RanBD1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved (fragment)

Species:

Leishmania donovani

UniProt:

A0A3Q8IEM6_LEIDO

TriTrypDb:

LdBPK_292690.1 , LdCL_290033000 , LDHU3_29.3960

Length:

677

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IEM6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEM6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	252	256	PF00656	0.672
CLV_C14_Caspase3-7	449	453	PF00656	0.595
CLV_C14_Caspase3-7	547	551	PF00656	0.632
CLV_NRD_NRD_1	136	138	PF00675	0.839
CLV_NRD_NRD_1	139	141	PF00675	0.805
CLV_NRD_NRD_1	207	209	PF00675	0.611
CLV_NRD_NRD_1	246	248	PF00675	0.766
CLV_NRD_NRD_1	58	60	PF00675	0.636
CLV_PCSK_FUR_1	137	141	PF00082	0.701
CLV_PCSK_KEX2_1	136	138	PF00082	0.839
CLV_PCSK_KEX2_1	139	141	PF00082	0.805
CLV_PCSK_KEX2_1	207	209	PF00082	0.611
CLV_PCSK_KEX2_1	230	232	PF00082	0.693
CLV_PCSK_KEX2_1	58	60	PF00082	0.527
CLV_PCSK_PC1ET2_1	230	232	PF00082	0.742
CLV_PCSK_SKI1_1	251	255	PF00082	0.681
CLV_PCSK_SKI1_1	423	427	PF00082	0.624
CLV_PCSK_SKI1_1	521	525	PF00082	0.604
CLV_PCSK_SKI1_1	595	599	PF00082	0.754
CLV_PCSK_SKI1_1	621	625	PF00082	0.596
DEG_APCC_DBOX_1	214	222	PF00400	0.624
DEG_SCF_FBW7_1	656	661	PF00400	0.587
DOC_MAPK_FxFP_2	650	653	PF00069	0.658
DOC_MAPK_FxFP_2	670	673	PF00069	0.449
DOC_MAPK_FxFP_2	96	99	PF00069	0.570
DOC_MAPK_RevD_3	216	231	PF00069	0.569
DOC_PP2B_LxvP_1	219	222	PF13499	0.697
DOC_PP2B_LxvP_1	279	282	PF13499	0.724
DOC_PP4_FxxP_1	185	188	PF00568	0.707
DOC_PP4_FxxP_1	197	200	PF00568	0.620
DOC_PP4_FxxP_1	28	31	PF00568	0.645
DOC_PP4_FxxP_1	361	364	PF00568	0.655
DOC_PP4_FxxP_1	459	462	PF00568	0.598
DOC_PP4_FxxP_1	557	560	PF00568	0.663
DOC_PP4_FxxP_1	650	653	PF00568	0.724
DOC_PP4_FxxP_1	670	673	PF00568	0.475
DOC_PP4_FxxP_1	96	99	PF00568	0.643
DOC_USP7_MATH_1	106	110	PF00917	0.682
DOC_USP7_MATH_1	113	117	PF00917	0.746
DOC_USP7_MATH_1	138	142	PF00917	0.679
DOC_USP7_MATH_1	188	192	PF00917	0.718
DOC_USP7_MATH_1	2	6	PF00917	0.559
DOC_USP7_MATH_1	211	215	PF00917	0.718
DOC_USP7_MATH_1	23	27	PF00917	0.732
DOC_USP7_MATH_1	241	245	PF00917	0.645
DOC_USP7_MATH_1	282	286	PF00917	0.723
DOC_USP7_MATH_1	351	355	PF00917	0.722
DOC_USP7_MATH_1	39	43	PF00917	0.695
DOC_USP7_MATH_1	404	408	PF00917	0.594
DOC_USP7_MATH_1	47	51	PF00917	0.556
DOC_USP7_MATH_1	502	506	PF00917	0.681
DOC_USP7_MATH_1	623	627	PF00917	0.657
DOC_USP7_MATH_1	658	662	PF00917	0.647
DOC_USP7_MATH_1	83	87	PF00917	0.655
DOC_USP7_UBL2_3	395	399	PF12436	0.649
DOC_USP7_UBL2_3	446	450	PF12436	0.587
DOC_USP7_UBL2_3	493	497	PF12436	0.622
DOC_USP7_UBL2_3	544	548	PF12436	0.667
DOC_USP7_UBL2_3	591	595	PF12436	0.685
DOC_WW_Pin1_4	102	107	PF00397	0.674
DOC_WW_Pin1_4	233	238	PF00397	0.647
DOC_WW_Pin1_4	326	331	PF00397	0.704
DOC_WW_Pin1_4	37	42	PF00397	0.618
DOC_WW_Pin1_4	415	420	PF00397	0.650
DOC_WW_Pin1_4	426	431	PF00397	0.620
DOC_WW_Pin1_4	513	518	PF00397	0.620
DOC_WW_Pin1_4	524	529	PF00397	0.598
DOC_WW_Pin1_4	600	605	PF00397	0.703
DOC_WW_Pin1_4	654	659	PF00397	0.619
DOC_WW_Pin1_4	664	669	PF00397	0.578
LIG_14-3-3_CanoR_1	137	147	PF00244	0.675
LIG_14-3-3_CanoR_1	215	219	PF00244	0.781
LIG_BIR_II_1	1	5	PF00653	0.630
LIG_BRCT_BRCA1_1	607	611	PF00533	0.720
LIG_BRCT_BRCA1_1	666	670	PF00533	0.669
LIG_EH_1	438	442	PF12763	0.593
LIG_EH_1	536	540	PF12763	0.631
LIG_EH_1	647	651	PF12763	0.661
LIG_FHA_1	130	136	PF00498	0.759
LIG_FHA_1	278	284	PF00498	0.725
LIG_FHA_1	286	292	PF00498	0.602
LIG_FHA_1	427	433	PF00498	0.663
LIG_FHA_1	525	531	PF00498	0.658
LIG_FHA_2	250	256	PF00498	0.745
LIG_FHA_2	655	661	PF00498	0.552
LIG_LIR_Apic_2	25	31	PF02991	0.641
LIG_LIR_Apic_2	33	39	PF02991	0.617
LIG_LIR_Apic_2	667	673	PF02991	0.543
LIG_LIR_Gen_1	10	21	PF02991	0.608
LIG_LIR_Nem_3	10	16	PF02991	0.601
LIG_LIR_Nem_3	191	196	PF02991	0.712
LIG_LIR_Nem_3	52	57	PF02991	0.570
LIG_LYPXL_S_1	192	196	PF13949	0.716
LIG_LYPXL_SIV_4	64	72	PF13949	0.650
LIG_LYPXL_yS_3	193	196	PF13949	0.717
LIG_LYPXL_yS_3	98	101	PF13949	0.574
LIG_PCNA_PIPBox_1	178	187	PF02747	0.713
LIG_PCNA_yPIPBox_3	172	185	PF02747	0.721
LIG_Pex14_2	624	628	PF04695	0.546
LIG_PTB_Apo_2	59	66	PF02174	0.559
LIG_PTB_Phospho_1	59	65	PF10480	0.558
LIG_SH2_CRK	65	69	PF00017	0.646
LIG_SH2_NCK_1	65	69	PF00017	0.646
LIG_SH2_STAT5	184	187	PF00017	0.707
LIG_SH2_STAT5	56	59	PF00017	0.576
LIG_SH3_1	207	213	PF00018	0.626
LIG_SH3_1	353	359	PF00018	0.724
LIG_SH3_2	210	215	PF14604	0.625
LIG_SH3_3	118	124	PF00018	0.674
LIG_SH3_3	144	150	PF00018	0.712
LIG_SH3_3	151	157	PF00018	0.636
LIG_SH3_3	207	213	PF00018	0.626
LIG_SH3_3	306	312	PF00018	0.798
LIG_SH3_3	353	359	PF00018	0.724
LIG_SH3_3	38	44	PF00018	0.675
LIG_SH3_3	434	440	PF00018	0.610
LIG_SH3_3	451	457	PF00018	0.519
LIG_SH3_3	532	538	PF00018	0.647
LIG_SH3_3	549	555	PF00018	0.532
LIG_SH3_3	650	656	PF00018	0.667
LIG_SH3_4	446	453	PF00018	0.592
LIG_SH3_4	544	551	PF00018	0.632
LIG_SUMO_SIM_par_1	217	224	PF11976	0.623
LIG_TRAF2_1	123	126	PF00917	0.657
LIG_TYR_ITIM	63	68	PF00017	0.639
MOD_CDK_SPxxK_3	600	607	PF00069	0.573
MOD_CK1_1	214	220	PF00069	0.710
MOD_CK1_1	285	291	PF00069	0.632
MOD_CK1_1	37	43	PF00069	0.621
MOD_CK1_1	671	677	PF00069	0.611
MOD_CK2_1	167	173	PF00069	0.673
MOD_CK2_1	654	660	PF00069	0.556
MOD_GlcNHglycan	108	111	PF01048	0.654
MOD_GlcNHglycan	117	120	PF01048	0.745
MOD_GlcNHglycan	169	172	PF01048	0.656
MOD_GlcNHglycan	267	270	PF01048	0.737
MOD_GlcNHglycan	36	39	PF01048	0.641
MOD_GlcNHglycan	406	410	PF01048	0.641
MOD_GlcNHglycan	443	446	PF01048	0.668
MOD_GlcNHglycan	49	52	PF01048	0.770
MOD_GlcNHglycan	504	508	PF01048	0.629
MOD_GlcNHglycan	541	544	PF01048	0.711
MOD_GlcNHglycan	600	603	PF01048	0.767
MOD_GlcNHglycan	607	610	PF01048	0.645
MOD_GlcNHglycan	625	628	PF01048	0.495
MOD_GlcNHglycan	642	645	PF01048	0.524
MOD_GlcNHglycan	68	71	PF01048	0.424
MOD_GlcNHglycan	91	94	PF01048	0.756
MOD_GSK3_1	102	109	PF00069	0.760
MOD_GSK3_1	217	224	PF00069	0.678
MOD_GSK3_1	261	268	PF00069	0.703
MOD_GSK3_1	271	278	PF00069	0.611
MOD_GSK3_1	30	37	PF00069	0.618
MOD_GSK3_1	324	331	PF00069	0.644
MOD_GSK3_1	426	433	PF00069	0.676
MOD_GSK3_1	524	531	PF00069	0.667
MOD_GSK3_1	605	612	PF00069	0.685
MOD_GSK3_1	632	639	PF00069	0.664
MOD_GSK3_1	654	661	PF00069	0.602
MOD_GSK3_1	662	669	PF00069	0.563
MOD_GSK3_1	84	91	PF00069	0.653
MOD_N-GLC_1	47	52	PF02516	0.702
MOD_N-GLC_1	83	88	PF02516	0.651
MOD_N-GLC_1	89	94	PF02516	0.664
MOD_NEK2_1	324	329	PF00069	0.661
MOD_NEK2_1	441	446	PF00069	0.615
MOD_NEK2_1	539	544	PF00069	0.652
MOD_NEK2_1	630	635	PF00069	0.636
MOD_NEK2_1	636	641	PF00069	0.651
MOD_NEK2_1	662	667	PF00069	0.722
MOD_NEK2_2	188	193	PF00069	0.632
MOD_PIKK_1	271	277	PF00454	0.741
MOD_PKA_1	139	145	PF00069	0.704
MOD_PKA_2	138	144	PF00069	0.642
MOD_PKA_2	214	220	PF00069	0.630
MOD_PKB_1	137	145	PF00069	0.775
MOD_Plk_1	124	130	PF00069	0.683
MOD_Plk_1	188	194	PF00069	0.677
MOD_Plk_1	201	207	PF00069	0.515
MOD_Plk_1	24	30	PF00069	0.573
MOD_Plk_1	259	265	PF00069	0.748
MOD_Plk_1	275	281	PF00069	0.526
MOD_Plk_1	301	307	PF00069	0.701
MOD_Plk_4	214	220	PF00069	0.651
MOD_Plk_4	365	371	PF00069	0.722
MOD_Plk_4	463	469	PF00069	0.665
MOD_ProDKin_1	102	108	PF00069	0.676
MOD_ProDKin_1	233	239	PF00069	0.649
MOD_ProDKin_1	326	332	PF00069	0.701
MOD_ProDKin_1	37	43	PF00069	0.619
MOD_ProDKin_1	415	421	PF00069	0.651
MOD_ProDKin_1	426	432	PF00069	0.622
MOD_ProDKin_1	513	519	PF00069	0.621
MOD_ProDKin_1	524	530	PF00069	0.599
MOD_ProDKin_1	600	606	PF00069	0.702
MOD_ProDKin_1	654	660	PF00069	0.620
MOD_ProDKin_1	664	670	PF00069	0.578
MOD_SUMO_for_1	597	600	PF00179	0.760
MOD_SUMO_rev_2	588	597	PF00179	0.667
TRG_ENDOCYTIC_2	193	196	PF00928	0.717
TRG_ENDOCYTIC_2	65	68	PF00928	0.647
TRG_ENDOCYTIC_2	98	101	PF00928	0.655
TRG_ER_diArg_1	135	137	PF00400	0.838
TRG_ER_diArg_1	138	140	PF00400	0.799
TRG_ER_diArg_1	206	208	PF00400	0.621
TRG_ER_diArg_1	231	234	PF00400	0.706
TRG_ER_diArg_1	57	59	PF00400	0.642
TRG_NLS_MonoCore_2	229	234	PF00514	0.747

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HHQ6	Leishmania braziliensis	65%	98%
A4I4X1	Leishmania infantum	93%	100%
E9AEC0	Leishmania major	92%	100%
E9ALG6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
V5BSK6	Trypanosoma cruzi	29%	100%