Kinesin, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Kinesin, putative

Gene product:

kinesin, putative (fragment)

Species:

Leishmania donovani

UniProt:

A0A3Q8IEL2_LEIDO

TriTrypDb:

LdBPK_292500.1 , LdCL_290031100 , LDHU3_29.3710

Length:

589

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 35

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005871	kinesin complex	3	2
GO:0005874	microtubule	6	4
GO:0005875	microtubule associated complex	2	2
GO:0032991	protein-containing complex	1	2
GO:0051286	cell tip	3	2
GO:0060187	cell pole	2	2
GO:0099080	supramolecular complex	2	4
GO:0099081	supramolecular polymer	3	4
GO:0099512	supramolecular fiber	4	4
GO:0099513	polymeric cytoskeletal fiber	5	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A0A3Q8IEL2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEL2

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	16
GO:0007018	microtubule-based movement	3	16
GO:0009987	cellular process	1	16

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	16
GO:0003774	cytoskeletal motor activity	1	16
GO:0003777	microtubule motor activity	2	16
GO:0003824	catalytic activity	1	7
GO:0005488	binding	1	16
GO:0005515	protein binding	2	16
GO:0005524	ATP binding	5	16
GO:0008017	microtubule binding	5	16
GO:0008092	cytoskeletal protein binding	3	16
GO:0015631	tubulin binding	4	16
GO:0016787	hydrolase activity	2	7
GO:0017076	purine nucleotide binding	4	16
GO:0030554	adenyl nucleotide binding	5	16
GO:0032553	ribonucleotide binding	3	16
GO:0032555	purine ribonucleotide binding	4	16
GO:0032559	adenyl ribonucleotide binding	5	16
GO:0035639	purine ribonucleoside triphosphate binding	4	16
GO:0036094	small molecule binding	2	16
GO:0043167	ion binding	2	16
GO:0043168	anion binding	3	16
GO:0097159	organic cyclic compound binding	2	16
GO:0097367	carbohydrate derivative binding	2	16
GO:0140657	ATP-dependent activity	1	16
GO:1901265	nucleoside phosphate binding	3	16
GO:1901363	heterocyclic compound binding	2	16
GO:0016462	pyrophosphatase activity	5	2
GO:0016817	hydrolase activity, acting on acid anhydrides	3	2
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	2
GO:0016887	ATP hydrolysis activity	7	2
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	171	173	PF00675	0.351
CLV_NRD_NRD_1	281	283	PF00675	0.304
CLV_NRD_NRD_1	425	427	PF00675	0.448
CLV_PCSK_FUR_1	45	49	PF00082	0.348
CLV_PCSK_KEX2_1	171	173	PF00082	0.372
CLV_PCSK_KEX2_1	424	426	PF00082	0.470
CLV_PCSK_KEX2_1	432	434	PF00082	0.496
CLV_PCSK_KEX2_1	463	465	PF00082	0.426
CLV_PCSK_KEX2_1	47	49	PF00082	0.394
CLV_PCSK_KEX2_1	559	561	PF00082	0.403
CLV_PCSK_PC1ET2_1	432	434	PF00082	0.495
CLV_PCSK_PC1ET2_1	463	465	PF00082	0.418
CLV_PCSK_PC1ET2_1	47	49	PF00082	0.406
CLV_PCSK_PC1ET2_1	559	561	PF00082	0.361
CLV_PCSK_SKI1_1	115	119	PF00082	0.439
CLV_PCSK_SKI1_1	148	152	PF00082	0.333
CLV_PCSK_SKI1_1	16	20	PF00082	0.572
CLV_PCSK_SKI1_1	355	359	PF00082	0.498
CLV_PCSK_SKI1_1	375	379	PF00082	0.450
CLV_PCSK_SKI1_1	389	393	PF00082	0.487
CLV_PCSK_SKI1_1	456	460	PF00082	0.557
CLV_PCSK_SKI1_1	467	471	PF00082	0.505
CLV_PCSK_SKI1_1	491	495	PF00082	0.576
CLV_PCSK_SKI1_1	505	509	PF00082	0.265
CLV_PCSK_SKI1_1	540	544	PF00082	0.484
CLV_PCSK_SKI1_1	69	73	PF00082	0.310
DEG_APCC_DBOX_1	559	567	PF00400	0.362
DEG_SPOP_SBC_1	477	481	PF00917	0.359
DOC_CYCLIN_RxL_1	112	120	PF00134	0.441
DOC_CYCLIN_RxL_1	344	356	PF00134	0.517
DOC_CYCLIN_yCln2_LP_2	496	502	PF00134	0.314
DOC_MAPK_gen_1	19	30	PF00069	0.388
DOC_MAPK_gen_1	375	384	PF00069	0.552
DOC_MAPK_gen_1	448	455	PF00069	0.417
DOC_MAPK_gen_1	460	470	PF00069	0.365
DOC_MAPK_gen_1	505	513	PF00069	0.406
DOC_MAPK_gen_1	6	15	PF00069	0.398
DOC_MAPK_MEF2A_6	213	222	PF00069	0.333
DOC_MAPK_MEF2A_6	375	384	PF00069	0.388
DOC_MAPK_MEF2A_6	389	396	PF00069	0.350
DOC_MAPK_MEF2A_6	6	15	PF00069	0.438
DOC_MAPK_NFAT4_5	389	397	PF00069	0.435
DOC_PP1_RVXF_1	503	510	PF00149	0.403
DOC_PP2B_LxvP_1	150	153	PF13499	0.333
DOC_PP4_FxxP_1	561	564	PF00568	0.437
DOC_USP7_MATH_1	22	26	PF00917	0.522
DOC_USP7_MATH_1	275	279	PF00917	0.317
DOC_USP7_MATH_1	359	363	PF00917	0.483
DOC_USP7_MATH_1	477	481	PF00917	0.539
DOC_WW_Pin1_4	314	319	PF00397	0.317
DOC_WW_Pin1_4	564	569	PF00397	0.473
LIG_14-3-3_CanoR_1	176	181	PF00244	0.434
LIG_14-3-3_CanoR_1	200	207	PF00244	0.403
LIG_14-3-3_CanoR_1	23	30	PF00244	0.570
LIG_14-3-3_CanoR_1	274	280	PF00244	0.317
LIG_14-3-3_CanoR_1	408	414	PF00244	0.636
LIG_14-3-3_CanoR_1	433	439	PF00244	0.609
LIG_14-3-3_CanoR_1	450	456	PF00244	0.407
LIG_14-3-3_CanoR_1	525	529	PF00244	0.481
LIG_14-3-3_CanoR_1	8	14	PF00244	0.474
LIG_Actin_WH2_2	345	360	PF00022	0.411
LIG_Actin_WH2_2	377	395	PF00022	0.491
LIG_Actin_WH2_2	496	514	PF00022	0.278
LIG_Actin_WH2_2	60	75	PF00022	0.322
LIG_APCC_ABBA_1	140	145	PF00400	0.317
LIG_APCC_ABBA_1	163	168	PF00400	0.333
LIG_BIR_II_1	1	5	PF00653	0.604
LIG_BRCT_BRCA1_1	222	226	PF00533	0.434
LIG_BRCT_BRCA1_1	284	288	PF00533	0.427
LIG_BRCT_BRCA1_1	300	304	PF00533	0.182
LIG_BRCT_BRCA1_1	442	446	PF00533	0.545
LIG_BRCT_BRCA1_1	505	509	PF00533	0.412
LIG_BRCT_BRCA1_1	531	535	PF00533	0.535
LIG_BRCT_BRCA1_2	442	448	PF00533	0.524
LIG_Clathr_ClatBox_1	579	583	PF01394	0.355
LIG_CtBP_PxDLS_1	499	503	PF00389	0.411
LIG_FHA_1	130	136	PF00498	0.403
LIG_FHA_1	24	30	PF00498	0.479
LIG_FHA_1	295	301	PF00498	0.304
LIG_FHA_1	308	314	PF00498	0.304
LIG_FHA_1	322	328	PF00498	0.304
LIG_FHA_1	44	50	PF00498	0.282
LIG_FHA_1	479	485	PF00498	0.410
LIG_FHA_1	565	571	PF00498	0.427
LIG_FHA_1	574	580	PF00498	0.462
LIG_FHA_1	92	98	PF00498	0.323
LIG_FHA_2	248	254	PF00498	0.394
LIG_FHA_2	492	498	PF00498	0.551
LIG_FHA_2	544	550	PF00498	0.433
LIG_GBD_Chelix_1	360	368	PF00786	0.439
LIG_LIR_Gen_1	223	234	PF02991	0.373
LIG_LIR_Gen_1	285	296	PF02991	0.320
LIG_LIR_Gen_1	527	535	PF02991	0.439
LIG_LIR_Gen_1	581	587	PF02991	0.452
LIG_LIR_Gen_1	62	72	PF02991	0.326
LIG_LIR_Gen_1	94	101	PF02991	0.400
LIG_LIR_Nem_3	223	229	PF02991	0.333
LIG_LIR_Nem_3	285	291	PF02991	0.320
LIG_LIR_Nem_3	347	352	PF02991	0.541
LIG_LIR_Nem_3	441	447	PF02991	0.509
LIG_LIR_Nem_3	527	531	PF02991	0.382
LIG_LIR_Nem_3	581	585	PF02991	0.433
LIG_LIR_Nem_3	62	67	PF02991	0.331
LIG_LIR_Nem_3	74	79	PF02991	0.353
LIG_LIR_Nem_3	94	98	PF02991	0.219
LIG_MAD2	512	520	PF02301	0.365
LIG_MYND_1	564	568	PF01753	0.524
LIG_NRBOX	295	301	PF00104	0.351
LIG_Pex14_2	52	56	PF04695	0.323
LIG_Rb_pABgroove_1	112	120	PF01858	0.441
LIG_Rb_pABgroove_1	529	537	PF01858	0.398
LIG_RPA_C_Fungi	421	433	PF08784	0.470
LIG_SH2_CRK	95	99	PF00017	0.441
LIG_SH2_STAP1	332	336	PF00017	0.309
LIG_SH2_STAT5	174	177	PF00017	0.351
LIG_SH2_STAT5	541	544	PF00017	0.436
LIG_SUMO_SIM_anti_2	381	388	PF11976	0.582
LIG_SUMO_SIM_anti_2	492	498	PF11976	0.388
LIG_SUMO_SIM_par_1	235	242	PF11976	0.333
LIG_UBA3_1	189	195	PF00899	0.351
LIG_WRC_WIRS_1	276	281	PF05994	0.317
LIG_WRC_WIRS_1	579	584	PF05994	0.436
MOD_CK1_1	211	217	PF00069	0.287
MOD_CK1_1	294	300	PF00069	0.315
MOD_CK1_1	326	332	PF00069	0.443
MOD_CK1_1	401	407	PF00069	0.538
MOD_CK1_1	91	97	PF00069	0.333
MOD_CK2_1	135	141	PF00069	0.333
MOD_CK2_1	247	253	PF00069	0.306
MOD_CK2_1	287	293	PF00069	0.453
MOD_CK2_1	359	365	PF00069	0.500
MOD_CK2_1	491	497	PF00069	0.579
MOD_CK2_1	542	548	PF00069	0.457
MOD_GlcNHglycan	184	187	PF01048	0.441
MOD_GlcNHglycan	253	257	PF01048	0.394
MOD_GlcNHglycan	56	59	PF01048	0.431
MOD_GlcNHglycan	90	93	PF01048	0.333
MOD_GSK3_1	129	136	PF00069	0.400
MOD_GSK3_1	207	214	PF00069	0.307
MOD_GSK3_1	243	250	PF00069	0.319
MOD_GSK3_1	287	294	PF00069	0.329
MOD_GSK3_1	312	319	PF00069	0.326
MOD_GSK3_1	321	328	PF00069	0.304
MOD_GSK3_1	344	351	PF00069	0.549
MOD_GSK3_1	543	550	PF00069	0.454
MOD_N-GLC_1	207	212	PF02516	0.317
MOD_N-GLC_1	265	270	PF02516	0.304
MOD_N-GLC_1	321	326	PF02516	0.332
MOD_N-GLC_2	80	82	PF02516	0.333
MOD_NEK2_1	207	212	PF00069	0.327
MOD_NEK2_1	218	223	PF00069	0.304
MOD_NEK2_1	291	296	PF00069	0.321
MOD_NEK2_1	300	305	PF00069	0.294
MOD_NEK2_1	312	317	PF00069	0.304
MOD_NEK2_1	323	328	PF00069	0.304
MOD_NEK2_1	337	342	PF00069	0.384
MOD_NEK2_1	409	414	PF00069	0.569
MOD_NEK2_1	542	547	PF00069	0.481
MOD_NEK2_2	129	134	PF00069	0.434
MOD_NEK2_2	287	292	PF00069	0.302
MOD_NEK2_2	451	456	PF00069	0.459
MOD_PIKK_1	220	226	PF00454	0.317
MOD_PIKK_1	398	404	PF00454	0.595
MOD_PK_1	176	182	PF00069	0.434
MOD_PK_1	344	350	PF00069	0.357
MOD_PKA_1	282	288	PF00069	0.427
MOD_PKA_2	199	205	PF00069	0.317
MOD_PKA_2	22	28	PF00069	0.500
MOD_PKA_2	247	253	PF00069	0.319
MOD_PKA_2	291	297	PF00069	0.304
MOD_PKA_2	524	530	PF00069	0.523
MOD_Plk_1	129	135	PF00069	0.434
MOD_Plk_1	265	271	PF00069	0.304
MOD_Plk_1	440	446	PF00069	0.520
MOD_Plk_1	491	497	PF00069	0.553
MOD_Plk_2-3	159	165	PF00069	0.351
MOD_Plk_4	135	141	PF00069	0.333
MOD_Plk_4	236	242	PF00069	0.346
MOD_Plk_4	265	271	PF00069	0.317
MOD_Plk_4	307	313	PF00069	0.312
MOD_Plk_4	344	350	PF00069	0.550
MOD_Plk_4	440	446	PF00069	0.560
MOD_Plk_4	491	497	PF00069	0.499
MOD_Plk_4	529	535	PF00069	0.482
MOD_Plk_4	93	99	PF00069	0.317
MOD_ProDKin_1	314	320	PF00069	0.317
MOD_ProDKin_1	564	570	PF00069	0.471
MOD_SUMO_rev_2	2	7	PF00179	0.587
MOD_SUMO_rev_2	255	265	PF00179	0.307
MOD_SUMO_rev_2	278	285	PF00179	0.430
MOD_SUMO_rev_2	290	297	PF00179	0.317
MOD_SUMO_rev_2	347	357	PF00179	0.428
MOD_SUMO_rev_2	370	380	PF00179	0.454
TRG_DiLeu_BaEn_4	387	393	PF01217	0.477
TRG_DiLeu_BaLyEn_6	295	300	PF01217	0.351
TRG_ENDOCYTIC_2	76	79	PF00928	0.400
TRG_ENDOCYTIC_2	95	98	PF00928	0.180
TRG_ER_diArg_1	13	16	PF00400	0.508
TRG_ER_diArg_1	153	156	PF00400	0.333
TRG_ER_diArg_1	171	173	PF00400	0.333
TRG_ER_diArg_1	423	426	PF00400	0.475
TRG_NES_CRM1_1	233	247	PF08389	0.343
TRG_Pf-PMV_PEXEL_1	115	119	PF00026	0.441
TRG_Pf-PMV_PEXEL_1	298	302	PF00026	0.317

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P569	Leptomonas seymouri	27%	67%
A0A0N1I0Y5	Leptomonas seymouri	30%	96%
A0A0N1PDD6	Leptomonas seymouri	31%	77%
A0A0S4IKE6	Bodo saltans	49%	100%
A0A0S4ILK1	Bodo saltans	34%	69%
A0A0S4IP49	Bodo saltans	27%	73%
A0A0S4JJ54	Bodo saltans	30%	84%
A0A0S4JXY6	Bodo saltans	31%	68%
A0A0S4KL43	Bodo saltans	29%	100%
A0A1X0NJN6	Trypanosomatidae	28%	100%
A0A1X0NP27	Trypanosomatidae	40%	80%
A0A1X0NQ03	Trypanosomatidae	27%	71%
A0A1X0P2B6	Trypanosomatidae	30%	96%
A0A1X0P9E3	Trypanosomatidae	56%	99%
A0A1X0P9H3	Trypanosomatidae	32%	68%
A0A1X0P9T0	Trypanosomatidae	32%	100%
A0A1X0PAG9	Trypanosomatidae	59%	99%
A0A3Q8IAZ2	Leishmania donovani	31%	100%
A0A3R7MDH9	Trypanosoma rangeli	28%	83%
A0A3S5IRH3	Trypanosoma rangeli	28%	97%
A0A3S7WPL3	Leishmania donovani	29%	66%
A0A3S7WS99	Leishmania donovani	30%	81%
A0A422MZ05	Trypanosoma rangeli	28%	87%
A0A422N3U0	Trypanosoma rangeli	27%	78%
A0A422NE49	Trypanosoma rangeli	31%	66%
A0A422NEQ8	Trypanosoma rangeli	32%	78%
A0A422NXU3	Trypanosoma rangeli	58%	100%
A4H4R6	Leishmania braziliensis	29%	67%
A4HAQ7	Leishmania braziliensis	27%	100%
A4HCT2	Leishmania braziliensis	31%	82%
A4HHN7	Leishmania braziliensis	67%	100%
A4HHN8	Leishmania braziliensis	88%	100%
A4HHY2	Leishmania braziliensis	29%	97%
A4HSA6	Leishmania infantum	33%	100%
A4HSZ5	Leishmania infantum	29%	66%
A4HVE9	Leishmania infantum	30%	81%
A4I0A6	Leishmania infantum	31%	100%
A4I4V3	Leishmania infantum	100%	100%
C9ZL08	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
C9ZQI8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	94%
C9ZTV8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	66%
C9ZU98	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	73%
E9AEA0	Leishmania major	70%	100%
E9AEA1	Leishmania major	95%	100%
E9AKY2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	66%
E9ALI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9ALI6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	99%
E9AW71	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9B0F9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
F4I1T9	Arabidopsis thaliana	32%	69%
P32364	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	90%
Q10E64	Oryza sativa subsp. japonica	33%	80%
Q1MTQ7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	93%
Q5VQ09	Oryza sativa subsp. japonica	32%	66%
Q6H638	Oryza sativa subsp. japonica	31%	67%
Q8GW44	Arabidopsis thaliana	33%	100%
Q965T6	Caenorhabditis elegans	35%	91%
Q9NF78	Leishmania major	31%	100%
Q9SCJ4	Arabidopsis thaliana	33%	72%
Q9UTL2	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
Q9V877	Drosophila melanogaster	28%	94%
Q9WV04	Mus musculus	29%	75%
V5B8X9	Trypanosoma cruzi	28%	84%
V5BAR9	Trypanosoma cruzi	33%	92%
V5BHY4	Trypanosoma cruzi	30%	79%
V5BIC1	Trypanosoma cruzi	33%	92%
V5BK25	Trypanosoma cruzi	29%	82%
V5D733	Trypanosoma cruzi	32%	79%
V5DFA7	Trypanosoma cruzi	32%	100%
V5DMS2	Trypanosoma cruzi	35%	100%
V5DTU1	Trypanosoma cruzi	61%	100%