Tetraspanin_family_putative/Pfam:PF00335

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tetraspanin family, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IEM4_LEIDO

TriTrypDb:

LdBPK_330180.1 , LdCL_330006700 , LDHU3_33.0200

Length:

307

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A0A3Q8IEM4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEM4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	2	6	PF00656	0.669
CLV_PCSK_KEX2_1	126	128	PF00082	0.345
CLV_PCSK_PC1ET2_1	126	128	PF00082	0.224
CLV_PCSK_SKI1_1	8	12	PF00082	0.480
DOC_MAPK_gen_1	126	134	PF00069	0.458
DOC_MAPK_gen_1	265	274	PF00069	0.302
DOC_MAPK_gen_1	57	67	PF00069	0.634
DOC_PP1_RVXF_1	231	237	PF00149	0.256
DOC_USP7_MATH_1	18	22	PF00917	0.744
DOC_USP7_MATH_1	89	93	PF00917	0.296
LIG_14-3-3_CanoR_1	127	131	PF00244	0.528
LIG_14-3-3_CanoR_1	244	252	PF00244	0.330
LIG_14-3-3_CanoR_1	8	16	PF00244	0.683
LIG_14-3-3_CanoR_1	94	104	PF00244	0.356
LIG_BIR_II_1	1	5	PF00653	0.658
LIG_BRCT_BRCA1_1	83	87	PF00533	0.436
LIG_FHA_1	112	118	PF00498	0.314
LIG_FHA_1	223	229	PF00498	0.335
LIG_FHA_1	259	265	PF00498	0.365
LIG_FHA_2	222	228	PF00498	0.338
LIG_GBD_Chelix_1	177	185	PF00786	0.515
LIG_LIR_Gen_1	140	149	PF02991	0.404
LIG_LIR_Gen_1	153	160	PF02991	0.300
LIG_LIR_Gen_1	279	290	PF02991	0.400
LIG_LIR_Gen_1	52	63	PF02991	0.606
LIG_LIR_Gen_1	84	95	PF02991	0.239
LIG_LIR_Nem_3	140	144	PF02991	0.404
LIG_LIR_Nem_3	147	151	PF02991	0.376
LIG_LIR_Nem_3	153	157	PF02991	0.300
LIG_LIR_Nem_3	266	271	PF02991	0.295
LIG_LIR_Nem_3	279	285	PF02991	0.400
LIG_LIR_Nem_3	38	43	PF02991	0.598
LIG_LIR_Nem_3	52	58	PF02991	0.555
LIG_LIR_Nem_3	84	90	PF02991	0.372
LIG_NRBOX	259	265	PF00104	0.302
LIG_Pex14_2	83	87	PF04695	0.390
LIG_SH2_CRK	141	145	PF00017	0.353
LIG_SH2_CRK	40	44	PF00017	0.625
LIG_SH2_CRK	61	65	PF00017	0.467
LIG_SH2_SRC	217	220	PF00017	0.267
LIG_SH2_STAT5	217	220	PF00017	0.311
LIG_SH2_STAT5	269	272	PF00017	0.321
LIG_SH3_3	207	213	PF00018	0.349
LIG_SH3_3	231	237	PF00018	0.265
LIG_SUMO_SIM_par_1	108	114	PF11976	0.312
LIG_WRC_WIRS_1	90	95	PF05994	0.267
MOD_CK1_1	21	27	PF00069	0.638
MOD_CK1_1	243	249	PF00069	0.289
MOD_CK1_1	276	282	PF00069	0.259
MOD_CK1_1	286	292	PF00069	0.312
MOD_CK1_1	85	91	PF00069	0.321
MOD_GlcNHglycan	186	190	PF01048	0.440
MOD_GlcNHglycan	20	23	PF01048	0.567
MOD_GlcNHglycan	285	288	PF01048	0.300
MOD_GlcNHglycan	5	8	PF01048	0.520
MOD_GlcNHglycan	68	71	PF01048	0.400
MOD_GlcNHglycan	87	90	PF01048	0.538
MOD_GlcNHglycan	99	102	PF01048	0.503
MOD_GSK3_1	236	243	PF00069	0.301
MOD_GSK3_1	259	266	PF00069	0.394
MOD_GSK3_1	66	73	PF00069	0.382
MOD_GSK3_1	81	88	PF00069	0.395
MOD_GSK3_1	89	96	PF00069	0.337
MOD_N-GLC_1	221	226	PF02516	0.496
MOD_N-GLC_1	49	54	PF02516	0.425
MOD_NEK2_1	137	142	PF00069	0.473
MOD_NEK2_1	185	190	PF00069	0.244
MOD_NEK2_1	240	245	PF00069	0.321
MOD_NEK2_1	263	268	PF00069	0.328
MOD_NEK2_1	283	288	PF00069	0.452
MOD_NEK2_1	49	54	PF00069	0.692
MOD_NEK2_1	93	98	PF00069	0.349
MOD_NEK2_2	70	75	PF00069	0.360
MOD_NEK2_2	82	87	PF00069	0.312
MOD_NEK2_2	89	94	PF00069	0.217
MOD_PKA_1	126	132	PF00069	0.441
MOD_PKA_2	126	132	PF00069	0.497
MOD_PKA_2	243	249	PF00069	0.302
MOD_PKA_2	93	99	PF00069	0.367
MOD_Plk_1	49	55	PF00069	0.658
MOD_Plk_4	126	132	PF00069	0.513
MOD_Plk_4	144	150	PF00069	0.330
MOD_Plk_4	259	265	PF00069	0.340
MOD_Plk_4	276	282	PF00069	0.223
MOD_Plk_4	50	56	PF00069	0.672
MOD_Plk_4	70	76	PF00069	0.374
MOD_SUMO_rev_2	180	185	PF00179	0.268
TRG_DiLeu_BaLyEn_6	5	10	PF01217	0.710
TRG_ENDOCYTIC_2	141	144	PF00928	0.335
TRG_ENDOCYTIC_2	154	157	PF00928	0.240
TRG_ENDOCYTIC_2	269	272	PF00928	0.353
TRG_ENDOCYTIC_2	40	43	PF00928	0.599
TRG_ENDOCYTIC_2	61	64	PF00928	0.567
TRG_ER_diArg_1	264	267	PF00400	0.276
TRG_Pf-PMV_PEXEL_1	8	12	PF00026	0.509

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P684	Leptomonas seymouri	42%	98%
A0A0S4JPS2	Bodo saltans	25%	100%
A0A422NDS8	Trypanosoma rangeli	27%	100%
A4HL54	Leishmania braziliensis	73%	100%
A4I8N3	Leishmania infantum	100%	100%
E9B3J5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q4K6	Leishmania major	91%	100%
V5BBB3	Trypanosoma cruzi	28%	100%