Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IEQ3_LEIDO

TriTrypDb:

LdBPK_301190.1 , LdCL_300017100 , LDHU3_30.1560

Length:

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A0A3Q8IEQ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEQ3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	88	90	PF00675	0.643
CLV_PCSK_KEX2_1	46	48	PF00082	0.594
CLV_PCSK_KEX2_1	70	72	PF00082	0.620
CLV_PCSK_KEX2_1	88	90	PF00082	0.643
CLV_PCSK_PC1ET2_1	46	48	PF00082	0.594
CLV_PCSK_PC1ET2_1	70	72	PF00082	0.620
CLV_PCSK_SKI1_1	57	61	PF00082	0.650
DEG_APCC_DBOX_1	70	78	PF00400	0.464
DOC_PP1_SILK_1	3	8	PF00149	0.605
DOC_USP7_MATH_1	75	79	PF00917	0.456
LIG_14-3-3_CanoR_1	10	16	PF00244	0.590
LIG_14-3-3_CanoR_1	57	66	PF00244	0.485
LIG_BIR_II_1	1	5	PF00653	0.657
LIG_BRCT_BRCA1_1	22	26	PF00533	0.598
LIG_EH1_1	2	10	PF00400	0.689
LIG_LIR_Gen_1	78	87	PF02991	0.400
LIG_LIR_Nem_3	23	29	PF02991	0.525
LIG_LIR_Nem_3	38	42	PF02991	0.391
LIG_SH2_CRK	29	33	PF00017	0.438
LIG_SH2_CRK	45	49	PF00017	0.390
LIG_SH2_STAP1	55	59	PF00017	0.463
LIG_SH2_STAT5	58	61	PF00017	0.447
LIG_SH3_1	47	53	PF00018	0.409
LIG_SH3_3	47	53	PF00018	0.409
LIG_WRC_WIRS_1	12	17	PF05994	0.589
MOD_CK1_1	20	26	PF00069	0.560
MOD_GSK3_1	11	18	PF00069	0.645
MOD_NEK2_1	15	20	PF00069	0.583
MOD_NEK2_1	32	37	PF00069	0.431
MOD_NEK2_1	83	88	PF00069	0.337
MOD_Plk_1	75	81	PF00069	0.455
MOD_Plk_4	32	38	PF00069	0.321
MOD_SUMO_for_1	53	56	PF00179	0.494
TRG_DiLeu_BaEn_3	61	67	PF01217	0.481
TRG_ENDOCYTIC_2	29	32	PF00928	0.357
TRG_ENDOCYTIC_2	45	48	PF00928	0.391
TRG_ENDOCYTIC_2	80	83	PF00928	0.390
TRG_ER_diArg_1	87	89	PF00400	0.440
TRG_Pf-PMV_PEXEL_1	57	61	PF00026	0.682

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMI3	Leptomonas seymouri	78%	100%
A0A422P532	Trypanosoma rangeli	56%	80%
A4HI67	Leishmania braziliensis	85%	100%
A4I5E4	Leishmania infantum	100%	100%
C9ZQS9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	99%
E9B0P2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q7J0	Leishmania major	91%	100%