MARVEL domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IEK1_LEIDO

TriTrypDb:

LdBPK_281220.1 , LdCL_280016800 , LDHU3_28.1530

Length:

254

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A0A3Q8IEK1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEK1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	7	11	PF00656	0.774
CLV_NRD_NRD_1	74	76	PF00675	0.566
CLV_PCSK_KEX2_1	74	76	PF00082	0.566
DEG_Nend_Nbox_1	1	3	PF02207	0.768
DOC_CKS1_1	101	106	PF01111	0.443
DOC_CYCLIN_yCln2_LP_2	101	107	PF00134	0.556
DOC_MAPK_gen_1	78	87	PF00069	0.614
DOC_MAPK_MEF2A_6	147	156	PF00069	0.441
DOC_PP1_RVXF_1	216	223	PF00149	0.387
DOC_USP7_MATH_1	145	149	PF00917	0.375
DOC_WW_Pin1_4	100	105	PF00397	0.393
DOC_WW_Pin1_4	64	69	PF00397	0.708
LIG_14-3-3_CanoR_1	109	117	PF00244	0.443
LIG_Actin_WH2_2	233	250	PF00022	0.504
LIG_APCC_ABBA_1	204	209	PF00400	0.361
LIG_BIR_III_4	48	52	PF00653	0.771
LIG_EH1_1	182	190	PF00400	0.585
LIG_EH1_1	194	202	PF00400	0.329
LIG_eIF4E_1	155	161	PF01652	0.454
LIG_eIF4E_1	183	189	PF01652	0.504
LIG_FHA_1	110	116	PF00498	0.394
LIG_FHA_1	229	235	PF00498	0.402
LIG_FHA_1	41	47	PF00498	0.691
LIG_FHA_1	87	93	PF00498	0.427
LIG_FHA_2	123	129	PF00498	0.397
LIG_GBD_Chelix_1	152	160	PF00786	0.454
LIG_GBD_Chelix_1	198	206	PF00786	0.498
LIG_LIR_Gen_1	148	159	PF02991	0.345
LIG_LIR_Gen_1	241	250	PF02991	0.433
LIG_LIR_Gen_1	82	92	PF02991	0.489
LIG_LIR_Nem_3	148	154	PF02991	0.374
LIG_LIR_Nem_3	169	174	PF02991	0.404
LIG_LIR_Nem_3	241	247	PF02991	0.433
LIG_LIR_Nem_3	82	87	PF02991	0.480
LIG_NRBOX	153	159	PF00104	0.454
LIG_NRBOX	233	239	PF00104	0.484
LIG_PCNA_yPIPBox_3	177	189	PF02747	0.397
LIG_Pex14_2	167	171	PF04695	0.329
LIG_Pex14_2	190	194	PF04695	0.329
LIG_PTB_Apo_2	216	223	PF02174	0.421
LIG_SH2_GRB2like	60	63	PF00017	0.785
LIG_SH2_PTP2	155	158	PF00017	0.454
LIG_SH2_STAP1	56	60	PF00017	0.663
LIG_SH2_STAT5	151	154	PF00017	0.412
LIG_SH2_STAT5	155	158	PF00017	0.439
LIG_SH2_STAT5	183	186	PF00017	0.407
LIG_SH2_STAT5	60	63	PF00017	0.691
LIG_SH2_STAT5	66	69	PF00017	0.639
LIG_SH3_2	70	75	PF14604	0.698
LIG_SH3_3	67	73	PF00018	0.707
LIG_SUMO_SIM_anti_2	89	94	PF11976	0.411
LIG_SUMO_SIM_anti_2	97	103	PF11976	0.301
LIG_SUMO_SIM_par_1	236	241	PF11976	0.454
LIG_SUMO_SIM_par_1	92	97	PF11976	0.420
MOD_CK1_1	111	117	PF00069	0.361
MOD_CK1_1	12	18	PF00069	0.719
MOD_CK1_1	236	242	PF00069	0.504
MOD_CK1_1	4	10	PF00069	0.746
MOD_CK2_1	122	128	PF00069	0.478
MOD_GlcNHglycan	3	6	PF01048	0.518
MOD_GlcNHglycan	96	99	PF01048	0.328
MOD_GSK3_1	107	114	PF00069	0.421
MOD_GSK3_1	12	19	PF00069	0.681
MOD_GSK3_1	4	11	PF00069	0.717
MOD_GSK3_1	40	47	PF00069	0.685
MOD_N-GLC_1	44	49	PF02516	0.574
MOD_N-GLC_2	210	212	PF02516	0.668
MOD_NEK2_1	1	6	PF00069	0.681
MOD_NEK2_1	166	171	PF00069	0.407
MOD_NEK2_1	184	189	PF00069	0.407
MOD_NEK2_1	211	216	PF00069	0.354
MOD_NEK2_1	228	233	PF00069	0.415
MOD_NEK2_1	238	243	PF00069	0.392
MOD_NEK2_1	55	60	PF00069	0.687
MOD_NEK2_1	8	13	PF00069	0.684
MOD_NEK2_1	94	99	PF00069	0.504
MOD_PK_1	116	122	PF00069	0.416
MOD_PK_1	21	27	PF00069	0.683
MOD_PKA_1	74	80	PF00069	0.714
MOD_PKA_2	108	114	PF00069	0.434
MOD_PKA_2	16	22	PF00069	0.796
MOD_PKA_2	32	38	PF00069	0.613
MOD_PKA_2	74	80	PF00069	0.714
MOD_Plk_1	40	46	PF00069	0.726
MOD_Plk_1	56	62	PF00069	0.774
MOD_Plk_1	9	15	PF00069	0.809
MOD_Plk_4	135	141	PF00069	0.461
MOD_Plk_4	166	172	PF00069	0.504
MOD_Plk_4	184	190	PF00069	0.234
MOD_Plk_4	21	27	PF00069	0.718
MOD_Plk_4	56	62	PF00069	0.786
MOD_Plk_4	86	92	PF00069	0.488
MOD_ProDKin_1	100	106	PF00069	0.393
MOD_ProDKin_1	64	70	PF00069	0.708
TRG_ENDOCYTIC_2	151	154	PF00928	0.376
TRG_ENDOCYTIC_2	155	158	PF00928	0.471
TRG_ER_diArg_1	130	133	PF00400	0.469
TRG_ER_diArg_1	73	75	PF00400	0.772
TRG_ER_diArg_1	78	81	PF00400	0.532
TRG_Pf-PMV_PEXEL_1	6	10	PF00026	0.394

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1D0	Leptomonas seymouri	42%	100%
A4I3I8	Leishmania infantum	98%	100%
E9AZT0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
Q4Q8F4	Leishmania major	82%	100%