Transmembrane protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IEM5_LEIDO

TriTrypDb:

LdBPK_310180.1 , LdCL_310006800 , LDHU3_31.0220

Length:

508

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9
GO:0005789	endoplasmic reticulum membrane	4	2
GO:0031090	organelle membrane	3	2

Expansion

Sequence features

A0A3Q8IEM5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEM5

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	2
GO:0006996	organelle organization	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0022607	cellular component assembly	4	2
GO:0034389	lipid droplet organization	5	2
GO:0044238	primary metabolic process	2	2
GO:0070925	organelle assembly	5	2
GO:0071704	organic substance metabolic process	2	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0140042	lipid droplet formation	6	2
GO:0140694	non-membrane-bounded organelle assembly	6	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	476	478	PF00675	0.534
CLV_NRD_NRD_1	494	496	PF00675	0.389
CLV_NRD_NRD_1	6	8	PF00675	0.582
CLV_PCSK_KEX2_1	476	478	PF00082	0.524
CLV_PCSK_KEX2_1	494	496	PF00082	0.389
CLV_PCSK_KEX2_1	6	8	PF00082	0.576
CLV_PCSK_SKI1_1	383	387	PF00082	0.590
CLV_PCSK_SKI1_1	397	401	PF00082	0.641
DEG_APCC_DBOX_1	66	74	PF00400	0.611
DOC_MAPK_gen_1	160	169	PF00069	0.438
DOC_MAPK_gen_1	303	313	PF00069	0.399
DOC_MAPK_gen_1	378	387	PF00069	0.403
DOC_MAPK_MEF2A_6	338	346	PF00069	0.426
DOC_MAPK_MEF2A_6	349	356	PF00069	0.348
DOC_PP1_RVXF_1	301	308	PF00149	0.381
DOC_PP1_RVXF_1	381	388	PF00149	0.392
DOC_PP2B_LxvP_1	9	12	PF13499	0.693
DOC_PP4_FxxP_1	146	149	PF00568	0.499
DOC_PP4_FxxP_1	309	312	PF00568	0.362
DOC_PP4_FxxP_1	350	353	PF00568	0.329
DOC_PP4_FxxP_1	456	459	PF00568	0.728
DOC_PP4_MxPP_1	470	473	PF00568	0.678
DOC_USP7_MATH_1	2	6	PF00917	0.746
DOC_USP7_MATH_1	268	272	PF00917	0.443
DOC_USP7_MATH_1	333	337	PF00917	0.453
DOC_USP7_MATH_1	419	423	PF00917	0.485
DOC_USP7_MATH_1	442	446	PF00917	0.668
DOC_USP7_MATH_1	53	57	PF00917	0.668
DOC_WW_Pin1_4	208	213	PF00397	0.476
DOC_WW_Pin1_4	348	353	PF00397	0.429
DOC_WW_Pin1_4	455	460	PF00397	0.613
DOC_WW_Pin1_4	499	504	PF00397	0.730
DOC_WW_Pin1_4	7	12	PF00397	0.710
LIG_14-3-3_CanoR_1	202	212	PF00244	0.494
LIG_14-3-3_CanoR_1	250	255	PF00244	0.427
LIG_14-3-3_CanoR_1	397	404	PF00244	0.432
LIG_14-3-3_CanoR_1	476	485	PF00244	0.785
LIG_14-3-3_CanoR_1	494	500	PF00244	0.597
LIG_14-3-3_CanoR_1	58	63	PF00244	0.688
LIG_Actin_WH2_2	481	496	PF00022	0.722
LIG_Actin_WH2_2	56	73	PF00022	0.636
LIG_BRCT_BRCA1_1	327	331	PF00533	0.461
LIG_BRCT_BRCA1_1	480	484	PF00533	0.659
LIG_BRCT_BRCA1_1	495	499	PF00533	0.746
LIG_CtBP_PxDLS_1	472	476	PF00389	0.616
LIG_DLG_GKlike_1	163	170	PF00625	0.454
LIG_FHA_1	114	120	PF00498	0.447
LIG_FHA_1	14	20	PF00498	0.573
LIG_FHA_1	151	157	PF00498	0.548
LIG_FHA_1	159	165	PF00498	0.514
LIG_FHA_1	195	201	PF00498	0.376
LIG_FHA_1	234	240	PF00498	0.368
LIG_FHA_1	287	293	PF00498	0.369
LIG_FHA_1	349	355	PF00498	0.423
LIG_FHA_1	387	393	PF00498	0.382
LIG_FHA_1	404	410	PF00498	0.230
LIG_FHA_1	488	494	PF00498	0.719
LIG_FHA_2	59	65	PF00498	0.643
LIG_GBD_Chelix_1	87	95	PF00786	0.362
LIG_LIR_Apic_2	145	149	PF02991	0.498
LIG_LIR_Apic_2	366	371	PF02991	0.397
LIG_LIR_Apic_2	454	459	PF02991	0.722
LIG_LIR_Gen_1	179	189	PF02991	0.451
LIG_LIR_Gen_1	295	305	PF02991	0.360
LIG_LIR_Gen_1	315	323	PF02991	0.356
LIG_LIR_Gen_1	345	354	PF02991	0.369
LIG_LIR_Gen_1	405	415	PF02991	0.344
LIG_LIR_Gen_1	483	493	PF02991	0.702
LIG_LIR_Gen_1	57	64	PF02991	0.627
LIG_LIR_Nem_3	179	185	PF02991	0.459
LIG_LIR_Nem_3	295	300	PF02991	0.364
LIG_LIR_Nem_3	315	319	PF02991	0.334
LIG_LIR_Nem_3	328	334	PF02991	0.339
LIG_LIR_Nem_3	345	350	PF02991	0.253
LIG_LIR_Nem_3	405	410	PF02991	0.310
LIG_LIR_Nem_3	483	488	PF02991	0.681
LIG_LIR_Nem_3	498	504	PF02991	0.752
LIG_LIR_Nem_3	57	63	PF02991	0.656
LIG_LIR_Nem_3	66	72	PF02991	0.609
LIG_NRBOX	425	431	PF00104	0.425
LIG_PALB2_WD40_1	292	300	PF16756	0.305
LIG_Pex14_1	314	318	PF04695	0.434
LIG_Pex14_1	398	402	PF04695	0.425
LIG_SH2_CRK	501	505	PF00017	0.604
LIG_SH2_PTP2	72	75	PF00017	0.362
LIG_SH2_PTP2	77	80	PF00017	0.310
LIG_SH2_SRC	72	75	PF00017	0.250
LIG_SH2_STAP1	235	239	PF00017	0.325
LIG_SH2_STAP1	316	320	PF00017	0.375
LIG_SH2_STAT5	235	238	PF00017	0.389
LIG_SH2_STAT5	318	321	PF00017	0.408
LIG_SH2_STAT5	60	63	PF00017	0.665
LIG_SH2_STAT5	69	72	PF00017	0.589
LIG_SH2_STAT5	77	80	PF00017	0.401
LIG_SH3_3	206	212	PF00018	0.423
LIG_SH3_3	327	333	PF00018	0.431
LIG_SH3_3	370	376	PF00018	0.334
LIG_SH3_3	8	14	PF00018	0.722
LIG_Sin3_3	82	89	PF02671	0.362
LIG_SUMO_SIM_anti_2	165	171	PF11976	0.449
LIG_SUMO_SIM_anti_2	339	345	PF11976	0.339
LIG_SUMO_SIM_anti_2	405	412	PF11976	0.356
LIG_SUMO_SIM_par_1	297	302	PF11976	0.365
LIG_SUMO_SIM_par_1	419	425	PF11976	0.387
LIG_SUMO_SIM_par_1	84	90	PF11976	0.401
LIG_TRAF2_1	244	247	PF00917	0.419
LIG_TRFH_1	222	226	PF08558	0.467
LIG_TYR_ITIM	70	75	PF00017	0.503
LIG_WRC_WIRS_1	404	409	PF05994	0.287
LIG_WRC_WIRS_1	443	448	PF05994	0.608
LIG_WRC_WIRS_1	59	64	PF05994	0.646
LIG_WW_2	11	14	PF00397	0.672
MOD_CDC14_SPxK_1	502	505	PF00782	0.678
MOD_CDK_SPK_2	208	213	PF00069	0.487
MOD_CDK_SPK_2	455	460	PF00069	0.613
MOD_CDK_SPxK_1	499	505	PF00069	0.731
MOD_CDK_SPxxK_3	499	506	PF00069	0.652
MOD_CK1_1	183	189	PF00069	0.440
MOD_CK1_1	422	428	PF00069	0.419
MOD_CK1_1	487	493	PF00069	0.722
MOD_CK1_1	98	104	PF00069	0.405
MOD_CK2_1	2	8	PF00069	0.742
MOD_CK2_1	333	339	PF00069	0.461
MOD_CK2_1	442	448	PF00069	0.669
MOD_CK2_1	477	483	PF00069	0.684
MOD_CK2_1	58	64	PF00069	0.604
MOD_GlcNHglycan	205	208	PF01048	0.704
MOD_GlcNHglycan	257	260	PF01048	0.546
MOD_GlcNHglycan	320	323	PF01048	0.632
MOD_GlcNHglycan	327	330	PF01048	0.619
MOD_GlcNHglycan	447	453	PF01048	0.397
MOD_GlcNHglycan	90	94	PF01048	0.474
MOD_GSK3_1	188	195	PF00069	0.345
MOD_GSK3_1	277	284	PF00069	0.350
MOD_GSK3_1	386	393	PF00069	0.358
MOD_GSK3_1	484	491	PF00069	0.723
MOD_GSK3_1	495	502	PF00069	0.699
MOD_GSK3_1	54	61	PF00069	0.653
MOD_GSK3_1	94	101	PF00069	0.495
MOD_N-GLC_1	292	297	PF02516	0.512
MOD_N-GLC_1	363	368	PF02516	0.503
MOD_N-GLC_1	499	504	PF02516	0.530
MOD_NEK2_1	156	161	PF00069	0.473
MOD_NEK2_1	188	193	PF00069	0.363
MOD_NEK2_1	279	284	PF00069	0.360
MOD_NEK2_1	292	297	PF00069	0.372
MOD_NEK2_1	363	368	PF00069	0.346
MOD_NEK2_1	386	391	PF00069	0.353
MOD_NEK2_1	488	493	PF00069	0.718
MOD_NEK2_1	62	67	PF00069	0.650
MOD_NEK2_1	95	100	PF00069	0.423
MOD_NEK2_2	194	199	PF00069	0.421
MOD_PIKK_1	158	164	PF00454	0.564
MOD_PIKK_1	488	494	PF00454	0.719
MOD_PK_1	281	287	PF00069	0.377
MOD_PKA_2	150	156	PF00069	0.484
MOD_PKA_2	478	484	PF00069	0.678
MOD_PKA_2	493	499	PF00069	0.732
MOD_Plk_1	138	144	PF00069	0.476
MOD_Plk_1	292	298	PF00069	0.309
MOD_Plk_1	31	37	PF00069	0.616
MOD_Plk_1	363	369	PF00069	0.303
MOD_Plk_1	488	494	PF00069	0.700
MOD_Plk_4	165	171	PF00069	0.472
MOD_Plk_4	217	223	PF00069	0.429
MOD_Plk_4	250	256	PF00069	0.303
MOD_Plk_4	403	409	PF00069	0.284
MOD_Plk_4	422	428	PF00069	0.367
MOD_Plk_4	58	64	PF00069	0.699
MOD_ProDKin_1	208	214	PF00069	0.477
MOD_ProDKin_1	348	354	PF00069	0.431
MOD_ProDKin_1	455	461	PF00069	0.614
MOD_ProDKin_1	499	505	PF00069	0.731
MOD_ProDKin_1	7	13	PF00069	0.708
MOD_SUMO_for_1	231	234	PF00179	0.436
MOD_SUMO_for_1	244	247	PF00179	0.293
MOD_SUMO_for_1	504	507	PF00179	0.663
TRG_DiLeu_BaEn_1	152	157	PF01217	0.457
TRG_DiLeu_BaLyEn_6	380	385	PF01217	0.359
TRG_ENDOCYTIC_2	316	319	PF00928	0.371
TRG_ENDOCYTIC_2	347	350	PF00928	0.320
TRG_ENDOCYTIC_2	485	488	PF00928	0.709
TRG_ENDOCYTIC_2	501	504	PF00928	0.567
TRG_ENDOCYTIC_2	60	63	PF00928	0.646
TRG_ENDOCYTIC_2	72	75	PF00928	0.168
TRG_ENDOCYTIC_2	77	80	PF00928	0.310
TRG_ER_diArg_1	358	361	PF00400	0.339
TRG_ER_diArg_1	475	477	PF00400	0.797
TRG_ER_diArg_1	493	495	PF00400	0.574
TRG_ER_diLys_1	505	508	PF00400	0.653
TRG_NES_CRM1_1	24	38	PF08389	0.648
TRG_Pf-PMV_PEXEL_1	135	139	PF00026	0.694
TRG_Pf-PMV_PEXEL_1	154	158	PF00026	0.652
TRG_Pf-PMV_PEXEL_1	397	401	PF00026	0.620

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8U6	Leptomonas seymouri	56%	100%
A0A0S4J1Q7	Bodo saltans	22%	100%
A0A1X0NJH4	Trypanosomatidae	36%	100%
A4HIZ2	Leishmania braziliensis	74%	100%
A4I6A9	Leishmania infantum	99%	100%
E9B1G5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q6P7	Leishmania major	93%	100%
V5BN41	Trypanosoma cruzi	40%	100%