Eukaryotic translation initiation factor 4E, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Eukaryotic translation initiation factor 4E-4

Species:

Leishmania donovani

UniProt:

A0A3Q8IEL7_LEIDO

TriTrypDb:

LdBPK_300460.1 , LdCL_300009700 , LDHU3_30.0640

Length:

448

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0010494	cytoplasmic stress granule	5	1
GO:0016281	eukaryotic translation initiation factor 4F complex	2	1
GO:0032991	protein-containing complex	1	1
GO:0035770	ribonucleoprotein granule	3	1
GO:0036464	cytoplasmic ribonucleoprotein granule	4	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0099080	supramolecular complex	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IEL7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEL7

PDB structure(s): 6h7b_B , 6h7b_D

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0003743	translation initiation factor activity	4	11
GO:0005488	binding	1	11
GO:0008135	translation factor activity, RNA binding	3	11
GO:0045182	translation regulator activity	1	11
GO:0090079	translation regulator activity, nucleic acid binding	2	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0000339	RNA cap binding	5	1
GO:0000340	RNA 7-methylguanosine cap binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	362	366	PF00656	0.515
CLV_MEL_PAP_1	127	133	PF00089	0.578
CLV_NRD_NRD_1	152	154	PF00675	0.721
CLV_NRD_NRD_1	194	196	PF00675	0.729
CLV_NRD_NRD_1	446	448	PF00675	0.509
CLV_PCSK_KEX2_1	152	154	PF00082	0.721
CLV_PCSK_KEX2_1	194	196	PF00082	0.729
CLV_PCSK_KEX2_1	445	447	PF00082	0.488
CLV_PCSK_SKI1_1	240	244	PF00082	0.619
DEG_ODPH_VHL_1	251	264	PF01847	0.594
DOC_ANK_TNKS_1	152	159	PF00023	0.711
DOC_CKS1_1	1	6	PF01111	0.541
DOC_MAPK_gen_1	383	391	PF00069	0.464
DOC_MAPK_MEF2A_6	385	393	PF00069	0.464
DOC_PP2B_LxvP_1	31	34	PF13499	0.497
DOC_PP4_FxxP_1	273	276	PF00568	0.470
DOC_PP4_MxPP_1	52	55	PF00568	0.546
DOC_USP7_MATH_1	123	127	PF00917	0.748
DOC_USP7_MATH_1	193	197	PF00917	0.700
DOC_USP7_MATH_1	310	314	PF00917	0.530
DOC_USP7_MATH_1	34	38	PF00917	0.683
DOC_USP7_MATH_1	91	95	PF00917	0.746
DOC_USP7_MATH_1	97	101	PF00917	0.543
DOC_WW_Pin1_4	10	15	PF00397	0.630
DOC_WW_Pin1_4	107	112	PF00397	0.577
DOC_WW_Pin1_4	116	121	PF00397	0.535
DOC_WW_Pin1_4	129	134	PF00397	0.564
DOC_WW_Pin1_4	172	177	PF00397	0.679
DOC_WW_Pin1_4	197	202	PF00397	0.634
DOC_WW_Pin1_4	244	249	PF00397	0.551
DOC_WW_Pin1_4	365	370	PF00397	0.520
DOC_WW_Pin1_4	84	89	PF00397	0.628
LIG_14-3-3_CanoR_1	194	198	PF00244	0.688
LIG_14-3-3_CanoR_1	240	246	PF00244	0.581
LIG_APCC_ABBA_1	320	325	PF00400	0.482
LIG_BIR_II_1	1	5	PF00653	0.587
LIG_BRCT_BRCA1_1	12	16	PF00533	0.548
LIG_CSL_BTD_1	407	410	PF09270	0.520
LIG_CSL_BTD_1	78	81	PF09270	0.502
LIG_deltaCOP1_diTrp_1	267	273	PF00928	0.466
LIG_EH1_1	293	301	PF00400	0.459
LIG_EVH1_1	50	54	PF00568	0.545
LIG_FHA_1	317	323	PF00498	0.486
LIG_FHA_1	416	422	PF00498	0.508
LIG_FHA_1	96	102	PF00498	0.563
LIG_FHA_2	1	7	PF00498	0.542
LIG_FHA_2	276	282	PF00498	0.547
LIG_FHA_2	360	366	PF00498	0.451
LIG_LIR_Apic_2	328	334	PF02991	0.520
LIG_LIR_Apic_2	48	53	PF02991	0.558
LIG_LIR_Apic_2	76	82	PF02991	0.508
LIG_LIR_Gen_1	267	276	PF02991	0.466
LIG_LIR_Gen_1	352	363	PF02991	0.452
LIG_LIR_Nem_3	267	273	PF02991	0.455
LIG_LIR_Nem_3	301	306	PF02991	0.452
LIG_LIR_Nem_3	352	358	PF02991	0.452
LIG_LIR_Nem_3	406	411	PF02991	0.520
LIG_LIR_Nem_3	59	65	PF02991	0.542
LIG_MAD2	240	248	PF02301	0.623
LIG_MAD2	304	312	PF02301	0.543
LIG_MYND_1	81	85	PF01753	0.504
LIG_PAM2_1	223	235	PF00658	0.626
LIG_PCNA_PIPBox_1	401	410	PF02747	0.543
LIG_PCNA_yPIPBox_3	395	408	PF02747	0.543
LIG_Pex14_1	270	274	PF04695	0.473
LIG_SH2_STAT3	232	235	PF00017	0.659
LIG_SH2_STAT5	232	235	PF00017	0.659
LIG_SH2_STAT5	274	277	PF00017	0.491
LIG_SH2_STAT5	321	324	PF00017	0.451
LIG_SH2_STAT5	420	423	PF00017	0.410
LIG_SH3_1	50	56	PF00018	0.495
LIG_SH3_2	55	60	PF14604	0.530
LIG_SH3_3	105	111	PF00018	0.598
LIG_SH3_3	181	187	PF00018	0.748
LIG_SH3_3	26	32	PF00018	0.682
LIG_SH3_3	48	54	PF00018	0.617
LIG_SH3_3	79	85	PF00018	0.610
LIG_WRC_WIRS_1	299	304	PF05994	0.451
LIG_WW_3	27	31	PF00397	0.661
MOD_CDK_SPxxK_3	365	372	PF00069	0.520
MOD_CK1_1	100	106	PF00069	0.645
MOD_CK1_1	110	116	PF00069	0.579
MOD_CK1_1	126	132	PF00069	0.516
MOD_CK1_1	206	212	PF00069	0.607
MOD_CK1_1	220	226	PF00069	0.435
MOD_CK1_1	298	304	PF00069	0.482
MOD_CK1_1	37	43	PF00069	0.595
MOD_CK1_1	415	421	PF00069	0.482
MOD_CK2_1	209	215	PF00069	0.494
MOD_CK2_1	275	281	PF00069	0.487
MOD_CK2_1	367	373	PF00069	0.496
MOD_Cter_Amidation	150	153	PF01082	0.726
MOD_GlcNHglycan	208	211	PF01048	0.693
MOD_GlcNHglycan	222	225	PF01048	0.531
MOD_GlcNHglycan	397	400	PF01048	0.362
MOD_GlcNHglycan	93	96	PF01048	0.712
MOD_GSK3_1	102	109	PF00069	0.587
MOD_GSK3_1	12	19	PF00069	0.622
MOD_GSK3_1	193	200	PF00069	0.654
MOD_GSK3_1	359	366	PF00069	0.451
MOD_GSK3_1	367	374	PF00069	0.451
MOD_GSK3_1	37	44	PF00069	0.582
MOD_GSK3_1	391	398	PF00069	0.543
MOD_GSK3_1	412	419	PF00069	0.585
MOD_GSK3_1	69	76	PF00069	0.701
MOD_GSK3_1	91	98	PF00069	0.636
MOD_N-GLC_1	143	148	PF02516	0.727
MOD_N-GLC_1	395	400	PF02516	0.280
MOD_N-GLC_1	46	51	PF02516	0.662
MOD_NEK2_1	16	21	PF00069	0.640
MOD_NEK2_1	315	320	PF00069	0.551
MOD_NEK2_1	359	364	PF00069	0.451
MOD_NEK2_1	391	396	PF00069	0.498
MOD_NEK2_1	412	417	PF00069	0.620
MOD_NEK2_1	73	78	PF00069	0.494
MOD_PIKK_1	241	247	PF00454	0.677
MOD_PK_1	295	301	PF00069	0.482
MOD_PKA_2	193	199	PF00069	0.720
MOD_PKA_2	206	212	PF00069	0.588
MOD_PKA_2	371	377	PF00069	0.451
MOD_Plk_1	395	401	PF00069	0.520
MOD_Plk_1	46	52	PF00069	0.580
MOD_Plk_4	288	294	PF00069	0.465
MOD_Plk_4	295	301	PF00069	0.455
MOD_Plk_4	316	322	PF00069	0.562
MOD_Plk_4	416	422	PF00069	0.522
MOD_Plk_4	97	103	PF00069	0.627
MOD_ProDKin_1	10	16	PF00069	0.632
MOD_ProDKin_1	107	113	PF00069	0.582
MOD_ProDKin_1	116	122	PF00069	0.537
MOD_ProDKin_1	129	135	PF00069	0.566
MOD_ProDKin_1	172	178	PF00069	0.681
MOD_ProDKin_1	197	203	PF00069	0.633
MOD_ProDKin_1	244	250	PF00069	0.550
MOD_ProDKin_1	365	371	PF00069	0.520
MOD_ProDKin_1	84	90	PF00069	0.624
MOD_SUMO_for_1	283	286	PF00179	0.543
MOD_SUMO_for_1	329	332	PF00179	0.451
TRG_DiLeu_BaEn_1	353	358	PF01217	0.543
TRG_ENDOCYTIC_2	62	65	PF00928	0.540
TRG_ER_diArg_1	445	447	PF00400	0.496
TRG_NLS_MonoExtC_3	441	446	PF00514	0.567
TRG_NLS_MonoExtN_4	440	446	PF00514	0.521
TRG_Pf-PMV_PEXEL_1	361	365	PF00026	0.278
TRG_Pf-PMV_PEXEL_1	402	406	PF00026	0.320

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7F6	Leptomonas seymouri	69%	99%
A0A0S4IMC6	Bodo saltans	38%	94%
A0A1X0P285	Trypanosomatidae	44%	100%
A0A422N533	Trypanosoma rangeli	46%	100%
A4HHZ6	Leishmania braziliensis	89%	99%
A4I573	Leishmania infantum	100%	100%
C9ZQJ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9B0H0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4Q7R3	Leishmania major	99%	100%