Zn-finger in ubiquitin-hydrolases and other protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zn-finger in ubiquitin-hydrolases and other protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IEL0_LEIDO

TriTrypDb:

LdBPK_343060.1 , LdCL_340039500 , LDHU3_34.5210

Length:

479

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IEL0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEL0

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	1
GO:0007165	signal transduction	2	1
GO:0007264	small GTPase mediated signal transduction	4	1
GO:0007265	Ras protein signal transduction	5	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016567	protein ubiquitination	7	1
GO:0019538	protein metabolic process	3	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0035556	intracellular signal transduction	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0005488	binding	1	12
GO:0008270	zinc ion binding	6	12
GO:0016787	hydrolase activity	2	2
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0046914	transition metal ion binding	5	12
GO:0004842	ubiquitin-protein transferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0019787	ubiquitin-like protein transferase activity	3	1
GO:0061630	ubiquitin protein ligase activity	5	1
GO:0061659	ubiquitin-like protein ligase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	287	291	PF00656	0.546
CLV_C14_Caspase3-7	67	71	PF00656	0.605
CLV_C14_Caspase3-7	7	11	PF00656	0.365
CLV_NRD_NRD_1	127	129	PF00675	0.531
CLV_NRD_NRD_1	357	359	PF00675	0.580
CLV_NRD_NRD_1	431	433	PF00675	0.561
CLV_NRD_NRD_1	466	468	PF00675	0.693
CLV_PCSK_KEX2_1	127	129	PF00082	0.521
CLV_PCSK_KEX2_1	292	294	PF00082	0.507
CLV_PCSK_KEX2_1	356	358	PF00082	0.588
CLV_PCSK_KEX2_1	431	433	PF00082	0.593
CLV_PCSK_KEX2_1	466	468	PF00082	0.715
CLV_PCSK_PC1ET2_1	292	294	PF00082	0.558
CLV_PCSK_PC1ET2_1	356	358	PF00082	0.576
CLV_PCSK_SKI1_1	272	276	PF00082	0.602
CLV_PCSK_SKI1_1	292	296	PF00082	0.263
CLV_PCSK_SKI1_1	368	372	PF00082	0.552
CLV_PCSK_SKI1_1	392	396	PF00082	0.527
CLV_PCSK_SKI1_1	414	418	PF00082	0.564
CLV_PCSK_SKI1_1	444	448	PF00082	0.715
DEG_Nend_UBRbox_2	1	3	PF02207	0.539
DEG_SPOP_SBC_1	49	53	PF00917	0.563
DOC_CYCLIN_yClb5_NLxxxL_5	368	374	PF00134	0.541
DOC_MAPK_MEF2A_6	158	166	PF00069	0.514
DOC_USP7_MATH_1	12	16	PF00917	0.598
DOC_USP7_MATH_1	145	149	PF00917	0.514
DOC_USP7_MATH_1	242	246	PF00917	0.700
DOC_USP7_MATH_1	25	29	PF00917	0.505
DOC_USP7_MATH_1	345	349	PF00917	0.592
DOC_USP7_MATH_1	394	398	PF00917	0.570
DOC_USP7_UBL2_3	260	264	PF12436	0.581
DOC_USP7_UBL2_3	269	273	PF12436	0.517
DOC_WW_Pin1_4	252	257	PF00397	0.731
DOC_WW_Pin1_4	98	103	PF00397	0.553
LIG_14-3-3_CanoR_1	321	331	PF00244	0.659
LIG_14-3-3_CanoR_1	357	367	PF00244	0.506
LIG_14-3-3_CanoR_1	408	416	PF00244	0.471
LIG_14-3-3_CanoR_1	50	55	PF00244	0.577
LIG_Actin_WH2_2	381	398	PF00022	0.498
LIG_AP2alpha_2	161	163	PF02296	0.464
LIG_EH1_1	210	218	PF00400	0.618
LIG_FHA_1	114	120	PF00498	0.560
LIG_FHA_1	196	202	PF00498	0.446
LIG_FHA_1	358	364	PF00498	0.595
LIG_FHA_1	379	385	PF00498	0.537
LIG_FHA_2	324	330	PF00498	0.621
LIG_FHA_2	339	345	PF00498	0.575
LIG_FHA_2	374	380	PF00498	0.571
LIG_FHA_2	417	423	PF00498	0.441
LIG_FHA_2	65	71	PF00498	0.629
LIG_LIR_Apic_2	75	81	PF02991	0.527
LIG_LIR_Gen_1	161	171	PF02991	0.453
LIG_LIR_Gen_1	174	181	PF02991	0.454
LIG_LIR_Gen_1	223	230	PF02991	0.687
LIG_LIR_Gen_1	335	343	PF02991	0.608
LIG_LIR_Nem_3	161	166	PF02991	0.453
LIG_LIR_Nem_3	223	229	PF02991	0.684
LIG_LIR_Nem_3	335	339	PF02991	0.597
LIG_LIR_Nem_3	341	346	PF02991	0.557
LIG_LIR_Nem_3	75	80	PF02991	0.518
LIG_SH2_CRK	281	285	PF00017	0.574
LIG_SH2_PTP2	336	339	PF00017	0.436
LIG_SH2_STAP1	270	274	PF00017	0.543
LIG_SH2_STAP1	281	285	PF00017	0.436
LIG_SH2_STAP1	296	300	PF00017	0.423
LIG_SH2_STAT3	135	138	PF00017	0.537
LIG_SH2_STAT3	296	299	PF00017	0.583
LIG_SH2_STAT3	97	100	PF00017	0.617
LIG_SH2_STAT5	170	173	PF00017	0.476
LIG_SH2_STAT5	336	339	PF00017	0.544
LIG_SH2_STAT5	55	58	PF00017	0.586
LIG_SH2_STAT5	79	82	PF00017	0.488
LIG_SH3_1	78	84	PF00018	0.580
LIG_SH3_3	78	84	PF00018	0.580
LIG_SUMO_SIM_anti_2	31	37	PF11976	0.520
LIG_SUMO_SIM_anti_2	443	449	PF11976	0.638
LIG_SUMO_SIM_par_1	212	221	PF11976	0.508
LIG_TYR_ITSM	73	80	PF00017	0.545
LIG_UBA3_1	350	356	PF00899	0.496
MOD_CK1_1	113	119	PF00069	0.608
MOD_CK1_1	220	226	PF00069	0.553
MOD_CK1_1	390	396	PF00069	0.552
MOD_CK2_1	323	329	PF00069	0.580
MOD_CK2_1	338	344	PF00069	0.579
MOD_CK2_1	373	379	PF00069	0.541
MOD_CK2_1	409	415	PF00069	0.493
MOD_Cter_Amidation	464	467	PF01082	0.660
MOD_GlcNHglycan	108	111	PF01048	0.550
MOD_GlcNHglycan	147	150	PF01048	0.614
MOD_GlcNHglycan	16	19	PF01048	0.495
MOD_GlcNHglycan	244	247	PF01048	0.672
MOD_GlcNHglycan	266	269	PF01048	0.675
MOD_GlcNHglycan	305	308	PF01048	0.691
MOD_GlcNHglycan	450	453	PF01048	0.634
MOD_GlcNHglycan	94	97	PF01048	0.555
MOD_GSK3_1	102	109	PF00069	0.504
MOD_GSK3_1	216	223	PF00069	0.593
MOD_GSK3_1	390	397	PF00069	0.454
MOD_GSK3_1	92	99	PF00069	0.545
MOD_NEK2_1	118	123	PF00069	0.518
MOD_NEK2_1	216	221	PF00069	0.545
MOD_NEK2_1	274	279	PF00069	0.577
MOD_NEK2_1	295	300	PF00069	0.532
MOD_NEK2_1	407	412	PF00069	0.474
MOD_NEK2_1	416	421	PF00069	0.391
MOD_NEK2_1	90	95	PF00069	0.569
MOD_OFUCOSY	117	123	PF10250	0.444
MOD_PIKK_1	110	116	PF00454	0.399
MOD_PIKK_1	195	201	PF00454	0.453
MOD_PIKK_1	295	301	PF00454	0.592
MOD_PIKK_1	426	432	PF00454	0.572
MOD_PIKK_1	96	102	PF00454	0.640
MOD_PKA_1	272	278	PF00069	0.630
MOD_PKA_1	357	363	PF00069	0.569
MOD_PKA_2	357	363	PF00069	0.516
MOD_PKA_2	407	413	PF00069	0.493
MOD_PKA_2	465	471	PF00069	0.760
MOD_PKA_2	49	55	PF00069	0.607
MOD_Plk_1	379	385	PF00069	0.500
MOD_Plk_1	90	96	PF00069	0.581
MOD_Plk_4	222	228	PF00069	0.615
MOD_Plk_4	31	37	PF00069	0.490
MOD_Plk_4	345	351	PF00069	0.540
MOD_Plk_4	50	56	PF00069	0.609
MOD_Plk_4	73	79	PF00069	0.645
MOD_ProDKin_1	252	258	PF00069	0.730
MOD_ProDKin_1	98	104	PF00069	0.548
MOD_SUMO_for_1	151	154	PF00179	0.514
MOD_SUMO_for_1	285	288	PF00179	0.543
MOD_SUMO_for_1	370	373	PF00179	0.507
MOD_SUMO_rev_2	257	266	PF00179	0.678
MOD_SUMO_rev_2	267	275	PF00179	0.572
MOD_SUMO_rev_2	287	294	PF00179	0.247
MOD_SUMO_rev_2	410	419	PF00179	0.518
TRG_DiLeu_BaEn_4	379	385	PF01217	0.583
TRG_ENDOCYTIC_2	176	179	PF00928	0.499
TRG_ENDOCYTIC_2	281	284	PF00928	0.565
TRG_ENDOCYTIC_2	336	339	PF00928	0.585
TRG_ENDOCYTIC_2	77	80	PF00928	0.506
TRG_ER_diArg_1	127	129	PF00400	0.531
TRG_ER_diArg_1	431	433	PF00400	0.564
TRG_Pf-PMV_PEXEL_1	293	297	PF00026	0.554
TRG_Pf-PMV_PEXEL_1	414	418	PF00026	0.531
TRG_Pf-PMV_PEXEL_1	431	436	PF00026	0.461

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAV0	Leptomonas seymouri	68%	80%
A0A0S4ILW6	Bodo saltans	30%	84%
A0A1X0PAX0	Trypanosomatidae	33%	94%
A0A422NNH1	Trypanosoma rangeli	34%	97%
A4HB46	Leishmania braziliensis	83%	100%
A4IA95	Leishmania infantum	100%	100%
C9ZLZ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	97%
E5KGE0	Arabidopsis thaliana	29%	98%
E9B5B7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O13747	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	88%
Q4Q2L6	Leishmania major	92%	99%
Q7Z569	Homo sapiens	23%	81%
Q95QN6	Caenorhabditis elegans	23%	81%
Q99MP8	Mus musculus	23%	81%
V5DLZ1	Trypanosoma cruzi	35%	95%