Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IEP4_LEIDO

TriTrypDb:

LdBPK_300980.1 , LdCL_300015000 , LDHU3_30.1290

Length:

937

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IEP4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEP4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	76	80	PF00656	0.674
CLV_C14_Caspase3-7	821	825	PF00656	0.541
CLV_MEL_PAP_1	538	544	PF00089	0.459
CLV_NRD_NRD_1	3	5	PF00675	0.505
CLV_NRD_NRD_1	623	625	PF00675	0.436
CLV_NRD_NRD_1	876	878	PF00675	0.507
CLV_PCSK_KEX2_1	3	5	PF00082	0.505
CLV_PCSK_KEX2_1	320	322	PF00082	0.455
CLV_PCSK_KEX2_1	623	625	PF00082	0.436
CLV_PCSK_KEX2_1	927	929	PF00082	0.475
CLV_PCSK_PC1ET2_1	320	322	PF00082	0.455
CLV_PCSK_PC1ET2_1	927	929	PF00082	0.475
CLV_PCSK_PC7_1	619	625	PF00082	0.411
CLV_PCSK_SKI1_1	332	336	PF00082	0.435
CLV_PCSK_SKI1_1	619	623	PF00082	0.470
CLV_PCSK_SKI1_1	699	703	PF00082	0.416
CLV_PCSK_SKI1_1	861	865	PF00082	0.458
CLV_PCSK_SKI1_1	877	881	PF00082	0.519
CLV_PCSK_SKI1_1	910	914	PF00082	0.396
DEG_APCC_DBOX_1	860	868	PF00400	0.466
DEG_MDM2_SWIB_1	828	836	PF02201	0.368
DEG_Nend_Nbox_1	1	3	PF02207	0.497
DEG_SPOP_SBC_1	505	509	PF00917	0.731
DEG_SPOP_SBC_1	54	58	PF00917	0.543
DOC_CYCLIN_RxL_1	858	868	PF00134	0.462
DOC_MAPK_gen_1	320	326	PF00069	0.415
DOC_PP1_RVXF_1	864	870	PF00149	0.363
DOC_PP2B_LxvP_1	172	175	PF13499	0.540
DOC_USP7_MATH_1	230	234	PF00917	0.748
DOC_USP7_MATH_1	370	374	PF00917	0.707
DOC_USP7_MATH_1	377	381	PF00917	0.650
DOC_USP7_MATH_1	505	509	PF00917	0.665
DOC_USP7_MATH_1	512	516	PF00917	0.585
DOC_USP7_MATH_1	53	57	PF00917	0.575
DOC_USP7_MATH_1	631	635	PF00917	0.580
DOC_USP7_MATH_1	691	695	PF00917	0.471
DOC_USP7_MATH_1	71	75	PF00917	0.453
DOC_USP7_MATH_1	732	736	PF00917	0.671
DOC_USP7_MATH_1	8	12	PF00917	0.472
DOC_USP7_UBL2_3	568	572	PF12436	0.617
DOC_USP7_UBL2_3	910	914	PF12436	0.377
DOC_WW_Pin1_4	238	243	PF00397	0.632
DOC_WW_Pin1_4	571	576	PF00397	0.825
DOC_WW_Pin1_4	589	594	PF00397	0.490
DOC_WW_Pin1_4	661	666	PF00397	0.521
DOC_WW_Pin1_4	67	72	PF00397	0.713
DOC_WW_Pin1_4	730	735	PF00397	0.600
DOC_WW_Pin1_4	789	794	PF00397	0.611
DOC_WW_Pin1_4	797	802	PF00397	0.655
DOC_WW_Pin1_4	81	86	PF00397	0.509
LIG_14-3-3_CanoR_1	246	252	PF00244	0.569
LIG_14-3-3_CanoR_1	267	271	PF00244	0.561
LIG_14-3-3_CanoR_1	3	7	PF00244	0.519
LIG_14-3-3_CanoR_1	321	327	PF00244	0.462
LIG_14-3-3_CanoR_1	38	46	PF00244	0.541
LIG_14-3-3_CanoR_1	406	411	PF00244	0.546
LIG_14-3-3_CanoR_1	476	480	PF00244	0.644
LIG_14-3-3_CanoR_1	541	550	PF00244	0.426
LIG_14-3-3_CanoR_1	613	622	PF00244	0.405
LIG_14-3-3_CanoR_1	637	647	PF00244	0.460
LIG_14-3-3_CanoR_1	751	755	PF00244	0.571
LIG_14-3-3_CanoR_1	877	885	PF00244	0.525
LIG_Actin_WH2_2	381	399	PF00022	0.429
LIG_Actin_WH2_2	532	550	PF00022	0.539
LIG_Actin_WH2_2	608	625	PF00022	0.531
LIG_BRCT_BRCA1_1	408	412	PF00533	0.436
LIG_BRCT_BRCA1_1	640	644	PF00533	0.480
LIG_CaM_IQ_9	461	477	PF13499	0.539
LIG_eIF4E_1	126	132	PF01652	0.488
LIG_eIF4E_1	441	447	PF01652	0.454
LIG_eIF4E_1	90	96	PF01652	0.510
LIG_FHA_1	103	109	PF00498	0.530
LIG_FHA_1	154	160	PF00498	0.472
LIG_FHA_1	321	327	PF00498	0.507
LIG_FHA_1	380	386	PF00498	0.514
LIG_FHA_1	459	465	PF00498	0.450
LIG_FHA_1	56	62	PF00498	0.701
LIG_FHA_1	590	596	PF00498	0.550
LIG_FHA_1	607	613	PF00498	0.299
LIG_FHA_1	837	843	PF00498	0.507
LIG_FHA_2	155	161	PF00498	0.460
LIG_FHA_2	286	292	PF00498	0.501
LIG_FHA_2	299	305	PF00498	0.424
LIG_FHA_2	344	350	PF00498	0.627
LIG_FHA_2	544	550	PF00498	0.559
LIG_FHA_2	612	618	PF00498	0.528
LIG_FHA_2	924	930	PF00498	0.600
LIG_GBD_Chelix_1	859	867	PF00786	0.345
LIG_IBAR_NPY_1	775	777	PF08397	0.500
LIG_Integrin_isoDGR_2	635	637	PF01839	0.514
LIG_LIR_Gen_1	160	169	PF02991	0.374
LIG_LIR_Gen_1	288	296	PF02991	0.355
LIG_LIR_Gen_1	641	650	PF02991	0.434
LIG_LIR_Gen_1	720	729	PF02991	0.606
LIG_LIR_Gen_1	826	836	PF02991	0.411
LIG_LIR_Gen_1	853	864	PF02991	0.341
LIG_LIR_Gen_1	883	893	PF02991	0.365
LIG_LIR_Nem_3	304	309	PF02991	0.402
LIG_LIR_Nem_3	672	677	PF02991	0.537
LIG_LIR_Nem_3	720	724	PF02991	0.550
LIG_LIR_Nem_3	771	777	PF02991	0.529
LIG_LIR_Nem_3	826	831	PF02991	0.390
LIG_LIR_Nem_3	853	859	PF02991	0.328
LIG_LIR_Nem_3	883	888	PF02991	0.442
LIG_LIR_Nem_3	894	900	PF02991	0.344
LIG_MYND_1	661	665	PF01753	0.635
LIG_NRBOX	253	259	PF00104	0.348
LIG_PCNA_yPIPBox_3	16	28	PF02747	0.589
LIG_Pex14_1	279	283	PF04695	0.445
LIG_Pex14_2	309	313	PF04695	0.391
LIG_Pex14_2	828	832	PF04695	0.342
LIG_SH2_CRK	885	889	PF00017	0.451
LIG_SH2_NCK_1	77	81	PF00017	0.651
LIG_SH2_SRC	677	680	PF00017	0.410
LIG_SH2_SRC	77	80	PF00017	0.565
LIG_SH2_STAP1	162	166	PF00017	0.368
LIG_SH2_STAP1	607	611	PF00017	0.408
LIG_SH2_STAP1	885	889	PF00017	0.429
LIG_SH2_STAP1	90	94	PF00017	0.459
LIG_SH2_STAT3	607	610	PF00017	0.413
LIG_SH2_STAT5	114	117	PF00017	0.469
LIG_SH2_STAT5	12	15	PF00017	0.547
LIG_SH2_STAT5	525	528	PF00017	0.474
LIG_SH2_STAT5	677	680	PF00017	0.457
LIG_SH2_STAT5	767	770	PF00017	0.624
LIG_SH2_STAT5	849	852	PF00017	0.365
LIG_SH2_STAT5	885	888	PF00017	0.443
LIG_SH3_1	655	661	PF00018	0.601
LIG_SH3_2	244	249	PF14604	0.496
LIG_SH3_3	241	247	PF00018	0.535
LIG_SH3_3	373	379	PF00018	0.670
LIG_SH3_3	405	411	PF00018	0.526
LIG_SH3_3	547	553	PF00018	0.588
LIG_SH3_3	590	596	PF00018	0.614
LIG_SH3_3	655	661	PF00018	0.555
LIG_SH3_3	770	776	PF00018	0.526
LIG_SH3_4	568	575	PF00018	0.600
LIG_Sin3_3	618	625	PF02671	0.498
LIG_SUMO_SIM_anti_2	331	338	PF11976	0.537
LIG_SUMO_SIM_par_1	531	537	PF11976	0.379
LIG_SUMO_SIM_par_1	600	606	PF11976	0.479
LIG_SUMO_SIM_par_1	84	91	PF11976	0.426
LIG_TRAF2_1	419	422	PF00917	0.397
LIG_TRAF2_1	42	45	PF00917	0.468
LIG_TRAF2_1	497	500	PF00917	0.554
LIG_WRC_WIRS_1	132	137	PF05994	0.529
LIG_WRC_WIRS_1	96	101	PF05994	0.512
LIG_WW_3	246	250	PF00397	0.443
MOD_CK1_1	102	108	PF00069	0.459
MOD_CK1_1	154	160	PF00069	0.472
MOD_CK1_1	233	239	PF00069	0.747
MOD_CK1_1	262	268	PF00069	0.520
MOD_CK1_1	294	300	PF00069	0.508
MOD_CK1_1	357	363	PF00069	0.631
MOD_CK1_1	380	386	PF00069	0.510
MOD_CK1_1	490	496	PF00069	0.713
MOD_CK1_1	504	510	PF00069	0.704
MOD_CK1_1	540	546	PF00069	0.493
MOD_CK1_1	574	580	PF00069	0.781
MOD_CK1_1	606	612	PF00069	0.501
MOD_CK1_1	65	71	PF00069	0.665
MOD_CK1_1	694	700	PF00069	0.554
MOD_CK1_1	733	739	PF00069	0.694
MOD_CK1_1	841	847	PF00069	0.555
MOD_CK2_1	154	160	PF00069	0.472
MOD_CK2_1	343	349	PF00069	0.610
MOD_CK2_1	416	422	PF00069	0.438
MOD_CK2_1	500	506	PF00069	0.627
MOD_CK2_1	602	608	PF00069	0.445
MOD_CK2_1	611	617	PF00069	0.370
MOD_CK2_1	736	742	PF00069	0.688
MOD_CK2_1	85	91	PF00069	0.443
MOD_CK2_1	923	929	PF00069	0.508
MOD_GlcNHglycan	107	111	PF01048	0.510
MOD_GlcNHglycan	153	156	PF01048	0.514
MOD_GlcNHglycan	213	216	PF01048	0.677
MOD_GlcNHglycan	235	238	PF01048	0.725
MOD_GlcNHglycan	249	252	PF01048	0.495
MOD_GlcNHglycan	379	382	PF01048	0.632
MOD_GlcNHglycan	39	42	PF01048	0.491
MOD_GlcNHglycan	503	506	PF01048	0.769
MOD_GlcNHglycan	51	54	PF01048	0.516
MOD_GlcNHglycan	514	517	PF01048	0.693
MOD_GlcNHglycan	542	545	PF01048	0.560
MOD_GlcNHglycan	576	579	PF01048	0.749
MOD_GlcNHglycan	689	692	PF01048	0.482
MOD_GlcNHglycan	71	74	PF01048	0.429
MOD_GlcNHglycan	730	733	PF01048	0.645
MOD_GlcNHglycan	759	762	PF01048	0.586
MOD_GlcNHglycan	770	773	PF01048	0.486
MOD_GSK3_1	127	134	PF00069	0.566
MOD_GSK3_1	151	158	PF00069	0.515
MOD_GSK3_1	200	207	PF00069	0.599
MOD_GSK3_1	225	232	PF00069	0.704
MOD_GSK3_1	261	268	PF00069	0.577
MOD_GSK3_1	291	298	PF00069	0.462
MOD_GSK3_1	377	384	PF00069	0.711
MOD_GSK3_1	402	409	PF00069	0.467
MOD_GSK3_1	448	455	PF00069	0.519
MOD_GSK3_1	49	56	PF00069	0.584
MOD_GSK3_1	500	507	PF00069	0.682
MOD_GSK3_1	514	521	PF00069	0.543
MOD_GSK3_1	563	570	PF00069	0.717
MOD_GSK3_1	576	583	PF00069	0.754
MOD_GSK3_1	602	609	PF00069	0.560
MOD_GSK3_1	65	72	PF00069	0.520
MOD_GSK3_1	687	694	PF00069	0.583
MOD_GSK3_1	728	735	PF00069	0.679
MOD_GSK3_1	750	757	PF00069	0.610
MOD_GSK3_1	783	790	PF00069	0.679
MOD_GSK3_1	81	88	PF00069	0.550
MOD_GSK3_1	837	844	PF00069	0.410
MOD_GSK3_1	873	880	PF00069	0.500
MOD_GSK3_1	95	102	PF00069	0.400
MOD_N-GLC_1	629	634	PF02516	0.473
MOD_N-GLC_1	883	888	PF02516	0.455
MOD_N-GLC_2	785	787	PF02516	0.608
MOD_NEK2_1	108	113	PF00069	0.400
MOD_NEK2_1	131	136	PF00069	0.515
MOD_NEK2_1	151	156	PF00069	0.303
MOD_NEK2_1	2	7	PF00069	0.449
MOD_NEK2_1	392	397	PF00069	0.397
MOD_NEK2_1	431	436	PF00069	0.668
MOD_NEK2_1	452	457	PF00069	0.409
MOD_NEK2_1	484	489	PF00069	0.724
MOD_NEK2_1	511	516	PF00069	0.732
MOD_NEK2_1	587	592	PF00069	0.634
MOD_NEK2_1	611	616	PF00069	0.537
MOD_NEK2_1	687	692	PF00069	0.473
MOD_NEK2_1	728	733	PF00069	0.563
MOD_NEK2_1	743	748	PF00069	0.647
MOD_NEK2_1	768	773	PF00069	0.705
MOD_NEK2_1	836	841	PF00069	0.489
MOD_NEK2_1	95	100	PF00069	0.413
MOD_NEK2_2	525	530	PF00069	0.488
MOD_PIKK_1	102	108	PF00454	0.546
MOD_PIKK_1	606	612	PF00454	0.584
MOD_PIKK_1	639	645	PF00454	0.518
MOD_PIKK_1	736	742	PF00454	0.671
MOD_PIKK_1	795	801	PF00454	0.613
MOD_PIKK_1	877	883	PF00454	0.522
MOD_PK_1	838	844	PF00069	0.469
MOD_PKA_1	320	326	PF00069	0.308
MOD_PKA_1	877	883	PF00069	0.522
MOD_PKA_2	2	8	PF00069	0.510
MOD_PKA_2	266	272	PF00069	0.406
MOD_PKA_2	320	326	PF00069	0.444
MOD_PKA_2	37	43	PF00069	0.491
MOD_PKA_2	370	376	PF00069	0.630
MOD_PKA_2	475	481	PF00069	0.525
MOD_PKA_2	48	54	PF00069	0.524
MOD_PKA_2	490	496	PF00069	0.670
MOD_PKA_2	540	546	PF00069	0.431
MOD_PKA_2	639	645	PF00069	0.453
MOD_PKA_2	680	686	PF00069	0.488
MOD_PKA_2	691	697	PF00069	0.396
MOD_PKA_2	750	756	PF00069	0.568
MOD_PKA_2	918	924	PF00069	0.587
MOD_Plk_1	121	127	PF00069	0.512
MOD_Plk_1	681	687	PF00069	0.461
MOD_Plk_1	810	816	PF00069	0.548
MOD_Plk_1	883	889	PF00069	0.405
MOD_Plk_1	891	897	PF00069	0.359
MOD_Plk_2-3	359	365	PF00069	0.773
MOD_Plk_4	127	133	PF00069	0.397
MOD_Plk_4	253	259	PF00069	0.348
MOD_Plk_4	291	297	PF00069	0.569
MOD_Plk_4	384	390	PF00069	0.384
MOD_Plk_4	424	430	PF00069	0.440
MOD_Plk_4	448	454	PF00069	0.536
MOD_Plk_4	534	540	PF00069	0.414
MOD_Plk_4	583	589	PF00069	0.682
MOD_Plk_4	8	14	PF00069	0.459
MOD_Plk_4	85	91	PF00069	0.528
MOD_Plk_4	883	889	PF00069	0.402
MOD_Plk_4	892	898	PF00069	0.353
MOD_Plk_4	95	101	PF00069	0.425
MOD_ProDKin_1	238	244	PF00069	0.630
MOD_ProDKin_1	571	577	PF00069	0.824
MOD_ProDKin_1	589	595	PF00069	0.485
MOD_ProDKin_1	661	667	PF00069	0.514
MOD_ProDKin_1	67	73	PF00069	0.718
MOD_ProDKin_1	730	736	PF00069	0.600
MOD_ProDKin_1	789	795	PF00069	0.610
MOD_ProDKin_1	797	803	PF00069	0.652
MOD_ProDKin_1	81	87	PF00069	0.491
TRG_DiLeu_BaEn_1	331	336	PF01217	0.438
TRG_DiLeu_BaEn_1	91	96	PF01217	0.382
TRG_DiLeu_BaLyEn_6	14	19	PF01217	0.496
TRG_DiLeu_BaLyEn_6	177	182	PF01217	0.423
TRG_ENDOCYTIC_2	162	165	PF00928	0.371
TRG_ENDOCYTIC_2	885	888	PF00928	0.419
TRG_ER_diArg_1	2	4	PF00400	0.556
TRG_ER_diArg_1	622	624	PF00400	0.600
TRG_Pf-PMV_PEXEL_1	17	21	PF00026	0.525
TRG_Pf-PMV_PEXEL_1	766	770	PF00026	0.521
TRG_Pf-PMV_PEXEL_1	898	902	PF00026	0.485

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3M8	Leptomonas seymouri	58%	100%
A0A0S4JAN9	Bodo saltans	29%	100%
A0A1X0P2C0	Trypanosomatidae	36%	100%
A0A422P4V0	Trypanosoma rangeli	35%	100%
A4HI47	Leishmania braziliensis	82%	99%
A4I5C3	Leishmania infantum	100%	100%
E9B0M1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q7L1	Leishmania major	95%	100%
V5BU87	Trypanosoma cruzi	36%	100%