E 150)	38%	100%
Q6CNG7	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	36%	100%
Q6EWQ6	Bos taurus	40%	100%
Q6FRN2	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	36%	98%
Q6KZL5	Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)	29%	100%
Q6RJS2	Brassica napus	37%	100%
Q75EW4	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	35%	99%
Q8DKP1	Thermosynechococcus vestitus (strain NIES-2133 / IAM M-273 / BP-1)	23%	95%
Q8KGF7	Chlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS)	26%	100%
Q8PV89	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	21%	100%
Q8SQN2	Encephalitozoon cuniculi (strain GB-M1)	36%	100%
Q8TS38	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	22%	100%
Q8TXD7	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	25%	100%
Q8U407	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	38%	100%
Q8YQL7	Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)	23%	99%
Q8ZT09	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	26%	100%
Q971T3	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	25%	100%
Q977X6	Methanosarcina thermophila	21%	100%
Q97BN6	Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)	28%	100%
Q97ZF1	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	25%	100%
Q9AXQ8	Dianthus caryophyllus	37%	100%
Q9AXQ9	Musa acuminata	37%	100%
Q9AXR0	Solanum lycopersicum	37%	99%
Q9FI94	Arabidopsis thaliana	36%	100%
Q9HL74	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	30%	100%
Q9HPX2	Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)	30%	100%
Q9M4B0	Senecio vulgaris	37%	100%
Q9SC13	Senecio vernalis	37%	100%
Q9SC14	Senecio vernalis	39%	100%
Q9SC80	Nicotiana tabacum	36%	100%
Q9V0N5	Pyrococcus abyssi (strain GE5 / Orsay)	36%	100%
Q9VSF4	Drosophila melanogaster	39%	100%
Q9XXJ0	Caenorhabditis elegans	39%	100%
Q9YE72	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	28%	100%
V5C0C4	Trypanosoma cruzi	62%	100%