Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IEH0_LEIDO

TriTrypDb:

LdBPK_302940.1 , LdCL_300035000 , LDHU3_30.3900

Length:

454

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IEH0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEH0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	407	411	PF00656	0.599
CLV_NRD_NRD_1	100	102	PF00675	0.662
CLV_NRD_NRD_1	149	151	PF00675	0.517
CLV_NRD_NRD_1	152	154	PF00675	0.487
CLV_NRD_NRD_1	228	230	PF00675	0.517
CLV_NRD_NRD_1	313	315	PF00675	0.470
CLV_NRD_NRD_1	387	389	PF00675	0.551
CLV_NRD_NRD_1	54	56	PF00675	0.537
CLV_NRD_NRD_1	9	11	PF00675	0.525
CLV_PCSK_FUR_1	384	388	PF00082	0.524
CLV_PCSK_FUR_1	52	56	PF00082	0.526
CLV_PCSK_KEX2_1	100	102	PF00082	0.662
CLV_PCSK_KEX2_1	149	151	PF00082	0.666
CLV_PCSK_KEX2_1	386	388	PF00082	0.551
CLV_PCSK_KEX2_1	54	56	PF00082	0.537
CLV_PCSK_KEX2_1	9	11	PF00082	0.525
CLV_PCSK_SKI1_1	10	14	PF00082	0.504
CLV_PCSK_SKI1_1	154	158	PF00082	0.485
CLV_PCSK_SKI1_1	370	374	PF00082	0.618
CLV_PCSK_SKI1_1	426	430	PF00082	0.719
DOC_CKS1_1	42	47	PF01111	0.533
DOC_CKS1_1	427	432	PF01111	0.663
DOC_CYCLIN_RxL_1	237	247	PF00134	0.493
DOC_MAPK_gen_1	149	159	PF00069	0.520
DOC_MAPK_MEF2A_6	9	16	PF00069	0.517
DOC_PP4_FxxP_1	42	45	PF00568	0.548
DOC_USP7_MATH_1	166	170	PF00917	0.487
DOC_USP7_MATH_1	179	183	PF00917	0.710
DOC_USP7_MATH_1	212	216	PF00917	0.679
DOC_USP7_MATH_1	269	273	PF00917	0.677
DOC_USP7_MATH_1	88	92	PF00917	0.531
DOC_WW_Pin1_4	265	270	PF00397	0.643
DOC_WW_Pin1_4	284	289	PF00397	0.622
DOC_WW_Pin1_4	41	46	PF00397	0.531
DOC_WW_Pin1_4	412	417	PF00397	0.723
DOC_WW_Pin1_4	426	431	PF00397	0.621
DOC_WW_Pin1_4	434	439	PF00397	0.665
DOC_WW_Pin1_4	448	453	PF00397	0.575
DOC_WW_Pin1_4	62	67	PF00397	0.549
LIG_14-3-3_CanoR_1	100	106	PF00244	0.597
LIG_14-3-3_CanoR_1	245	249	PF00244	0.719
LIG_14-3-3_CanoR_1	279	286	PF00244	0.743
LIG_14-3-3_CanoR_1	337	341	PF00244	0.561
LIG_14-3-3_CanoR_1	439	449	PF00244	0.728
LIG_14-3-3_CanoR_1	52	58	PF00244	0.696
LIG_APCC_ABBA_1	12	17	PF00400	0.520
LIG_BIR_II_1	1	5	PF00653	0.577
LIG_BIR_III_4	261	265	PF00653	0.707
LIG_BRCT_BRCA1_1	189	193	PF00533	0.580
LIG_CaM_IQ_9	309	324	PF13499	0.474
LIG_FHA_1	341	347	PF00498	0.489
LIG_FHA_1	441	447	PF00498	0.686
LIG_FHA_2	26	32	PF00498	0.515
LIG_FHA_2	77	83	PF00498	0.653
LIG_GBD_Chelix_1	217	225	PF00786	0.582
LIG_Integrin_isoDGR_2	185	187	PF01839	0.708
LIG_LIR_Apic_2	41	45	PF02991	0.660
LIG_LIR_Gen_1	80	90	PF02991	0.512
LIG_LIR_Nem_3	80	86	PF02991	0.518
LIG_SH2_STAP1	83	87	PF00017	0.500
LIG_SH3_3	118	124	PF00018	0.707
LIG_SH3_3	263	269	PF00018	0.653
LIG_SH3_3	410	416	PF00018	0.769
LIG_SH3_3	432	438	PF00018	0.732
LIG_SUMO_SIM_anti_2	155	160	PF11976	0.557
LIG_SUMO_SIM_par_1	43	49	PF11976	0.533
LIG_TRAF2_1	21	24	PF00917	0.508
LIG_WRC_WIRS_1	39	44	PF05994	0.657
MOD_CDC14_SPxK_1	451	454	PF00782	0.624
MOD_CDK_SPK_2	265	270	PF00069	0.643
MOD_CDK_SPK_2	434	439	PF00069	0.712
MOD_CDK_SPxK_1	448	454	PF00069	0.635
MOD_CDK_SPxxK_3	412	419	PF00069	0.650
MOD_CDK_SPxxK_3	434	441	PF00069	0.709
MOD_CK1_1	247	253	PF00069	0.751
MOD_CK1_1	278	284	PF00069	0.691
MOD_CK1_1	38	44	PF00069	0.653
MOD_CK1_1	380	386	PF00069	0.513
MOD_CK1_1	393	399	PF00069	0.650
MOD_CK2_1	18	24	PF00069	0.522
MOD_CK2_1	207	213	PF00069	0.691
MOD_CK2_1	25	31	PF00069	0.529
MOD_CK2_1	76	82	PF00069	0.531
MOD_GlcNHglycan	164	167	PF01048	0.627
MOD_GlcNHglycan	168	171	PF01048	0.642
MOD_GlcNHglycan	20	23	PF01048	0.501
MOD_GlcNHglycan	213	217	PF01048	0.663
MOD_GlcNHglycan	249	252	PF01048	0.680
MOD_GlcNHglycan	261	265	PF01048	0.749
MOD_GlcNHglycan	288	291	PF01048	0.728
MOD_GlcNHglycan	326	329	PF01048	0.504
MOD_GlcNHglycan	392	395	PF01048	0.615
MOD_GSK3_1	162	169	PF00069	0.594
MOD_GSK3_1	187	194	PF00069	0.717
MOD_GSK3_1	207	214	PF00069	0.690
MOD_GSK3_1	260	267	PF00069	0.653
MOD_GSK3_1	275	282	PF00069	0.592
MOD_GSK3_1	336	343	PF00069	0.620
MOD_GSK3_1	382	389	PF00069	0.568
MOD_GSK3_1	414	421	PF00069	0.697
MOD_GSK3_1	426	433	PF00069	0.603
MOD_GSK3_1	53	60	PF00069	0.649
MOD_N-GLC_1	179	184	PF02516	0.659
MOD_NEK2_1	16	21	PF00069	0.532
MOD_NEK2_1	193	198	PF00069	0.657
MOD_NEK2_1	244	249	PF00069	0.551
MOD_NEK2_1	25	30	PF00069	0.388
MOD_NEK2_1	340	345	PF00069	0.466
MOD_NEK2_1	358	363	PF00069	0.486
MOD_NEK2_1	40	45	PF00069	0.469
MOD_NEK2_1	5	10	PF00069	0.605
MOD_NEK2_1	67	72	PF00069	0.566
MOD_PIKK_1	100	106	PF00454	0.598
MOD_PIKK_1	187	193	PF00454	0.604
MOD_PIKK_1	216	222	PF00454	0.705
MOD_PIKK_1	345	351	PF00454	0.470
MOD_PIKK_1	377	383	PF00454	0.538
MOD_PIKK_1	386	392	PF00454	0.560
MOD_PK_1	279	285	PF00069	0.684
MOD_PKA_1	100	106	PF00069	0.567
MOD_PKA_1	386	392	PF00069	0.511
MOD_PKA_2	244	250	PF00069	0.566
MOD_PKA_2	269	275	PF00069	0.638
MOD_PKA_2	278	284	PF00069	0.627
MOD_PKA_2	336	342	PF00069	0.467
MOD_PKA_2	35	41	PF00069	0.521
MOD_PKA_2	386	392	PF00069	0.552
MOD_PKA_2	399	405	PF00069	0.637
MOD_PKA_2	418	424	PF00069	0.662
MOD_PKA_2	53	59	PF00069	0.595
MOD_PKA_2	99	105	PF00069	0.633
MOD_PKB_1	375	383	PF00069	0.489
MOD_PKB_1	384	392	PF00069	0.563
MOD_Plk_1	16	22	PF00069	0.517
MOD_Plk_1	170	176	PF00069	0.759
MOD_Plk_1	212	218	PF00069	0.564
MOD_Plk_4	170	176	PF00069	0.700
MOD_Plk_4	35	41	PF00069	0.552
MOD_ProDKin_1	265	271	PF00069	0.643
MOD_ProDKin_1	284	290	PF00069	0.620
MOD_ProDKin_1	41	47	PF00069	0.531
MOD_ProDKin_1	412	418	PF00069	0.723
MOD_ProDKin_1	426	432	PF00069	0.620
MOD_ProDKin_1	434	440	PF00069	0.662
MOD_ProDKin_1	448	454	PF00069	0.577
MOD_ProDKin_1	62	68	PF00069	0.546
MOD_SUMO_for_1	301	304	PF00179	0.548
MOD_SUMO_for_1	333	336	PF00179	0.553
MOD_SUMO_rev_2	366	372	PF00179	0.530
TRG_DiLeu_BaEn_1	237	242	PF01217	0.506
TRG_DiLeu_BaEn_1	304	309	PF01217	0.477
TRG_DiLeu_BaEn_1	368	373	PF01217	0.612
TRG_DiLeu_BaEn_1	82	87	PF01217	0.505
TRG_DiLeu_LyEn_5	237	242	PF01217	0.480
TRG_ENDOCYTIC_2	83	86	PF00928	0.503
TRG_ER_diArg_1	375	378	PF00400	0.541
TRG_ER_diArg_1	384	387	PF00400	0.473
TRG_ER_diArg_1	52	55	PF00400	0.522
TRG_NES_CRM1_1	367	382	PF08389	0.612
TRG_Pf-PMV_PEXEL_1	129	133	PF00026	0.552
TRG_Pf-PMV_PEXEL_1	370	374	PF00026	0.518
TRG_Pf-PMV_PEXEL_1	377	381	PF00026	0.450
TRG_Pf-PMV_PEXEL_1	422	427	PF00026	0.718

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUI5	Leptomonas seymouri	46%	71%
A4HIM6	Leishmania braziliensis	70%	100%
A4I5X1	Leishmania infantum	100%	100%
E9B165	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q700	Leishmania major	88%	100%