LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Tetratricopeptide repeat family protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Tetratricopeptide repeat family protein
Gene product:
Putative intraflagellar transport protein C3
Species:
Leishmania donovani
UniProt:
A0A3Q8IEI7_LEIDO
TriTrypDb:
LdBPK_292870.1 , LdCL_290034800 , LDHU3_29.4190
Length:
568

Annotations

Annotations by Jardim et al.

Flagella, intraflagellar transport C3 (PIFTC3) Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 6
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 7
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 14
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005929 cilium 4 2
GO:0031514 motile cilium 5 2
GO:0042995 cell projection 2 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0110165 cellular anatomical entity 1 3
GO:0120025 plasma membrane bounded cell projection 3 2
GO:0005815 microtubule organizing center 2 1
GO:0030990 intraciliary transport particle 2 1
GO:0030992 intraciliary transport particle B 2 1
GO:0032991 protein-containing complex 1 1
GO:0036064 ciliary basal body 3 1
GO:0097546 ciliary base 2 1

Expansion

Sequence features

A0A3Q8IEI7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEI7

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 1
GO:0007017 microtubule-based process 2 1
GO:0007018 microtubule-based movement 3 1
GO:0009987 cellular process 1 1
GO:0010970 transport along microtubule 4 1
GO:0030705 cytoskeleton-dependent intracellular transport 4 1
GO:0031503 protein-containing complex localization 2 1
GO:0035720 intraciliary anterograde transport 4 1
GO:0035735 intraciliary transport involved in cilium assembly 4 1
GO:0042073 intraciliary transport 3 1
GO:0046907 intracellular transport 3 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
GO:0051641 cellular localization 2 1
GO:0051649 establishment of localization in cell 3 1
GO:0099111 microtubule-based transport 4 1
Molecular functions
Term Name Level Count
GO:0005488 binding 1 1
GO:0044877 protein-containing complex binding 2 1
GO:0120170 intraciliary transport particle B binding 3 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 492 496 PF00656 0.479
CLV_NRD_NRD_1 18 20 PF00675 0.682
CLV_NRD_NRD_1 9 11 PF00675 0.679
CLV_PCSK_KEX2_1 566 568 PF00082 0.619
CLV_PCSK_PC1ET2_1 566 568 PF00082 0.625
CLV_PCSK_SKI1_1 129 133 PF00082 0.408
CLV_PCSK_SKI1_1 179 183 PF00082 0.435
CLV_PCSK_SKI1_1 240 244 PF00082 0.549
CLV_PCSK_SKI1_1 348 352 PF00082 0.553
CLV_PCSK_SKI1_1 388 392 PF00082 0.418
CLV_PCSK_SKI1_1 561 565 PF00082 0.530
CLV_PCSK_SKI1_1 85 89 PF00082 0.436
DEG_Nend_Nbox_1 1 3 PF02207 0.658
DOC_MAPK_gen_1 186 195 PF00069 0.541
DOC_MAPK_gen_1 240 250 PF00069 0.565
DOC_MAPK_gen_1 447 457 PF00069 0.431
DOC_MAPK_gen_1 504 511 PF00069 0.398
DOC_MAPK_MEF2A_6 186 195 PF00069 0.425
DOC_MAPK_MEF2A_6 243 252 PF00069 0.575
DOC_MAPK_MEF2A_6 378 387 PF00069 0.407
DOC_MAPK_NFAT4_5 243 251 PF00069 0.571
DOC_PP1_SILK_1 465 470 PF00149 0.552
DOC_USP7_MATH_1 241 245 PF00917 0.552
DOC_USP7_MATH_1 417 421 PF00917 0.413
DOC_USP7_MATH_1 423 427 PF00917 0.491
DOC_USP7_MATH_1 521 525 PF00917 0.464
DOC_USP7_UBL2_3 243 247 PF12436 0.549
DOC_USP7_UBL2_3 557 561 PF12436 0.445
DOC_WW_Pin1_4 24 29 PF00397 0.678
LIG_14-3-3_CanoR_1 168 178 PF00244 0.561
LIG_14-3-3_CanoR_1 254 258 PF00244 0.527
LIG_14-3-3_CanoR_1 477 483 PF00244 0.547
LIG_APCC_ABBA_1 81 86 PF00400 0.380
LIG_BRCT_BRCA1_1 371 375 PF00533 0.395
LIG_deltaCOP1_diTrp_1 65 72 PF00928 0.536
LIG_FHA_1 170 176 PF00498 0.556
LIG_FHA_1 254 260 PF00498 0.550
LIG_FHA_1 43 49 PF00498 0.466
LIG_FHA_1 434 440 PF00498 0.432
LIG_FHA_2 136 142 PF00498 0.478
LIG_FHA_2 152 158 PF00498 0.402
LIG_FHA_2 25 31 PF00498 0.676
LIG_FHA_2 318 324 PF00498 0.489
LIG_FHA_2 44 50 PF00498 0.300
LIG_FXI_DFP_1 377 381 PF00024 0.463
LIG_LIR_Gen_1 308 318 PF02991 0.430
LIG_LIR_Gen_1 349 358 PF02991 0.443
LIG_LIR_Gen_1 397 407 PF02991 0.407
LIG_LIR_Nem_3 176 181 PF02991 0.431
LIG_LIR_Nem_3 185 191 PF02991 0.441
LIG_LIR_Nem_3 203 207 PF02991 0.440
LIG_LIR_Nem_3 349 354 PF02991 0.439
LIG_LIR_Nem_3 372 377 PF02991 0.407
LIG_LIR_Nem_3 379 383 PF02991 0.403
LIG_LIR_Nem_3 397 403 PF02991 0.249
LIG_LIR_Nem_3 65 69 PF02991 0.570
LIG_LIR_Nem_3 82 87 PF02991 0.313
LIG_MLH1_MIPbox_1 371 375 PF16413 0.395
LIG_NRP_CendR_1 566 568 PF00754 0.681
LIG_Pex14_2 512 516 PF04695 0.428
LIG_PTB_Apo_2 105 112 PF02174 0.426
LIG_PTB_Apo_2 470 477 PF02174 0.402
LIG_PTB_Phospho_1 470 476 PF10480 0.393
LIG_REV1ctd_RIR_1 372 380 PF16727 0.412
LIG_SH2_CRK 178 182 PF00017 0.420
LIG_SH2_CRK 188 192 PF00017 0.414
LIG_SH2_GRB2like 106 109 PF00017 0.570
LIG_SH2_GRB2like 219 222 PF00017 0.569
LIG_SH2_NCK_1 414 418 PF00017 0.545
LIG_SH2_SRC 402 405 PF00017 0.383
LIG_SH2_SRC 414 417 PF00017 0.547
LIG_SH2_SRC 500 503 PF00017 0.441
LIG_SH2_STAP1 171 175 PF00017 0.527
LIG_SH2_STAP1 205 209 PF00017 0.405
LIG_SH2_STAP1 219 223 PF00017 0.448
LIG_SH2_STAP1 310 314 PF00017 0.570
LIG_SH2_STAP1 435 439 PF00017 0.427
LIG_SH2_STAP1 483 487 PF00017 0.382
LIG_SH2_STAT3 333 336 PF00017 0.554
LIG_SH2_STAT5 100 103 PF00017 0.421
LIG_SH2_STAT5 166 169 PF00017 0.540
LIG_SH2_STAT5 171 174 PF00017 0.479
LIG_SH2_STAT5 194 197 PF00017 0.415
LIG_SH2_STAT5 199 202 PF00017 0.437
LIG_SH2_STAT5 215 218 PF00017 0.325
LIG_SH2_STAT5 258 261 PF00017 0.633
LIG_SH2_STAT5 324 327 PF00017 0.389
LIG_SH2_STAT5 333 336 PF00017 0.438
LIG_SH2_STAT5 353 356 PF00017 0.340
LIG_SH2_STAT5 373 376 PF00017 0.307
LIG_SH2_STAT5 386 389 PF00017 0.408
LIG_SH2_STAT5 393 396 PF00017 0.449
LIG_SH2_STAT5 402 405 PF00017 0.383
LIG_SH2_STAT5 435 438 PF00017 0.428
LIG_SH2_STAT5 456 459 PF00017 0.470
LIG_SH2_STAT5 500 503 PF00017 0.441
LIG_SH3_3 119 125 PF00018 0.586
LIG_SH3_3 284 290 PF00018 0.536
LIG_SUMO_SIM_anti_2 208 213 PF11976 0.413
LIG_SUMO_SIM_anti_2 523 530 PF11976 0.399
LIG_SUMO_SIM_par_1 420 427 PF11976 0.560
LIG_SUMO_SIM_par_1 86 92 PF11976 0.458
LIG_TRAF2_1 27 30 PF00917 0.669
LIG_TRAF2_1 320 323 PF00917 0.521
LIG_TRAF2_1 517 520 PF00917 0.457
LIG_TYR_ITIM 202 207 PF00017 0.534
LIG_UBA3_1 130 137 PF00899 0.427
LIG_UBA3_1 384 391 PF00899 0.419
LIG_UBA3_1 525 530 PF00899 0.482
LIG_UBA3_1 552 561 PF00899 0.430
MOD_CK1_1 356 362 PF00069 0.556
MOD_CK1_1 42 48 PF00069 0.450
MOD_CK1_1 434 440 PF00069 0.410
MOD_CK1_1 54 60 PF00069 0.494
MOD_CK2_1 107 113 PF00069 0.472
MOD_CK2_1 135 141 PF00069 0.477
MOD_CK2_1 24 30 PF00069 0.654
MOD_CK2_1 317 323 PF00069 0.454
MOD_CK2_1 43 49 PF00069 0.298
MOD_CK2_1 493 499 PF00069 0.599
MOD_CK2_1 59 65 PF00069 0.474
MOD_Cter_Amidation 502 505 PF01082 0.416
MOD_GlcNHglycan 221 224 PF01048 0.450
MOD_GlcNHglycan 356 359 PF01048 0.558
MOD_GlcNHglycan 4 7 PF01048 0.674
MOD_GlcNHglycan 478 481 PF01048 0.528
MOD_GlcNHglycan 53 56 PF01048 0.545
MOD_GlcNHglycan 69 72 PF01048 0.323
MOD_GSK3_1 215 222 PF00069 0.454
MOD_GSK3_1 356 363 PF00069 0.461
MOD_GSK3_1 39 46 PF00069 0.457
MOD_GSK3_1 392 399 PF00069 0.568
MOD_GSK3_1 50 57 PF00069 0.476
MOD_N-GLC_1 107 112 PF02516 0.404
MOD_N-GLC_1 59 64 PF02516 0.400
MOD_N-GLC_1 96 101 PF02516 0.494
MOD_N-GLC_2 473 475 PF02516 0.394
MOD_NEK2_1 1 6 PF00069 0.673
MOD_NEK2_1 107 112 PF00069 0.559
MOD_NEK2_1 252 257 PF00069 0.521
MOD_NEK2_1 433 438 PF00069 0.431
MOD_NEK2_1 439 444 PF00069 0.396
MOD_NEK2_1 461 466 PF00069 0.629
MOD_NEK2_1 50 55 PF00069 0.465
MOD_NEK2_1 67 72 PF00069 0.402
MOD_NEK2_2 386 391 PF00069 0.416
MOD_PIKK_1 318 324 PF00454 0.564
MOD_PIKK_1 337 343 PF00454 0.488
MOD_PKA_2 253 259 PF00069 0.541
MOD_PKA_2 360 366 PF00069 0.578
MOD_PKA_2 476 482 PF00069 0.550
MOD_Plk_1 205 211 PF00069 0.409
MOD_Plk_1 396 402 PF00069 0.409
MOD_Plk_1 417 423 PF00069 0.420
MOD_Plk_1 431 437 PF00069 0.439
MOD_Plk_1 532 538 PF00069 0.462
MOD_Plk_1 59 65 PF00069 0.488
MOD_Plk_1 96 102 PF00069 0.509
MOD_Plk_4 207 213 PF00069 0.519
MOD_Plk_4 253 259 PF00069 0.642
MOD_Plk_4 280 286 PF00069 0.568
MOD_Plk_4 369 375 PF00069 0.416
MOD_Plk_4 396 402 PF00069 0.414
MOD_Plk_4 417 423 PF00069 0.558
MOD_Plk_4 43 49 PF00069 0.555
MOD_Plk_4 434 440 PF00069 0.399
MOD_Plk_4 521 527 PF00069 0.464
MOD_Plk_4 96 102 PF00069 0.509
MOD_ProDKin_1 24 30 PF00069 0.672
MOD_SUMO_for_1 242 245 PF00179 0.537
MOD_SUMO_for_1 429 432 PF00179 0.444
MOD_SUMO_for_1 457 460 PF00179 0.503
MOD_SUMO_rev_2 140 145 PF00179 0.427
MOD_SUMO_rev_2 244 249 PF00179 0.537
MOD_SUMO_rev_2 558 565 PF00179 0.480
TRG_DiLeu_BaEn_1 245 250 PF01217 0.429
TRG_DiLeu_BaEn_1 308 313 PF01217 0.415
TRG_DiLeu_BaLyEn_6 466 471 PF01217 0.541
TRG_ENDOCYTIC_2 178 181 PF00928 0.422
TRG_ENDOCYTIC_2 188 191 PF00928 0.421
TRG_ENDOCYTIC_2 194 197 PF00928 0.395
TRG_ENDOCYTIC_2 199 202 PF00928 0.401
TRG_ENDOCYTIC_2 204 207 PF00928 0.411
TRG_ENDOCYTIC_2 234 237 PF00928 0.577
TRG_ENDOCYTIC_2 310 313 PF00928 0.421
TRG_ENDOCYTIC_2 373 376 PF00928 0.414
TRG_ENDOCYTIC_2 69 72 PF00928 0.403
TRG_ENDOCYTIC_2 84 87 PF00928 0.423
TRG_ER_diLys_1 564 568 PF00400 0.586
TRG_NES_CRM1_1 279 291 PF08389 0.539
TRG_NES_CRM1_1 460 474 PF08389 0.577
TRG_Pf-PMV_PEXEL_1 469 474 PF00026 0.536

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6K7 Leptomonas seymouri 83% 100%
A0A0S4KM55 Bodo saltans 64% 100%
A0A1X0PAC6 Trypanosomatidae 68% 100%
A0A3R7NBU5 Trypanosoma rangeli 68% 100%
A0AVF1 Homo sapiens 49% 100%
A4HHT3 Leishmania braziliensis 93% 100%
A4I4Z3 Leishmania infantum 100% 100%
A4III8 Xenopus tropicalis 51% 100%
A8JA42 Chlamydomonas reinhardtii 48% 100%
C9ZKK5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 68% 100%
E9AED8 Leishmania major 98% 100%
E9ALE8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 99% 100%
Q4R7Z9 Macaca fascicularis 50% 100%
Q57ZL2 Trypanosoma brucei brucei (strain 927/4 GUTat10.1) 68% 100%
Q5PR66 Danio rerio 52% 100%
Q5U2N8 Rattus norvegicus 50% 100%
Q8BS45 Mus musculus 50% 100%
Q95QT8 Caenorhabditis elegans 35% 99%
V5BXA0 Trypanosoma cruzi 69% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS