Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IEJ3_LEIDO

TriTrypDb:

LdBPK_281010.1 , LdCL_280014700 , LDHU3_28.1220

Length:

189

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IEJ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEJ3

PDB structure(s): 7ane_j

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	15	17	PF00675	0.514
CLV_NRD_NRD_1	153	155	PF00675	0.459
CLV_NRD_NRD_1	54	56	PF00675	0.544
CLV_PCSK_KEX2_1	107	109	PF00082	0.403
CLV_PCSK_KEX2_1	53	55	PF00082	0.493
CLV_PCSK_PC1ET2_1	107	109	PF00082	0.403
CLV_PCSK_SKI1_1	138	142	PF00082	0.462
CLV_PCSK_SKI1_1	87	91	PF00082	0.449
DEG_Nend_Nbox_1	1	3	PF02207	0.586
DOC_CKS1_1	79	84	PF01111	0.503
DOC_CYCLIN_yCln2_LP_2	124	127	PF00134	0.445
DOC_MAPK_gen_1	107	113	PF00069	0.507
DOC_MAPK_gen_1	53	61	PF00069	0.507
DOC_PP2B_LxvP_1	124	127	PF13499	0.445
DOC_USP7_MATH_1	72	76	PF00917	0.465
DOC_USP7_UBL2_3	130	134	PF12436	0.519
DOC_WW_Pin1_4	15	20	PF00397	0.522
DOC_WW_Pin1_4	172	177	PF00397	0.543
DOC_WW_Pin1_4	75	80	PF00397	0.496
LIG_14-3-3_CanoR_1	108	114	PF00244	0.393
LIG_14-3-3_CanoR_1	53	62	PF00244	0.485
LIG_CSL_BTD_1	76	79	PF09270	0.507
LIG_FHA_1	2	8	PF00498	0.493
LIG_FHA_1	92	98	PF00498	0.392
LIG_FHA_2	91	97	PF00498	0.403
LIG_LIR_Gen_1	43	48	PF02991	0.379
LIG_LIR_Nem_3	163	168	PF02991	0.464
LIG_LIR_Nem_3	38	44	PF02991	0.428
LIG_Pex14_2	100	104	PF04695	0.386
LIG_SH2_GRB2like	165	168	PF00017	0.446
LIG_SH2_STAP1	44	48	PF00017	0.376
LIG_SH2_STAT5	150	153	PF00017	0.460
LIG_SH2_STAT5	165	168	PF00017	0.470
LIG_SH2_STAT5	64	67	PF00017	0.407
LIG_SH3_3	170	176	PF00018	0.500
LIG_SH3_3	181	187	PF00018	0.434
LIG_SH3_3	22	28	PF00018	0.463
LIG_SH3_3	76	82	PF00018	0.518
LIG_SUMO_SIM_par_1	93	98	PF11976	0.420
LIG_TRAF2_1	175	178	PF00917	0.497
LIG_UBA3_1	61	67	PF00899	0.422
MOD_CDK_SPxxK_3	172	179	PF00069	0.581
MOD_CK1_1	75	81	PF00069	0.491
MOD_CK2_1	172	178	PF00069	0.469
MOD_GlcNHglycan	121	124	PF01048	0.497
MOD_GSK3_1	168	175	PF00069	0.483
MOD_LATS_1	52	58	PF00433	0.481
MOD_NEK2_1	1	6	PF00069	0.568
MOD_NEK2_1	119	124	PF00069	0.474
MOD_NEK2_1	90	95	PF00069	0.406
MOD_PIKK_1	81	87	PF00454	0.525
MOD_PKA_1	54	60	PF00069	0.538
MOD_PKA_2	109	115	PF00069	0.400
MOD_PKA_2	54	60	PF00069	0.538
MOD_Plk_4	168	174	PF00069	0.507
MOD_Plk_4	3	9	PF00069	0.519
MOD_Plk_4	72	78	PF00069	0.470
MOD_ProDKin_1	15	21	PF00069	0.522
MOD_ProDKin_1	172	178	PF00069	0.542
MOD_ProDKin_1	75	81	PF00069	0.495
TRG_DiLeu_BaLyEn_6	57	62	PF01217	0.477
TRG_ENDOCYTIC_2	44	47	PF00928	0.382
TRG_ER_diArg_1	108	111	PF00400	0.414
TRG_ER_diArg_1	30	33	PF00400	0.396
TRG_ER_diArg_1	53	55	PF00400	0.605
TRG_Pf-PMV_PEXEL_1	11	15	PF00026	0.583

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1S3	Leptomonas seymouri	90%	100%
A0A0S4IPU5	Bodo saltans	68%	100%
A0A1X0NYN8	Trypanosomatidae	82%	100%
A0A3R7R7Q0	Trypanosoma rangeli	80%	100%
A4HGD6	Leishmania braziliensis	93%	100%
A4I3G9	Leishmania infantum	99%	100%
D0A7W7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	83%	100%
E9AZQ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
Q4Q8H5	Leishmania major	98%	100%