C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IEI9_LEIDO

TriTrypDb:

LdBPK_303420.1 , LdCL_300039800 , LDHU3_30.4520

Length:

624

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IEI9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEI9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	157	161	PF00656	0.708
CLV_C14_Caspase3-7	584	588	PF00656	0.693
CLV_C14_Caspase3-7	66	70	PF00656	0.823
CLV_NRD_NRD_1	143	145	PF00675	0.843
CLV_NRD_NRD_1	227	229	PF00675	0.750
CLV_NRD_NRD_1	293	295	PF00675	0.849
CLV_PCSK_KEX2_1	143	145	PF00082	0.843
CLV_PCSK_KEX2_1	194	196	PF00082	0.826
CLV_PCSK_KEX2_1	227	229	PF00082	0.667
CLV_PCSK_KEX2_1	293	295	PF00082	0.849
CLV_PCSK_PC1ET2_1	194	196	PF00082	0.826
CLV_PCSK_SKI1_1	138	142	PF00082	0.630
CLV_PCSK_SKI1_1	287	291	PF00082	0.767
CLV_PCSK_SKI1_1	350	354	PF00082	0.861
CLV_PCSK_SKI1_1	366	370	PF00082	0.597
CLV_PCSK_SKI1_1	590	594	PF00082	0.774
DEG_SPOP_SBC_1	102	106	PF00917	0.745
DEG_SPOP_SBC_1	130	134	PF00917	0.741
DEG_SPOP_SBC_1	276	280	PF00917	0.666
DEG_SPOP_SBC_1	42	46	PF00917	0.815
DEG_SPOP_SBC_1	494	498	PF00917	0.779
DEG_SPOP_SBC_1	64	68	PF00917	0.758
DOC_CKS1_1	570	575	PF01111	0.738
DOC_MAPK_DCC_7	144	154	PF00069	0.854
DOC_MAPK_MEF2A_6	121	130	PF00069	0.642
DOC_PP1_RVXF_1	239	246	PF00149	0.780
DOC_PP1_RVXF_1	285	291	PF00149	0.720
DOC_PP2B_LxvP_1	152	155	PF13499	0.848
DOC_USP7_MATH_1	101	105	PF00917	0.822
DOC_USP7_MATH_1	110	114	PF00917	0.695
DOC_USP7_MATH_1	215	219	PF00917	0.767
DOC_USP7_MATH_1	259	263	PF00917	0.805
DOC_USP7_MATH_1	329	333	PF00917	0.778
DOC_USP7_MATH_1	345	349	PF00917	0.669
DOC_USP7_MATH_1	352	356	PF00917	0.744
DOC_USP7_MATH_1	41	45	PF00917	0.695
DOC_USP7_MATH_1	494	498	PF00917	0.784
DOC_USP7_MATH_1	51	55	PF00917	0.801
DOC_USP7_MATH_1	581	585	PF00917	0.820
DOC_USP7_MATH_1	62	66	PF00917	0.597
DOC_USP7_MATH_1	75	79	PF00917	0.721
DOC_WW_Pin1_4	122	127	PF00397	0.816
DOC_WW_Pin1_4	147	152	PF00397	0.728
DOC_WW_Pin1_4	180	185	PF00397	0.679
DOC_WW_Pin1_4	301	306	PF00397	0.787
DOC_WW_Pin1_4	338	343	PF00397	0.782
DOC_WW_Pin1_4	350	355	PF00397	0.686
DOC_WW_Pin1_4	397	402	PF00397	0.802
DOC_WW_Pin1_4	495	500	PF00397	0.843
DOC_WW_Pin1_4	521	526	PF00397	0.778
DOC_WW_Pin1_4	528	533	PF00397	0.736
DOC_WW_Pin1_4	569	574	PF00397	0.735
DOC_WW_Pin1_4	614	619	PF00397	0.739
DOC_WW_Pin1_4	73	78	PF00397	0.803
LIG_14-3-3_CanoR_1	138	143	PF00244	0.740
LIG_14-3-3_CanoR_1	227	236	PF00244	0.786
LIG_14-3-3_CanoR_1	241	246	PF00244	0.664
LIG_14-3-3_CanoR_1	268	276	PF00244	0.754
LIG_14-3-3_CanoR_1	312	320	PF00244	0.748
LIG_14-3-3_CanoR_1	375	385	PF00244	0.687
LIG_14-3-3_CanoR_1	407	417	PF00244	0.840
LIG_14-3-3_CanoR_1	492	500	PF00244	0.864
LIG_14-3-3_CanoR_1	543	549	PF00244	0.816
LIG_14-3-3_CanoR_1	9	19	PF00244	0.723
LIG_BIR_III_4	25	29	PF00653	0.686
LIG_FHA_1	109	115	PF00498	0.836
LIG_FHA_1	125	131	PF00498	0.598
LIG_FHA_1	305	311	PF00498	0.618
LIG_FHA_1	454	460	PF00498	0.593
LIG_FHA_1	529	535	PF00498	0.824
LIG_FHA_1	543	549	PF00498	0.581
LIG_FHA_1	597	603	PF00498	0.682
LIG_FHA_1	66	72	PF00498	0.822
LIG_FHA_2	290	296	PF00498	0.777
LIG_FHA_2	369	375	PF00498	0.862
LIG_GBD_Chelix_1	206	214	PF00786	0.775
LIG_LIR_Apic_2	515	521	PF02991	0.697
LIG_LIR_Apic_2	567	573	PF02991	0.804
LIG_LIR_Gen_1	545	554	PF02991	0.739
LIG_LIR_Gen_1	597	608	PF02991	0.768
LIG_LIR_Nem_3	545	549	PF02991	0.739
LIG_LIR_Nem_3	597	603	PF02991	0.760
LIG_MYND_1	614	618	PF01753	0.602
LIG_PAM2_1	86	98	PF00658	0.818
LIG_PTAP_UEV_1	524	529	PF05743	0.646
LIG_SH2_CRK	197	201	PF00017	0.853
LIG_SH2_CRK	518	522	PF00017	0.710
LIG_SH2_CRK	546	550	PF00017	0.820
LIG_SH2_CRK	570	574	PF00017	0.814
LIG_SH2_NCK_1	514	518	PF00017	0.776
LIG_SH2_NCK_1	570	574	PF00017	0.698
LIG_SH2_STAP1	514	518	PF00017	0.776
LIG_SH2_STAT5	30	33	PF00017	0.786
LIG_SH2_STAT5	313	316	PF00017	0.748
LIG_SH2_STAT5	514	517	PF00017	0.772
LIG_SH2_STAT5	546	549	PF00017	0.818
LIG_SH3_1	179	185	PF00018	0.668
LIG_SH3_1	197	203	PF00018	0.770
LIG_SH3_1	415	421	PF00018	0.810
LIG_SH3_3	14	20	PF00018	0.701
LIG_SH3_3	179	185	PF00018	0.704
LIG_SH3_3	197	203	PF00018	0.709
LIG_SH3_3	230	236	PF00018	0.840
LIG_SH3_3	279	285	PF00018	0.635
LIG_SH3_3	328	334	PF00018	0.757
LIG_SH3_3	355	361	PF00018	0.728
LIG_SH3_3	395	401	PF00018	0.837
LIG_SH3_3	413	419	PF00018	0.597
LIG_SH3_3	472	478	PF00018	0.732
LIG_SH3_3	517	523	PF00018	0.729
LIG_SUMO_SIM_par_1	531	537	PF11976	0.812
LIG_SUMO_SIM_par_1	590	597	PF11976	0.696
LIG_WRC_WIRS_1	260	265	PF05994	0.693
LIG_WRC_WIRS_1	558	563	PF05994	0.776
LIG_WW_1	401	404	PF00397	0.735
MOD_CK1_1	106	112	PF00069	0.765
MOD_CK1_1	113	119	PF00069	0.654
MOD_CK1_1	131	137	PF00069	0.520
MOD_CK1_1	174	180	PF00069	0.788
MOD_CK1_1	218	224	PF00069	0.849
MOD_CK1_1	249	255	PF00069	0.834
MOD_CK1_1	275	281	PF00069	0.792
MOD_CK1_1	283	289	PF00069	0.748
MOD_CK1_1	304	310	PF00069	0.628
MOD_CK1_1	332	338	PF00069	0.827
MOD_CK1_1	348	354	PF00069	0.661
MOD_CK1_1	411	417	PF00069	0.792
MOD_CK1_1	560	566	PF00069	0.813
MOD_CK1_1	65	71	PF00069	0.824
MOD_CK1_1	76	82	PF00069	0.616
MOD_CK2_1	368	374	PF00069	0.862
MOD_DYRK1A_RPxSP_1	350	354	PF00069	0.686
MOD_GlcNHglycan	105	108	PF01048	0.544
MOD_GlcNHglycan	138	141	PF01048	0.754
MOD_GlcNHglycan	210	213	PF01048	0.801
MOD_GlcNHglycan	219	223	PF01048	0.646
MOD_GlcNHglycan	229	232	PF01048	0.544
MOD_GlcNHglycan	25	29	PF01048	0.764
MOD_GlcNHglycan	251	254	PF01048	0.778
MOD_GlcNHglycan	32	35	PF01048	0.667
MOD_GlcNHglycan	350	353	PF01048	0.663
MOD_GlcNHglycan	387	390	PF01048	0.745
MOD_GlcNHglycan	410	413	PF01048	0.718
MOD_GlcNHglycan	539	542	PF01048	0.666
MOD_GlcNHglycan	88	91	PF01048	0.813
MOD_GlcNHglycan	99	102	PF01048	0.656
MOD_GSK3_1	106	113	PF00069	0.682
MOD_GSK3_1	124	131	PF00069	0.519
MOD_GSK3_1	138	145	PF00069	0.605
MOD_GSK3_1	154	161	PF00069	0.675
MOD_GSK3_1	223	230	PF00069	0.795
MOD_GSK3_1	239	246	PF00069	0.603
MOD_GSK3_1	249	256	PF00069	0.578
MOD_GSK3_1	268	275	PF00069	0.576
MOD_GSK3_1	276	283	PF00069	0.705
MOD_GSK3_1	316	323	PF00069	0.772
MOD_GSK3_1	332	339	PF00069	0.650
MOD_GSK3_1	346	353	PF00069	0.640
MOD_GSK3_1	403	410	PF00069	0.835
MOD_GSK3_1	533	540	PF00069	0.699
MOD_GSK3_1	544	551	PF00069	0.635
MOD_GSK3_1	553	560	PF00069	0.485
MOD_GSK3_1	60	67	PF00069	0.709
MOD_GSK3_1	604	611	PF00069	0.671
MOD_GSK3_1	614	621	PF00069	0.595
MOD_GSK3_1	69	76	PF00069	0.485
MOD_GSK3_1	80	87	PF00069	0.622
MOD_GSK3_1	97	104	PF00069	0.553
MOD_N-GLC_1	215	220	PF02516	0.846
MOD_N-GLC_1	249	254	PF02516	0.757
MOD_NEK2_1	142	147	PF00069	0.661
MOD_NEK2_1	245	250	PF00069	0.694
MOD_NEK2_1	487	492	PF00069	0.840
MOD_NEK2_1	512	517	PF00069	0.785
MOD_NEK2_1	548	553	PF00069	0.821
MOD_NEK2_1	608	613	PF00069	0.720
MOD_NEK2_2	259	264	PF00069	0.757
MOD_NEK2_2	481	486	PF00069	0.656
MOD_PIKK_1	154	160	PF00454	0.811
MOD_PIKK_1	171	177	PF00454	0.608
MOD_PIKK_1	243	249	PF00454	0.780
MOD_PIKK_1	280	286	PF00454	0.747
MOD_PIKK_1	352	358	PF00454	0.785
MOD_PIKK_1	420	426	PF00454	0.763
MOD_PIKK_1	453	459	PF00454	0.610
MOD_PIKK_1	553	559	PF00454	0.816
MOD_PIKK_1	575	581	PF00454	0.750
MOD_PIKK_1	618	624	PF00454	0.617
MOD_PKA_1	227	233	PF00069	0.655
MOD_PKA_2	142	148	PF00069	0.792
MOD_PKA_2	158	164	PF00069	0.630
MOD_PKA_2	226	232	PF00069	0.872
MOD_PKA_2	267	273	PF00069	0.750
MOD_PKA_2	311	317	PF00069	0.743
MOD_PKA_2	542	548	PF00069	0.739
MOD_PKB_1	136	144	PF00069	0.621
MOD_Plk_4	259	265	PF00069	0.669
MOD_Plk_4	277	283	PF00069	0.557
MOD_Plk_4	481	487	PF00069	0.871
MOD_Plk_4	544	550	PF00069	0.817
MOD_Plk_4	564	570	PF00069	0.475
MOD_ProDKin_1	122	128	PF00069	0.815
MOD_ProDKin_1	147	153	PF00069	0.728
MOD_ProDKin_1	180	186	PF00069	0.681
MOD_ProDKin_1	301	307	PF00069	0.787
MOD_ProDKin_1	338	344	PF00069	0.780
MOD_ProDKin_1	350	356	PF00069	0.688
MOD_ProDKin_1	397	403	PF00069	0.804
MOD_ProDKin_1	495	501	PF00069	0.845
MOD_ProDKin_1	521	527	PF00069	0.779
MOD_ProDKin_1	528	534	PF00069	0.735
MOD_ProDKin_1	569	575	PF00069	0.737
MOD_ProDKin_1	614	620	PF00069	0.741
MOD_ProDKin_1	73	79	PF00069	0.803
MOD_SUMO_for_1	603	606	PF00179	0.551
MOD_SUMO_rev_2	374	383	PF00179	0.644
TRG_DiLeu_BaLyEn_6	587	592	PF01217	0.717
TRG_ENDOCYTIC_2	546	549	PF00928	0.818
TRG_ER_diArg_1	142	144	PF00400	0.764
TRG_ER_diArg_1	363	366	PF00400	0.859

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HIS5	Leishmania braziliensis	63%	100%
A4I621	Leishmania infantum	100%	100%
E9B1B2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q6V2	Leishmania major	85%	100%