DUF4379 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4379), putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IEK2_LEIDO

TriTrypDb:

LdBPK_292290.1 , LdCL_290029000 , LDHU3_29.3380

Length:

463

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IEK2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEK2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	121	125	PF00656	0.777
CLV_C14_Caspase3-7	127	131	PF00656	0.750
CLV_C14_Caspase3-7	178	182	PF00656	0.837
CLV_C14_Caspase3-7	187	191	PF00656	0.680
CLV_C14_Caspase3-7	206	210	PF00656	0.740
CLV_NRD_NRD_1	115	117	PF00675	0.517
CLV_NRD_NRD_1	196	198	PF00675	0.768
CLV_NRD_NRD_1	199	201	PF00675	0.634
CLV_NRD_NRD_1	33	35	PF00675	0.814
CLV_NRD_NRD_1	443	445	PF00675	0.503
CLV_NRD_NRD_1	446	448	PF00675	0.473
CLV_NRD_NRD_1	99	101	PF00675	0.738
CLV_PCSK_FUR_1	197	201	PF00082	0.804
CLV_PCSK_FUR_1	441	445	PF00082	0.430
CLV_PCSK_KEX2_1	101	103	PF00082	0.695
CLV_PCSK_KEX2_1	115	117	PF00082	0.549
CLV_PCSK_KEX2_1	164	166	PF00082	0.688
CLV_PCSK_KEX2_1	196	198	PF00082	0.762
CLV_PCSK_KEX2_1	199	201	PF00082	0.630
CLV_PCSK_KEX2_1	33	35	PF00082	0.814
CLV_PCSK_KEX2_1	443	445	PF00082	0.496
CLV_PCSK_KEX2_1	446	448	PF00082	0.481
CLV_PCSK_KEX2_1	86	88	PF00082	0.790
CLV_PCSK_PC1ET2_1	101	103	PF00082	0.802
CLV_PCSK_PC1ET2_1	164	166	PF00082	0.633
CLV_PCSK_PC1ET2_1	86	88	PF00082	0.738
CLV_PCSK_PC7_1	111	117	PF00082	0.777
CLV_PCSK_SKI1_1	282	286	PF00082	0.484
CLV_PCSK_SKI1_1	297	301	PF00082	0.335
CLV_PCSK_SKI1_1	456	460	PF00082	0.725
DEG_APCC_DBOX_1	318	326	PF00400	0.411
DEG_APCC_DBOX_1	445	453	PF00400	0.436
DEG_SPOP_SBC_1	217	221	PF00917	0.618
DOC_CYCLIN_RxL_1	240	251	PF00134	0.640
DOC_MAPK_gen_1	317	325	PF00069	0.513
DOC_MAPK_JIP1_4	319	325	PF00069	0.411
DOC_PP1_RVXF_1	417	423	PF00149	0.411
DOC_PP4_FxxP_1	140	143	PF00568	0.829
DOC_PP4_FxxP_1	334	337	PF00568	0.411
DOC_USP7_MATH_1	223	227	PF00917	0.734
DOC_USP7_MATH_1	77	81	PF00917	0.840
DOC_WW_Pin1_4	219	224	PF00397	0.639
DOC_WW_Pin1_4	409	414	PF00397	0.513
DOC_WW_Pin1_4	92	97	PF00397	0.716
LIG_14-3-3_CanoR_1	100	106	PF00244	0.748
LIG_14-3-3_CanoR_1	311	316	PF00244	0.495
LIG_14-3-3_CanoR_1	380	387	PF00244	0.506
LIG_14-3-3_CanoR_1	444	450	PF00244	0.471
LIG_14-3-3_CanoR_1	45	51	PF00244	0.720
LIG_BRCT_BRCA1_1	136	140	PF00533	0.849
LIG_BRCT_BRCA1_1	291	295	PF00533	0.513
LIG_BRCT_BRCA1_1	62	66	PF00533	0.705
LIG_deltaCOP1_diTrp_1	287	295	PF00928	0.436
LIG_EH_1	331	335	PF12763	0.411
LIG_FHA_1	203	209	PF00498	0.775
LIG_FHA_1	231	237	PF00498	0.603
LIG_FHA_1	310	316	PF00498	0.641
LIG_FHA_1	457	463	PF00498	0.739
LIG_FHA_2	149	155	PF00498	0.768
LIG_FHA_2	176	182	PF00498	0.837
LIG_LIR_Apic_2	137	143	PF02991	0.836
LIG_LIR_Apic_2	347	353	PF02991	0.411
LIG_LIR_Nem_3	397	401	PF02991	0.378
LIG_MYND_1	333	337	PF01753	0.411
LIG_SH2_NCK_1	256	260	PF00017	0.411
LIG_SH2_STAP1	359	363	PF00017	0.411
LIG_SH2_STAT5	244	247	PF00017	0.573
LIG_SH3_3	368	374	PF00018	0.436
LIG_SH3_3	91	97	PF00018	0.613
LIG_TRAF2_1	152	155	PF00917	0.845
LIG_TRAF2_1	388	391	PF00917	0.679
LIG_TRAF2_1	72	75	PF00917	0.774
MOD_CK1_1	104	110	PF00069	0.709
MOD_CK1_1	219	225	PF00069	0.682
MOD_CK1_1	341	347	PF00069	0.429
MOD_CK1_1	389	395	PF00069	0.560
MOD_CK1_1	445	451	PF00069	0.438
MOD_CK1_1	46	52	PF00069	0.761
MOD_CK2_1	148	154	PF00069	0.737
MOD_CK2_1	171	177	PF00069	0.724
MOD_CK2_1	181	187	PF00069	0.789
MOD_CK2_1	218	224	PF00069	0.768
MOD_CK2_1	69	75	PF00069	0.745
MOD_GlcNHglycan	106	109	PF01048	0.790
MOD_GlcNHglycan	112	115	PF01048	0.619
MOD_GlcNHglycan	166	169	PF01048	0.735
MOD_GlcNHglycan	171	174	PF01048	0.700
MOD_GlcNHglycan	274	277	PF01048	0.353
MOD_GlcNHglycan	291	294	PF01048	0.353
MOD_GlcNHglycan	301	304	PF01048	0.348
MOD_GlcNHglycan	338	343	PF01048	0.336
MOD_GlcNHglycan	382	385	PF01048	0.586
MOD_GlcNHglycan	40	43	PF01048	0.788
MOD_GlcNHglycan	45	48	PF01048	0.767
MOD_GSK3_1	134	141	PF00069	0.846
MOD_GSK3_1	169	176	PF00069	0.800
MOD_GSK3_1	215	222	PF00069	0.743
MOD_GSK3_1	409	416	PF00069	0.513
MOD_GSK3_1	45	52	PF00069	0.797
MOD_GSK3_1	60	67	PF00069	0.777
MOD_LATS_1	454	460	PF00433	0.711
MOD_N-GLC_1	309	314	PF02516	0.620
MOD_N-GLC_2	91	93	PF02516	0.663
MOD_NEK2_1	203	208	PF00069	0.685
MOD_NEK2_1	272	277	PF00069	0.513
MOD_NEK2_1	378	383	PF00069	0.507
MOD_NEK2_1	60	65	PF00069	0.768
MOD_PIKK_1	181	187	PF00454	0.838
MOD_PIKK_1	378	384	PF00454	0.673
MOD_PIKK_1	70	76	PF00454	0.795
MOD_PKA_1	101	107	PF00069	0.744
MOD_PKA_1	164	170	PF00069	0.676
MOD_PKA_2	101	107	PF00069	0.748
MOD_PKA_2	110	116	PF00069	0.741
MOD_PKA_2	164	170	PF00069	0.741
MOD_PKA_2	310	316	PF00069	0.539
MOD_PKA_2	344	350	PF00069	0.375
MOD_PKA_2	355	361	PF00069	0.453
MOD_PKA_2	442	448	PF00069	0.419
MOD_PKA_2	68	74	PF00069	0.752
MOD_Plk_1	129	135	PF00069	0.550
MOD_Plk_1	389	395	PF00069	0.662
MOD_Plk_1	431	437	PF00069	0.411
MOD_Plk_1	60	66	PF00069	0.642
MOD_Plk_2-3	142	148	PF00069	0.817
MOD_Plk_4	203	209	PF00069	0.585
MOD_Plk_4	344	350	PF00069	0.355
MOD_Plk_4	389	395	PF00069	0.640
MOD_ProDKin_1	219	225	PF00069	0.639
MOD_ProDKin_1	409	415	PF00069	0.513
MOD_ProDKin_1	92	98	PF00069	0.715
MOD_SUMO_for_1	16	19	PF00179	0.636
MOD_SUMO_for_1	163	166	PF00179	0.620
MOD_SUMO_for_1	335	338	PF00179	0.402
MOD_SUMO_rev_2	409	418	PF00179	0.389
MOD_SUMO_rev_2	79	88	PF00179	0.812
TRG_DiLeu_BaEn_4	390	396	PF01217	0.661
TRG_ENDOCYTIC_2	244	247	PF00928	0.615
TRG_ER_diArg_1	115	117	PF00400	0.746
TRG_ER_diArg_1	196	199	PF00400	0.760
TRG_ER_diArg_1	442	444	PF00400	0.506
TRG_NLS_Bipartite_1	86	104	PF00514	0.807
TRG_NLS_MonoExtN_4	97	104	PF00514	0.660

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKX8	Leptomonas seymouri	52%	98%
A4HHL8	Leishmania braziliensis	73%	100%
A4I4S7	Leishmania infantum	99%	100%
E9AE80	Leishmania major	89%	100%
E9ALK5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%