LeishMANIAdb
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FAD linked oxidase, C-terminal domain family protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
FAD linked oxidase, C-terminal domain family protein
Gene product:
actin interacting protein-like protein
Species:
Leishmania donovani
UniProt:
A0A3Q8IEJ5_LEIDO
TriTrypDb:
LdBPK_230980.1 , LdCL_230016400 , LDHU3_23.1330
Length:
519

Annotations

Annotations by Jardim et al.

Structural Proteins, Actin interacting -like

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005739 mitochondrion 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A0A3Q8IEJ5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEJ5

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 11
GO:0003824 catalytic activity 1 11
GO:0005488 binding 1 11
GO:0036094 small molecule binding 2 11
GO:0043167 ion binding 2 11
GO:0043168 anion binding 3 11
GO:0050660 flavin adenine dinucleotide binding 4 11
GO:0071949 FAD binding 5 11
GO:0097159 organic cyclic compound binding 2 11
GO:1901265 nucleoside phosphate binding 3 11
GO:1901363 heterocyclic compound binding 2 11
GO:0008762 UDP-N-acetylmuramate dehydrogenase activity 5 1
GO:0016491 oxidoreductase activity 2 1
GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 3 1
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 280 284 PF00656 0.266
CLV_C14_Caspase3-7 447 451 PF00656 0.309
CLV_NRD_NRD_1 211 213 PF00675 0.376
CLV_NRD_NRD_1 42 44 PF00675 0.458
CLV_PCSK_KEX2_1 42 44 PF00082 0.420
CLV_PCSK_KEX2_1 478 480 PF00082 0.407
CLV_PCSK_PC1ET2_1 42 44 PF00082 0.420
CLV_PCSK_PC1ET2_1 478 480 PF00082 0.399
CLV_PCSK_SKI1_1 18 22 PF00082 0.410
CLV_PCSK_SKI1_1 221 225 PF00082 0.316
CLV_PCSK_SKI1_1 310 314 PF00082 0.379
CLV_PCSK_SKI1_1 407 411 PF00082 0.309
CLV_PCSK_SKI1_1 46 50 PF00082 0.400
CLV_PCSK_SKI1_1 492 496 PF00082 0.256
DEG_MDM2_SWIB_1 57 65 PF02201 0.392
DEG_SCF_FBW7_1 122 129 PF00400 0.287
DOC_CYCLIN_RxL_1 508 518 PF00134 0.494
DOC_CYCLIN_yCln2_LP_2 155 161 PF00134 0.284
DOC_MAPK_DCC_7 152 161 PF00069 0.249
DOC_MAPK_gen_1 478 484 PF00069 0.266
DOC_MAPK_MEF2A_6 374 381 PF00069 0.312
DOC_USP7_MATH_1 126 130 PF00917 0.344
DOC_USP7_MATH_2 5 11 PF00917 0.370
DOC_USP7_UBL2_3 21 25 PF12436 0.404
DOC_USP7_UBL2_3 345 349 PF12436 0.232
DOC_USP7_UBL2_3 42 46 PF12436 0.501
DOC_WW_Pin1_4 1 6 PF00397 0.629
DOC_WW_Pin1_4 122 127 PF00397 0.330
DOC_WW_Pin1_4 13 18 PF00397 0.509
DOC_WW_Pin1_4 287 292 PF00397 0.284
DOC_WW_Pin1_4 66 71 PF00397 0.390
LIG_14-3-3_CanoR_1 486 494 PF00244 0.265
LIG_BRCT_BRCA1_1 15 19 PF00533 0.495
LIG_BRCT_BRCA1_1 313 317 PF00533 0.289
LIG_BRCT_BRCA1_2 15 21 PF00533 0.497
LIG_eIF4E_1 218 224 PF01652 0.341
LIG_FHA_1 100 106 PF00498 0.266
LIG_FHA_1 123 129 PF00498 0.421
LIG_FHA_1 130 136 PF00498 0.376
LIG_FHA_1 228 234 PF00498 0.286
LIG_FHA_1 365 371 PF00498 0.245
LIG_FHA_1 404 410 PF00498 0.399
LIG_FHA_1 485 491 PF00498 0.271
LIG_FHA_1 49 55 PF00498 0.586
LIG_FHA_1 67 73 PF00498 0.231
LIG_FHA_2 2 8 PF00498 0.598
LIG_FHA_2 47 53 PF00498 0.412
LIG_IBAR_NPY_1 508 510 PF08397 0.266
LIG_LIR_Gen_1 16 27 PF02991 0.440
LIG_LIR_Gen_1 257 265 PF02991 0.258
LIG_LIR_Gen_1 277 287 PF02991 0.217
LIG_LIR_Gen_1 28 37 PF02991 0.330
LIG_LIR_Gen_1 314 321 PF02991 0.306
LIG_LIR_Gen_1 331 339 PF02991 0.262
LIG_LIR_Nem_3 16 22 PF02991 0.446
LIG_LIR_Nem_3 257 261 PF02991 0.268
LIG_LIR_Nem_3 28 33 PF02991 0.303
LIG_LIR_Nem_3 313 319 PF02991 0.280
LIG_LIR_Nem_3 331 335 PF02991 0.334
LIG_LIR_Nem_3 397 403 PF02991 0.312
LIG_LIR_Nem_3 480 484 PF02991 0.388
LIG_LYPXL_S_1 453 457 PF13949 0.399
LIG_LYPXL_yS_3 454 457 PF13949 0.399
LIG_MLH1_MIPbox_1 313 317 PF16413 0.272
LIG_Pex14_2 57 61 PF04695 0.385
LIG_PTB_Apo_2 300 307 PF02174 0.265
LIG_SH2_CRK 510 514 PF00017 0.344
LIG_SH2_SRC 356 359 PF00017 0.373
LIG_SH2_STAP1 297 301 PF00017 0.456
LIG_SH2_STAP1 390 394 PF00017 0.395
LIG_SH2_STAP1 458 462 PF00017 0.266
LIG_SH2_STAT5 29 32 PF00017 0.354
LIG_SH2_STAT5 316 319 PF00017 0.284
LIG_SH2_STAT5 460 463 PF00017 0.337
LIG_SH2_STAT5 481 484 PF00017 0.324
LIG_SH2_STAT5 87 90 PF00017 0.266
LIG_SH3_3 389 395 PF00018 0.290
LIG_SH3_3 69 75 PF00018 0.284
LIG_SUMO_SIM_anti_2 420 425 PF11976 0.269
LIG_SUMO_SIM_anti_2 91 97 PF11976 0.335
LIG_SUMO_SIM_par_1 437 442 PF11976 0.401
LIG_UBA3_1 155 164 PF00899 0.307
LIG_UBA3_1 204 213 PF00899 0.378
LIG_UBA3_1 252 256 PF00899 0.342
MOD_CDC14_SPxK_1 290 293 PF00782 0.330
MOD_CDK_SPK_2 13 18 PF00069 0.520
MOD_CDK_SPxK_1 287 293 PF00069 0.399
MOD_CDK_SPxxK_3 1 8 PF00069 0.612
MOD_CK1_1 129 135 PF00069 0.270
MOD_CK1_1 163 169 PF00069 0.266
MOD_CK1_1 187 193 PF00069 0.344
MOD_CK1_1 227 233 PF00069 0.286
MOD_CK1_1 286 292 PF00069 0.399
MOD_CK1_1 485 491 PF00069 0.265
MOD_CK1_1 99 105 PF00069 0.399
MOD_CK2_1 1 7 PF00069 0.619
MOD_CK2_1 257 263 PF00069 0.298
MOD_CK2_1 274 280 PF00069 0.220
MOD_CK2_1 29 35 PF00069 0.357
MOD_CK2_1 441 447 PF00069 0.379
MOD_CK2_1 46 52 PF00069 0.319
MOD_GlcNHglycan 138 141 PF01048 0.325
MOD_GlcNHglycan 276 279 PF01048 0.266
MOD_GlcNHglycan 313 316 PF01048 0.282
MOD_GlcNHglycan 350 353 PF01048 0.449
MOD_GlcNHglycan 362 365 PF01048 0.325
MOD_GlcNHglycan 38 41 PF01048 0.433
MOD_GlcNHglycan 382 385 PF01048 0.176
MOD_GlcNHglycan 468 471 PF01048 0.272
MOD_GlcNHglycan 98 101 PF01048 0.338
MOD_GSK3_1 122 129 PF00069 0.405
MOD_GSK3_1 160 167 PF00069 0.287
MOD_GSK3_1 21 28 PF00069 0.363
MOD_GSK3_1 283 290 PF00069 0.281
MOD_GSK3_1 360 367 PF00069 0.265
MOD_GSK3_1 7 14 PF00069 0.498
MOD_GSK3_1 96 103 PF00069 0.287
MOD_N-GLC_1 100 105 PF02516 0.287
MOD_N-GLC_1 122 127 PF02516 0.287
MOD_N-GLC_1 171 176 PF02516 0.399
MOD_NEK2_1 115 120 PF00069 0.399
MOD_NEK2_1 160 165 PF00069 0.330
MOD_NEK2_1 207 212 PF00069 0.366
MOD_NEK2_1 320 325 PF00069 0.266
MOD_NEK2_1 360 365 PF00069 0.302
MOD_NEK2_1 441 446 PF00069 0.423
MOD_NEK2_1 482 487 PF00069 0.266
MOD_PIKK_1 358 364 PF00454 0.266
MOD_PKA_2 485 491 PF00069 0.265
MOD_PKA_2 7 13 PF00069 0.341
MOD_Plk_1 100 106 PF00069 0.287
MOD_Plk_1 297 303 PF00069 0.287
MOD_Plk_1 390 396 PF00069 0.266
MOD_Plk_2-3 257 263 PF00069 0.276
MOD_Plk_4 100 106 PF00069 0.287
MOD_Plk_4 164 170 PF00069 0.287
MOD_Plk_4 25 31 PF00069 0.391
MOD_Plk_4 257 263 PF00069 0.340
MOD_ProDKin_1 1 7 PF00069 0.619
MOD_ProDKin_1 122 128 PF00069 0.330
MOD_ProDKin_1 13 19 PF00069 0.501
MOD_ProDKin_1 287 293 PF00069 0.284
MOD_ProDKin_1 66 72 PF00069 0.387
MOD_SUMO_rev_2 214 223 PF00179 0.360
TRG_DiLeu_BaEn_1 489 494 PF01217 0.309
TRG_ENDOCYTIC_2 185 188 PF00928 0.266
TRG_ENDOCYTIC_2 316 319 PF00928 0.276
TRG_ENDOCYTIC_2 356 359 PF00928 0.373
TRG_ENDOCYTIC_2 400 403 PF00928 0.312
TRG_ENDOCYTIC_2 426 429 PF00928 0.266
TRG_ENDOCYTIC_2 454 457 PF00928 0.399
TRG_ENDOCYTIC_2 481 484 PF00928 0.284
TRG_ENDOCYTIC_2 510 513 PF00928 0.266
TRG_NLS_MonoExtC_3 41 46 PF00514 0.405
TRG_NLS_MonoExtN_4 42 47 PF00514 0.400

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6Q0 Leptomonas seymouri 79% 100%
A0A0N1PE88 Leptomonas seymouri 25% 100%
A0A0N1PEY1 Leptomonas seymouri 22% 83%
A0A0S4IT80 Bodo saltans 50% 100%
A0A0S4JD99 Bodo saltans 25% 100%
A0A0S4JV88 Bodo saltans 22% 82%
A0A1X0NXE7 Trypanosomatidae 68% 100%
A0A1X0P026 Trypanosomatidae 26% 100%
A0A3Q8IDH3 Leishmania donovani 26% 100%
A0A3Q8IDH5 Leishmania donovani 24% 100%
A0A3Q8IRN9 Leishmania donovani 23% 100%
A0A422N8Z9 Trypanosoma rangeli 67% 100%
A1L258 Danio rerio 40% 97%
A4HCV1 Leishmania braziliensis 87% 100%
A4HFX9 Leishmania braziliensis 25% 100%
A4I0D2 Leishmania infantum 100% 100%
A4I309 Leishmania infantum 24% 100%
A4I481 Leishmania infantum 26% 100%
A4I507 Leishmania infantum 23% 100%
A4VGK4 Pseudomonas stutzeri (strain A1501) 34% 100%
B8B7X6 Oryza sativa subsp. indica 39% 93%
D4MUV9 Anaerostipes hadrus 29% 100%
E9ADI2 Leishmania major 24% 100%
E9ADN0 Leishmania major 25% 100%
E9AM50 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
E9AW96 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
E9AZA6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
E9B0D7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 23% 100%
F1QXM5 Danio rerio 27% 100%
H6LBS1 Acetobacterium woodii (strain ATCC 29683 / DSM 1030 / JCM 2381 / KCTC 1655 / WB1) 28% 100%
O23240 Arabidopsis thaliana 41% 93%
O29853 Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) 28% 100%
O45218 Caenorhabditis elegans 22% 87%
P0AEP9 Escherichia coli (strain K12) 28% 100%
P0AEQ0 Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) 28% 100%
P0DV35 Xanthomonas citri pv. viticola (strain LMG 965 / NCPPB 2475 / ICMP 3867 / CFBP 7660) 30% 100%
P32891 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 27% 88%
P39976 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 40% 100%
P46681 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 40% 98%
P84850 Rattus norvegicus 40% 97%
P94535 Bacillus subtilis (strain 168) 30% 100%
P97275 Cavia porcellus 24% 79%
P9WIT0 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) 27% 100%
P9WIT1 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 27% 100%
Q12627 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 27% 90%
Q1JPD3 Bos taurus 42% 95%
Q4QB82 Leishmania major 95% 100%
Q7TNG8 Mus musculus 27% 100%
Q7XI14 Oryza sativa subsp. japonica 39% 93%
Q7YWB6 Leishmania major 23% 100%
Q86WU2 Homo sapiens 24% 100%
Q8CIM3 Mus musculus 40% 97%
Q8N465 Homo sapiens 41% 100%
Q94AX4 Arabidopsis thaliana 27% 92%
Q9C1X2 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 41% 99%
V5D7M3 Trypanosoma cruzi 67% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS