F-box domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IEP2_LEIDO

TriTrypDb:

LdBPK_300110.1 , LdCL_300006200 , LDHU3_30.0210

Length:

427

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 8
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	10
GO:0042995	cell projection	2	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0110165	cellular anatomical entity	1	10
GO:0120025	plasma membrane bounded cell projection	3	10

Expansion

Sequence features

A0A3Q8IEP2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEP2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	110	114	PF00656	0.489
CLV_NRD_NRD_1	148	150	PF00675	0.608
CLV_NRD_NRD_1	186	188	PF00675	0.544
CLV_PCSK_KEX2_1	148	150	PF00082	0.491
CLV_PCSK_KEX2_1	186	188	PF00082	0.544
CLV_PCSK_SKI1_1	186	190	PF00082	0.489
CLV_PCSK_SKI1_1	264	268	PF00082	0.484
DEG_Nend_UBRbox_2	1	3	PF02207	0.599
DEG_SCF_FBW7_1	368	375	PF00400	0.468
DOC_CDC14_PxL_1	225	233	PF14671	0.488
DOC_CKS1_1	369	374	PF01111	0.552
DOC_CYCLIN_RxL_1	390	400	PF00134	0.540
DOC_CYCLIN_yCln2_LP_2	99	105	PF00134	0.430
DOC_MAPK_gen_1	393	403	PF00069	0.524
DOC_MAPK_gen_1	69	77	PF00069	0.547
DOC_MAPK_MEF2A_6	69	77	PF00069	0.564
DOC_PP1_RVXF_1	391	398	PF00149	0.488
DOC_USP7_MATH_1	133	137	PF00917	0.558
DOC_USP7_MATH_1	168	172	PF00917	0.565
DOC_WW_Pin1_4	124	129	PF00397	0.562
DOC_WW_Pin1_4	166	171	PF00397	0.547
DOC_WW_Pin1_4	26	31	PF00397	0.540
DOC_WW_Pin1_4	36	41	PF00397	0.509
DOC_WW_Pin1_4	368	373	PF00397	0.554
LIG_14-3-3_CanoR_1	148	155	PF00244	0.533
LIG_14-3-3_CanoR_1	186	195	PF00244	0.446
LIG_14-3-3_CanoR_1	258	267	PF00244	0.444
LIG_14-3-3_CanoR_1	396	402	PF00244	0.491
LIG_14-3-3_CanoR_1	405	409	PF00244	0.456
LIG_14-3-3_CanoR_1	72	78	PF00244	0.497
LIG_Actin_WH2_1	264	280	PF00022	0.532
LIG_BRCT_BRCA1_1	393	397	PF00533	0.515
LIG_eIF4E_1	410	416	PF01652	0.384
LIG_FHA_1	1	7	PF00498	0.551
LIG_FHA_1	149	155	PF00498	0.464
LIG_FHA_1	231	237	PF00498	0.470
LIG_FHA_1	274	280	PF00498	0.529
LIG_FHA_1	298	304	PF00498	0.520
LIG_FHA_1	319	325	PF00498	0.636
LIG_FHA_1	369	375	PF00498	0.501
LIG_FHA_1	390	396	PF00498	0.539
LIG_FHA_1	398	404	PF00498	0.459
LIG_FHA_1	65	71	PF00498	0.503
LIG_FHA_1	91	97	PF00498	0.462
LIG_FHA_2	108	114	PF00498	0.476
LIG_FHA_2	230	236	PF00498	0.489
LIG_FHA_2	358	364	PF00498	0.512
LIG_FHA_2	385	391	PF00498	0.492
LIG_FHA_2	74	80	PF00498	0.554
LIG_LIR_Apic_2	407	413	PF02991	0.590
LIG_LIR_Gen_1	290	299	PF02991	0.479
LIG_LIR_Gen_1	305	314	PF02991	0.345
LIG_LIR_Nem_3	290	295	PF02991	0.473
LIG_LIR_Nem_3	333	337	PF02991	0.502
LIG_NRBOX	116	122	PF00104	0.466
LIG_SH2_CRK	181	185	PF00017	0.539
LIG_SH2_CRK	334	338	PF00017	0.561
LIG_SH2_SRC	54	57	PF00017	0.402
LIG_SH2_STAT5	12	15	PF00017	0.549
LIG_SH2_STAT5	307	310	PF00017	0.529
LIG_SH2_STAT5	381	384	PF00017	0.466
LIG_SH2_STAT5	54	57	PF00017	0.557
LIG_SH3_3	162	168	PF00018	0.543
LIG_SH3_3	283	289	PF00018	0.440
LIG_SH3_4	199	206	PF00018	0.546
LIG_SUMO_SIM_anti_2	163	169	PF11976	0.524
LIG_SUMO_SIM_anti_2	263	269	PF11976	0.553
LIG_SUMO_SIM_anti_2	421	427	PF11976	0.261
LIG_SUMO_SIM_par_1	163	169	PF11976	0.501
LIG_SUMO_SIM_par_1	232	238	PF11976	0.498
LIG_SUMO_SIM_par_1	278	283	PF11976	0.463
LIG_SUMO_SIM_par_1	371	378	PF11976	0.456
LIG_SUMO_SIM_par_1	399	404	PF11976	0.488
LIG_TYR_ITIM	332	337	PF00017	0.554
LIG_WRC_WIRS_1	292	297	PF05994	0.503
MOD_CDC14_SPxK_1	39	42	PF00782	0.517
MOD_CDK_SPxK_1	36	42	PF00069	0.503
MOD_CK1_1	119	125	PF00069	0.510
MOD_CK1_1	156	162	PF00069	0.423
MOD_CK1_1	333	339	PF00069	0.546
MOD_CK1_1	375	381	PF00069	0.431
MOD_CK1_1	38	44	PF00069	0.588
MOD_CK2_1	119	125	PF00069	0.530
MOD_CK2_1	240	246	PF00069	0.520
MOD_CK2_1	257	263	PF00069	0.382
MOD_CK2_1	357	363	PF00069	0.340
MOD_CK2_1	377	383	PF00069	0.418
MOD_GlcNHglycan	121	124	PF01048	0.481
MOD_GlcNHglycan	144	147	PF01048	0.541
MOD_GlcNHglycan	155	158	PF01048	0.447
MOD_GlcNHglycan	18	21	PF01048	0.603
MOD_GlcNHglycan	281	285	PF01048	0.443
MOD_GlcNHglycan	61	64	PF01048	0.526
MOD_GSK3_1	107	114	PF00069	0.514
MOD_GSK3_1	129	136	PF00069	0.453
MOD_GSK3_1	138	145	PF00069	0.433
MOD_GSK3_1	168	175	PF00069	0.544
MOD_GSK3_1	230	237	PF00069	0.446
MOD_GSK3_1	287	294	PF00069	0.517
MOD_GSK3_1	36	43	PF00069	0.541
MOD_GSK3_1	368	375	PF00069	0.477
MOD_GSK3_1	397	404	PF00069	0.458
MOD_GSK3_1	420	427	PF00069	0.537
MOD_N-GLC_1	357	362	PF02516	0.519
MOD_NEK2_1	212	217	PF00069	0.519
MOD_NEK2_1	234	239	PF00069	0.447
MOD_NEK2_1	257	262	PF00069	0.515
MOD_NEK2_1	330	335	PF00069	0.459
MOD_NEK2_1	354	359	PF00069	0.424
MOD_NEK2_1	377	382	PF00069	0.405
MOD_NEK2_1	389	394	PF00069	0.382
MOD_NEK2_1	397	402	PF00069	0.216
MOD_NEK2_1	418	423	PF00069	0.477
MOD_NEK2_1	73	78	PF00069	0.459
MOD_NEK2_2	250	255	PF00069	0.506
MOD_NEK2_2	64	69	PF00069	0.456
MOD_PIKK_1	199	205	PF00454	0.538
MOD_PIKK_1	210	216	PF00454	0.421
MOD_PIKK_1	294	300	PF00454	0.520
MOD_PIKK_1	318	324	PF00454	0.580
MOD_PIKK_1	90	96	PF00454	0.472
MOD_PKA_1	148	154	PF00069	0.483
MOD_PKA_1	186	192	PF00069	0.531
MOD_PKA_2	138	144	PF00069	0.538
MOD_PKA_2	147	153	PF00069	0.483
MOD_PKA_2	186	192	PF00069	0.533
MOD_PKA_2	257	263	PF00069	0.464
MOD_PKA_2	404	410	PF00069	0.484
MOD_PKB_1	137	145	PF00069	0.526
MOD_Plk_1	357	363	PF00069	0.523
MOD_Plk_1	48	54	PF00069	0.647
MOD_Plk_4	111	117	PF00069	0.565
MOD_Plk_4	212	218	PF00069	0.481
MOD_Plk_4	291	297	PF00069	0.476
MOD_Plk_4	372	378	PF00069	0.428
MOD_Plk_4	420	426	PF00069	0.399
MOD_ProDKin_1	124	130	PF00069	0.561
MOD_ProDKin_1	166	172	PF00069	0.550
MOD_ProDKin_1	26	32	PF00069	0.539
MOD_ProDKin_1	36	42	PF00069	0.507
MOD_ProDKin_1	368	374	PF00069	0.547
MOD_SUMO_rev_2	57	62	PF00179	0.503
TRG_DiLeu_BaEn_1	263	268	PF01217	0.512
TRG_DiLeu_BaEn_1	363	368	PF01217	0.325
TRG_DiLeu_BaEn_2	290	296	PF01217	0.509
TRG_DiLeu_BaLyEn_6	180	185	PF01217	0.335
TRG_DiLeu_BaLyEn_6	226	231	PF01217	0.431
TRG_DiLeu_BaLyEn_6	369	374	PF01217	0.462
TRG_ENDOCYTIC_2	181	184	PF00928	0.551
TRG_ENDOCYTIC_2	334	337	PF00928	0.524
TRG_ER_diArg_1	137	140	PF00400	0.618
TRG_ER_diArg_1	185	187	PF00400	0.536
TRG_NES_CRM1_1	270	281	PF08389	0.530
TRG_Pf-PMV_PEXEL_1	223	227	PF00026	0.419

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2N3	Leptomonas seymouri	49%	99%
A0A1X0P2E5	Trypanosomatidae	27%	100%
A4HHV6	Leishmania braziliensis	78%	100%
A4I506	Leishmania infantum	99%	100%
C9ZQF6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	98%
E9B0D6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q7U4	Leishmania major	93%	100%
V5BLE7	Trypanosoma cruzi	26%	100%