Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleus and spindle associated protein 4, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IEJ0_LEIDO

TriTrypDb:

LdBPK_342800.1 , LdCL_340036100 , LDHU3_34.4800

Length:

182

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0005819	spindle	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IEJ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEJ0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	67	71	PF00656	0.505
CLV_NRD_NRD_1	154	156	PF00675	0.453
CLV_NRD_NRD_1	174	176	PF00675	0.288
CLV_PCSK_KEX2_1	156	158	PF00082	0.459
CLV_PCSK_KEX2_1	165	167	PF00082	0.384
CLV_PCSK_KEX2_1	179	181	PF00082	0.441
CLV_PCSK_PC1ET2_1	156	158	PF00082	0.524
CLV_PCSK_PC1ET2_1	165	167	PF00082	0.537
CLV_PCSK_PC1ET2_1	179	181	PF00082	0.558
CLV_PCSK_PC7_1	175	181	PF00082	0.543
CLV_PCSK_SKI1_1	176	180	PF00082	0.428
DOC_MAPK_gen_1	144	153	PF00069	0.536
DOC_MAPK_gen_1	155	164	PF00069	0.526
DOC_MAPK_MEF2A_6	155	164	PF00069	0.499
DOC_MAPK_NFAT4_5	157	165	PF00069	0.499
DOC_USP7_MATH_1	119	123	PF00917	0.571
DOC_USP7_MATH_1	50	54	PF00917	0.489
LIG_14-3-3_CanoR_1	26	35	PF00244	0.431
LIG_14-3-3_CanoR_1	7	11	PF00244	0.741
LIG_BRCT_BRCA1_1	52	56	PF00533	0.559
LIG_CaM_IQ_9	76	91	PF13499	0.421
LIG_CtBP_PxDLS_1	65	69	PF00389	0.422
LIG_FAT_LD_1	69	77	PF03623	0.498
LIG_FHA_1	109	115	PF00498	0.481
LIG_FHA_2	165	171	PF00498	0.509
LIG_LIR_Gen_1	53	64	PF02991	0.489
LIG_LIR_Nem_3	131	135	PF02991	0.494
LIG_LIR_Nem_3	53	59	PF02991	0.519
LIG_NRP_CendR_1	179	182	PF00754	0.541
LIG_SH2_STAT3	135	138	PF00017	0.499
LIG_SH2_STAT5	135	138	PF00017	0.499
LIG_SH2_STAT5	75	78	PF00017	0.453
LIG_SUMO_SIM_anti_2	6	12	PF11976	0.635
LIG_SUMO_SIM_par_1	149	154	PF11976	0.527
LIG_SUMO_SIM_par_1	36	42	PF11976	0.485
LIG_WRC_WIRS_1	56	61	PF05994	0.439
MOD_CK1_1	122	128	PF00069	0.510
MOD_CK1_1	54	60	PF00069	0.567
MOD_CK2_1	122	128	PF00069	0.441
MOD_CK2_1	164	170	PF00069	0.511
MOD_GlcNHglycan	121	124	PF01048	0.465
MOD_GlcNHglycan	125	128	PF01048	0.428
MOD_GlcNHglycan	140	143	PF01048	0.432
MOD_GlcNHglycan	52	56	PF01048	0.575
MOD_GlcNHglycan	59	62	PF01048	0.645
MOD_GSK3_1	119	126	PF00069	0.453
MOD_GSK3_1	27	34	PF00069	0.442
MOD_GSK3_1	50	57	PF00069	0.590
MOD_N-GLC_1	119	124	PF02516	0.428
MOD_N-GLC_1	138	143	PF02516	0.411
MOD_NEK2_1	59	64	PF00069	0.539
MOD_PIKK_1	98	104	PF00454	0.607
MOD_PKA_2	27	33	PF00069	0.509
MOD_PKA_2	6	12	PF00069	0.562
MOD_PKA_2	98	104	PF00069	0.467
MOD_Plk_2-3	6	12	PF00069	0.675
MOD_Plk_4	6	12	PF00069	0.675
MOD_SUMO_rev_2	122	132	PF00179	0.490
MOD_SUMO_rev_2	158	167	PF00179	0.434
TRG_DiLeu_BaEn_1	6	11	PF01217	0.634
TRG_ER_diArg_1	166	169	PF00400	0.489
TRG_NLS_Bipartite_1	155	169	PF00514	0.553
TRG_NLS_MonoExtC_3	164	170	PF00514	0.582
TRG_Pf-PMV_PEXEL_1	148	152	PF00026	0.527
TRG_PTS2	1	15	PF00400	0.561

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVR9	Leptomonas seymouri	66%	98%
A0A3R7NC13	Trypanosoma rangeli	31%	100%
A4HB16	Leishmania braziliensis	76%	100%
A4IA73	Leishmania infantum	99%	100%
C9ZM34	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9B586	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q2P7	Leishmania major	92%	100%
V5B5F2	Trypanosoma cruzi	33%	100%