Paraflagellar_rod_protein_1D_putative/GeneDB:LmjF.29.1750/GeneDB:LmjF.29.1760/GeneDB:LmjF.29.1770

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

paraflagellar rod protein 1D, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IEH2_LEIDO

TriTrypDb:

LdBPK_291890.1 , LdCL_290024400 , LdCL_290024500 , LdCL_290024600 , LDHU3_29.2690 , LDHU3_29.2700 , LDHU3_29.2710

Length:

595

Annotations

Annotations by Jardim et al.

Flagella, paraflagellar rod 1D

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 8
Forrest at al. (procyclic)	no	yes: 8
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 28

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 8

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 24

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 44
NetGPI	no	yes: 0, no: 44

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	3
GO:0005929	cilium	4	45
GO:0005930	axoneme	2	1
GO:0031514	motile cilium	5	45
GO:0031974	membrane-enclosed lumen	2	3
GO:0031981	nuclear lumen	5	3
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	3
GO:0042995	cell projection	2	45
GO:0043226	organelle	2	45
GO:0043227	membrane-bounded organelle	3	45

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Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3Q8IEH2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEH2

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	45
GO:0005515	protein binding	2	45
GO:0005516	calmodulin binding	3	45

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	149	153	PF00656	0.426
CLV_C14_Caspase3-7	512	516	PF00656	0.323
CLV_NRD_NRD_1	13	15	PF00675	0.533
CLV_NRD_NRD_1	147	149	PF00675	0.413
CLV_NRD_NRD_1	270	272	PF00675	0.328
CLV_NRD_NRD_1	346	348	PF00675	0.335
CLV_NRD_NRD_1	357	359	PF00675	0.312
CLV_NRD_NRD_1	535	537	PF00675	0.321
CLV_PCSK_KEX2_1	147	149	PF00082	0.412
CLV_PCSK_KEX2_1	269	271	PF00082	0.297

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2I5	Leptomonas seymouri	96%	100%
A0A0N0P5J5	Leptomonas seymouri	23%	75%
A0A0N1IFZ5	Leptomonas seymouri	66%	100%
A0A0S4IZY8	Bodo saltans	67%	100%
A0A0S4J193	Bodo saltans	25%	96%
A0A0S4J561	Bodo saltans	28%	84%
A0A0S4JS20	Bodo saltans	87%	100%
A0A1X0NR57	Trypanosomatidae	23%	75%
A0A1X0NYU4	Trypanosomatidae	65%	99%
A0A1X0P0B7	Trypanosomatidae	88%	100%

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