Qb-SNARE_protein_putative/GeneDB:LmjF.23.1740

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IEP1_LEIDO

TriTrypDb:

LdBPK_231790.1 , LdCL_230025000 , LDHU3_23.2360

Length:

250

Annotations

LeishMANIAdb annotations

Similar to other Eukaryotic vesicle-associated V-SNARE proteins, especially VTI1.. Localization: Vesicular (by homology)

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 19
NetGPI	no	yes: 0, no: 20

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	16
GO:0016020	membrane	2	21
GO:0110165	cellular anatomical entity	1	21
GO:0005794	Golgi apparatus	5	5
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0005789	endoplasmic reticulum membrane	4	2
GO:0010008	endosome membrane	5	2
GO:0012506	vesicle membrane	4	2
GO:0012507	ER to Golgi transport vesicle membrane	6	2
GO:0030658	transport vesicle membrane	5	2
GO:0030659	cytoplasmic vesicle membrane	5	2
GO:0030662	coated vesicle membrane	5	2
GO:0031090	organelle membrane	3	2
GO:0031201	SNARE complex	3	2
GO:0031902	late endosome membrane	6	2
GO:0032991	protein-containing complex	1	2
GO:0098588	bounding membrane of organelle	4	2
GO:0098796	membrane protein complex	2	2

Expansion

Sequence features

A0A3Q8IEP1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEP1

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	20
GO:0008104	protein localization	4	20
GO:0009987	cellular process	1	20
GO:0015031	protein transport	4	20
GO:0033036	macromolecule localization	2	20
GO:0045184	establishment of protein localization	3	20
GO:0051179	localization	1	20
GO:0051234	establishment of localization	2	20
GO:0051641	cellular localization	2	20
GO:0070727	cellular macromolecule localization	3	20
GO:0071702	organic substance transport	4	20
GO:0071705	nitrogen compound transport	4	20
GO:0006886	intracellular protein transport	4	14
GO:0046907	intracellular transport	3	14
GO:0051649	establishment of localization in cell	3	14
GO:0016192	vesicle-mediated transport	4	11
GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	6	2
GO:0048193	Golgi vesicle transport	5	2
GO:0006906	vesicle fusion	6	2
GO:0006996	organelle organization	4	2
GO:0016043	cellular component organization	3	2
GO:0016050	vesicle organization	5	2
GO:0048284	organelle fusion	5	2
GO:0061024	membrane organization	4	2
GO:0061025	membrane fusion	5	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0090174	organelle membrane fusion	6	2

Molecular functions
Term	Name	Level	Count
GO:0005484	SNAP receptor activity	3	7
GO:0030674	protein-macromolecule adaptor activity	2	7
GO:0060090	molecular adaptor activity	1	7
GO:0000149	SNARE binding	3	2
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	142	146	PF00656	0.729
CLV_NRD_NRD_1	169	171	PF00675	0.485
CLV_NRD_NRD_1	98	100	PF00675	0.361
CLV_PCSK_SKI1_1	70	74	PF00082	0.351
DEG_APCC_DBOX_1	183	191	PF00400	0.696
DOC_CYCLIN_RxL_1	149	160	PF00134	0.704
DOC_MAPK_gen_1	227	235	PF00069	0.425
DOC_MAPK_MEF2A_6	229	237	PF00069	0.280
LIG_14-3-3_CanoR_1	191	200	PF00244	0.645
LIG_Actin_WH2_2	98	115	PF00022	0.534
LIG_BIR_II_1	1	5	PF00653	0.598
LIG_BRCT_BRCA1_1	1	5	PF00533	0.580
LIG_FHA_1	120	126	PF00498	0.681
LIG_FHA_1	157	163	PF00498	0.587
LIG_FHA_1	164	170	PF00498	0.558
LIG_FHA_1	177	183	PF00498	0.645
LIG_FHA_1	192	198	PF00498	0.508
LIG_FHA_1	202	208	PF00498	0.637
LIG_FHA_1	48	54	PF00498	0.698
LIG_FHA_2	140	146	PF00498	0.672
LIG_FHA_2	190	196	PF00498	0.644
LIG_LIR_Apic_2	41	47	PF02991	0.713
LIG_LIR_Nem_3	2	8	PF02991	0.604
LIG_Pex14_2	242	246	PF04695	0.393
LIG_SH2_CRK	44	48	PF00017	0.674
LIG_SH2_STAP1	8	12	PF00017	0.596
LIG_SH2_STAT3	175	178	PF00017	0.584
LIG_SH2_STAT5	175	178	PF00017	0.676
LIG_SUMO_SIM_par_1	152	160	PF11976	0.718
LIG_TRAF2_1	7	10	PF00917	0.612
LIG_UBA3_1	153	161	PF00899	0.704
MOD_CK1_1	186	192	PF00069	0.681
MOD_CK2_1	189	195	PF00069	0.618
MOD_CK2_1	31	37	PF00069	0.694
MOD_CK2_1	4	10	PF00069	0.582
MOD_GlcNHglycan	1	4	PF01048	0.414
MOD_GlcNHglycan	129	132	PF01048	0.409
MOD_GlcNHglycan	33	36	PF01048	0.472
MOD_GSK3_1	47	54	PF00069	0.654
MOD_LATS_1	36	42	PF00433	0.638
MOD_N-GLC_1	12	17	PF02516	0.396
MOD_NEK2_1	112	117	PF00069	0.646
MOD_NEK2_1	12	17	PF00069	0.590
MOD_NEK2_1	127	132	PF00069	0.562
MOD_NEK2_1	176	181	PF00069	0.658
MOD_NEK2_1	221	226	PF00069	0.595
MOD_NEK2_1	72	77	PF00069	0.576
MOD_NEK2_2	165	170	PF00069	0.647
MOD_PIKK_1	145	151	PF00454	0.673
MOD_PIKK_1	189	195	PF00454	0.620
MOD_PKA_2	112	118	PF00069	0.670
MOD_PKA_2	183	189	PF00069	0.735
MOD_Plk_1	12	18	PF00069	0.614
MOD_Plk_4	72	78	PF00069	0.611
TRG_DiLeu_BaLyEn_6	149	154	PF01217	0.700
TRG_ER_diArg_1	213	216	PF00400	0.630
TRG_Pf-PMV_PEXEL_1	152	157	PF00026	0.480
TRG_Pf-PMV_PEXEL_1	17	21	PF00026	0.498
TRG_Pf-PMV_PEXEL_1	215	220	PF00026	0.441

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6G6	Leptomonas seymouri	35%	92%
A0A0N1HXG1	Leptomonas seymouri	68%	99%
A0A0S4IRD2	Bodo saltans	30%	86%
A0A1X0NWY4	Trypanosomatidae	34%	81%
A0A1X0NY79	Trypanosomatidae	36%	86%
A0A3S5IRB0	Trypanosoma rangeli	41%	90%
A0A3S7WY13	Leishmania donovani	36%	100%
A0A422NJV1	Trypanosoma rangeli	39%	100%
A4HD24	Leishmania braziliensis	85%	100%
A4HD25	Leishmania braziliensis	35%	100%
A4I0L1	Leishmania infantum	100%	100%
A4I0L2	Leishmania infantum	36%	100%
C9ZVI1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AWH2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9AWH3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
O89116	Mus musculus	24%	100%
Q4QAZ8	Leishmania major	36%	100%
Q4QAZ9	Leishmania major	96%	100%
Q96AJ9	Homo sapiens	23%	100%
Q9JI51	Rattus norvegicus	23%	100%
V5ARB2	Trypanosoma cruzi	37%	90%
V5BFR7	Trypanosoma cruzi	39%	96%