LeishMANIAdb
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DNA-binding protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
DNA-binding protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3Q8IEL8_LEIDO
TriTrypDb:
LdBPK_330020.1 , LdCL_330005100 , LDHU3_33.0030
Length:
109

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IEL8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEL8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_SKI1_1 44 48 PF00082 0.350
CLV_PCSK_SKI1_1 70 74 PF00082 0.341
DOC_MAPK_gen_1 38 47 PF00069 0.403
DOC_PP2B_LxvP_1 73 76 PF13499 0.434
LIG_14-3-3_CanoR_1 49 58 PF00244 0.427
LIG_BRCT_BRCA1_1 99 103 PF00533 0.388
LIG_EH_1 100 104 PF12763 0.509
LIG_FHA_1 13 19 PF00498 0.486
LIG_FHA_1 35 41 PF00498 0.505
LIG_IRF3_LxIS_1 16 21 PF10401 0.316
LIG_PALB2_WD40_1 53 61 PF16756 0.459
LIG_SH2_STAT3 26 29 PF00017 0.484
LIG_SUMO_SIM_par_1 14 21 PF11976 0.442
MOD_CK1_1 12 18 PF00069 0.440
MOD_CK1_1 66 72 PF00069 0.486
MOD_CK1_1 78 84 PF00069 0.402
MOD_GlcNHglycan 11 14 PF01048 0.418
MOD_GlcNHglycan 19 23 PF01048 0.394
MOD_GlcNHglycan 3 7 PF01048 0.479
MOD_GlcNHglycan 65 68 PF01048 0.497
MOD_GSK3_1 2 9 PF00069 0.443
MOD_NEK2_1 36 41 PF00069 0.428
MOD_Plk_4 12 18 PF00069 0.465
TRG_ENDOCYTIC_2 92 95 PF00928 0.482
TRG_Pf-PMV_PEXEL_1 49 53 PF00026 0.404

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IKZ7 Leptomonas seymouri 70% 100%
A0A0S4KHD0 Bodo saltans 53% 100%
A0A1X0P3H9 Trypanosomatidae 61% 100%
A0A3R7KVB4 Trypanosoma rangeli 60% 100%
A4HL38 Leishmania braziliensis 80% 100%
A4I8L8 Leishmania infantum 98% 100%
C9ZPU1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 58% 100%
E9B3H9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
Q4Q4M1 Leishmania major 93% 100%
V5DB11 Trypanosoma cruzi 61% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS