S-adenosylmethionine decarboxylase proenzyme

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

S-adenosylmethionine decarboxylase

Species:

Leishmania donovani

UniProt:

A0A3Q8IEH8_LEIDO

TriTrypDb:

LdBPK_303150.1 , LdCL_300037100 , LDHU3_30.4190

Length:

382

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IEH8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEH8

Function

Biological processes
Term	Name	Level	Count
GO:0006576	biogenic amine metabolic process	5	12
GO:0006595	polyamine metabolic process	6	12
GO:0006596	polyamine biosynthetic process	7	12
GO:0006597	spermine biosynthetic process	8	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0008215	spermine metabolic process	7	12
GO:0008216	spermidine metabolic process	7	12
GO:0008295	spermidine biosynthetic process	8	12
GO:0009058	biosynthetic process	2	12
GO:0009308	amine metabolic process	4	12
GO:0009309	amine biosynthetic process	5	12
GO:0009987	cellular process	1	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0042401	biogenic amine biosynthetic process	6	12
GO:0044237	cellular metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044271	cellular nitrogen compound biosynthetic process	4	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901566	organonitrogen compound biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004014	adenosylmethionine decarboxylase activity	5	12
GO:0016829	lyase activity	2	12
GO:0016830	carbon-carbon lyase activity	3	12
GO:0016831	carboxy-lyase activity	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	49	53	PF00656	0.272
CLV_PCSK_KEX2_1	37	39	PF00082	0.218
CLV_PCSK_PC1ET2_1	37	39	PF00082	0.218
CLV_PCSK_SKI1_1	228	232	PF00082	0.287
CLV_PCSK_SKI1_1	293	297	PF00082	0.332
CLV_PCSK_SKI1_1	98	102	PF00082	0.255
DEG_APCC_DBOX_1	123	131	PF00400	0.383
DEG_Nend_UBRbox_3	1	3	PF02207	0.586
DOC_MAPK_gen_1	291	298	PF00069	0.311
DOC_MAPK_gen_1	300	310	PF00069	0.276
DOC_MAPK_gen_1	37	43	PF00069	0.253
DOC_MAPK_MEF2A_6	303	310	PF00069	0.252
DOC_PP4_FxxP_1	309	312	PF00568	0.272
DOC_PP4_FxxP_1	32	35	PF00568	0.238
DOC_SPAK_OSR1_1	303	307	PF12202	0.238
DOC_USP7_MATH_1	146	150	PF00917	0.332
DOC_USP7_MATH_1	171	175	PF00917	0.253
DOC_USP7_MATH_1	188	192	PF00917	0.253
DOC_USP7_UBL2_3	206	210	PF12436	0.375
DOC_WW_Pin1_4	266	271	PF00397	0.250
DOC_WW_Pin1_4	311	316	PF00397	0.397
LIG_14-3-3_CanoR_1	187	197	PF00244	0.297
LIG_14-3-3_CanoR_1	228	237	PF00244	0.351
LIG_14-3-3_CanoR_1	303	307	PF00244	0.281
LIG_14-3-3_CanoR_1	44	48	PF00244	0.438
LIG_AP2alpha_1	213	217	PF02296	0.274
LIG_APCC_ABBA_1	306	311	PF00400	0.272
LIG_BRCT_BRCA1_1	213	217	PF00533	0.200
LIG_BRCT_BRCA1_1	89	93	PF00533	0.251
LIG_deltaCOP1_diTrp_1	126	132	PF00928	0.238
LIG_deltaCOP1_diTrp_1	238	248	PF00928	0.254
LIG_eIF4E_1	333	339	PF01652	0.259
LIG_FHA_1	104	110	PF00498	0.238
LIG_FHA_1	222	228	PF00498	0.238
LIG_FHA_1	238	244	PF00498	0.238
LIG_FHA_1	263	269	PF00498	0.240
LIG_FHA_1	303	309	PF00498	0.334
LIG_FHA_1	358	364	PF00498	0.445
LIG_FHA_2	218	224	PF00498	0.253
LIG_FHA_2	229	235	PF00498	0.253
LIG_FHA_2	240	246	PF00498	0.272
LIG_FHA_2	267	273	PF00498	0.238
LIG_FHA_2	340	346	PF00498	0.252
LIG_FHA_2	47	53	PF00498	0.288
LIG_FHA_2	5	11	PF00498	0.588
LIG_HOMEOBOX	139	142	PF00046	0.259
LIG_LIR_Apic_2	31	35	PF02991	0.255
LIG_LIR_Gen_1	126	137	PF02991	0.238
LIG_LIR_Gen_1	152	162	PF02991	0.274
LIG_LIR_Gen_1	260	270	PF02991	0.243
LIG_LIR_Nem_3	126	132	PF02991	0.238
LIG_LIR_Nem_3	152	157	PF02991	0.218
LIG_LIR_Nem_3	174	180	PF02991	0.239
LIG_LIR_Nem_3	275	279	PF02991	0.272
LIG_LIR_Nem_3	331	336	PF02991	0.249
LIG_LIR_Nem_3	59	65	PF02991	0.271
LIG_PCNA_yPIPBox_3	76	86	PF02747	0.139
LIG_Pex14_2	213	217	PF04695	0.254
LIG_SH2_CRK	336	340	PF00017	0.332
LIG_SH2_SRC	182	185	PF00017	0.272
LIG_SH2_STAP1	182	186	PF00017	0.272
LIG_SH2_STAP1	253	257	PF00017	0.272
LIG_SH2_STAP1	288	292	PF00017	0.283
LIG_SH2_STAT5	167	170	PF00017	0.301
LIG_SH2_STAT5	177	180	PF00017	0.319
LIG_SH2_STAT5	350	353	PF00017	0.281
LIG_SH2_STAT5	357	360	PF00017	0.359
LIG_SH2_STAT5	85	88	PF00017	0.289
LIG_SH3_3	295	301	PF00018	0.238
LIG_SH3_3	309	315	PF00018	0.238
LIG_SUMO_SIM_anti_2	10	16	PF11976	0.419
LIG_SUMO_SIM_par_1	98	103	PF11976	0.240
LIG_TRAF2_1	362	365	PF00917	0.592
LIG_UBA3_1	14	22	PF00899	0.456
LIG_UBA3_1	92	96	PF00899	0.332
MOD_CDK_SPxxK_3	311	318	PF00069	0.383
MOD_CK1_1	221	227	PF00069	0.328
MOD_CK1_1	275	281	PF00069	0.238
MOD_CK1_1	5	11	PF00069	0.572
MOD_CK1_1	60	66	PF00069	0.303
MOD_CK1_1	75	81	PF00069	0.272
MOD_CK2_1	217	223	PF00069	0.253
MOD_CK2_1	339	345	PF00069	0.238
MOD_GlcNHglycan	120	123	PF01048	0.332
MOD_GlcNHglycan	220	223	PF01048	0.263
MOD_GlcNHglycan	62	65	PF01048	0.412
MOD_GSK3_1	100	107	PF00069	0.253
MOD_GSK3_1	188	195	PF00069	0.271
MOD_GSK3_1	217	224	PF00069	0.245
MOD_GSK3_1	262	269	PF00069	0.252
MOD_GSK3_1	53	60	PF00069	0.352
MOD_GSK3_1	81	88	PF00069	0.238
MOD_N-GLC_1	135	140	PF02516	0.238
MOD_N-GLC_1	286	291	PF02516	0.278
MOD_N-GLC_1	5	10	PF02516	0.485
MOD_N-GLC_2	2	4	PF02516	0.532
MOD_N-GLC_2	79	81	PF02516	0.139
MOD_NEK2_1	109	114	PF00069	0.297
MOD_NEK2_1	17	22	PF00069	0.408
MOD_NEK2_1	197	202	PF00069	0.238
MOD_NEK2_1	217	222	PF00069	0.117
MOD_NEK2_1	339	344	PF00069	0.334
MOD_NEK2_1	57	62	PF00069	0.315
MOD_NEK2_1	87	92	PF00069	0.289
MOD_NEK2_2	239	244	PF00069	0.259
MOD_PIKK_1	192	198	PF00454	0.272
MOD_PKA_2	302	308	PF00069	0.221
MOD_PKA_2	340	346	PF00069	0.324
MOD_PKA_2	43	49	PF00069	0.438
MOD_PKA_2	75	81	PF00069	0.259
MOD_Plk_1	135	141	PF00069	0.238
MOD_Plk_1	192	198	PF00069	0.286
MOD_Plk_1	57	63	PF00069	0.306
MOD_Plk_1	88	94	PF00069	0.238
MOD_Plk_4	10	16	PF00069	0.436
MOD_Plk_4	105	111	PF00069	0.238
MOD_Plk_4	128	134	PF00069	0.238
MOD_Plk_4	197	203	PF00069	0.238
MOD_Plk_4	57	63	PF00069	0.332
MOD_Plk_4	81	87	PF00069	0.260
MOD_Plk_4	88	94	PF00069	0.215
MOD_ProDKin_1	266	272	PF00069	0.250
MOD_ProDKin_1	311	317	PF00069	0.397
TRG_DiLeu_BaEn_2	127	133	PF01217	0.238
TRG_DiLeu_BaEn_2	88	94	PF01217	0.251
TRG_ENDOCYTIC_2	177	180	PF00928	0.257
TRG_ENDOCYTIC_2	182	185	PF00928	0.248
TRG_ENDOCYTIC_2	263	266	PF00928	0.238
TRG_ENDOCYTIC_2	336	339	PF00928	0.323
TRG_ENDOCYTIC_2	350	353	PF00928	0.330
TRG_Pf-PMV_PEXEL_1	55	59	PF00026	0.300

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Z0	Leptomonas seymouri	91%	98%
A0A0N1PCH0	Leptomonas seymouri	26%	100%
A0A0S4JHX8	Bodo saltans	70%	100%
A0A0S4JRG8	Bodo saltans	28%	100%
A0A1X0P1C0	Trypanosomatidae	27%	100%
A0A1X0P1E2	Trypanosomatidae	71%	100%
A0A3S7X3S7	Leishmania donovani	25%	100%
A0A422P0Q5	Trypanosoma rangeli	25%	100%
A0A422P0V0	Trypanosoma rangeli	72%	100%
A2XV58	Oryza sativa subsp. indica	35%	96%
A4HIP5	Leishmania braziliensis	91%	100%
A4HIP6	Leishmania braziliensis	26%	85%
A4I5Z2	Leishmania infantum	100%	100%
A4I5Z3	Leishmania infantum	25%	85%
A5HNV6	Trypanosoma brucei brucei	28%	100%
C9ZRB5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	100%
C9ZRB7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
D3Z6H8	Mus musculus	33%	100%
E9B185	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
E9B186	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	85%
O02655	Caenorhabditis elegans	33%	100%
O04009	Nicotiana tabacum	33%	100%
O24575	Zea mays	35%	96%
O49972	Brassica juncea	32%	100%
O65354	Helianthus annuus	32%	100%
O76240	Trypanosoma cruzi	74%	100%
O80402	Nicotiana sylvestris	33%	100%
P0DMN7	Mus musculus	33%	100%
P17707	Homo sapiens	33%	100%
P17708	Rattus norvegicus	33%	100%
P21182	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	96%
P28918	Mesocricetus auratus	33%	100%
P46255	Spinacia oleracea	32%	100%
P50243	Bos taurus	33%	100%
P50244	Trypanosoma brucei brucei	63%	100%
P79888	Xenopus laevis	32%	100%
P82185	Mus spretus	33%	100%
P91931	Drosophila melanogaster	33%	100%
Q04694	Solanum tuberosum	33%	100%
Q0JC10	Oryza sativa subsp. japonica	35%	96%
Q25264	Leishmania donovani	100%	100%
Q27883	Onchocerca volvulus	34%	100%
Q38IY3	Solanum chilense	30%	100%
Q39676	Dianthus caryophyllus	34%	100%
Q39677	Dianthus caryophyllus	34%	100%
Q3E9D5	Arabidopsis thaliana	28%	100%
Q42613	Brassica juncea	32%	100%
Q42679	Catharanthus roseus	33%	100%
Q42829	Hordeum chilense	34%	97%
Q43820	Pisum sativum	34%	100%
Q4Q6X8	Leishmania major	25%	85%
Q4Q6X9	Leishmania major	98%	100%
Q8T1E3	Dictyostelium discoideum	35%	100%
Q96286	Arabidopsis thaliana	31%	100%
Q96471	Ipomoea nil	34%	100%
Q96555	Datura stramonium	33%	100%
Q9AXE3	Daucus carota	31%	100%
Q9LSU6	Arabidopsis thaliana	35%	100%
Q9M4D8	Vicia faba	34%	100%
Q9M6K1	Ipomoea batatas	33%	100%
Q9NGA0	Leishmania infantum	99%	97%
Q9P7E3	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%
Q9S7T9	Arabidopsis thaliana	31%	100%
Q9SDM8	Brassica juncea	31%	100%
V5B784	Trypanosoma cruzi	28%	100%
V5DNV4	Trypanosoma cruzi	74%	100%