EF-hand domain family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IEH7_LEIDO

TriTrypDb:

LdBPK_230590.1 , LdCL_230011400 , LDHU3_23.0830

Length:

307

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IEH7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEH7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0005509	calcium ion binding	5	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	89	93	PF00656	0.688
CLV_NRD_NRD_1	124	126	PF00675	0.738
CLV_NRD_NRD_1	13	15	PF00675	0.680
CLV_PCSK_KEX2_1	13	15	PF00082	0.626
CLV_PCSK_SKI1_1	139	143	PF00082	0.672
CLV_PCSK_SKI1_1	302	306	PF00082	0.479
CLV_Separin_Metazoa	72	76	PF03568	0.648
DOC_CDC14_PxL_1	197	205	PF14671	0.544
DOC_CDC14_PxL_1	48	56	PF14671	0.634
DOC_CKS1_1	61	66	PF01111	0.628
DOC_CYCLIN_yCln2_LP_2	170	176	PF00134	0.703
DOC_MAPK_MEF2A_6	222	229	PF00069	0.622
DOC_PP2B_LxvP_1	170	173	PF13499	0.712
DOC_USP7_MATH_1	141	145	PF00917	0.714
DOC_USP7_MATH_1	150	154	PF00917	0.498
DOC_USP7_MATH_1	212	216	PF00917	0.715
DOC_USP7_MATH_1	220	224	PF00917	0.662
DOC_USP7_MATH_1	40	44	PF00917	0.716
DOC_USP7_UBL2_3	135	139	PF12436	0.807
DOC_WW_Pin1_4	105	110	PF00397	0.665
DOC_WW_Pin1_4	165	170	PF00397	0.691
DOC_WW_Pin1_4	60	65	PF00397	0.640
DOC_WW_Pin1_4	97	102	PF00397	0.831
LIG_14-3-3_CanoR_1	14	22	PF00244	0.667
LIG_APCC_ABBA_1	197	202	PF00400	0.619
LIG_BIR_II_1	1	5	PF00653	0.605
LIG_BIR_III_2	37	41	PF00653	0.715
LIG_BIR_III_4	239	243	PF00653	0.619
LIG_EH1_1	67	75	PF00400	0.535
LIG_eIF4E_1	16	22	PF01652	0.665
LIG_FHA_1	16	22	PF00498	0.527
LIG_FHA_2	295	301	PF00498	0.486
LIG_FHA_2	5	11	PF00498	0.592
LIG_LIR_Gen_1	191	201	PF02991	0.562
LIG_LIR_Gen_1	231	240	PF02991	0.560
LIG_LIR_Gen_1	45	54	PF02991	0.742
LIG_LIR_Nem_3	191	196	PF02991	0.484
LIG_LIR_Nem_3	231	236	PF02991	0.561
LIG_LIR_Nem_3	45	51	PF02991	0.756
LIG_LYPXL_S_1	199	203	PF13949	0.540
LIG_LYPXL_yS_3	200	203	PF13949	0.549
LIG_PCNA_yPIPBox_3	60	74	PF02747	0.677
LIG_SH2_STAT5	16	19	PF00017	0.668
LIG_SH2_STAT5	195	198	PF00017	0.507
LIG_SH3_3	173	179	PF00018	0.731
LIG_SH3_3	224	230	PF00018	0.667
LIG_SUMO_SIM_par_1	293	300	PF11976	0.511
LIG_TRAF2_1	43	46	PF00917	0.585
LIG_TRAF2_1	7	10	PF00917	0.663
LIG_TYR_ITIM	198	203	PF00017	0.533
MOD_CDK_SPxxK_3	97	104	PF00069	0.822
MOD_CK1_1	129	135	PF00069	0.646
MOD_CK1_1	159	165	PF00069	0.786
MOD_CK1_1	181	187	PF00069	0.636
MOD_CK2_1	225	231	PF00069	0.558
MOD_CK2_1	4	10	PF00069	0.598
MOD_CK2_1	40	46	PF00069	0.684
MOD_GlcNHglycan	128	131	PF01048	0.732
MOD_GlcNHglycan	151	155	PF01048	0.631
MOD_GlcNHglycan	159	162	PF01048	0.702
MOD_GlcNHglycan	163	166	PF01048	0.705
MOD_GlcNHglycan	180	183	PF01048	0.647
MOD_GlcNHglycan	190	193	PF01048	0.517
MOD_GlcNHglycan	207	210	PF01048	0.527
MOD_GlcNHglycan	222	225	PF01048	0.496
MOD_GlcNHglycan	34	37	PF01048	0.681
MOD_GlcNHglycan	78	81	PF01048	0.571
MOD_GSK3_1	110	117	PF00069	0.721
MOD_GSK3_1	129	136	PF00069	0.700
MOD_GSK3_1	157	164	PF00069	0.745
MOD_GSK3_1	201	208	PF00069	0.641
MOD_GSK3_1	210	217	PF00069	0.634
MOD_GSK3_1	28	35	PF00069	0.650
MOD_N-GLC_1	165	170	PF02516	0.677
MOD_N-GLC_1	188	193	PF02516	0.457
MOD_NEK2_1	142	147	PF00069	0.684
MOD_NEK2_1	188	193	PF00069	0.632
MOD_NEK2_1	210	215	PF00069	0.777
MOD_NEK2_1	225	230	PF00069	0.392
MOD_NEK2_1	28	33	PF00069	0.616
MOD_NEK2_1	76	81	PF00069	0.536
MOD_NEK2_2	242	247	PF00069	0.486
MOD_PIKK_1	114	120	PF00454	0.820
MOD_PIKK_1	201	207	PF00454	0.526
MOD_PIKK_1	63	69	PF00454	0.558
MOD_PKA_1	126	132	PF00069	0.621
MOD_PKA_2	205	211	PF00069	0.774
MOD_Plk_1	188	194	PF00069	0.549
MOD_ProDKin_1	105	111	PF00069	0.667
MOD_ProDKin_1	165	171	PF00069	0.690
MOD_ProDKin_1	60	66	PF00069	0.634
MOD_ProDKin_1	97	103	PF00069	0.832
TRG_DiLeu_BaEn_1	259	264	PF01217	0.697
TRG_ENDOCYTIC_2	195	198	PF00928	0.507
TRG_ENDOCYTIC_2	200	203	PF00928	0.549
TRG_ER_diArg_1	13	15	PF00400	0.680
TRG_NES_CRM1_1	280	293	PF08389	0.475
TRG_NLS_MonoCore_2	124	129	PF00514	0.720
TRG_NLS_MonoExtN_4	123	130	PF00514	0.759

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYT7	Leptomonas seymouri	37%	94%
A4HCS0	Leishmania braziliensis	71%	100%
A4I094	Leishmania infantum	100%	100%
E9ACS4	Leishmania major	88%	100%
E9AW58	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%