Ribonuclease inhibitor-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ribonuclease inhibitor-like protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IEN3_LEIDO

TriTrypDb:

LdBPK_292920.1 , LdCL_290035300 , LDHU3_29.4260

Length:

736

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	17
GO:0042995	cell projection	2	17
GO:0043226	organelle	2	17
GO:0043227	membrane-bounded organelle	3	17
GO:0110165	cellular anatomical entity	1	18
GO:0120025	plasma membrane bounded cell projection	3	17
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1

Expansion

Sequence features

A0A3Q8IEN3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEN3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	40	44	PF00656	0.636
CLV_C14_Caspase3-7	620	624	PF00656	0.605
CLV_C14_Caspase3-7	648	652	PF00656	0.462
CLV_C14_Caspase3-7	703	707	PF00656	0.544
CLV_NRD_NRD_1	496	498	PF00675	0.301
CLV_NRD_NRD_1	592	594	PF00675	0.504
CLV_NRD_NRD_1	605	607	PF00675	0.425
CLV_NRD_NRD_1	672	674	PF00675	0.478
CLV_NRD_NRD_1	720	722	PF00675	0.541
CLV_NRD_NRD_1	730	732	PF00675	0.640
CLV_PCSK_KEX2_1	196	198	PF00082	0.382
CLV_PCSK_KEX2_1	496	498	PF00082	0.301
CLV_PCSK_KEX2_1	580	582	PF00082	0.475
CLV_PCSK_KEX2_1	592	594	PF00082	0.469
CLV_PCSK_KEX2_1	605	607	PF00082	0.429
CLV_PCSK_KEX2_1	646	648	PF00082	0.552
CLV_PCSK_KEX2_1	672	674	PF00082	0.507
CLV_PCSK_KEX2_1	720	722	PF00082	0.614
CLV_PCSK_KEX2_1	730	732	PF00082	0.669
CLV_PCSK_PC1ET2_1	196	198	PF00082	0.382
CLV_PCSK_PC1ET2_1	580	582	PF00082	0.561
CLV_PCSK_PC1ET2_1	646	648	PF00082	0.592
CLV_PCSK_SKI1_1	221	225	PF00082	0.453
CLV_PCSK_SKI1_1	460	464	PF00082	0.395
CLV_PCSK_SKI1_1	548	552	PF00082	0.567
CLV_PCSK_SKI1_1	58	62	PF00082	0.516
CLV_PCSK_SKI1_1	673	677	PF00082	0.481
CLV_Separin_Metazoa	255	259	PF03568	0.382
DEG_APCC_DBOX_1	57	65	PF00400	0.489
DEG_APCC_KENBOX_2	564	568	PF00400	0.430
DEG_Nend_UBRbox_2	1	3	PF02207	0.728
DEG_SCF_FBW7_2	245	251	PF00400	0.503
DOC_ANK_TNKS_1	72	79	PF00023	0.662
DOC_CKS1_1	245	250	PF01111	0.499
DOC_CYCLIN_RxL_1	218	228	PF00134	0.448
DOC_CYCLIN_RxL_1	491	504	PF00134	0.271
DOC_CYCLIN_yClb5_NLxxxL_5	490	499	PF00134	0.315
DOC_MAPK_gen_1	196	206	PF00069	0.395
DOC_MAPK_gen_1	443	452	PF00069	0.431
DOC_MAPK_gen_1	486	495	PF00069	0.315
DOC_MAPK_gen_1	720	726	PF00069	0.578
DOC_MAPK_HePTP_8	194	206	PF00069	0.315
DOC_MAPK_MEF2A_6	197	206	PF00069	0.302
DOC_PP2B_LxvP_1	550	553	PF13499	0.478
DOC_PP4_FxxP_1	148	151	PF00568	0.469
DOC_USP7_MATH_1	23	27	PF00917	0.654
DOC_USP7_MATH_1	4	8	PF00917	0.753
DOC_USP7_UBL2_3	482	486	PF12436	0.414
DOC_WW_Pin1_4	244	249	PF00397	0.514
DOC_WW_Pin1_4	8	13	PF00397	0.719
LIG_14-3-3_CanoR_1	169	176	PF00244	0.489
LIG_14-3-3_CanoR_1	197	202	PF00244	0.440
LIG_14-3-3_CanoR_1	265	273	PF00244	0.425
LIG_14-3-3_CanoR_1	293	303	PF00244	0.339
LIG_14-3-3_CanoR_1	31	37	PF00244	0.679
LIG_14-3-3_CanoR_1	51	60	PF00244	0.559
LIG_14-3-3_CanoR_1	513	519	PF00244	0.338
LIG_14-3-3_CanoR_1	630	636	PF00244	0.551
LIG_APCC_ABBAyCdc20_2	199	205	PF00400	0.315
LIG_BIR_III_4	367	371	PF00653	0.390
LIG_BRCT_BRCA1_1	508	512	PF00533	0.395
LIG_BRCT_BRCA1_1	56	60	PF00533	0.550
LIG_Clathr_ClatBox_1	201	205	PF01394	0.367
LIG_CtBP_PxDLS_1	477	482	PF00389	0.315
LIG_DLG_GKlike_1	287	294	PF00625	0.419
LIG_FHA_1	107	113	PF00498	0.542
LIG_FHA_1	379	385	PF00498	0.368
LIG_FHA_1	462	468	PF00498	0.452
LIG_FHA_1	547	553	PF00498	0.587
LIG_FHA_1	635	641	PF00498	0.466
LIG_FHA_1	659	665	PF00498	0.580
LIG_FHA_1	66	72	PF00498	0.579
LIG_FHA_2	106	112	PF00498	0.484
LIG_FHA_2	317	323	PF00498	0.431
LIG_FHA_2	618	624	PF00498	0.392
LIG_FHA_2	646	652	PF00498	0.532
LIG_LIR_Gen_1	132	141	PF02991	0.417
LIG_LIR_Gen_1	171	178	PF02991	0.446
LIG_LIR_Gen_1	352	361	PF02991	0.339
LIG_LIR_Gen_1	522	533	PF02991	0.324
LIG_LIR_Gen_1	82	91	PF02991	0.507
LIG_LIR_Nem_3	132	138	PF02991	0.416
LIG_LIR_Nem_3	171	176	PF02991	0.453
LIG_LIR_Nem_3	352	356	PF02991	0.352
LIG_LIR_Nem_3	522	528	PF02991	0.312
LIG_LIR_Nem_3	82	88	PF02991	0.502
LIG_MYND_1	72	76	PF01753	0.676
LIG_PCNA_yPIPBox_3	403	413	PF02747	0.455
LIG_Rb_LxCxE_1	255	270	PF01857	0.194
LIG_SH2_STAP1	45	49	PF00017	0.624
LIG_SH2_STAP1	530	534	PF00017	0.335
LIG_SH2_STAP1	67	71	PF00017	0.516
LIG_SH2_STAP1	81	85	PF00017	0.584
LIG_SH2_STAT5	353	356	PF00017	0.397
LIG_SH2_STAT5	410	413	PF00017	0.479
LIG_SH2_STAT5	67	70	PF00017	0.514
LIG_SH2_STAT5	81	84	PF00017	0.542
LIG_SUMO_SIM_par_1	174	179	PF11976	0.286
LIG_SUMO_SIM_par_1	228	233	PF11976	0.341
LIG_SUMO_SIM_par_1	371	376	PF11976	0.429
LIG_TYR_ITIM	351	356	PF00017	0.450
LIG_WRC_WIRS_1	85	90	PF05994	0.476
MOD_CK1_1	106	112	PF00069	0.490
MOD_CK1_1	168	174	PF00069	0.432
MOD_CK1_1	378	384	PF00069	0.394
MOD_CK1_1	405	411	PF00069	0.379
MOD_CK1_1	412	418	PF00069	0.377
MOD_CK1_1	511	517	PF00069	0.269
MOD_CK1_1	54	60	PF00069	0.665
MOD_CK1_1	546	552	PF00069	0.580
MOD_CK1_1	619	625	PF00069	0.471
MOD_CK1_1	7	13	PF00069	0.572
MOD_CK2_1	280	286	PF00069	0.362
MOD_CK2_1	308	314	PF00069	0.488
MOD_CK2_1	316	322	PF00069	0.431
MOD_CK2_1	7	13	PF00069	0.700
MOD_Cter_Amidation	728	731	PF01082	0.665
MOD_GlcNHglycan	139	142	PF01048	0.421
MOD_GlcNHglycan	158	161	PF01048	0.401
MOD_GlcNHglycan	177	181	PF01048	0.276
MOD_GlcNHglycan	25	28	PF01048	0.544
MOD_GlcNHglycan	282	285	PF01048	0.367
MOD_GlcNHglycan	310	313	PF01048	0.479
MOD_GlcNHglycan	375	378	PF01048	0.394
MOD_GSK3_1	37	44	PF00069	0.606
MOD_GSK3_1	373	380	PF00069	0.363
MOD_GSK3_1	4	11	PF00069	0.649
MOD_GSK3_1	405	412	PF00069	0.372
MOD_GSK3_1	461	468	PF00069	0.333
MOD_GSK3_1	634	641	PF00069	0.553
MOD_N-GLC_1	197	202	PF02516	0.296
MOD_N-GLC_1	225	230	PF02516	0.368
MOD_N-GLC_1	266	271	PF02516	0.344
MOD_N-GLC_1	287	292	PF02516	0.365
MOD_N-GLC_1	294	299	PF02516	0.306
MOD_N-GLC_1	402	407	PF02516	0.421
MOD_N-GLC_1	430	435	PF02516	0.287
MOD_N-GLC_1	465	470	PF02516	0.315
MOD_N-GLC_1	486	491	PF02516	0.263
MOD_N-GLC_1	514	519	PF02516	0.291
MOD_N-GLC_1	546	551	PF02516	0.574
MOD_N-GLC_1	638	643	PF02516	0.417
MOD_N-GLC_2	459	461	PF02516	0.431
MOD_NEK2_1	176	181	PF00069	0.270
MOD_NEK2_1	266	271	PF00069	0.305
MOD_NEK2_1	280	285	PF00069	0.260
MOD_NEK2_1	294	299	PF00069	0.191
MOD_NEK2_1	32	37	PF00069	0.621
MOD_NEK2_1	373	378	PF00069	0.355
MOD_NEK2_1	409	414	PF00069	0.371
MOD_NEK2_1	437	442	PF00069	0.286
MOD_NEK2_1	52	57	PF00069	0.641
MOD_NEK2_1	645	650	PF00069	0.660
MOD_PIKK_1	698	704	PF00454	0.647
MOD_PKA_2	168	174	PF00069	0.499
MOD_PKA_2	543	549	PF00069	0.440
MOD_PKA_2	629	635	PF00069	0.499
MOD_Plk_1	103	109	PF00069	0.457
MOD_Plk_1	197	203	PF00069	0.296
MOD_Plk_1	225	231	PF00069	0.367
MOD_Plk_1	402	408	PF00069	0.417
MOD_Plk_1	430	436	PF00069	0.299
MOD_Plk_1	486	492	PF00069	0.263
MOD_Plk_1	514	520	PF00069	0.276
MOD_Plk_1	526	532	PF00069	0.270
MOD_Plk_1	546	552	PF00069	0.576
MOD_Plk_4	171	177	PF00069	0.398
MOD_Plk_4	225	231	PF00069	0.369
MOD_Plk_4	32	38	PF00069	0.651
MOD_Plk_4	405	411	PF00069	0.487
MOD_Plk_4	546	552	PF00069	0.603
MOD_ProDKin_1	244	250	PF00069	0.508
MOD_ProDKin_1	8	14	PF00069	0.719
MOD_SUMO_for_1	707	710	PF00179	0.650
MOD_SUMO_rev_2	703	709	PF00179	0.636
TRG_DiLeu_BaLyEn_6	110	115	PF01217	0.454
TRG_DiLeu_BaLyEn_6	685	690	PF01217	0.576
TRG_DiLeu_BaLyEn_6	70	75	PF01217	0.677
TRG_ENDOCYTIC_2	173	176	PF00928	0.344
TRG_ENDOCYTIC_2	353	356	PF00928	0.406
TRG_ENDOCYTIC_2	525	528	PF00928	0.317
TRG_ER_diArg_1	495	497	PF00400	0.301
TRG_ER_diArg_1	591	593	PF00400	0.518
TRG_ER_diArg_1	604	606	PF00400	0.457
TRG_ER_diArg_1	671	673	PF00400	0.513
TRG_ER_diArg_1	719	721	PF00400	0.691
TRG_Pf-PMV_PEXEL_1	113	117	PF00026	0.437
TRG_Pf-PMV_PEXEL_1	119	123	PF00026	0.202
TRG_Pf-PMV_PEXEL_1	189	193	PF00026	0.355
TRG_Pf-PMV_PEXEL_1	221	225	PF00026	0.453
TRG_Pf-PMV_PEXEL_1	497	502	PF00026	0.475
TRG_Pf-PMV_PEXEL_1	606	610	PF00026	0.418
TRG_Pf-PMV_PEXEL_1	676	680	PF00026	0.557
TRG_Pf-PMV_PEXEL_1	73	77	PF00026	0.683

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I557	Leptomonas seymouri	72%	100%
A0A0S4IPG0	Bodo saltans	45%	97%
A0A0S4JDM4	Bodo saltans	22%	100%
A0A0S4JL02	Bodo saltans	24%	99%
A0A1X0NMB3	Trypanosomatidae	24%	100%
A0A1X0P9A4	Trypanosomatidae	51%	100%
A0A3R7RCX5	Trypanosoma rangeli	24%	100%
A0A422MZT7	Trypanosoma rangeli	24%	85%
A0A422NEU0	Trypanosoma rangeli	52%	100%
A4HHT8	Leishmania braziliensis	83%	100%
A4I4Y7	Leishmania infantum	100%	100%
C9ZKJ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	97%
E9AEE3	Leishmania major	93%	100%
E9ALE3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5BC66	Trypanosoma cruzi	52%	100%
V5C1B4	Trypanosoma cruzi	23%	85%