Helicase conserved C-terminal domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Helicase conserved C-terminal domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IEK4_LEIDO

TriTrypDb:

LdCL_230018100

Length:

454

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IEK4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEK4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0004386	helicase activity	2	2
GO:0140640	catalytic activity, acting on a nucleic acid	2	2
GO:0140657	ATP-dependent activity	1	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	229	233	PF00656	0.527
CLV_C14_Caspase3-7	322	326	PF00656	0.505
CLV_NRD_NRD_1	346	348	PF00675	0.473
CLV_NRD_NRD_1	349	351	PF00675	0.433
CLV_NRD_NRD_1	69	71	PF00675	0.199
CLV_PCSK_FUR_1	347	351	PF00082	0.447
CLV_PCSK_FUR_1	67	71	PF00082	0.199
CLV_PCSK_KEX2_1	346	348	PF00082	0.473
CLV_PCSK_KEX2_1	349	351	PF00082	0.433
CLV_PCSK_KEX2_1	69	71	PF00082	0.199
CLV_PCSK_SKI1_1	306	310	PF00082	0.545
CLV_PCSK_SKI1_1	444	448	PF00082	0.441
DEG_APCC_DBOX_1	443	451	PF00400	0.447
DEG_Nend_UBRbox_2	1	3	PF02207	0.401
DEG_SPOP_SBC_1	298	302	PF00917	0.528
DOC_CYCLIN_yCln2_LP_2	384	390	PF00134	0.494
DOC_MAPK_gen_1	153	162	PF00069	0.289
DOC_MAPK_gen_1	346	354	PF00069	0.439
DOC_MAPK_HePTP_8	109	121	PF00069	0.400
DOC_MAPK_MEF2A_6	112	121	PF00069	0.400
DOC_MAPK_MEF2A_6	15	22	PF00069	0.400
DOC_PP1_RVXF_1	348	355	PF00149	0.431
DOC_PP2B_LxvP_1	102	105	PF13499	0.400
DOC_USP7_MATH_1	241	245	PF00917	0.511
DOC_USP7_MATH_1	298	302	PF00917	0.528
DOC_USP7_MATH_1	377	381	PF00917	0.524
DOC_USP7_MATH_1	63	67	PF00917	0.400
DOC_WW_Pin1_4	279	284	PF00397	0.522
DOC_WW_Pin1_4	394	399	PF00397	0.488
DOC_WW_Pin1_4	82	87	PF00397	0.400
LIG_14-3-3_CanoR_1	25	29	PF00244	0.400
LIG_14-3-3_CanoR_1	277	283	PF00244	0.529
LIG_14-3-3_CanoR_1	349	355	PF00244	0.424
LIG_14-3-3_CanoR_1	69	74	PF00244	0.400
LIG_BIR_III_4	268	272	PF00653	0.543
LIG_BIR_III_4	58	62	PF00653	0.400
LIG_Clathr_ClatBox_1	129	133	PF01394	0.400
LIG_EVH1_1	249	253	PF00568	0.436
LIG_EVH1_2	250	254	PF00568	0.431
LIG_FHA_1	124	130	PF00498	0.400
LIG_FHA_1	150	156	PF00498	0.309
LIG_FHA_1	387	393	PF00498	0.486
LIG_FHA_1	414	420	PF00498	0.467
LIG_FHA_2	164	170	PF00498	0.326
LIG_FHA_2	227	233	PF00498	0.520
LIG_FHA_2	280	286	PF00498	0.522
LIG_FHA_2	308	314	PF00498	0.537
LIG_LIR_Nem_3	248	252	PF02991	0.442
LIG_SH2_PTP2	19	22	PF00017	0.400
LIG_SH2_STAT3	134	137	PF00017	0.400
LIG_SH2_STAT5	19	22	PF00017	0.400
LIG_SH3_3	247	253	PF00018	0.446
LIG_SH3_3	416	422	PF00018	0.457
LIG_SH3_CIN85_PxpxPR_1	251	256	PF14604	0.434
LIG_SUMO_SIM_par_1	128	133	PF11976	0.400
LIG_SUMO_SIM_par_1	169	175	PF11976	0.305
LIG_TRAF2_1	233	236	PF00917	0.532
LIG_TYR_ITIM	17	22	PF00017	0.199
MOD_CK1_1	213	219	PF00069	0.357
MOD_CK1_1	226	232	PF00069	0.511
MOD_CK1_1	273	279	PF00069	0.538
MOD_CK1_1	291	297	PF00069	0.527
MOD_CK1_1	41	47	PF00069	0.199
MOD_CK1_1	77	83	PF00069	0.199
MOD_CK2_1	192	198	PF00069	0.350
MOD_CK2_1	230	236	PF00069	0.530
MOD_CK2_1	307	313	PF00069	0.541
MOD_Cter_Amidation	347	350	PF01082	0.452
MOD_GlcNHglycan	232	235	PF01048	0.530
MOD_GlcNHglycan	278	281	PF01048	0.529
MOD_GlcNHglycan	290	293	PF01048	0.524
MOD_GlcNHglycan	301	304	PF01048	0.535
MOD_GlcNHglycan	43	46	PF01048	0.199
MOD_GSK3_1	218	225	PF00069	0.404
MOD_GSK3_1	226	233	PF00069	0.514
MOD_GSK3_1	241	248	PF00069	0.499
MOD_GSK3_1	272	279	PF00069	0.539
MOD_GSK3_1	37	44	PF00069	0.199
MOD_GSK3_1	74	81	PF00069	0.199
MOD_N-GLC_1	38	43	PF02516	0.199
MOD_NEK2_1	108	113	PF00069	0.199
MOD_NEK2_1	192	197	PF00069	0.352
MOD_NEK2_1	38	43	PF00069	0.199
MOD_NEK2_2	123	128	PF00069	0.199
MOD_NEK2_2	399	404	PF00069	0.492
MOD_PIKK_1	213	219	PF00454	0.357
MOD_PIKK_1	226	232	PF00454	0.511
MOD_PIKK_1	241	247	PF00454	0.502
MOD_PKA_1	69	75	PF00069	0.199
MOD_PKA_2	213	219	PF00069	0.357
MOD_PKA_2	223	229	PF00069	0.478
MOD_PKA_2	24	30	PF00069	0.199
MOD_PKA_2	276	282	PF00069	0.533
MOD_PKA_2	69	75	PF00069	0.199
MOD_PKB_1	67	75	PF00069	0.199
MOD_Plk_1	23	29	PF00069	0.199
MOD_Plk_1	38	44	PF00069	0.199
MOD_Plk_2-3	163	169	PF00069	0.328
MOD_Plk_4	123	129	PF00069	0.199
MOD_ProDKin_1	279	285	PF00069	0.522
MOD_ProDKin_1	394	400	PF00069	0.489
MOD_ProDKin_1	82	88	PF00069	0.199
MOD_SUMO_for_1	308	311	PF00179	0.539
MOD_SUMO_for_1	354	357	PF00179	0.429
TRG_DiLeu_BaLyEn_6	156	161	PF01217	0.283
TRG_DiLeu_BaLyEn_6	388	393	PF01217	0.489
TRG_ENDOCYTIC_2	19	22	PF00928	0.199
TRG_ER_diArg_1	346	349	PF00400	0.463
TRG_ER_diArg_1	67	70	PF00400	0.199
TRG_Pf-PMV_PEXEL_1	159	163	PF00026	0.291

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0P0WGX7	ORYSJ	36%	46%
A2BGR3	DANRE	42%	31%
A4IHD2	XENTR	40%	33%
A4PBL4	ORYSJ	38%	46%
A6QQR4	BOVIN	37%	37%
A6ZL17	YEAS7	38%	49%
A6ZU34	YEAS7	41%	30%
A9X4T1	BOMMO	46%	33%
B0R061	DANRE	53%	47%
B3LN76	YEAS1	38%	49%
B3MMA5	DROAN	38%	57%
B3NAN8	DROER	38%	58%
B4GS98	DROPE	38%	58%
B4JCS7	DROGR	38%	58%
B4KHL5	DROMO	38%	58%
B4M9A8	DROVI	38%	58%
B4MX21	DROWI	32%	58%
B4NXB8	DROYA	37%	58%
B5VE38	YEAS6	38%	49%
C7GQI8	YEAS2	38%	49%
D3Z9Z9	RAT	49%	44%
E1B7X9	BOVIN	48%	44%
E7F1C4	DANRE	47%	48%
F1Q8K0	DANRE	40%	62%
F4HW51	ARATH	36%	31%
F4I2H2	ARATH	52%	53%
F4IV45	ARATH	46%	52%
F4J9M5	ARATH	43%	41%
F4JTF6	ARATH	46%	38%
F4JY24	ARATH	39%	42%
F4K128	ARATH	42%	43%
F8VPZ5	MOUSE	38%	31%
G5EDG2	CAEEL	40%	46%
O10302	NPVOP	41%	91%
O12944	CHICK	40%	62%
O13682	SCHPO	42%	35%
O13762	SCHPO	40%	51%
O14139	SCHPO	37%	33%
O16102	DROME	32%	51%
O42861	SCHPO	45%	49%
O60177	SCHPO	39%	44%
O60264	HUMAN	45%	43%
O74842	SCHPO	47%	35%
O76460	DROME	38%	58%
P0CO18	CRYNJ	41%	36%
P0CO19	CRYNB	41%	36%
P0CQ66	CRYNJ	40%	38%
P0CQ67	CRYNB	40%	38%
P28370	HUMAN	44%	43%
P31244	YEAST	35%	57%
P31380	YEAST	45%	40%
P32597	YEAST	44%	33%
P32657	YEAST	37%	31%
P32849	YEAST	40%	39%
P32863	YEAST	42%	51%
P34739	DROME	43%	43%
P36607	SCHPO	42%	40%
P38086	YEAST	38%	47%
P38144	YEAST	42%	40%
P40352	YEAST	39%	42%
P41410	SCHPO	44%	53%
P41877	CAEEL	42%	45%
P43610	YEAST	46%	53%
P47264	MYCGE	35%	44%
P53115	YEAST	41%	30%
P54509	BACSU	34%	82%
P70270	MOUSE	40%	61%
P75093	MYCPN	36%	44%
P79051	SCHPO	32%	53%
P87114	SCHPO	47%	48%
P94593	BACSU	35%	49%
Q03468	HUMAN	43%	30%
Q04692	MOUSE	49%	44%
Q08773	YEAST	40%	41%
Q0PCS3	ARATH	40%	50%
Q10332	SCHPO	40%	55%
Q14527	HUMAN	40%	45%
Q24368	DROME	40%	44%
Q29KH2	DROPS	38%	58%
Q2NKX8	HUMAN	46%	36%
Q2UTQ9	ASPOR	46%	31%
Q3B7N1	BOVIN	45%	51%
Q4IJ84	GIBZE	38%	39%
Q4PGG5	USTMA	33%	33%
Q4WVM1	ASPFU	31%	36%
Q59KI4	CANAL	46%	33%
Q5A310	CANAL	41%	43%
Q5ACX1	CANAL	37%	42%
Q5BHD6	EMENI	44%	38%
Q5FWR0	XENTR	48%	45%
Q5NC05	MOUSE	44%	40%
Q60848	MOUSE	45%	55%
Q60EX7	ORYSJ	46%	40%
Q6BGY8	DEBHA	41%	33%
Q6BIP2	DEBHA	40%	38%
Q6C2R8	YARLI	41%	44%
Q6CJM4	KLULA	40%	41%
Q6CNY4	KLULA	42%	30%
Q6FK48	CANGA	38%	31%
Q6FV37	CANGA	40%	31%
Q6FY76	CANGA	39%	39%
Q6PCN7	MOUSE	41%	45%
Q6PFE3	MOUSE	45%	51%
Q6PGB8	MOUSE	44%	43%
Q74Z27	ASHGO	42%	32%
Q753V5	ASHGO	39%	42%
Q759G7	ASHGO	40%	31%
Q7F2E4	ORYSJ	35%	38%
Q7G8Y3	ORYSJ	38%	41%
Q7S1P9	NEUCR	43%	37%
Q7ZU90	DANRE	45%	44%
Q86WJ1	HUMAN	44%	51%
Q8BHK9	MOUSE	46%	37%
Q8RWY3	ARATH	39%	43%
Q8RXS6	ARATH	35%	30%
Q8W103	ARATH	46%	42%
Q91ZW3	MOUSE	45%	43%
Q92698	HUMAN	40%	61%
Q94BR5	ARATH	43%	46%
Q95216	RABIT	35%	45%
Q99NG0	MOUSE	41%	31%
Q9CXF7	MOUSE	45%	50%
Q9DG67	CHICK	40%	49%
Q9FF61	ARATH	36%	52%
Q9FIY7	ARATH	48%	36%
Q9FNI6	ARATH	43%	44%
Q9GQN5	DROME	42%	35%
Q9H4L7	HUMAN	48%	44%
Q9LHE4	ARATH	43%	43%
Q9NRZ9	HUMAN	44%	54%
Q9P793	SCHPO	40%	32%
Q9S775	ARATH	44%	33%
Q9U7E0	CAEEL	41%	33%
Q9UNY4	HUMAN	38%	39%
Q9UR24	SCHPO	40%	47%
Q9US25	SCHPO	43%	33%
Q9UTN6	SCHPO	46%	38%
Q9VL72	DROME	44%	54%
Q9XFH4	ARATH	44%	59%
Q9Y4B4	HUMAN	41%	31%
Q9Y620	HUMAN	45%	50%
Q9ZUL5	ARATH	46%	60%
Q9ZV43	ARATH	39%	38%