LeishMANIAdb
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Divalent cation transporter, putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Divalent cation transporter, putative
Gene product:
divalent cation transporter, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8IEP9_LEIDO
TriTrypDb:
LdBPK_282060.1 * , LdCL_280025700 , LDHU3_28.2730
Length:
678

Annotations

LeishMANIAdb annotations

A bacterial-type Mg2+ transporter found in kinetoplastids.. Expanded extensively on multiple lineages, especially T cruzi

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 7
GO:0110165 cellular anatomical entity 1 7

Expansion

Sequence features

A0A3Q8IEP9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEP9

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 6
GO:0006811 monoatomic ion transport 4 6
GO:0006812 monoatomic cation transport 5 6
GO:0015693 magnesium ion transport 7 6
GO:0030001 metal ion transport 6 6
GO:0051179 localization 1 6
GO:0051234 establishment of localization 2 6
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 6
GO:0008324 monoatomic cation transmembrane transporter activity 4 6
GO:0015075 monoatomic ion transmembrane transporter activity 3 6
GO:0015318 inorganic molecular entity transmembrane transporter activity 3 6
GO:0022857 transmembrane transporter activity 2 6
GO:0022890 inorganic cation transmembrane transporter activity 4 6
GO:0046873 metal ion transmembrane transporter activity 5 6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 230 234 PF00656 0.635
CLV_C14_Caspase3-7 240 244 PF00656 0.466
CLV_NRD_NRD_1 191 193 PF00675 0.708
CLV_NRD_NRD_1 236 238 PF00675 0.842
CLV_NRD_NRD_1 411 413 PF00675 0.743
CLV_PCSK_KEX2_1 190 192 PF00082 0.711
CLV_PCSK_KEX2_1 236 238 PF00082 0.842
CLV_PCSK_KEX2_1 411 413 PF00082 0.743
CLV_PCSK_SKI1_1 485 489 PF00082 0.346
CLV_PCSK_SKI1_1 534 538 PF00082 0.324
CLV_PCSK_SKI1_1 87 91 PF00082 0.683
DEG_SPOP_SBC_1 101 105 PF00917 0.521
DEG_SPOP_SBC_1 637 641 PF00917 0.419
DOC_ANK_TNKS_1 307 314 PF00023 0.541
DOC_CDC14_PxL_1 110 118 PF14671 0.554
DOC_CDC14_PxL_1 619 627 PF14671 0.436
DOC_CKS1_1 288 293 PF01111 0.473
DOC_CKS1_1 448 453 PF01111 0.515
DOC_CYCLIN_yCln2_LP_2 115 118 PF00134 0.551
DOC_CYCLIN_yCln2_LP_2 418 424 PF00134 0.615
DOC_CYCLIN_yCln2_LP_2 540 546 PF00134 0.563
DOC_MAPK_gen_1 377 385 PF00069 0.414
DOC_MAPK_gen_1 516 524 PF00069 0.609
DOC_MAPK_gen_1 532 541 PF00069 0.451
DOC_MAPK_MEF2A_6 439 448 PF00069 0.455
DOC_PP2B_LxvP_1 115 118 PF13499 0.607
DOC_PP2B_LxvP_1 539 542 PF13499 0.546
DOC_PP4_FxxP_1 144 147 PF00568 0.636
DOC_PP4_FxxP_1 448 451 PF00568 0.604
DOC_USP7_MATH_1 123 127 PF00917 0.570
DOC_USP7_MATH_1 153 157 PF00917 0.566
DOC_USP7_MATH_1 164 168 PF00917 0.525
DOC_USP7_MATH_1 274 278 PF00917 0.570
DOC_USP7_MATH_1 296 300 PF00917 0.448
DOC_USP7_MATH_1 325 329 PF00917 0.552
DOC_USP7_MATH_1 339 343 PF00917 0.533
DOC_USP7_MATH_1 429 433 PF00917 0.514
DOC_WW_Pin1_4 149 154 PF00397 0.608
DOC_WW_Pin1_4 28 33 PF00397 0.588
DOC_WW_Pin1_4 287 292 PF00397 0.488
DOC_WW_Pin1_4 397 402 PF00397 0.636
DOC_WW_Pin1_4 447 452 PF00397 0.532
DOC_WW_Pin1_4 453 458 PF00397 0.490
DOC_WW_Pin1_4 544 549 PF00397 0.546
DOC_WW_Pin1_4 638 643 PF00397 0.346
DOC_WW_Pin1_4 97 102 PF00397 0.549
LIG_14-3-3_CanoR_1 236 242 PF00244 0.564
LIG_14-3-3_CanoR_1 341 347 PF00244 0.560
LIG_14-3-3_CanoR_1 35 45 PF00244 0.563
LIG_14-3-3_CanoR_1 551 559 PF00244 0.617
LIG_14-3-3_CanoR_1 561 567 PF00244 0.555
LIG_14-3-3_CanoR_1 582 588 PF00244 0.597
LIG_14-3-3_CanoR_1 594 602 PF00244 0.472
LIG_BIR_II_1 1 5 PF00653 0.550
LIG_BIR_III_2 160 164 PF00653 0.618
LIG_BRCT_BRCA1_1 298 302 PF00533 0.412
LIG_BRCT_BRCA1_1 41 45 PF00533 0.494
LIG_FHA_1 288 294 PF00498 0.470
LIG_FHA_1 482 488 PF00498 0.530
LIG_FHA_1 513 519 PF00498 0.564
LIG_FHA_1 611 617 PF00498 0.433
LIG_FHA_1 648 654 PF00498 0.375
LIG_FHA_2 238 244 PF00498 0.537
LIG_FHA_2 633 639 PF00498 0.419
LIG_HP1_1 291 295 PF01393 0.446
LIG_LIR_Gen_1 42 53 PF02991 0.585
LIG_LIR_Gen_1 641 651 PF02991 0.307
LIG_LIR_Gen_1 94 101 PF02991 0.566
LIG_LIR_Nem_3 243 248 PF02991 0.542
LIG_LIR_Nem_3 42 48 PF02991 0.587
LIG_LIR_Nem_3 640 646 PF02991 0.316
LIG_LIR_Nem_3 94 99 PF02991 0.556
LIG_MAD2 534 542 PF02301 0.546
LIG_MYND_1 114 118 PF01753 0.547
LIG_NRBOX 535 541 PF00104 0.546
LIG_Pex14_2 245 249 PF04695 0.535
LIG_SH2_CRK 663 667 PF00017 0.635
LIG_SH2_CRK 668 672 PF00017 0.612
LIG_SH2_CRK 96 100 PF00017 0.619
LIG_SH2_PTP2 254 257 PF00017 0.390
LIG_SH2_STAT5 248 251 PF00017 0.498
LIG_SH2_STAT5 254 257 PF00017 0.450
LIG_SH2_STAT5 459 462 PF00017 0.428
LIG_SH2_STAT5 479 482 PF00017 0.455
LIG_SH2_STAT5 604 607 PF00017 0.519
LIG_SH2_STAT5 67 70 PF00017 0.537
LIG_SH3_3 111 117 PF00018 0.611
LIG_SH3_3 129 135 PF00018 0.594
LIG_SH3_3 285 291 PF00018 0.506
LIG_SH3_3 398 404 PF00018 0.626
LIG_SH3_3 411 417 PF00018 0.453
LIG_SH3_3 448 454 PF00018 0.567
LIG_SH3_3 627 633 PF00018 0.404
LIG_SH3_3 95 101 PF00018 0.550
LIG_SUMO_SIM_anti_2 172 182 PF11976 0.412
LIG_SUMO_SIM_anti_2 462 471 PF11976 0.306
LIG_SUMO_SIM_anti_2 610 616 PF11976 0.516
LIG_SUMO_SIM_par_1 172 182 PF11976 0.412
LIG_SUMO_SIM_par_1 336 342 PF11976 0.495
LIG_SUMO_SIM_par_1 652 657 PF11976 0.427
LIG_TRAF2_1 171 174 PF00917 0.583
LIG_TYR_ITIM 661 666 PF00017 0.611
LIG_WRC_WIRS_1 301 306 PF05994 0.454
MOD_CDK_SPK_2 397 402 PF00069 0.553
MOD_CDK_SPxK_1 447 453 PF00069 0.517
MOD_CDK_SPxxK_3 28 35 PF00069 0.629
MOD_CDK_SPxxK_3 544 551 PF00069 0.619
MOD_CK1_1 100 106 PF00069 0.538
MOD_CK1_1 133 139 PF00069 0.610
MOD_CK1_1 152 158 PF00069 0.620
MOD_CK1_1 211 217 PF00069 0.629
MOD_CK1_1 266 272 PF00069 0.547
MOD_CK1_1 28 34 PF00069 0.628
MOD_CK1_1 328 334 PF00069 0.558
MOD_CK1_1 342 348 PF00069 0.564
MOD_CK1_1 349 355 PF00069 0.538
MOD_CK1_1 39 45 PF00069 0.495
MOD_CK1_1 431 437 PF00069 0.502
MOD_CK1_1 471 477 PF00069 0.439
MOD_CK1_1 550 556 PF00069 0.619
MOD_CK1_1 562 568 PF00069 0.544
MOD_CK1_1 589 595 PF00069 0.539
MOD_CK2_1 169 175 PF00069 0.500
MOD_CK2_1 213 219 PF00069 0.632
MOD_CK2_1 632 638 PF00069 0.419
MOD_CK2_1 9 15 PF00069 0.553
MOD_Cter_Amidation 409 412 PF01082 0.777
MOD_GlcNHglycan 125 128 PF01048 0.760
MOD_GlcNHglycan 194 197 PF01048 0.680
MOD_GlcNHglycan 210 213 PF01048 0.632
MOD_GlcNHglycan 233 236 PF01048 0.761
MOD_GlcNHglycan 304 307 PF01048 0.633
MOD_GlcNHglycan 341 344 PF01048 0.807
MOD_GlcNHglycan 38 41 PF01048 0.782
MOD_GlcNHglycan 473 476 PF01048 0.370
MOD_GlcNHglycan 49 52 PF01048 0.702
MOD_GlcNHglycan 588 591 PF01048 0.345
MOD_GSK3_1 123 130 PF00069 0.561
MOD_GSK3_1 133 140 PF00069 0.594
MOD_GSK3_1 149 156 PF00069 0.627
MOD_GSK3_1 192 199 PF00069 0.539
MOD_GSK3_1 208 215 PF00069 0.506
MOD_GSK3_1 218 225 PF00069 0.563
MOD_GSK3_1 263 270 PF00069 0.561
MOD_GSK3_1 274 281 PF00069 0.506
MOD_GSK3_1 296 303 PF00069 0.444
MOD_GSK3_1 323 330 PF00069 0.551
MOD_GSK3_1 342 349 PF00069 0.522
MOD_GSK3_1 364 371 PF00069 0.543
MOD_GSK3_1 428 435 PF00069 0.468
MOD_GSK3_1 449 456 PF00069 0.508
MOD_GSK3_1 463 470 PF00069 0.486
MOD_GSK3_1 555 562 PF00069 0.561
MOD_GSK3_1 565 572 PF00069 0.526
MOD_GSK3_1 603 610 PF00069 0.537
MOD_GSK3_1 632 639 PF00069 0.346
MOD_GSK3_1 97 104 PF00069 0.520
MOD_LATS_1 229 235 PF00433 0.565
MOD_N-GLC_1 381 386 PF02516 0.696
MOD_N-GLC_1 46 51 PF02516 0.763
MOD_N-GLC_1 583 588 PF02516 0.363
MOD_N-GLC_2 458 460 PF02516 0.656
MOD_NEK2_1 1 6 PF00069 0.549
MOD_NEK2_1 297 302 PF00069 0.415
MOD_NEK2_1 346 351 PF00069 0.558
MOD_NEK2_1 362 367 PF00069 0.455
MOD_NEK2_1 46 51 PF00069 0.494
MOD_NEK2_1 480 485 PF00069 0.546
MOD_NEK2_1 512 517 PF00069 0.564
MOD_NEK2_1 549 554 PF00069 0.507
MOD_NEK2_1 654 659 PF00069 0.424
MOD_NEK2_2 164 169 PF00069 0.602
MOD_PIKK_1 16 22 PF00454 0.595
MOD_PIKK_1 282 288 PF00454 0.549
MOD_PIKK_1 550 556 PF00454 0.536
MOD_PIKK_1 607 613 PF00454 0.546
MOD_PIKK_1 70 76 PF00454 0.535
MOD_PKA_2 550 556 PF00069 0.563
MOD_PKA_2 566 572 PF00069 0.546
MOD_PKB_1 190 198 PF00069 0.581
MOD_Plk_1 297 303 PF00069 0.467
MOD_Plk_1 368 374 PF00069 0.573
MOD_Plk_1 381 387 PF00069 0.486
MOD_Plk_1 583 589 PF00069 0.563
MOD_Plk_2-3 213 219 PF00069 0.636
MOD_Plk_4 297 303 PF00069 0.482
MOD_Plk_4 468 474 PF00069 0.411
MOD_Plk_4 566 572 PF00069 0.486
MOD_Plk_4 9 15 PF00069 0.497
MOD_ProDKin_1 149 155 PF00069 0.608
MOD_ProDKin_1 28 34 PF00069 0.586
MOD_ProDKin_1 287 293 PF00069 0.480
MOD_ProDKin_1 397 403 PF00069 0.634
MOD_ProDKin_1 447 453 PF00069 0.530
MOD_ProDKin_1 544 550 PF00069 0.546
MOD_ProDKin_1 638 644 PF00069 0.346
MOD_ProDKin_1 97 103 PF00069 0.549
TRG_DiLeu_BaLyEn_6 111 116 PF01217 0.557
TRG_DiLeu_BaLyEn_6 591 596 PF01217 0.546
TRG_ENDOCYTIC_2 254 257 PF00928 0.458
TRG_ENDOCYTIC_2 663 666 PF00928 0.696
TRG_ENDOCYTIC_2 96 99 PF00928 0.623
TRG_ER_diArg_1 190 192 PF00400 0.511
TRG_ER_diArg_1 411 413 PF00400 0.545
TRG_Pf-PMV_PEXEL_1 485 490 PF00026 0.339
TRG_Pf-PMV_PEXEL_1 534 538 PF00026 0.346

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I5F0 Leptomonas seymouri 45% 93%
A4HGP8 Leishmania braziliensis 68% 99%
A4I3S1 Leishmania infantum 100% 100%
E9B013 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%
Q4Q872 Leishmania major 90% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS