F-box domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IEP6_LEIDO

TriTrypDb:

LdBPK_343650.1 , LdCL_340045900 , LDHU3_34.5900

Length:

259

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IEP6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEP6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	65	69	PF00082	0.548
CLV_PCSK_SKI1_1	93	97	PF00082	0.606
DEG_APCC_DBOX_1	28	36	PF00400	0.367
DOC_MAPK_gen_1	26	34	PF00069	0.469
DOC_PP2B_LxvP_1	185	188	PF13499	0.513
DOC_PP4_FxxP_1	152	155	PF00568	0.504
DOC_USP7_MATH_1	122	126	PF00917	0.679
DOC_USP7_MATH_1	142	146	PF00917	0.438
DOC_USP7_MATH_1	188	192	PF00917	0.516
DOC_WW_Pin1_4	144	149	PF00397	0.694
DOC_WW_Pin1_4	4	9	PF00397	0.721
LIG_14-3-3_CanoR_1	135	141	PF00244	0.697
LIG_14-3-3_CanoR_1	179	185	PF00244	0.462
LIG_BIR_II_1	1	5	PF00653	0.698
LIG_BRCT_BRCA1_1	155	159	PF00533	0.531
LIG_BRCT_BRCA1_1	190	194	PF00533	0.406
LIG_FHA_1	246	252	PF00498	0.508
LIG_FHA_1	41	47	PF00498	0.504
LIG_FHA_2	211	217	PF00498	0.547
LIG_FHA_2	230	236	PF00498	0.514
LIG_FHA_2	58	64	PF00498	0.528
LIG_LIR_Gen_1	156	167	PF02991	0.538
LIG_LIR_Gen_1	183	190	PF02991	0.467
LIG_LIR_Gen_1	59	68	PF02991	0.538
LIG_LIR_Nem_3	156	162	PF02991	0.464
LIG_LIR_Nem_3	17	22	PF02991	0.523
LIG_LIR_Nem_3	183	187	PF02991	0.520
LIG_LIR_Nem_3	191	196	PF02991	0.412
LIG_LIR_Nem_3	220	226	PF02991	0.411
LIG_LIR_Nem_3	59	64	PF02991	0.538
LIG_LIR_Nem_3	66	71	PF02991	0.520
LIG_MLH1_MIPbox_1	190	194	PF16413	0.498
LIG_NRBOX	108	114	PF00104	0.490
LIG_PCNA_yPIPBox_3	89	103	PF02747	0.407
LIG_SH2_STAP1	219	223	PF00017	0.364
LIG_SH2_STAT5	22	25	PF00017	0.393
LIG_SH2_STAT5	80	83	PF00017	0.656
LIG_SH3_3	10	16	PF00018	0.576
LIG_SH3_3	118	124	PF00018	0.656
LIG_SUMO_SIM_anti_2	30	36	PF11976	0.561
LIG_TRAF2_1	166	169	PF00917	0.542
LIG_TRAF2_1	8	11	PF00917	0.734
MOD_CDK_SPK_2	4	9	PF00069	0.637
MOD_CK1_1	125	131	PF00069	0.739
MOD_CK1_1	2	8	PF00069	0.725
MOD_CK2_1	229	235	PF00069	0.489
MOD_CK2_1	4	10	PF00069	0.751
MOD_CK2_1	57	63	PF00069	0.501
MOD_CMANNOS	181	184	PF00535	0.390
MOD_GlcNHglycan	4	7	PF01048	0.744
MOD_GlcNHglycan	74	77	PF01048	0.551
MOD_GSK3_1	122	129	PF00069	0.622
MOD_GSK3_1	153	160	PF00069	0.495
MOD_GSK3_1	218	225	PF00069	0.460
MOD_GSK3_1	74	81	PF00069	0.601
MOD_N-GLC_1	57	62	PF02516	0.542
MOD_N-GLC_2	176	178	PF02516	0.469
MOD_NEK2_1	105	110	PF00069	0.507
MOD_NEK2_1	157	162	PF00069	0.519
MOD_NEK2_1	78	83	PF00069	0.638
MOD_PIKK_1	142	148	PF00454	0.581
MOD_PIKK_1	150	156	PF00454	0.450
MOD_PKA_2	134	140	PF00069	0.545
MOD_Plk_1	188	194	PF00069	0.536
MOD_Plk_1	57	63	PF00069	0.544
MOD_Plk_4	153	159	PF00069	0.411
MOD_Plk_4	180	186	PF00069	0.500
MOD_Plk_4	57	63	PF00069	0.555
MOD_ProDKin_1	144	150	PF00069	0.679
MOD_ProDKin_1	4	10	PF00069	0.718
MOD_SUMO_rev_2	59	67	PF00179	0.553
MOD_SUMO_rev_2	90	95	PF00179	0.614

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE51	Leptomonas seymouri	55%	98%
A0A0S4KKN8	Bodo saltans	28%	92%
A0A1X0ND66	Trypanosomatidae	35%	100%
A0A422NSY2	Trypanosoma rangeli	37%	100%
A4HBA5	Leishmania braziliensis	69%	100%
A4IAF3	Leishmania infantum	99%	100%
C9ZLU1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9B5H7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4Q2F8	Leishmania major	86%	100%