Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IEK8_LEIDO

TriTrypDb:

LdBPK_324000.1 , LdCL_320046000 , LDHU3_32.5130

Length:

291

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IEK8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEK8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	225	229	PF00656	0.555
CLV_NRD_NRD_1	120	122	PF00675	0.552
CLV_NRD_NRD_1	213	215	PF00675	0.418
CLV_NRD_NRD_1	232	234	PF00675	0.575
CLV_NRD_NRD_1	278	280	PF00675	0.564
CLV_NRD_NRD_1	34	36	PF00675	0.629
CLV_NRD_NRD_1	82	84	PF00675	0.623
CLV_PCSK_FUR_1	80	84	PF00082	0.621
CLV_PCSK_KEX2_1	232	234	PF00082	0.575
CLV_PCSK_KEX2_1	278	280	PF00082	0.695
CLV_PCSK_KEX2_1	283	285	PF00082	0.722
CLV_PCSK_KEX2_1	34	36	PF00082	0.629
CLV_PCSK_KEX2_1	82	84	PF00082	0.623
CLV_PCSK_PC1ET2_1	283	285	PF00082	0.746
CLV_PCSK_PC7_1	279	285	PF00082	0.565
CLV_PCSK_SKI1_1	121	125	PF00082	0.623
CLV_PCSK_SKI1_1	185	189	PF00082	0.496
CLV_PCSK_SKI1_1	83	87	PF00082	0.621
CLV_Separin_Metazoa	180	184	PF03568	0.516
DEG_Nend_UBRbox_1	1	4	PF02207	0.699
DEG_SPOP_SBC_1	265	269	PF00917	0.665
DOC_MAPK_gen_1	183	190	PF00069	0.482
DOC_MAPK_MEF2A_6	158	167	PF00069	0.641
DOC_PP1_RVXF_1	107	113	PF00149	0.507
DOC_USP7_MATH_1	231	235	PF00917	0.572
DOC_USP7_MATH_1	38	42	PF00917	0.726
DOC_WW_Pin1_4	268	273	PF00397	0.747
LIG_Actin_WH2_2	71	89	PF00022	0.622
LIG_FHA_1	190	196	PF00498	0.581
LIG_FHA_2	23	29	PF00498	0.715
LIG_LIR_Gen_1	271	280	PF02991	0.668
LIG_LIR_Nem_3	271	276	PF02991	0.675
LIG_MYND_3	174	178	PF01753	0.529
LIG_PTAP_UEV_1	146	151	PF05743	0.611
LIG_SH2_NCK_1	256	260	PF00017	0.566
LIG_SH2_STAT5	208	211	PF00017	0.596
LIG_SH3_1	158	164	PF00018	0.650
LIG_SH3_3	135	141	PF00018	0.752
LIG_SH3_3	144	150	PF00018	0.665
LIG_SH3_3	158	164	PF00018	0.646
LIG_SUMO_SIM_anti_2	245	252	PF11976	0.529
LIG_SUMO_SIM_par_1	22	28	PF11976	0.559
LIG_SUMO_SIM_par_1	245	252	PF11976	0.529
LIG_TRAF2_1	169	172	PF00917	0.634
MOD_CK1_1	249	255	PF00069	0.721
MOD_CK1_1	257	263	PF00069	0.679
MOD_CK1_1	46	52	PF00069	0.554
MOD_CK1_1	53	59	PF00069	0.492
MOD_CK2_1	126	132	PF00069	0.615
MOD_CK2_1	156	162	PF00069	0.681
MOD_CK2_1	53	59	PF00069	0.714
MOD_Cter_Amidation	276	279	PF01082	0.574
MOD_GlcNHglycan	128	131	PF01048	0.651
MOD_GlcNHglycan	238	241	PF01048	0.528
MOD_GlcNHglycan	257	260	PF01048	0.650
MOD_GlcNHglycan	40	43	PF01048	0.562
MOD_GlcNHglycan	6	9	PF01048	0.695
MOD_GlcNHglycan	87	90	PF01048	0.678
MOD_GSK3_1	260	267	PF00069	0.793
MOD_GSK3_1	268	275	PF00069	0.689
MOD_GSK3_1	43	50	PF00069	0.679
MOD_N-GLC_1	265	270	PF02516	0.618
MOD_NEK2_1	1	6	PF00069	0.581
MOD_NEK2_1	126	131	PF00069	0.608
MOD_NEK2_1	85	90	PF00069	0.681
MOD_NEK2_1	95	100	PF00069	0.616
MOD_PIKK_1	189	195	PF00454	0.607
MOD_PIKK_1	257	263	PF00454	0.688
MOD_PIKK_1	266	272	PF00454	0.599
MOD_PIKK_1	43	49	PF00454	0.673
MOD_PIKK_1	95	101	PF00454	0.553
MOD_PKA_2	1	7	PF00069	0.607
MOD_PKA_2	231	237	PF00069	0.640
MOD_Plk_4	246	252	PF00069	0.734
MOD_ProDKin_1	268	274	PF00069	0.744
TRG_ER_diArg_1	102	105	PF00400	0.625
TRG_ER_diArg_1	182	185	PF00400	0.534
TRG_NES_CRM1_1	242	255	PF08389	0.642
TRG_Pf-PMV_PEXEL_1	158	162	PF00026	0.690

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HL22	Leishmania braziliensis	57%	99%
A4I8K3	Leishmania infantum	99%	100%
E9B3G3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q4N7	Leishmania major	86%	100%