CAP-Gly domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CAP-Gly domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IEJ2_LEIDO

TriTrypDb:

LdBPK_190890.1 , LdCL_190014300 , LDHU3_19.1090

Length:

666

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0035371	microtubule plus-end	3	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990752	microtubule end	2	1

Expansion

Sequence features

A0A3Q8IEJ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEJ2

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0007017	microtubule-based process	2	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0031122	cytoplasmic microtubule organization	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0097435	supramolecular fiber organization	4	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0008017	microtubule binding	5	1
GO:0008092	cytoskeletal protein binding	3	1
GO:0015631	tubulin binding	4	1
GO:0051010	microtubule plus-end binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	646	650	PF00656	0.639
CLV_NRD_NRD_1	117	119	PF00675	0.615
CLV_NRD_NRD_1	304	306	PF00675	0.524
CLV_NRD_NRD_1	33	35	PF00675	0.411
CLV_NRD_NRD_1	499	501	PF00675	0.486
CLV_NRD_NRD_1	548	550	PF00675	0.505
CLV_PCSK_KEX2_1	117	119	PF00082	0.615
CLV_PCSK_KEX2_1	209	211	PF00082	0.682
CLV_PCSK_KEX2_1	318	320	PF00082	0.511
CLV_PCSK_KEX2_1	32	34	PF00082	0.397
CLV_PCSK_KEX2_1	499	501	PF00082	0.674
CLV_PCSK_KEX2_1	548	550	PF00082	0.552
CLV_PCSK_PC1ET2_1	209	211	PF00082	0.682
CLV_PCSK_PC1ET2_1	318	320	PF00082	0.448
CLV_PCSK_SKI1_1	191	195	PF00082	0.618
CLV_PCSK_SKI1_1	275	279	PF00082	0.578
CLV_PCSK_SKI1_1	34	38	PF00082	0.513
CLV_PCSK_SKI1_1	358	362	PF00082	0.587
CLV_PCSK_SKI1_1	656	660	PF00082	0.748
CLV_PCSK_SKI1_1	67	71	PF00082	0.418
DEG_SCF_FBW7_1	658	665	PF00400	0.690
DOC_CKS1_1	659	664	PF01111	0.770
DOC_CYCLIN_RxL_1	480	490	PF00134	0.697
DOC_CYCLIN_RxL_1	636	649	PF00134	0.596
DOC_CYCLIN_yCln2_LP_2	86	92	PF00134	0.566
DOC_MAPK_gen_1	279	288	PF00069	0.538
DOC_MAPK_gen_1	32	39	PF00069	0.411
DOC_MAPK_gen_1	594	603	PF00069	0.619
DOC_MAPK_gen_1	623	632	PF00069	0.776
DOC_MAPK_MEF2A_6	165	172	PF00069	0.476
DOC_MAPK_MEF2A_6	463	470	PF00069	0.613
DOC_MAPK_MEF2A_6	626	634	PF00069	0.694
DOC_MAPK_RevD_3	21	34	PF00069	0.634
DOC_PP1_RVXF_1	174	180	PF00149	0.528
DOC_PP1_RVXF_1	639	646	PF00149	0.627
DOC_PP1_SILK_1	34	39	PF00149	0.513
DOC_PP2B_LxvP_1	86	89	PF13499	0.533
DOC_PP4_FxxP_1	579	582	PF00568	0.518
DOC_PP4_FxxP_1	659	662	PF00568	0.739
DOC_PP4_FxxP_1	81	84	PF00568	0.411
DOC_USP7_MATH_1	16	20	PF00917	0.446
DOC_USP7_MATH_1	193	197	PF00917	0.558
DOC_USP7_MATH_1	257	261	PF00917	0.739
DOC_USP7_MATH_1	265	269	PF00917	0.430
DOC_USP7_MATH_1	293	297	PF00917	0.593
DOC_USP7_MATH_1	339	343	PF00917	0.611
DOC_USP7_MATH_1	413	417	PF00917	0.676
DOC_USP7_MATH_1	515	519	PF00917	0.654
DOC_USP7_MATH_1	6	10	PF00917	0.716
DOC_USP7_UBL2_3	154	158	PF12436	0.686
DOC_WW_Pin1_4	578	583	PF00397	0.727
DOC_WW_Pin1_4	658	663	PF00397	0.736
LIG_14-3-3_CanoR_1	523	527	PF00244	0.707
LIG_14-3-3_CanoR_1	594	599	PF00244	0.633
LIG_14-3-3_CanoR_1	609	618	PF00244	0.533
LIG_14-3-3_CanoR_1	8	16	PF00244	0.641
LIG_Actin_WH2_2	130	147	PF00022	0.642
LIG_BIR_II_1	1	5	PF00653	0.706
LIG_DLG_GKlike_1	594	601	PF00625	0.658
LIG_FHA_1	391	397	PF00498	0.679
LIG_FHA_1	505	511	PF00498	0.495
LIG_FHA_2	157	163	PF00498	0.625
LIG_FHA_2	228	234	PF00498	0.545
LIG_FHA_2	329	335	PF00498	0.550
LIG_FHA_2	354	360	PF00498	0.588
LIG_LIR_Apic_2	612	618	PF02991	0.684
LIG_LIR_Gen_1	18	28	PF02991	0.526
LIG_LIR_Nem_3	18	23	PF02991	0.498
LIG_LIR_Nem_3	47	53	PF02991	0.420
LIG_NRBOX	373	379	PF00104	0.562
LIG_NRBOX	597	603	PF00104	0.657
LIG_RPA_C_Fungi	213	225	PF08784	0.691
LIG_SH2_SRC	90	93	PF00017	0.626
LIG_SH2_STAP1	591	595	PF00017	0.550
LIG_SH2_STAT5	71	74	PF00017	0.353
LIG_SH3_2	89	94	PF14604	0.494
LIG_SH3_3	10	16	PF00018	0.693
LIG_SH3_3	22	28	PF00018	0.364
LIG_SH3_3	86	92	PF00018	0.566
LIG_SUMO_SIM_anti_2	18	25	PF11976	0.505
LIG_TRAF2_1	108	111	PF00917	0.571
LIG_TRAF2_1	417	420	PF00917	0.582
LIG_WRC_WIRS_1	17	22	PF05994	0.509
MOD_CK1_1	133	139	PF00069	0.605
MOD_CK1_1	353	359	PF00069	0.537
MOD_CK1_1	453	459	PF00069	0.796
MOD_CK2_1	16	22	PF00069	0.516
MOD_CK2_1	193	199	PF00069	0.646
MOD_CK2_1	328	334	PF00069	0.481
MOD_CK2_1	353	359	PF00069	0.584
MOD_Cter_Amidation	546	549	PF01082	0.451
MOD_GlcNHglycan	102	105	PF01048	0.668
MOD_GlcNHglycan	195	198	PF01048	0.647
MOD_GlcNHglycan	215	218	PF01048	0.359
MOD_GlcNHglycan	266	270	PF01048	0.692
MOD_GlcNHglycan	415	418	PF01048	0.610
MOD_GlcNHglycan	566	570	PF01048	0.675
MOD_GlcNHglycan	611	614	PF01048	0.737
MOD_GlcNHglycan	653	656	PF01048	0.592
MOD_GlcNHglycan	9	12	PF01048	0.754
MOD_GSK3_1	126	133	PF00069	0.575
MOD_GSK3_1	386	393	PF00069	0.592
MOD_GSK3_1	447	454	PF00069	0.774
MOD_GSK3_1	565	572	PF00069	0.775
MOD_GSK3_1	605	612	PF00069	0.573
MOD_GSK3_1	658	665	PF00069	0.711
MOD_N-GLC_1	258	263	PF02516	0.681
MOD_NEK2_1	130	135	PF00069	0.607
MOD_NEK2_1	328	333	PF00069	0.538
MOD_NEK2_1	487	492	PF00069	0.552
MOD_NEK2_1	504	509	PF00069	0.374
MOD_NEK2_1	643	648	PF00069	0.566
MOD_PIKK_1	248	254	PF00454	0.748
MOD_PIKK_1	487	493	PF00454	0.553
MOD_PIKK_1	617	623	PF00454	0.610
MOD_PKA_2	451	457	PF00069	0.740
MOD_PKA_2	522	528	PF00069	0.705
MOD_PKA_2	608	614	PF00069	0.729
MOD_PKA_2	625	631	PF00069	0.663
MOD_PKA_2	7	13	PF00069	0.759
MOD_Plk_1	130	136	PF00069	0.542
MOD_Plk_1	237	243	PF00069	0.704
MOD_Plk_1	504	510	PF00069	0.490
MOD_Plk_1	605	611	PF00069	0.480
MOD_Plk_2-3	156	162	PF00069	0.691
MOD_Plk_2-3	462	468	PF00069	0.665
MOD_Plk_4	16	22	PF00069	0.516
MOD_ProDKin_1	578	584	PF00069	0.718
MOD_ProDKin_1	658	664	PF00069	0.738
MOD_SUMO_for_1	104	107	PF00179	0.569
MOD_SUMO_for_1	157	160	PF00179	0.698
MOD_SUMO_for_1	354	357	PF00179	0.579
MOD_SUMO_rev_2	160	167	PF00179	0.517
MOD_SUMO_rev_2	184	193	PF00179	0.617
MOD_SUMO_rev_2	300	307	PF00179	0.560
MOD_SUMO_rev_2	379	387	PF00179	0.511
TRG_DiLeu_BaEn_1	373	378	PF01217	0.561
TRG_DiLeu_BaEn_1	420	425	PF01217	0.604
TRG_DiLeu_BaEn_4	369	375	PF01217	0.658
TRG_DiLeu_BaLyEn_6	638	643	PF01217	0.738
TRG_DiLeu_LyEn_5	420	425	PF01217	0.506
TRG_ER_diArg_1	116	118	PF00400	0.431
TRG_ER_diArg_1	32	34	PF00400	0.411
TRG_ER_diArg_1	421	424	PF00400	0.515
TRG_ER_diArg_1	481	484	PF00400	0.709
TRG_Pf-PMV_PEXEL_1	423	427	PF00026	0.661
TRG_Pf-PMV_PEXEL_1	596	600	PF00026	0.565

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSH8	Leptomonas seymouri	37%	93%
A4HA45	Leishmania braziliensis	69%	95%
A4HYB1	Leishmania infantum	100%	100%
E9AS44	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	98%
Q4QDC2	Leishmania major	88%	98%