Inositol-pentakisphosphate 2-kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

inositol-pentakisphosphate 2-kinase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IEN4_LEIDO

TriTrypDb:

LdBPK_343490.1 , LdCL_340044300 , LDHU3_34.5730

Length:

458

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A0A3Q8IEN4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEN4

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016310	phosphorylation	5	12
GO:0044237	cellular metabolic process	2	12
GO:0005975	carbohydrate metabolic process	3	1
GO:0006020	inositol metabolic process	4	1
GO:0006066	alcohol metabolic process	3	1
GO:0009058	biosynthetic process	2	1
GO:0019637	organophosphate metabolic process	3	1
GO:0019751	polyol metabolic process	4	1
GO:0032958	inositol phosphate biosynthetic process	5	1
GO:0043647	inositol phosphate metabolic process	4	1
GO:0044238	primary metabolic process	2	1
GO:0044262	obsolete cellular carbohydrate metabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0044283	small molecule biosynthetic process	3	1
GO:0046165	alcohol biosynthetic process	4	1
GO:0046173	polyol biosynthetic process	5	1
GO:0046835	carbohydrate phosphorylation	4	1
GO:0052746	obsolete inositol phosphorylation	5	1
GO:0071704	organic substance metabolic process	2	1
GO:0090407	organophosphate biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1
GO:1901615	organic hydroxy compound metabolic process	3	1
GO:1901617	organic hydroxy compound biosynthetic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016301	kinase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035299	inositol pentakisphosphate 2-kinase activity	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	263	267	PF00656	0.517
CLV_C14_Caspase3-7	336	340	PF00656	0.396
CLV_NRD_NRD_1	241	243	PF00675	0.388
CLV_NRD_NRD_1	384	386	PF00675	0.262
CLV_NRD_NRD_1	413	415	PF00675	0.257
CLV_NRD_NRD_1	69	71	PF00675	0.499
CLV_PCSK_KEX2_1	344	346	PF00082	0.353
CLV_PCSK_KEX2_1	413	415	PF00082	0.386
CLV_PCSK_KEX2_1	69	71	PF00082	0.546
CLV_PCSK_PC1ET2_1	344	346	PF00082	0.240
CLV_PCSK_SKI1_1	197	201	PF00082	0.241
CLV_PCSK_SKI1_1	213	217	PF00082	0.171
CLV_PCSK_SKI1_1	251	255	PF00082	0.320
CLV_PCSK_SKI1_1	42	46	PF00082	0.452
DEG_APCC_DBOX_1	218	226	PF00400	0.539
DEG_APCC_KENBOX_2	315	319	PF00400	0.396
DEG_Nend_UBRbox_2	1	3	PF02207	0.523
DOC_ANK_TNKS_1	176	183	PF00023	0.396
DOC_MAPK_MEF2A_6	13	22	PF00069	0.423
DOC_MAPK_MEF2A_6	374	382	PF00069	0.462
DOC_SPAK_OSR1_1	366	370	PF12202	0.480
DOC_USP7_MATH_1	192	196	PF00917	0.492
DOC_USP7_MATH_1	215	219	PF00917	0.532
DOC_USP7_MATH_1	450	454	PF00917	0.480
DOC_USP7_MATH_1	81	85	PF00917	0.435
DOC_USP7_MATH_2	291	297	PF00917	0.474
DOC_WW_Pin1_4	287	292	PF00397	0.586
DOC_WW_Pin1_4	347	352	PF00397	0.513
LIG_14-3-3_CanoR_1	213	222	PF00244	0.535
LIG_14-3-3_CanoR_1	366	376	PF00244	0.456
LIG_14-3-3_CanoR_1	385	389	PF00244	0.503
LIG_Actin_WH2_2	218	236	PF00022	0.504
LIG_BIR_III_2	288	292	PF00653	0.491
LIG_BIR_III_4	122	126	PF00653	0.457
LIG_Clathr_ClatBox_1	113	117	PF01394	0.518
LIG_eIF4E_1	206	212	PF01652	0.448
LIG_FHA_1	129	135	PF00498	0.480
LIG_FHA_1	250	256	PF00498	0.544
LIG_FHA_1	398	404	PF00498	0.540
LIG_FHA_2	252	258	PF00498	0.546
LIG_FHA_2	324	330	PF00498	0.457
LIG_FHA_2	336	342	PF00498	0.452
LIG_FHA_2	370	376	PF00498	0.442
LIG_LIR_Apic_2	138	143	PF02991	0.539
LIG_LIR_Apic_2	350	356	PF02991	0.466
LIG_LIR_Gen_1	2	11	PF02991	0.504
LIG_LIR_Gen_1	77	87	PF02991	0.477
LIG_LIR_Nem_3	2	8	PF02991	0.508
LIG_LIR_Nem_3	56	62	PF02991	0.372
LIG_LIR_Nem_3	77	82	PF02991	0.358
LIG_SH2_CRK	79	83	PF00017	0.400
LIG_SH2_CRK	90	94	PF00017	0.314
LIG_SH2_NCK_1	79	83	PF00017	0.467
LIG_SH2_PTP2	353	356	PF00017	0.539
LIG_SH2_STAP1	130	134	PF00017	0.509
LIG_SH2_STAP1	167	171	PF00017	0.491
LIG_SH2_STAP1	360	364	PF00017	0.491
LIG_SH2_STAP1	79	83	PF00017	0.400
LIG_SH2_STAT5	130	133	PF00017	0.539
LIG_SH2_STAT5	206	209	PF00017	0.437
LIG_SH2_STAT5	210	213	PF00017	0.437
LIG_SH2_STAT5	353	356	PF00017	0.512
LIG_SH2_STAT5	368	371	PF00017	0.398
LIG_SH3_1	386	392	PF00018	0.396
LIG_SH3_3	15	21	PF00018	0.473
LIG_SH3_3	202	208	PF00018	0.523
LIG_SH3_3	267	273	PF00018	0.539
LIG_SH3_3	386	392	PF00018	0.549
LIG_SH3_3	69	75	PF00018	0.564
LIG_SH3_5	356	360	PF00018	0.491
LIG_SUMO_SIM_anti_2	375	380	PF11976	0.448
LIG_SUMO_SIM_par_1	251	257	PF11976	0.491
LIG_SUMO_SIM_par_1	377	383	PF11976	0.463
LIG_SUMO_SIM_par_1	422	428	PF11976	0.462
LIG_TRAF2_1	254	257	PF00917	0.557
LIG_TRAF2_1	290	293	PF00917	0.513
LIG_TYR_ITIM	171	176	PF00017	0.491
MOD_CDK_SPK_2	347	352	PF00069	0.457
MOD_CK1_1	186	192	PF00069	0.540
MOD_CK1_1	195	201	PF00069	0.578
MOD_CK1_1	27	33	PF00069	0.609
MOD_CK1_1	333	339	PF00069	0.578
MOD_CK1_1	347	353	PF00069	0.367
MOD_CK1_1	98	104	PF00069	0.491
MOD_CK2_1	214	220	PF00069	0.546
MOD_CK2_1	251	257	PF00069	0.550
MOD_CK2_1	287	293	PF00069	0.504
MOD_CK2_1	323	329	PF00069	0.487
MOD_Cter_Amidation	67	70	PF01082	0.418
MOD_GlcNHglycan	137	140	PF01048	0.361
MOD_GlcNHglycan	188	191	PF01048	0.278
MOD_GlcNHglycan	197	200	PF01048	0.257
MOD_GlcNHglycan	202	205	PF01048	0.240
MOD_GlcNHglycan	285	288	PF01048	0.323
MOD_GlcNHglycan	29	32	PF01048	0.680
MOD_GSK3_1	234	241	PF00069	0.523
MOD_GSK3_1	283	290	PF00069	0.542
MOD_GSK3_1	323	330	PF00069	0.396
MOD_GSK3_1	380	387	PF00069	0.493
MOD_N-GLC_1	104	109	PF02516	0.319
MOD_N-GLC_1	95	100	PF02516	0.443
MOD_NEK2_1	1	6	PF00069	0.476
MOD_NEK2_1	367	372	PF00069	0.437
MOD_NEK2_2	192	197	PF00069	0.440
MOD_PIKK_1	384	390	PF00454	0.457
MOD_PKA_1	242	248	PF00069	0.457
MOD_PKA_1	344	350	PF00069	0.440
MOD_PKA_2	344	350	PF00069	0.493
MOD_PKA_2	384	390	PF00069	0.554
MOD_PKA_2	450	456	PF00069	0.478
MOD_PKA_2	47	53	PF00069	0.345
MOD_Plk_1	1	7	PF00069	0.441
MOD_Plk_1	128	134	PF00069	0.556
MOD_Plk_1	265	271	PF00069	0.559
MOD_Plk_1	374	380	PF00069	0.437
MOD_Plk_1	98	104	PF00069	0.539
MOD_Plk_4	1	7	PF00069	0.466
MOD_Plk_4	374	380	PF00069	0.443
MOD_Plk_4	81	87	PF00069	0.484
MOD_Plk_4	98	104	PF00069	0.547
MOD_ProDKin_1	287	293	PF00069	0.586
MOD_ProDKin_1	347	353	PF00069	0.513
MOD_SUMO_rev_2	129	136	PF00179	0.467
MOD_SUMO_rev_2	425	430	PF00179	0.505
TRG_ENDOCYTIC_2	167	170	PF00928	0.518
TRG_ENDOCYTIC_2	173	176	PF00928	0.507
TRG_ENDOCYTIC_2	59	62	PF00928	0.437
TRG_ENDOCYTIC_2	79	82	PF00928	0.434
TRG_ENDOCYTIC_2	90	93	PF00928	0.426
TRG_ER_diArg_1	412	414	PF00400	0.457
TRG_ER_diArg_1	45	48	PF00400	0.458
TRG_ER_diArg_1	69	71	PF00400	0.472

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDW9	Leptomonas seymouri	55%	100%
A0A0S4KLU4	Bodo saltans	27%	92%
A0A1X0PAD2	Trypanosomatidae	32%	100%
A0A3R7K0N1	Trypanosoma rangeli	32%	99%
A4HB89	Leishmania braziliensis	75%	100%
A4IAD7	Leishmania infantum	99%	100%
C9ZLV8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	99%
E9B5G1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q2H4	Leishmania major	91%	100%
V5B6A7	Trypanosoma cruzi	31%	90%