LeishMANIAdb
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DNA polymerase kappa

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
DNA polymerase kappa
Gene product:
DNA polymerase kappa, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8IEM0_LEIDO
TriTrypDb:
LdBPK_281530.1 * , LdCL_280020000 , LDHU3_28.1960
Length:
754

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

A0A3Q8IEM0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEM0

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 12
GO:0006259 DNA metabolic process 4 12
GO:0006281 DNA repair 5 12
GO:0006725 cellular aromatic compound metabolic process 3 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0006950 response to stress 2 12
GO:0006974 DNA damage response 4 12
GO:0008152 metabolic process 1 12
GO:0009987 cellular process 1 12
GO:0033554 cellular response to stress 3 12
GO:0034641 cellular nitrogen compound metabolic process 3 12
GO:0043170 macromolecule metabolic process 3 12
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0044260 obsolete cellular macromolecule metabolic process 3 12
GO:0046483 heterocycle metabolic process 3 12
GO:0050896 response to stimulus 1 12
GO:0051716 cellular response to stimulus 2 12
GO:0071704 organic substance metabolic process 2 12
GO:0090304 nucleic acid metabolic process 4 12
GO:1901360 organic cyclic compound metabolic process 3 12
GO:0000731 DNA synthesis involved in DNA repair 6 2
GO:0006301 postreplication repair 6 2
GO:0009058 biosynthetic process 2 2
GO:0009059 macromolecule biosynthetic process 4 2
GO:0018130 heterocycle biosynthetic process 4 2
GO:0019438 aromatic compound biosynthetic process 4 2
GO:0019985 translesion synthesis 7 2
GO:0034654 nucleobase-containing compound biosynthetic process 4 2
GO:0042276 error-prone translesion synthesis 8 2
GO:0044249 cellular biosynthetic process 3 2
GO:0044271 cellular nitrogen compound biosynthetic process 4 2
GO:0071897 DNA biosynthetic process 5 2
GO:1901362 organic cyclic compound biosynthetic process 4 2
GO:1901576 organic substance biosynthetic process 3 2
GO:0006260 DNA replication 5 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 12
GO:0003677 DNA binding 4 12
GO:0003684 damaged DNA binding 5 12
GO:0003824 catalytic activity 1 12
GO:0003887 DNA-directed DNA polymerase activity 5 12
GO:0005488 binding 1 12
GO:0016740 transferase activity 2 12
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 12
GO:0016779 nucleotidyltransferase activity 4 12
GO:0034061 DNA polymerase activity 4 12
GO:0097159 organic cyclic compound binding 2 12
GO:0140097 catalytic activity, acting on DNA 3 12
GO:0140640 catalytic activity, acting on a nucleic acid 2 12
GO:1901363 heterocyclic compound binding 2 12
GO:0043167 ion binding 2 1
GO:0043169 cation binding 3 1
GO:0046872 metal ion binding 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 677 681 PF00656 0.662
CLV_NRD_NRD_1 147 149 PF00675 0.387
CLV_NRD_NRD_1 178 180 PF00675 0.414
CLV_NRD_NRD_1 213 215 PF00675 0.282
CLV_NRD_NRD_1 273 275 PF00675 0.219
CLV_NRD_NRD_1 31 33 PF00675 0.567
CLV_NRD_NRD_1 364 366 PF00675 0.367
CLV_NRD_NRD_1 454 456 PF00675 0.395
CLV_NRD_NRD_1 504 506 PF00675 0.282
CLV_NRD_NRD_1 532 534 PF00675 0.275
CLV_NRD_NRD_1 577 579 PF00675 0.240
CLV_NRD_NRD_1 606 608 PF00675 0.240
CLV_NRD_NRD_1 651 653 PF00675 0.658
CLV_NRD_NRD_1 663 665 PF00675 0.562
CLV_PCSK_KEX2_1 213 215 PF00082 0.308
CLV_PCSK_KEX2_1 31 33 PF00082 0.569
CLV_PCSK_KEX2_1 363 365 PF00082 0.354
CLV_PCSK_KEX2_1 532 534 PF00082 0.219
CLV_PCSK_KEX2_1 577 579 PF00082 0.240
CLV_PCSK_KEX2_1 605 607 PF00082 0.240
CLV_PCSK_KEX2_1 650 652 PF00082 0.660
CLV_PCSK_KEX2_1 665 667 PF00082 0.551
CLV_PCSK_PC1ET2_1 665 667 PF00082 0.668
CLV_PCSK_SKI1_1 23 27 PF00082 0.531
CLV_PCSK_SKI1_1 32 36 PF00082 0.544
CLV_PCSK_SKI1_1 520 524 PF00082 0.249
CLV_PCSK_SKI1_1 577 581 PF00082 0.240
CLV_Separin_Metazoa 574 578 PF03568 0.440
DEG_APCC_DBOX_1 22 30 PF00400 0.502
DEG_APCC_DBOX_1 445 453 PF00400 0.341
DEG_APCC_DBOX_1 519 527 PF00400 0.447
DEG_APCC_DBOX_1 576 584 PF00400 0.440
DEG_SCF_FBW7_1 54 61 PF00400 0.564
DEG_SCF_FBW7_1 62 69 PF00400 0.537
DEG_SPOP_SBC_1 478 482 PF00917 0.544
DEG_SPOP_SBC_1 712 716 PF00917 0.564
DOC_ANK_TNKS_1 665 672 PF00023 0.554
DOC_CKS1_1 55 60 PF01111 0.577
DOC_CKS1_1 63 68 PF01111 0.560
DOC_MAPK_gen_1 184 193 PF00069 0.404
DOC_MAPK_MEF2A_6 227 236 PF00069 0.375
DOC_MAPK_MEF2A_6 289 296 PF00069 0.450
DOC_MIT_MIM_1 594 606 PF04212 0.416
DOC_PP1_RVXF_1 139 146 PF00149 0.514
DOC_PP2B_LxvP_1 583 586 PF13499 0.455
DOC_PP4_FxxP_1 126 129 PF00568 0.512
DOC_SPAK_OSR1_1 351 355 PF12202 0.440
DOC_USP7_MATH_1 102 106 PF00917 0.661
DOC_USP7_MATH_1 119 123 PF00917 0.590
DOC_USP7_MATH_1 477 481 PF00917 0.595
DOC_USP7_MATH_1 711 715 PF00917 0.590
DOC_USP7_UBL2_3 165 169 PF12436 0.394
DOC_USP7_UBL2_3 560 564 PF12436 0.440
DOC_WW_Pin1_4 10 15 PF00397 0.647
DOC_WW_Pin1_4 378 383 PF00397 0.416
DOC_WW_Pin1_4 38 43 PF00397 0.610
DOC_WW_Pin1_4 46 51 PF00397 0.614
DOC_WW_Pin1_4 54 59 PF00397 0.488
DOC_WW_Pin1_4 62 67 PF00397 0.577
DOC_WW_Pin1_4 70 75 PF00397 0.645
DOC_WW_Pin1_4 716 721 PF00397 0.657
LIG_14-3-3_CanoR_1 110 119 PF00244 0.534
LIG_14-3-3_CanoR_1 23 29 PF00244 0.613
LIG_14-3-3_CanoR_1 32 42 PF00244 0.689
LIG_14-3-3_CanoR_1 455 459 PF00244 0.357
LIG_14-3-3_CanoR_1 505 509 PF00244 0.416
LIG_14-3-3_CanoR_1 532 538 PF00244 0.463
LIG_14-3-3_CanoR_1 640 649 PF00244 0.462
LIG_14-3-3_CanoR_1 76 83 PF00244 0.535
LIG_Actin_WH2_2 519 534 PF00022 0.498
LIG_APCC_ABBA_1 232 237 PF00400 0.252
LIG_APCC_ABBA_1 566 571 PF00400 0.455
LIG_BIR_II_1 1 5 PF00653 0.610
LIG_BRCT_BRCA1_1 307 311 PF00533 0.455
LIG_BRCT_BRCA1_1 634 638 PF00533 0.484
LIG_Clathr_ClatBox_1 324 328 PF01394 0.419
LIG_FHA_1 158 164 PF00498 0.432
LIG_FHA_1 267 273 PF00498 0.418
LIG_FHA_1 379 385 PF00498 0.449
LIG_FHA_1 62 68 PF00498 0.554
LIG_FHA_1 637 643 PF00498 0.552
LIG_FHA_1 78 84 PF00498 0.510
LIG_FHA_2 436 442 PF00498 0.343
LIG_FHA_2 535 541 PF00498 0.434
LIG_FHA_2 701 707 PF00498 0.588
LIG_GSK3_LRP6_1 62 67 PF00069 0.538
LIG_LIR_Apic_2 125 129 PF02991 0.513
LIG_LIR_Apic_2 389 394 PF02991 0.518
LIG_LIR_Gen_1 228 236 PF02991 0.371
LIG_LIR_Gen_1 239 247 PF02991 0.429
LIG_LIR_Gen_1 457 466 PF02991 0.319
LIG_LIR_Gen_1 589 599 PF02991 0.439
LIG_LIR_Nem_3 207 212 PF02991 0.439
LIG_LIR_Nem_3 220 226 PF02991 0.395
LIG_LIR_Nem_3 228 232 PF02991 0.331
LIG_LIR_Nem_3 239 245 PF02991 0.435
LIG_LIR_Nem_3 308 314 PF02991 0.474
LIG_LIR_Nem_3 457 461 PF02991 0.298
LIG_LIR_Nem_3 511 517 PF02991 0.474
LIG_LIR_Nem_3 589 594 PF02991 0.425
LIG_MLH1_MIPbox_1 634 638 PF16413 0.484
LIG_NRBOX 579 585 PF00104 0.455
LIG_PCNA_PIPBox_1 331 340 PF02747 0.455
LIG_PCNA_PIPBox_1 631 640 PF02747 0.512
LIG_PCNA_yPIPBox_3 179 192 PF02747 0.370
LIG_PCNA_yPIPBox_3 631 640 PF02747 0.512
LIG_PTB_Apo_2 247 254 PF02174 0.455
LIG_PTB_Phospho_1 247 253 PF10480 0.455
LIG_Rb_pABgroove_1 466 474 PF01858 0.384
LIG_REV1ctd_RIR_1 635 644 PF16727 0.533
LIG_SH2_CRK 391 395 PF00017 0.387
LIG_SH2_CRK 528 532 PF00017 0.439
LIG_SH2_GRB2like 174 177 PF00017 0.353
LIG_SH2_NCK_1 253 257 PF00017 0.462
LIG_SH2_SRC 253 256 PF00017 0.419
LIG_SH2_STAP1 198 202 PF00017 0.380
LIG_SH2_STAP1 318 322 PF00017 0.465
LIG_SH2_STAP1 458 462 PF00017 0.299
LIG_SH2_STAT3 276 279 PF00017 0.409
LIG_SH2_STAT5 144 147 PF00017 0.382
LIG_SH2_STAT5 174 177 PF00017 0.423
LIG_SH2_STAT5 233 236 PF00017 0.299
LIG_SH2_STAT5 271 274 PF00017 0.486
LIG_SH2_STAT5 337 340 PF00017 0.449
LIG_SH2_STAT5 411 414 PF00017 0.488
LIG_SH2_STAT5 451 454 PF00017 0.338
LIG_SH2_STAT5 569 572 PF00017 0.442
LIG_SH2_STAT5 682 685 PF00017 0.513
LIG_SH3_1 60 66 PF00018 0.521
LIG_SH3_2 55 60 PF14604 0.549
LIG_SH3_3 292 298 PF00018 0.455
LIG_SH3_3 39 45 PF00018 0.603
LIG_SH3_3 47 53 PF00018 0.613
LIG_SH3_3 56 62 PF00018 0.595
LIG_SH3_3 705 711 PF00018 0.687
LIG_SH3_4 393 400 PF00018 0.348
LIG_SUMO_SIM_par_1 293 300 PF11976 0.455
LIG_SUMO_SIM_par_1 692 700 PF11976 0.602
LIG_TYR_ITIM 526 531 PF00017 0.275
LIG_UBA3_1 163 169 PF00899 0.408
LIG_UBA3_1 449 456 PF00899 0.438
LIG_WRC_WIRS_1 123 128 PF05994 0.470
LIG_WRC_WIRS_1 226 231 PF05994 0.289
MOD_CDK_SPK_2 41 46 PF00069 0.562
MOD_CDK_SPxK_1 54 60 PF00069 0.529
MOD_CDK_SPxK_1 70 76 PF00069 0.560
MOD_CK1_1 101 107 PF00069 0.584
MOD_CK1_1 109 115 PF00069 0.708
MOD_CK1_1 122 128 PF00069 0.584
MOD_CK1_1 168 174 PF00069 0.416
MOD_CK1_1 201 207 PF00069 0.391
MOD_CK1_1 228 234 PF00069 0.348
MOD_CK1_1 264 270 PF00069 0.319
MOD_CK1_1 41 47 PF00069 0.666
MOD_CK1_1 426 432 PF00069 0.377
MOD_CK1_1 482 488 PF00069 0.557
MOD_CK1_1 534 540 PF00069 0.276
MOD_CK1_1 610 616 PF00069 0.533
MOD_CK1_1 697 703 PF00069 0.604
MOD_CK1_1 719 725 PF00069 0.795
MOD_CK1_1 8 14 PF00069 0.597
MOD_CK1_1 88 94 PF00069 0.628
MOD_CK2_1 435 441 PF00069 0.333
MOD_CK2_1 534 540 PF00069 0.267
MOD_CK2_1 620 626 PF00069 0.551
MOD_CK2_1 683 689 PF00069 0.601
MOD_CK2_1 700 706 PF00069 0.596
MOD_Cter_Amidation 503 506 PF01082 0.416
MOD_GlcNHglycan 104 107 PF01048 0.561
MOD_GlcNHglycan 153 156 PF01048 0.413
MOD_GlcNHglycan 279 282 PF01048 0.487
MOD_GlcNHglycan 307 310 PF01048 0.301
MOD_GlcNHglycan 374 377 PF01048 0.349
MOD_GlcNHglycan 481 484 PF01048 0.739
MOD_GlcNHglycan 622 625 PF01048 0.564
MOD_GlcNHglycan 7 10 PF01048 0.648
MOD_GlcNHglycan 727 730 PF01048 0.569
MOD_GlcNHglycan 743 747 PF01048 0.708
MOD_GlcNHglycan 80 83 PF01048 0.638
MOD_GlcNHglycan 91 94 PF01048 0.611
MOD_GlcNHglycan 99 103 PF01048 0.583
MOD_GSK3_1 106 113 PF00069 0.663
MOD_GSK3_1 130 137 PF00069 0.689
MOD_GSK3_1 165 172 PF00069 0.377
MOD_GSK3_1 261 268 PF00069 0.247
MOD_GSK3_1 4 11 PF00069 0.594
MOD_GSK3_1 478 485 PF00069 0.611
MOD_GSK3_1 54 61 PF00069 0.677
MOD_GSK3_1 610 617 PF00069 0.600
MOD_GSK3_1 62 69 PF00069 0.606
MOD_GSK3_1 626 633 PF00069 0.517
MOD_GSK3_1 641 648 PF00069 0.631
MOD_GSK3_1 712 719 PF00069 0.665
MOD_GSK3_1 85 92 PF00069 0.665
MOD_GSK3_1 98 105 PF00069 0.549
MOD_LATS_1 558 564 PF00433 0.297
MOD_N-GLC_1 134 139 PF02516 0.525
MOD_N-GLC_1 169 174 PF02516 0.371
MOD_N-GLC_1 722 727 PF02516 0.499
MOD_N-GLC_1 89 94 PF02516 0.596
MOD_NEK2_1 192 197 PF00069 0.432
MOD_NEK2_1 265 270 PF00069 0.289
MOD_NEK2_1 343 348 PF00069 0.271
MOD_NEK2_1 35 40 PF00069 0.562
MOD_NEK2_1 372 377 PF00069 0.290
MOD_NEK2_1 461 466 PF00069 0.354
MOD_NEK2_1 543 548 PF00069 0.264
MOD_NEK2_1 632 637 PF00069 0.463
MOD_NEK2_1 642 647 PF00069 0.463
MOD_NEK2_1 713 718 PF00069 0.757
MOD_NEK2_2 119 124 PF00069 0.476
MOD_NEK2_2 198 203 PF00069 0.362
MOD_PIKK_1 543 549 PF00454 0.281
MOD_PIKK_1 697 703 PF00454 0.557
MOD_PKA_2 109 115 PF00069 0.546
MOD_PKA_2 426 432 PF00069 0.357
MOD_PKA_2 454 460 PF00069 0.360
MOD_PKA_2 504 510 PF00069 0.243
MOD_PKA_2 531 537 PF00069 0.276
MOD_PKA_2 75 81 PF00069 0.661
MOD_PKB_1 605 613 PF00069 0.458
MOD_Plk_1 169 175 PF00069 0.373
MOD_Plk_1 198 204 PF00069 0.365
MOD_Plk_1 510 516 PF00069 0.289
MOD_Plk_4 122 128 PF00069 0.551
MOD_Plk_4 169 175 PF00069 0.373
MOD_Plk_4 228 234 PF00069 0.322
MOD_Plk_4 24 30 PF00069 0.595
MOD_Plk_4 261 267 PF00069 0.247
MOD_Plk_4 426 432 PF00069 0.373
MOD_ProDKin_1 10 16 PF00069 0.645
MOD_ProDKin_1 378 384 PF00069 0.243
MOD_ProDKin_1 38 44 PF00069 0.610
MOD_ProDKin_1 46 52 PF00069 0.613
MOD_ProDKin_1 54 60 PF00069 0.491
MOD_ProDKin_1 62 68 PF00069 0.579
MOD_ProDKin_1 70 76 PF00069 0.647
MOD_ProDKin_1 716 722 PF00069 0.654
MOD_SUMO_rev_2 146 150 PF00179 0.369
MOD_SUMO_rev_2 172 181 PF00179 0.429
MOD_SUMO_rev_2 704 711 PF00179 0.572
TRG_DiLeu_BaEn_1 21 26 PF01217 0.561
TRG_DiLeu_BaLyEn_6 187 192 PF01217 0.279
TRG_DiLeu_BaLyEn_6 592 597 PF01217 0.283
TRG_ENDOCYTIC_2 226 229 PF00928 0.364
TRG_ENDOCYTIC_2 233 236 PF00928 0.295
TRG_ENDOCYTIC_2 253 256 PF00928 0.150
TRG_ENDOCYTIC_2 458 461 PF00928 0.349
TRG_ENDOCYTIC_2 472 475 PF00928 0.541
TRG_ENDOCYTIC_2 528 531 PF00928 0.250
TRG_ER_diArg_1 212 214 PF00400 0.297
TRG_ER_diArg_1 363 365 PF00400 0.278
TRG_ER_diArg_1 446 449 PF00400 0.337
TRG_ER_diArg_1 531 533 PF00400 0.247
TRG_ER_diArg_1 576 578 PF00400 0.276
TRG_ER_diArg_1 604 607 PF00400 0.276
TRG_ER_diArg_1 649 652 PF00400 0.672
TRG_ER_diArg_1 664 667 PF00400 0.552
TRG_NES_CRM1_1 323 336 PF08389 0.298
TRG_NES_CRM1_1 574 589 PF08389 0.286
TRG_NLS_Bipartite_1 650 669 PF00514 0.501
TRG_NLS_MonoCore_2 664 669 PF00514 0.552
TRG_NLS_MonoExtC_3 663 668 PF00514 0.578
TRG_NLS_MonoExtN_4 664 669 PF00514 0.552
TRG_Pf-PMV_PEXEL_1 210 215 PF00026 0.376
TRG_Pf-PMV_PEXEL_1 357 361 PF00026 0.276
TRG_Pf-PMV_PEXEL_1 364 368 PF00026 0.232
TRG_Pf-PMV_PEXEL_1 578 582 PF00026 0.297
TRG_Pf-PMV_PEXEL_1 668 672 PF00026 0.513

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P7I6 Leptomonas seymouri 56% 100%
A0A0S4JDU0 Bodo saltans 38% 85%
A0A3S7X1J7 Leishmania donovani 36% 100%
A4HGJ3 Leishmania braziliensis 72% 99%
A4I3M0 Leishmania infantum 99% 100%
A4I3M1 Leishmania infantum 36% 100%
E9AZW1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
E9AZW2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 100%
P34409 Caenorhabditis elegans 31% 100%
Q4Q8C4 Leishmania major 36% 100%
Q4Q8C5 Leishmania major 89% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS