5-formyltetrahydrofolate cyclo-ligase family, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

5-formyltetrahydrofolate cyclo-ligase family, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IEK9_LEIDO

TriTrypDb:

LdBPK_231270.1 , LdCL_230019800 , LDHU3_23.1670

Length:

449

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IEK9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEK9

Function

Biological processes
Term	Name	Level	Count
GO:0006575	cellular modified amino acid metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006730	one-carbon metabolic process	3	1
GO:0006760	folic acid-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009396	folic acid-containing compound biosynthetic process	5	1
GO:0009987	cellular process	1	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0035999	tetrahydrofolate interconversion	4	1
GO:0042398	cellular modified amino acid biosynthetic process	4	1
GO:0042558	pteridine-containing compound metabolic process	4	1
GO:0042559	pteridine-containing compound biosynthetic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0044281	small molecule metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046653	tetrahydrofolate metabolic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0016874	ligase activity	2	3
GO:0016879	ligase activity, forming carbon-nitrogen bonds	3	1
GO:0016882	cyclo-ligase activity	4	1
GO:0030272	5-formyltetrahydrofolate cyclo-ligase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	277	281	PF00656	0.383
CLV_MEL_PAP_1	353	359	PF00089	0.610
CLV_NRD_NRD_1	13	15	PF00675	0.361
CLV_NRD_NRD_1	22	24	PF00675	0.363
CLV_NRD_NRD_1	346	348	PF00675	0.489
CLV_PCSK_FUR_1	20	24	PF00082	0.431
CLV_PCSK_KEX2_1	22	24	PF00082	0.421
CLV_PCSK_KEX2_1	345	347	PF00082	0.470
CLV_PCSK_SKI1_1	10	14	PF00082	0.379
CLV_PCSK_SKI1_1	23	27	PF00082	0.403
DEG_Nend_UBRbox_3	1	3	PF02207	0.624
DEG_SPOP_SBC_1	148	152	PF00917	0.667
DEG_SPOP_SBC_1	62	66	PF00917	0.525
DOC_CKS1_1	118	123	PF01111	0.457
DOC_CYCLIN_yCln2_LP_2	202	208	PF00134	0.495
DOC_CYCLIN_yCln2_LP_2	77	83	PF00134	0.505
DOC_MAPK_DCC_7	135	144	PF00069	0.470
DOC_MAPK_gen_1	10	21	PF00069	0.504
DOC_MAPK_HePTP_8	132	144	PF00069	0.454
DOC_MAPK_MEF2A_6	135	144	PF00069	0.715
DOC_MAPK_MEF2A_6	169	177	PF00069	0.472
DOC_MAPK_RevD_3	7	23	PF00069	0.436
DOC_PP2B_LxvP_1	77	80	PF13499	0.581
DOC_PP2B_LxvP_1	81	84	PF13499	0.454
DOC_PP2B_PxIxI_1	409	415	PF00149	0.538
DOC_PP4_FxxP_1	262	265	PF00568	0.357
DOC_USP7_MATH_1	148	152	PF00917	0.696
DOC_USP7_MATH_1	300	304	PF00917	0.456
DOC_USP7_MATH_1	349	353	PF00917	0.632
DOC_USP7_MATH_1	431	435	PF00917	0.456
DOC_USP7_MATH_1	62	66	PF00917	0.570
DOC_USP7_MATH_1	69	73	PF00917	0.688
DOC_USP7_UBL2_3	11	15	PF12436	0.515
DOC_WW_Pin1_4	117	122	PF00397	0.354
DOC_WW_Pin1_4	142	147	PF00397	0.777
DOC_WW_Pin1_4	221	226	PF00397	0.649
DOC_WW_Pin1_4	287	292	PF00397	0.503
DOC_WW_Pin1_4	434	439	PF00397	0.425
DOC_WW_Pin1_4	79	84	PF00397	0.581
LIG_14-3-3_CanoR_1	212	219	PF00244	0.527
LIG_14-3-3_CanoR_1	23	29	PF00244	0.467
LIG_14-3-3_CanoR_1	401	410	PF00244	0.472
LIG_14-3-3_CanoR_1	430	436	PF00244	0.330
LIG_14-3-3_CanoR_1	60	67	PF00244	0.655
LIG_Actin_WH2_2	386	403	PF00022	0.357
LIG_AP2alpha_1	332	336	PF02296	0.492
LIG_APCC_ABBA_1	92	97	PF00400	0.334
LIG_eIF4E_1	270	276	PF01652	0.518
LIG_FHA_1	118	124	PF00498	0.398
LIG_FHA_1	127	133	PF00498	0.411
LIG_FHA_1	211	217	PF00498	0.592
LIG_FHA_1	296	302	PF00498	0.513
LIG_FHA_1	4	10	PF00498	0.420
LIG_HCF-1_HBM_1	41	44	PF13415	0.449
LIG_LIR_Gen_1	256	265	PF02991	0.362
LIG_LIR_Gen_1	41	51	PF02991	0.307
LIG_LIR_Nem_3	256	261	PF02991	0.360
LIG_LIR_Nem_3	334	339	PF02991	0.440
LIG_LIR_Nem_3	41	47	PF02991	0.321
LIG_Pex14_2	332	336	PF04695	0.492
LIG_SH2_CRK	258	262	PF00017	0.419
LIG_SH2_SRC	44	47	PF00017	0.433
LIG_SH2_STAP1	258	262	PF00017	0.419
LIG_SH2_STAP1	333	337	PF00017	0.440
LIG_SH2_STAP1	44	48	PF00017	0.448
LIG_SH2_STAT5	46	49	PF00017	0.435
LIG_SH2_STAT5	91	94	PF00017	0.354
LIG_SH2_STAT5	95	98	PF00017	0.351
LIG_SH3_3	119	125	PF00018	0.369
LIG_SH3_3	154	160	PF00018	0.729
LIG_SH3_3	183	189	PF00018	0.329
LIG_SH3_3	308	314	PF00018	0.471
LIG_SH3_3	380	386	PF00018	0.481
LIG_SH3_3	432	438	PF00018	0.409
LIG_SH3_3	77	83	PF00018	0.487
LIG_SUMO_SIM_par_1	120	127	PF11976	0.371
LIG_TYR_ITIM	89	94	PF00017	0.375
LIG_UBA3_1	18	26	PF00899	0.496
MOD_CK1_1	211	217	PF00069	0.612
MOD_CK1_1	224	230	PF00069	0.676
MOD_CK1_1	352	358	PF00069	0.575
MOD_CK1_1	402	408	PF00069	0.654
MOD_CK1_1	415	421	PF00069	0.638
MOD_CK1_1	434	440	PF00069	0.281
MOD_CK1_1	63	69	PF00069	0.689
MOD_CK2_1	198	204	PF00069	0.555
MOD_CK2_1	223	229	PF00069	0.614
MOD_GlcNHglycan	169	172	PF01048	0.404
MOD_GlcNHglycan	272	275	PF01048	0.505
MOD_GlcNHglycan	380	383	PF01048	0.556
MOD_GlcNHglycan	438	441	PF01048	0.482
MOD_GlcNHglycan	56	59	PF01048	0.664
MOD_GSK3_1	126	133	PF00069	0.506
MOD_GSK3_1	148	155	PF00069	0.749
MOD_GSK3_1	208	215	PF00069	0.502
MOD_GSK3_1	374	381	PF00069	0.602
MOD_GSK3_1	400	407	PF00069	0.623
MOD_GSK3_1	414	421	PF00069	0.656
MOD_N-GLC_1	198	203	PF02516	0.393
MOD_NEK2_1	198	203	PF00069	0.509
MOD_NEK2_1	241	246	PF00069	0.652
MOD_NEK2_1	378	383	PF00069	0.527
MOD_NEK2_1	400	405	PF00069	0.486
MOD_NEK2_2	339	344	PF00069	0.508
MOD_PIKK_1	33	39	PF00454	0.503
MOD_PK_1	106	112	PF00069	0.536
MOD_PKA_2	211	217	PF00069	0.557
MOD_PKA_2	270	276	PF00069	0.577
MOD_PKA_2	400	406	PF00069	0.687
MOD_Plk_1	198	204	PF00069	0.397
MOD_Plk_1	305	311	PF00069	0.523
MOD_Plk_1	415	421	PF00069	0.552
MOD_Plk_4	149	155	PF00069	0.577
MOD_Plk_4	182	188	PF00069	0.342
MOD_Plk_4	198	204	PF00069	0.532
MOD_Plk_4	305	311	PF00069	0.535
MOD_Plk_4	431	437	PF00069	0.428
MOD_ProDKin_1	117	123	PF00069	0.361
MOD_ProDKin_1	142	148	PF00069	0.584
MOD_ProDKin_1	221	227	PF00069	0.652
MOD_ProDKin_1	287	293	PF00069	0.503
MOD_ProDKin_1	434	440	PF00069	0.429
MOD_ProDKin_1	79	85	PF00069	0.565
MOD_SUMO_for_1	25	28	PF00179	0.445
TRG_DiLeu_BaLyEn_6	82	87	PF01217	0.472
TRG_ENDOCYTIC_2	258	261	PF00928	0.425
TRG_ENDOCYTIC_2	333	336	PF00928	0.440
TRG_ENDOCYTIC_2	44	47	PF00928	0.322
TRG_ENDOCYTIC_2	91	94	PF00928	0.314
TRG_ENDOCYTIC_2	95	98	PF00928	0.304
TRG_ER_diArg_1	19	22	PF00400	0.417
TRG_ER_diArg_1	285	288	PF00400	0.403
TRG_ER_diArg_1	345	347	PF00400	0.464
TRG_ER_FFAT_1	273	284	PF00635	0.391
TRG_Pf-PMV_PEXEL_1	346	351	PF00026	0.633

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1K4	Leptomonas seymouri	41%	100%
A0A1X0NWU1	Trypanosomatidae	27%	100%
A0A3R7KPU1	Trypanosoma rangeli	26%	100%
A4HCX6	Leishmania braziliensis	72%	100%
A4I0F9	Leishmania infantum	100%	100%
C9ZV81	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AWC2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QB50	Leishmania major	90%	100%
V5DFL5	Trypanosoma cruzi	29%	100%