Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IEH1_LEIDO

TriTrypDb:

LdBPK_342520.1 , LdCL_340032800 , LDHU3_34.4120

Length:

572

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IEH1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEH1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	472	476	PF00656	0.632
CLV_NRD_NRD_1	119	121	PF00675	0.588
CLV_NRD_NRD_1	447	449	PF00675	0.549
CLV_NRD_NRD_1	92	94	PF00675	0.678
CLV_PCSK_FUR_1	324	328	PF00082	0.563
CLV_PCSK_FUR_1	330	334	PF00082	0.591
CLV_PCSK_KEX2_1	119	121	PF00082	0.640
CLV_PCSK_KEX2_1	326	328	PF00082	0.579
CLV_PCSK_KEX2_1	329	331	PF00082	0.613
CLV_PCSK_KEX2_1	332	334	PF00082	0.619
CLV_PCSK_KEX2_1	447	449	PF00082	0.567
CLV_PCSK_KEX2_1	92	94	PF00082	0.678
CLV_PCSK_PC1ET2_1	326	328	PF00082	0.650
CLV_PCSK_PC1ET2_1	329	331	PF00082	0.659
CLV_PCSK_PC1ET2_1	332	334	PF00082	0.628
CLV_PCSK_PC7_1	322	328	PF00082	0.562
CLV_PCSK_PC7_1	443	449	PF00082	0.558
CLV_PCSK_SKI1_1	431	435	PF00082	0.629
DEG_APCC_DBOX_1	442	450	PF00400	0.515
DEG_SCF_FBW7_1	65	72	PF00400	0.606
DEG_SPOP_SBC_1	283	287	PF00917	0.588
DOC_CKS1_1	66	71	PF01111	0.569
DOC_CYCLIN_yCln2_LP_2	146	152	PF00134	0.538
DOC_PP2B_LxvP_1	146	149	PF13499	0.657
DOC_PP4_FxxP_1	53	56	PF00568	0.686
DOC_USP7_MATH_1	159	163	PF00917	0.654
DOC_USP7_MATH_1	167	171	PF00917	0.702
DOC_USP7_MATH_1	183	187	PF00917	0.666
DOC_USP7_MATH_1	281	285	PF00917	0.738
DOC_USP7_MATH_1	348	352	PF00917	0.644
DOC_USP7_MATH_1	353	357	PF00917	0.648
DOC_USP7_MATH_1	388	392	PF00917	0.637
DOC_USP7_MATH_1	395	399	PF00917	0.631
DOC_USP7_MATH_1	413	417	PF00917	0.681
DOC_USP7_MATH_1	482	486	PF00917	0.704
DOC_WW_Pin1_4	102	107	PF00397	0.666
DOC_WW_Pin1_4	223	228	PF00397	0.707
DOC_WW_Pin1_4	243	248	PF00397	0.588
DOC_WW_Pin1_4	257	262	PF00397	0.711
DOC_WW_Pin1_4	270	275	PF00397	0.737
DOC_WW_Pin1_4	335	340	PF00397	0.590
DOC_WW_Pin1_4	408	413	PF00397	0.791
DOC_WW_Pin1_4	421	426	PF00397	0.598
DOC_WW_Pin1_4	556	561	PF00397	0.608
DOC_WW_Pin1_4	61	66	PF00397	0.622
DOC_WW_Pin1_4	79	84	PF00397	0.528
LIG_14-3-3_CanoR_1	169	177	PF00244	0.625
LIG_14-3-3_CanoR_1	182	188	PF00244	0.600
LIG_14-3-3_CanoR_1	39	45	PF00244	0.503
LIG_14-3-3_CanoR_1	390	399	PF00244	0.572
LIG_14-3-3_CanoR_1	420	428	PF00244	0.710
LIG_CaM_IQ_9	314	329	PF13499	0.602
LIG_FHA_1	107	113	PF00498	0.687
LIG_FHA_1	134	140	PF00498	0.492
LIG_FHA_1	182	188	PF00498	0.667
LIG_FHA_1	285	291	PF00498	0.753
LIG_FHA_1	422	428	PF00498	0.746
LIG_FHA_2	152	158	PF00498	0.614
LIG_FHA_2	169	175	PF00498	0.628
LIG_FHA_2	470	476	PF00498	0.701
LIG_LIR_Apic_2	245	251	PF02991	0.630
LIG_LIR_Apic_2	63	69	PF02991	0.591
LIG_LIR_Gen_1	299	308	PF02991	0.495
LIG_LIR_Gen_1	364	373	PF02991	0.592
LIG_LIR_Gen_1	450	461	PF02991	0.630
LIG_LIR_Gen_1	532	539	PF02991	0.597
LIG_LIR_Gen_1	544	554	PF02991	0.626
LIG_LIR_Gen_1	68	78	PF02991	0.551
LIG_LIR_Nem_3	294	300	PF02991	0.550
LIG_LIR_Nem_3	364	369	PF02991	0.576
LIG_LIR_Nem_3	450	456	PF02991	0.611
LIG_LIR_Nem_3	532	537	PF02991	0.595
LIG_LIR_Nem_3	68	74	PF02991	0.550
LIG_Pex14_1	297	301	PF04695	0.500
LIG_Pex14_1	304	308	PF04695	0.492
LIG_SH2_CRK	115	119	PF00017	0.643
LIG_SH2_CRK	308	312	PF00017	0.509
LIG_SH2_CRK	453	457	PF00017	0.626
LIG_SH2_CRK	66	70	PF00017	0.659
LIG_SH2_SRC	366	369	PF00017	0.599
LIG_SH2_STAP1	298	302	PF00017	0.495
LIG_SH2_STAP1	312	316	PF00017	0.530
LIG_SH2_STAP1	366	370	PF00017	0.571
LIG_SH2_STAT3	307	310	PF00017	0.498
LIG_SH2_STAT3	312	315	PF00017	0.524
LIG_SH3_1	493	499	PF00018	0.590
LIG_SH3_2	409	414	PF14604	0.704
LIG_SH3_3	258	264	PF00018	0.723
LIG_SH3_3	287	293	PF00018	0.599
LIG_SH3_3	406	412	PF00018	0.789
LIG_SH3_3	422	428	PF00018	0.628
LIG_SH3_3	493	499	PF00018	0.705
LIG_SH3_3	78	84	PF00018	0.520
LIG_TRAF2_1	171	174	PF00917	0.608
LIG_TRAF2_1	316	319	PF00917	0.506
LIG_TYR_ITSM	362	369	PF00017	0.601
LIG_WW_3	262	266	PF00397	0.690
MOD_CDC14_SPxK_1	411	414	PF00782	0.734
MOD_CDC14_SPxK_1	64	67	PF00782	0.624
MOD_CDK_SPK_2	421	426	PF00069	0.775
MOD_CDK_SPxK_1	408	414	PF00069	0.744
MOD_CDK_SPxK_1	61	67	PF00069	0.637
MOD_CDK_SPxxK_3	335	342	PF00069	0.594
MOD_CK1_1	105	111	PF00069	0.731
MOD_CK1_1	125	131	PF00069	0.600
MOD_CK1_1	186	192	PF00069	0.690
MOD_CK1_1	284	290	PF00069	0.716
MOD_CK1_1	335	341	PF00069	0.654
MOD_CK1_1	393	399	PF00069	0.655
MOD_CK1_1	416	422	PF00069	0.676
MOD_CK2_1	151	157	PF00069	0.614
MOD_CK2_1	167	173	PF00069	0.632
MOD_CK2_1	348	354	PF00069	0.692
MOD_CK2_1	388	394	PF00069	0.575
MOD_CK2_1	94	100	PF00069	0.671
MOD_Cter_Amidation	327	330	PF01082	0.655
MOD_DYRK1A_RPxSP_1	223	227	PF00069	0.657
MOD_GlcNHglycan	161	164	PF01048	0.728
MOD_GlcNHglycan	189	192	PF01048	0.746
MOD_GlcNHglycan	233	236	PF01048	0.690
MOD_GlcNHglycan	257	260	PF01048	0.687
MOD_GlcNHglycan	350	353	PF01048	0.733
MOD_GlcNHglycan	399	402	PF01048	0.681
MOD_GlcNHglycan	484	487	PF01048	0.682
MOD_GlcNHglycan	526	529	PF01048	0.785
MOD_GlcNHglycan	9	12	PF01048	0.583
MOD_GSK3_1	100	107	PF00069	0.652
MOD_GSK3_1	182	189	PF00069	0.825
MOD_GSK3_1	219	226	PF00069	0.746
MOD_GSK3_1	237	244	PF00069	0.612
MOD_GSK3_1	266	273	PF00069	0.711
MOD_GSK3_1	343	350	PF00069	0.662
MOD_GSK3_1	393	400	PF00069	0.719
MOD_GSK3_1	452	459	PF00069	0.487
MOD_GSK3_1	520	527	PF00069	0.728
MOD_GSK3_1	552	559	PF00069	0.703
MOD_GSK3_1	61	68	PF00069	0.736
MOD_N-GLC_1	542	547	PF02516	0.641
MOD_NEK2_1	17	22	PF00069	0.629
MOD_NEK2_1	242	247	PF00069	0.705
MOD_NEK2_1	456	461	PF00069	0.605
MOD_NEK2_1	94	99	PF00069	0.588
MOD_NEK2_2	237	242	PF00069	0.546
MOD_PIKK_1	122	128	PF00454	0.560
MOD_PIKK_1	419	425	PF00454	0.665
MOD_PKA_1	332	338	PF00069	0.687
MOD_PKA_2	159	165	PF00069	0.693
MOD_PKA_2	168	174	PF00069	0.636
MOD_PKA_2	181	187	PF00069	0.599
MOD_PKA_2	332	338	PF00069	0.714
MOD_PKA_2	419	425	PF00069	0.646
MOD_PKA_2	524	530	PF00069	0.633
MOD_PKA_2	552	558	PF00069	0.663
MOD_PKB_1	180	188	PF00069	0.669
MOD_PKB_1	540	548	PF00069	0.586
MOD_Plk_1	353	359	PF00069	0.649
MOD_Plk_1	393	399	PF00069	0.597
MOD_Plk_1	542	548	PF00069	0.555
MOD_Plk_2-3	168	174	PF00069	0.669
MOD_Plk_4	40	46	PF00069	0.451
MOD_ProDKin_1	102	108	PF00069	0.663
MOD_ProDKin_1	223	229	PF00069	0.706
MOD_ProDKin_1	243	249	PF00069	0.587
MOD_ProDKin_1	257	263	PF00069	0.712
MOD_ProDKin_1	270	276	PF00069	0.738
MOD_ProDKin_1	335	341	PF00069	0.590
MOD_ProDKin_1	408	414	PF00069	0.795
MOD_ProDKin_1	421	427	PF00069	0.595
MOD_ProDKin_1	556	562	PF00069	0.605
MOD_ProDKin_1	61	67	PF00069	0.619
MOD_ProDKin_1	79	85	PF00069	0.531
TRG_DiLeu_BaEn_4	173	179	PF01217	0.611
TRG_DiLeu_BaEn_4	451	457	PF01217	0.599
TRG_ENDOCYTIC_2	115	118	PF00928	0.639
TRG_ENDOCYTIC_2	302	305	PF00928	0.497
TRG_ENDOCYTIC_2	308	311	PF00928	0.501
TRG_ENDOCYTIC_2	366	369	PF00928	0.578
TRG_ENDOCYTIC_2	453	456	PF00928	0.623
TRG_ER_diArg_1	118	120	PF00400	0.593
TRG_ER_diArg_1	446	448	PF00400	0.699
TRG_ER_diArg_1	565	568	PF00400	0.685
TRG_ER_diArg_1	91	93	PF00400	0.660
TRG_NLS_MonoExtC_3	325	330	PF00514	0.550
TRG_NLS_MonoExtN_4	324	330	PF00514	0.551
TRG_Pf-PMV_PEXEL_1	119	123	PF00026	0.682
TRG_Pf-PMV_PEXEL_1	223	228	PF00026	0.605
TRG_Pf-PMV_PEXEL_1	447	451	PF00026	0.602

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P607	Leptomonas seymouri	29%	100%
A4HAY6	Leishmania braziliensis	57%	97%
A4IA45	Leishmania infantum	99%	100%
E9B559	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4Q2S6	Leishmania major	86%	100%