ATPase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

ATPase-like protein

Gene product:

ATPase-like protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IEP0_LEIDO

TriTrypDb:

LdBPK_281910.1 , LdCL_280024100 , LDHU3_28.2520

Length:

584

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005694	chromosome	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IEP0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEP0

Function

Biological processes
Term	Name	Level	Count
GO:0007049	cell cycle	2	6
GO:0009987	cellular process	1	7
GO:0022414	reproductive process	1	7
GO:0051321	meiotic cell cycle	2	6
GO:0000075	cell cycle checkpoint signaling	4	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006310	DNA recombination	5	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0007131	reciprocal meiotic recombination	3	1
GO:0007165	signal transduction	2	1
GO:0008152	metabolic process	1	1
GO:0010564	regulation of cell cycle process	5	1
GO:0010639	negative regulation of organelle organization	6	1
GO:0010948	negative regulation of cell cycle process	6	1
GO:0022402	cell cycle process	2	1
GO:0033043	regulation of organelle organization	5	1
GO:0033313	meiotic cell cycle checkpoint signaling	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0035556	intracellular signal transduction	3	1
GO:0035825	homologous recombination	6	1
GO:0040020	regulation of meiotic nuclear division	5	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0045786	negative regulation of cell cycle	5	1
GO:0045835	negative regulation of meiotic nuclear division	6	1
GO:0046483	heterocycle metabolic process	3	1
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051128	regulation of cellular component organization	4	1
GO:0051129	negative regulation of cellular component organization	5	1
GO:0051445	regulation of meiotic cell cycle	4	1
GO:0051447	negative regulation of meiotic cell cycle	5	1
GO:0051598	meiotic recombination checkpoint signaling	4	1
GO:0051726	regulation of cell cycle	4	1
GO:0051783	regulation of nuclear division	6	1
GO:0051784	negative regulation of nuclear division	7	1
GO:0065007	biological regulation	1	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:0140527	reciprocal homologous recombination	7	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901987	regulation of cell cycle phase transition	6	1
GO:1901988	negative regulation of cell cycle phase transition	7	1
GO:1903046	meiotic cell cycle process	2	1
GO:2000241	regulation of reproductive process	3	1
GO:2000242	negative regulation of reproductive process	4	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0016462	pyrophosphatase activity	5	7
GO:0016787	hydrolase activity	2	7
GO:0016817	hydrolase activity, acting on acid anhydrides	3	7
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	7
GO:0016887	ATP hydrolysis activity	7	7
GO:0017076	purine nucleotide binding	4	7
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	148	152	PF00656	0.639
CLV_C14_Caspase3-7	191	195	PF00656	0.312
CLV_C14_Caspase3-7	69	73	PF00656	0.531
CLV_NRD_NRD_1	52	54	PF00675	0.399
CLV_PCSK_KEX2_1	186	188	PF00082	0.384
CLV_PCSK_KEX2_1	268	270	PF00082	0.472
CLV_PCSK_KEX2_1	356	358	PF00082	0.313
CLV_PCSK_KEX2_1	382	384	PF00082	0.485
CLV_PCSK_KEX2_1	52	54	PF00082	0.399
CLV_PCSK_PC1ET2_1	186	188	PF00082	0.384
CLV_PCSK_PC1ET2_1	268	270	PF00082	0.440
CLV_PCSK_PC1ET2_1	356	358	PF00082	0.313
CLV_PCSK_PC1ET2_1	382	384	PF00082	0.470
CLV_PCSK_SKI1_1	213	217	PF00082	0.313
CLV_PCSK_SKI1_1	268	272	PF00082	0.313
CLV_PCSK_SKI1_1	515	519	PF00082	0.389
DEG_APCC_DBOX_1	246	254	PF00400	0.313
DEG_APCC_DBOX_1	558	566	PF00400	0.510
DEG_SPOP_SBC_1	468	472	PF00917	0.695
DEG_SPOP_SBC_1	5	9	PF00917	0.638
DOC_CDC14_PxL_1	517	525	PF14671	0.370
DOC_CDC14_PxL_1	70	78	PF14671	0.419
DOC_CYCLIN_RxL_1	365	375	PF00134	0.402
DOC_MAPK_MEF2A_6	19	26	PF00069	0.396
DOC_PP1_RVXF_1	211	218	PF00149	0.357
DOC_PP2B_LxvP_1	117	120	PF13499	0.505
DOC_PP4_FxxP_1	217	220	PF00568	0.313
DOC_PP4_FxxP_1	552	555	PF00568	0.445
DOC_SPAK_OSR1_1	368	372	PF12202	0.357
DOC_USP7_MATH_1	120	124	PF00917	0.686
DOC_USP7_MATH_1	162	166	PF00917	0.495
DOC_USP7_MATH_1	202	206	PF00917	0.380
DOC_USP7_MATH_1	301	305	PF00917	0.313
DOC_USP7_MATH_1	311	315	PF00917	0.313
DOC_USP7_MATH_1	390	394	PF00917	0.652
DOC_USP7_MATH_1	423	427	PF00917	0.632
DOC_USP7_MATH_1	456	460	PF00917	0.551
DOC_USP7_MATH_1	5	9	PF00917	0.638
DOC_USP7_MATH_2	12	18	PF00917	0.604
DOC_WW_Pin1_4	156	161	PF00397	0.400
DOC_WW_Pin1_4	483	488	PF00397	0.727
DOC_WW_Pin1_4	6	11	PF00397	0.730
LIG_14-3-3_CanoR_1	198	204	PF00244	0.376
LIG_14-3-3_CanoR_1	239	245	PF00244	0.440
LIG_14-3-3_CanoR_1	261	270	PF00244	0.313
LIG_14-3-3_CanoR_1	27	35	PF00244	0.510
LIG_14-3-3_CanoR_1	4	10	PF00244	0.737
LIG_BIR_III_2	72	76	PF00653	0.544
LIG_BRCT_BRCA1_1	181	185	PF00533	0.377
LIG_BRCT_BRCA1_1	204	208	PF00533	0.473
LIG_BRCT_BRCA1_1	259	263	PF00533	0.313
LIG_Clathr_ClatBox_1	21	25	PF01394	0.372
LIG_EH1_1	495	503	PF00400	0.424
LIG_eIF4E_1	245	251	PF01652	0.313
LIG_eIF4E_1	496	502	PF01652	0.411
LIG_FHA_1	153	159	PF00498	0.429
LIG_FHA_1	16	22	PF00498	0.490
LIG_FHA_1	337	343	PF00498	0.313
LIG_FHA_1	390	396	PF00498	0.670
LIG_FHA_1	65	71	PF00498	0.468
LIG_FHA_2	26	32	PF00498	0.498
LIG_FHA_2	321	327	PF00498	0.320
LIG_FHA_2	495	501	PF00498	0.466
LIG_FHA_2	96	102	PF00498	0.414
LIG_GBD_Chelix_1	232	240	PF00786	0.440
LIG_GBD_Chelix_1	317	325	PF00786	0.373
LIG_Integrin_isoDGR_2	513	515	PF01839	0.394
LIG_LIR_Gen_1	167	175	PF02991	0.379
LIG_LIR_Gen_1	17	26	PF02991	0.411
LIG_LIR_Gen_1	210	217	PF02991	0.342
LIG_LIR_Gen_1	44	50	PF02991	0.438
LIG_LIR_Gen_1	96	105	PF02991	0.417
LIG_LIR_LC3C_4	18	23	PF02991	0.452
LIG_LIR_Nem_3	167	173	PF02991	0.383
LIG_LIR_Nem_3	17	23	PF02991	0.450
LIG_LIR_Nem_3	210	214	PF02991	0.354
LIG_LIR_Nem_3	32	38	PF02991	0.410
LIG_LIR_Nem_3	44	48	PF02991	0.366
LIG_Pex14_1	170	174	PF04695	0.352
LIG_Pex14_2	259	263	PF04695	0.313
LIG_SH2_CRK	373	377	PF00017	0.495
LIG_SH2_NCK_1	373	377	PF00017	0.429
LIG_SH2_PTP2	359	362	PF00017	0.290
LIG_SH2_PTP2	45	48	PF00017	0.369
LIG_SH2_SRC	192	195	PF00017	0.305
LIG_SH2_SRC	561	564	PF00017	0.496
LIG_SH2_STAT5	192	195	PF00017	0.362
LIG_SH2_STAT5	20	23	PF00017	0.483
LIG_SH2_STAT5	359	362	PF00017	0.290
LIG_SH2_STAT5	45	48	PF00017	0.369
LIG_SH2_STAT5	496	499	PF00017	0.416
LIG_SH2_STAT5	533	536	PF00017	0.465
LIG_SH2_STAT5	561	564	PF00017	0.496
LIG_SH3_3	357	363	PF00018	0.455
LIG_SH3_3	382	388	PF00018	0.439
LIG_SH3_3	478	484	PF00018	0.632
LIG_SH3_3	58	64	PF00018	0.414
LIG_SH3_3	7	13	PF00018	0.716
LIG_SH3_3	86	92	PF00018	0.402
LIG_SH3_4	461	468	PF00018	0.670
LIG_SH3_5	557	561	PF00018	0.534
LIG_SUMO_SIM_anti_2	574	579	PF11976	0.396
LIG_SUMO_SIM_par_1	20	25	PF11976	0.387
LIG_SUMO_SIM_par_1	333	340	PF11976	0.312
LIG_SUMO_SIM_par_1	66	72	PF11976	0.526
LIG_TRAF2_1	375	378	PF00917	0.365
LIG_TYR_ITIM	371	376	PF00017	0.369
LIG_TYR_ITSM	16	23	PF00017	0.508
MOD_CK1_1	123	129	PF00069	0.627
MOD_CK1_1	142	148	PF00069	0.450
MOD_CK1_1	152	158	PF00069	0.480
MOD_CK1_1	257	263	PF00069	0.313
MOD_CK1_1	6	12	PF00069	0.683
MOD_CK1_1	90	96	PF00069	0.541
MOD_CK2_1	372	378	PF00069	0.457
MOD_CK2_1	494	500	PF00069	0.490
MOD_CK2_1	95	101	PF00069	0.419
MOD_Cter_Amidation	266	269	PF01082	0.440
MOD_GlcNHglycan	122	125	PF01048	0.689
MOD_GlcNHglycan	144	147	PF01048	0.643
MOD_GlcNHglycan	151	154	PF01048	0.537
MOD_GlcNHglycan	265	268	PF01048	0.313
MOD_GlcNHglycan	303	306	PF01048	0.313
MOD_GlcNHglycan	435	438	PF01048	0.754
MOD_GlcNHglycan	491	494	PF01048	0.543
MOD_GlcNHglycan	541	544	PF01048	0.644
MOD_GlcNHglycan	581	584	PF01048	0.600
MOD_GSK3_1	119	126	PF00069	0.694
MOD_GSK3_1	152	159	PF00069	0.585
MOD_GSK3_1	175	182	PF00069	0.482
MOD_GSK3_1	203	210	PF00069	0.475
MOD_GSK3_1	220	227	PF00069	0.271
MOD_GSK3_1	25	32	PF00069	0.384
MOD_GSK3_1	257	264	PF00069	0.323
MOD_GSK3_1	336	343	PF00069	0.313
MOD_GSK3_1	485	492	PF00069	0.501
MOD_N-GLC_1	340	345	PF02516	0.313
MOD_NEK2_1	197	202	PF00069	0.450
MOD_NEK2_1	240	245	PF00069	0.317
MOD_NEK2_1	263	268	PF00069	0.319
MOD_NEK2_1	337	342	PF00069	0.322
MOD_NEK2_1	372	377	PF00069	0.439
MOD_NEK2_1	41	46	PF00069	0.366
MOD_NEK2_1	529	534	PF00069	0.483
MOD_NEK2_2	311	316	PF00069	0.313
MOD_PIKK_1	127	133	PF00454	0.537
MOD_PIKK_1	320	326	PF00454	0.313
MOD_PKA_2	197	203	PF00069	0.473
MOD_PKA_2	26	32	PF00069	0.498
MOD_PKA_2	3	9	PF00069	0.742
MOD_PKA_2	301	307	PF00069	0.313
MOD_Plk_1	15	21	PF00069	0.547
MOD_Plk_1	36	42	PF00069	0.388
MOD_Plk_1	447	453	PF00069	0.684
MOD_Plk_1	87	93	PF00069	0.426
MOD_Plk_2-3	188	194	PF00069	0.361
MOD_Plk_4	169	175	PF00069	0.351
MOD_Plk_4	188	194	PF00069	0.490
MOD_Plk_4	240	246	PF00069	0.415
MOD_Plk_4	254	260	PF00069	0.252
MOD_Plk_4	390	396	PF00069	0.677
MOD_ProDKin_1	156	162	PF00069	0.395
MOD_ProDKin_1	483	489	PF00069	0.726
MOD_ProDKin_1	6	12	PF00069	0.724
MOD_SUMO_rev_2	326	334	PF00179	0.289
TRG_DiLeu_BaEn_1	37	42	PF01217	0.497
TRG_DiLeu_BaEn_4	447	453	PF01217	0.684
TRG_DiLeu_BaLyEn_6	72	77	PF01217	0.534
TRG_ENDOCYTIC_2	20	23	PF00928	0.516
TRG_ENDOCYTIC_2	373	376	PF00928	0.491
TRG_ENDOCYTIC_2	45	48	PF00928	0.369
TRG_ER_diArg_1	52	54	PF00400	0.399
TRG_NES_CRM1_1	37	49	PF08389	0.493
TRG_Pf-PMV_PEXEL_1	230	234	PF00026	0.313

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P830	Leptomonas seymouri	55%	100%
A2XUN8	Oryza sativa subsp. indica	40%	100%
A4HGN2	Leishmania braziliensis	80%	100%
B9L3S8	Thermomicrobium roseum (strain ATCC 27502 / DSM 5159 / P-2)	26%	84%
E9AHG7	Leishmania infantum	99%	100%
E9AZZ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q887	Leishmania major	94%	100%
Q7XK25	Oryza sativa subsp. japonica	40%	100%