Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IEG9_LEIDO

TriTrypDb:

LdBPK_190600.1 , LdCL_190011000 , LDHU3_19.0670

Length:

777

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IEG9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEG9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	197	201	PF00656	0.621
CLV_C14_Caspase3-7	685	689	PF00656	0.602
CLV_NRD_NRD_1	282	284	PF00675	0.823
CLV_NRD_NRD_1	399	401	PF00675	0.818
CLV_NRD_NRD_1	456	458	PF00675	0.559
CLV_NRD_NRD_1	488	490	PF00675	0.650
CLV_NRD_NRD_1	69	71	PF00675	0.754
CLV_PCSK_FUR_1	472	476	PF00082	0.579
CLV_PCSK_KEX2_1	282	284	PF00082	0.749
CLV_PCSK_KEX2_1	474	476	PF00082	0.676
CLV_PCSK_KEX2_1	488	490	PF00082	0.446
CLV_PCSK_PC1ET2_1	474	476	PF00082	0.676
CLV_PCSK_SKI1_1	481	485	PF00082	0.608
CLV_PCSK_SKI1_1	498	502	PF00082	0.455
CLV_PCSK_SKI1_1	535	539	PF00082	0.721
DEG_SPOP_SBC_1	212	216	PF00917	0.748
DEG_SPOP_SBC_1	37	41	PF00917	0.757
DOC_ANK_TNKS_1	335	342	PF00023	0.742
DOC_CKS1_1	204	209	PF01111	0.746
DOC_CKS1_1	743	748	PF01111	0.774
DOC_MAPK_MEF2A_6	619	627	PF00069	0.623
DOC_PP1_RVXF_1	708	715	PF00149	0.657
DOC_PP2B_LxvP_1	108	111	PF13499	0.619
DOC_PP2B_LxvP_1	83	86	PF13499	0.638
DOC_PP2B_PxIxI_1	206	212	PF00149	0.705
DOC_USP7_MATH_1	100	104	PF00917	0.732
DOC_USP7_MATH_1	129	133	PF00917	0.740
DOC_USP7_MATH_1	162	166	PF00917	0.814
DOC_USP7_MATH_1	168	172	PF00917	0.736
DOC_USP7_MATH_1	183	187	PF00917	0.576
DOC_USP7_MATH_1	189	193	PF00917	0.632
DOC_USP7_MATH_1	199	203	PF00917	0.562
DOC_USP7_MATH_1	212	216	PF00917	0.672
DOC_USP7_MATH_1	250	254	PF00917	0.801
DOC_USP7_MATH_1	266	270	PF00917	0.543
DOC_USP7_MATH_1	292	296	PF00917	0.737
DOC_USP7_MATH_1	37	41	PF00917	0.801
DOC_USP7_MATH_1	386	390	PF00917	0.866
DOC_USP7_MATH_1	526	530	PF00917	0.744
DOC_USP7_MATH_1	548	552	PF00917	0.610
DOC_USP7_MATH_1	574	578	PF00917	0.633
DOC_USP7_MATH_1	635	639	PF00917	0.671
DOC_USP7_MATH_1	683	687	PF00917	0.677
DOC_USP7_MATH_1	746	750	PF00917	0.704
DOC_WW_Pin1_4	103	108	PF00397	0.830
DOC_WW_Pin1_4	146	151	PF00397	0.748
DOC_WW_Pin1_4	164	169	PF00397	0.636
DOC_WW_Pin1_4	175	180	PF00397	0.635
DOC_WW_Pin1_4	191	196	PF00397	0.755
DOC_WW_Pin1_4	203	208	PF00397	0.592
DOC_WW_Pin1_4	360	365	PF00397	0.739
DOC_WW_Pin1_4	408	413	PF00397	0.623
DOC_WW_Pin1_4	596	601	PF00397	0.676
DOC_WW_Pin1_4	742	747	PF00397	0.851
DOC_WW_Pin1_4	78	83	PF00397	0.835
LIG_14-3-3_CanoR_1	131	138	PF00244	0.825
LIG_14-3-3_CanoR_1	265	271	PF00244	0.817
LIG_14-3-3_CanoR_1	282	291	PF00244	0.525
LIG_14-3-3_CanoR_1	429	437	PF00244	0.755
LIG_14-3-3_CanoR_1	640	649	PF00244	0.736
LIG_14-3-3_CanoR_1	70	74	PF00244	0.814
LIG_Actin_WH2_2	332	348	PF00022	0.706
LIG_BIR_III_2	20	24	PF00653	0.746
LIG_eIF4E_1	649	655	PF01652	0.586
LIG_EVH1_1	757	761	PF00568	0.670
LIG_EVH1_2	109	113	PF00568	0.762
LIG_FHA_1	186	192	PF00498	0.755
LIG_FHA_1	204	210	PF00498	0.513
LIG_FHA_1	351	357	PF00498	0.760
LIG_FHA_1	388	394	PF00498	0.686
LIG_FHA_2	673	679	PF00498	0.696
LIG_IRF3_LxIS_1	51	57	PF10401	0.533
LIG_LIR_Apic_2	232	236	PF02991	0.798
LIG_LIR_Apic_2	631	637	PF02991	0.668
LIG_LIR_Nem_3	446	452	PF02991	0.659
LIG_LIR_Nem_3	454	459	PF02991	0.516
LIG_LIR_Nem_3	706	712	PF02991	0.769
LIG_SH2_CRK	233	237	PF00017	0.809
LIG_SH2_CRK	449	453	PF00017	0.653
LIG_SH2_CRK	709	713	PF00017	0.750
LIG_SH2_STAT3	138	141	PF00017	0.862
LIG_SH2_STAT5	451	454	PF00017	0.640
LIG_SH2_STAT5	663	666	PF00017	0.642
LIG_SH3_3	104	110	PF00018	0.821
LIG_SH3_3	201	207	PF00018	0.823
LIG_SH3_3	301	307	PF00018	0.704
LIG_SH3_3	358	364	PF00018	0.725
LIG_SH3_3	434	440	PF00018	0.791
LIG_SH3_3	573	579	PF00018	0.815
LIG_SH3_3	583	589	PF00018	0.641
LIG_SH3_3	620	626	PF00018	0.793
LIG_SH3_3	713	719	PF00018	0.767
LIG_SH3_3	752	758	PF00018	0.738
LIG_SH3_3	764	770	PF00018	0.640
LIG_SUMO_SIM_par_1	599	606	PF11976	0.626
LIG_TRAF2_1	494	497	PF00917	0.562
LIG_WW_2	755	758	PF00397	0.659
MOD_CDC14_SPxK_1	149	152	PF00782	0.651
MOD_CDK_SPxK_1	146	152	PF00069	0.649
MOD_CDK_SPxxK_3	191	198	PF00069	0.771
MOD_CK1_1	103	109	PF00069	0.837
MOD_CK1_1	132	138	PF00069	0.777
MOD_CK1_1	166	172	PF00069	0.727
MOD_CK1_1	194	200	PF00069	0.843
MOD_CK1_1	216	222	PF00069	0.616
MOD_CK1_1	258	264	PF00069	0.816
MOD_CK1_1	40	46	PF00069	0.816
MOD_CK1_1	430	436	PF00069	0.682
MOD_CK1_1	50	56	PF00069	0.664
MOD_CK1_1	57	63	PF00069	0.572
MOD_CK1_1	64	70	PF00069	0.688
MOD_CK1_1	686	692	PF00069	0.751
MOD_CK1_1	727	733	PF00069	0.828
MOD_CK1_1	749	755	PF00069	0.700
MOD_CK2_1	134	140	PF00069	0.566
MOD_CK2_1	490	496	PF00069	0.506
MOD_CK2_1	600	606	PF00069	0.654
MOD_GlcNHglycan	127	130	PF01048	0.818
MOD_GlcNHglycan	170	173	PF01048	0.776
MOD_GlcNHglycan	185	188	PF01048	0.583
MOD_GlcNHglycan	200	204	PF01048	0.561
MOD_GlcNHglycan	223	226	PF01048	0.772
MOD_GlcNHglycan	266	269	PF01048	0.706
MOD_GlcNHglycan	270	273	PF01048	0.727
MOD_GlcNHglycan	358	361	PF01048	0.784
MOD_GlcNHglycan	384	387	PF01048	0.828
MOD_GlcNHglycan	40	43	PF01048	0.639
MOD_GlcNHglycan	405	408	PF01048	0.666
MOD_GlcNHglycan	432	435	PF01048	0.639
MOD_GlcNHglycan	459	462	PF01048	0.426
MOD_GlcNHglycan	492	495	PF01048	0.600
MOD_GlcNHglycan	528	531	PF01048	0.671
MOD_GlcNHglycan	550	553	PF01048	0.697
MOD_GlcNHglycan	56	59	PF01048	0.679
MOD_GlcNHglycan	596	599	PF01048	0.717
MOD_GlcNHglycan	63	66	PF01048	0.775
MOD_GlcNHglycan	643	646	PF01048	0.519
MOD_GlcNHglycan	726	729	PF01048	0.728
MOD_GlcNHglycan	748	751	PF01048	0.753
MOD_GlcNHglycan	89	92	PF01048	0.797
MOD_GSK3_1	121	128	PF00069	0.837
MOD_GSK3_1	129	136	PF00069	0.696
MOD_GSK3_1	162	169	PF00069	0.839
MOD_GSK3_1	181	188	PF00069	0.531
MOD_GSK3_1	190	197	PF00069	0.663
MOD_GSK3_1	199	206	PF00069	0.544
MOD_GSK3_1	212	219	PF00069	0.561
MOD_GSK3_1	250	257	PF00069	0.807
MOD_GSK3_1	264	271	PF00069	0.678
MOD_GSK3_1	274	281	PF00069	0.609
MOD_GSK3_1	292	299	PF00069	0.636
MOD_GSK3_1	341	348	PF00069	0.779
MOD_GSK3_1	356	363	PF00069	0.544
MOD_GSK3_1	36	43	PF00069	0.807
MOD_GSK3_1	382	389	PF00069	0.850
MOD_GSK3_1	50	57	PF00069	0.595
MOD_GSK3_1	574	581	PF00069	0.696
MOD_GSK3_1	590	597	PF00069	0.757
MOD_GSK3_1	668	675	PF00069	0.686
MOD_GSK3_1	682	689	PF00069	0.574
MOD_GSK3_1	69	76	PF00069	0.576
MOD_GSK3_1	737	744	PF00069	0.751
MOD_LATS_1	196	202	PF00433	0.838
MOD_N-GLC_1	255	260	PF02516	0.778
MOD_N-GLC_1	278	283	PF02516	0.621
MOD_NEK2_1	125	130	PF00069	0.852
MOD_NEK2_1	244	249	PF00069	0.694
MOD_NEK2_1	270	275	PF00069	0.750
MOD_NEK2_1	287	292	PF00069	0.521
MOD_NEK2_1	324	329	PF00069	0.740
MOD_NEK2_1	345	350	PF00069	0.672
MOD_NEK2_1	590	595	PF00069	0.622
MOD_NEK2_2	341	346	PF00069	0.742
MOD_PIKK_1	375	381	PF00454	0.751
MOD_PIKK_1	683	689	PF00454	0.779
MOD_PIKK_1	73	79	PF00454	0.856
MOD_PIKK_1	749	755	PF00454	0.777
MOD_PIKK_1	8	14	PF00454	0.777
MOD_PKA_1	282	288	PF00069	0.727
MOD_PKA_1	457	463	PF00069	0.566
MOD_PKA_2	130	136	PF00069	0.823
MOD_PKA_2	264	270	PF00069	0.613
MOD_PKA_2	281	287	PF00069	0.622
MOD_PKA_2	387	393	PF00069	0.687
MOD_PKA_2	47	53	PF00069	0.558
MOD_PKA_2	641	647	PF00069	0.745
MOD_PKA_2	69	75	PF00069	0.853
MOD_Plk_1	199	205	PF00069	0.750
MOD_Plk_1	255	261	PF00069	0.764
MOD_Plk_1	630	636	PF00069	0.726
MOD_Plk_2-3	422	428	PF00069	0.738
MOD_Plk_2-3	630	636	PF00069	0.764
MOD_Plk_4	270	276	PF00069	0.674
MOD_Plk_4	351	357	PF00069	0.723
MOD_Plk_4	669	675	PF00069	0.567
MOD_ProDKin_1	103	109	PF00069	0.827
MOD_ProDKin_1	146	152	PF00069	0.750
MOD_ProDKin_1	164	170	PF00069	0.638
MOD_ProDKin_1	175	181	PF00069	0.634
MOD_ProDKin_1	191	197	PF00069	0.754
MOD_ProDKin_1	203	209	PF00069	0.594
MOD_ProDKin_1	360	366	PF00069	0.740
MOD_ProDKin_1	408	414	PF00069	0.618
MOD_ProDKin_1	596	602	PF00069	0.672
MOD_ProDKin_1	742	748	PF00069	0.852
MOD_ProDKin_1	78	84	PF00069	0.832
MOD_SUMO_for_1	473	476	PF00179	0.639
MOD_SUMO_rev_2	135	144	PF00179	0.568
TRG_DiLeu_BaEn_1	497	502	PF01217	0.697
TRG_DiLeu_BaEn_1	650	655	PF01217	0.540
TRG_DiLeu_BaLyEn_6	597	602	PF01217	0.665
TRG_ENDOCYTIC_2	239	242	PF00928	0.809
TRG_ENDOCYTIC_2	449	452	PF00928	0.654
TRG_ENDOCYTIC_2	453	456	PF00928	0.564
TRG_ENDOCYTIC_2	709	712	PF00928	0.746
TRG_ER_diArg_1	3	6	PF00400	0.821
TRG_ER_diArg_1	487	489	PF00400	0.680
TRG_Pf-PMV_PEXEL_1	450	454	PF00026	0.644

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HA18	Leishmania braziliensis	54%	97%
A4HY81	Leishmania infantum	99%	100%
E9AS12	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	95%
Q4QDG1	Leishmania major	83%	98%