Tubulin_cofactor_C_domain-containing_protein_1_pu tative/GeneDB:LmjF.27.1760

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tubulin cofactor C domain-containing protein 1, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IEG6_LEIDO

TriTrypDb:

LdBPK_271660.1 , LdCL_270023600 , LDHU3_27.2540

Length:

571

Annotations

Annotations by Jardim et al.

Structural Proteins, Tubulin cofactor C domain-containing 1 Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000922	spindle pole	2	1
GO:0005737	cytoplasm	2	1
GO:0005815	microtubule organizing center	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IEG6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEG6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	216	220	PF00656	0.377
CLV_C14_Caspase3-7	512	516	PF00656	0.598
CLV_NRD_NRD_1	177	179	PF00675	0.538
CLV_NRD_NRD_1	3	5	PF00675	0.703
CLV_NRD_NRD_1	505	507	PF00675	0.429
CLV_PCSK_KEX2_1	179	181	PF00082	0.586
CLV_PCSK_KEX2_1	3	5	PF00082	0.703
CLV_PCSK_KEX2_1	505	507	PF00082	0.429
CLV_PCSK_PC1ET2_1	179	181	PF00082	0.568
CLV_PCSK_SKI1_1	137	141	PF00082	0.431
DEG_APCC_DBOX_1	136	144	PF00400	0.429
DEG_SPOP_SBC_1	30	34	PF00917	0.584
DOC_CKS1_1	115	120	PF01111	0.550
DOC_CKS1_1	389	394	PF01111	0.413
DOC_MAPK_DCC_7	159	168	PF00069	0.334
DOC_MAPK_gen_1	83	91	PF00069	0.449
DOC_MAPK_MEF2A_6	159	168	PF00069	0.334
DOC_MAPK_RevD_3	166	180	PF00069	0.483
DOC_PP2B_LxvP_1	495	498	PF13499	0.504
DOC_PP2B_LxvP_1	55	58	PF13499	0.485
DOC_USP7_MATH_1	153	157	PF00917	0.427
DOC_USP7_MATH_1	30	34	PF00917	0.687
DOC_USP7_MATH_1	431	435	PF00917	0.366
DOC_USP7_MATH_1	5	9	PF00917	0.706
DOC_USP7_MATH_1	516	520	PF00917	0.514
DOC_USP7_MATH_2	468	474	PF00917	0.538
DOC_WW_Pin1_4	114	119	PF00397	0.530
DOC_WW_Pin1_4	300	305	PF00397	0.524
DOC_WW_Pin1_4	388	393	PF00397	0.307
DOC_WW_Pin1_4	446	451	PF00397	0.464
LIG_14-3-3_CanoR_1	125	129	PF00244	0.606
LIG_14-3-3_CanoR_1	159	164	PF00244	0.387
LIG_14-3-3_CanoR_1	214	218	PF00244	0.426
LIG_14-3-3_CanoR_1	314	322	PF00244	0.413
LIG_14-3-3_CanoR_1	539	544	PF00244	0.491
LIG_Actin_WH2_2	510	527	PF00022	0.552
LIG_Actin_WH2_2	533	551	PF00022	0.442
LIG_BIR_II_1	1	5	PF00653	0.593
LIG_BRCT_BRCA1_1	240	244	PF00533	0.377
LIG_BRCT_BRCA1_1	472	476	PF00533	0.547
LIG_BRCT_BRCA1_1	5	9	PF00533	0.703
LIG_EVH1_2	467	471	PF00568	0.435
LIG_FHA_1	250	256	PF00498	0.391
LIG_FHA_1	277	283	PF00498	0.653
LIG_FHA_1	297	303	PF00498	0.321
LIG_FHA_1	346	352	PF00498	0.378
LIG_FHA_1	382	388	PF00498	0.324
LIG_FHA_1	389	395	PF00498	0.338
LIG_FHA_1	519	525	PF00498	0.555
LIG_FHA_1	61	67	PF00498	0.394
LIG_FHA_2	214	220	PF00498	0.374
LIG_FHA_2	549	555	PF00498	0.548
LIG_IRF3_LxIS_1	316	323	PF10401	0.426
LIG_LIR_Gen_1	259	266	PF02991	0.510
LIG_LIR_Gen_1	303	312	PF02991	0.591
LIG_LIR_Gen_1	384	394	PF02991	0.413
LIG_LIR_Gen_1	469	478	PF02991	0.580
LIG_LIR_Gen_1	97	108	PF02991	0.342
LIG_LIR_Nem_3	104	109	PF02991	0.448
LIG_LIR_Nem_3	259	264	PF02991	0.517
LIG_LIR_Nem_3	303	308	PF02991	0.592
LIG_LIR_Nem_3	384	389	PF02991	0.406
LIG_LIR_Nem_3	469	474	PF02991	0.442
LIG_LIR_Nem_3	97	103	PF02991	0.348
LIG_LYPXL_S_1	435	439	PF13949	0.497
LIG_LYPXL_yS_3	436	439	PF13949	0.491
LIG_MYND_1	393	397	PF01753	0.312
LIG_MYND_2	392	396	PF01753	0.312
LIG_NRBOX	166	172	PF00104	0.451
LIG_NRBOX	222	228	PF00104	0.352
LIG_Pex14_2	103	107	PF04695	0.455
LIG_Pex14_2	244	248	PF04695	0.532
LIG_PTB_Apo_2	41	48	PF02174	0.376
LIG_SH2_CRK	305	309	PF00017	0.635
LIG_SH2_PTP2	386	389	PF00017	0.362
LIG_SH2_SRC	331	334	PF00017	0.413
LIG_SH2_STAT3	195	198	PF00017	0.436
LIG_SH2_STAT5	120	123	PF00017	0.545
LIG_SH2_STAT5	195	198	PF00017	0.388
LIG_SH2_STAT5	225	228	PF00017	0.482
LIG_SH2_STAT5	261	264	PF00017	0.523
LIG_SH2_STAT5	386	389	PF00017	0.413
LIG_SH3_3	158	164	PF00018	0.373
LIG_SH3_3	231	237	PF00018	0.407
LIG_SH3_3	386	392	PF00018	0.413
LIG_SH3_3	454	460	PF00018	0.384
LIG_SH3_3	471	477	PF00018	0.411
LIG_SUMO_SIM_anti_2	254	259	PF11976	0.350
LIG_TRAF2_1	551	554	PF00917	0.510
LIG_TRFH_1	305	309	PF08558	0.635
LIG_TYR_ITSM	382	389	PF00017	0.413
LIG_UBA3_1	170	179	PF00899	0.467
LIG_WRC_WIRS_1	432	437	PF05994	0.483
MOD_CK1_1	14	20	PF00069	0.741
MOD_CK1_1	213	219	PF00069	0.521
MOD_CK1_1	318	324	PF00069	0.306
MOD_CK1_1	342	348	PF00069	0.449
MOD_CK1_1	378	384	PF00069	0.394
MOD_CK1_1	408	414	PF00069	0.680
MOD_CK1_1	420	426	PF00069	0.521
MOD_CK1_1	446	452	PF00069	0.430
MOD_CK1_1	485	491	PF00069	0.598
MOD_CK1_1	59	65	PF00069	0.424
MOD_CK1_1	72	78	PF00069	0.407
MOD_CK2_1	265	271	PF00069	0.410
MOD_CK2_1	548	554	PF00069	0.502
MOD_GlcNHglycan	109	112	PF01048	0.496
MOD_GlcNHglycan	13	16	PF01048	0.627
MOD_GlcNHglycan	204	207	PF01048	0.475
MOD_GlcNHglycan	22	25	PF01048	0.557
MOD_GlcNHglycan	276	279	PF01048	0.592
MOD_GlcNHglycan	354	357	PF01048	0.321
MOD_GlcNHglycan	368	371	PF01048	0.235
MOD_GlcNHglycan	407	410	PF01048	0.707
MOD_GlcNHglycan	422	425	PF01048	0.549
MOD_GlcNHglycan	445	448	PF01048	0.377
MOD_GlcNHglycan	480	483	PF01048	0.533
MOD_GlcNHglycan	5	8	PF01048	0.624
MOD_GlcNHglycan	518	521	PF01048	0.490
MOD_GlcNHglycan	58	61	PF01048	0.462
MOD_GSK3_1	13	20	PF00069	0.617
MOD_GSK3_1	274	281	PF00069	0.545
MOD_GSK3_1	296	303	PF00069	0.513
MOD_GSK3_1	310	317	PF00069	0.445
MOD_GSK3_1	336	343	PF00069	0.325
MOD_GSK3_1	352	359	PF00069	0.435
MOD_GSK3_1	405	412	PF00069	0.698
MOD_GSK3_1	416	423	PF00069	0.684
MOD_GSK3_1	442	449	PF00069	0.469
MOD_GSK3_1	466	473	PF00069	0.484
MOD_GSK3_1	478	485	PF00069	0.491
MOD_GSK3_1	5	12	PF00069	0.672
MOD_GSK3_1	56	63	PF00069	0.449
MOD_GSK3_1	560	567	PF00069	0.605
MOD_GSK3_1	70	77	PF00069	0.427
MOD_LATS_1	537	543	PF00433	0.545
MOD_N-GLC_1	289	294	PF02516	0.475
MOD_N-GLC_1	318	323	PF02516	0.340
MOD_N-GLC_1	345	350	PF02516	0.281
MOD_N-GLC_1	378	383	PF02516	0.347
MOD_N-GLC_1	482	487	PF02516	0.642
MOD_NEK2_1	107	112	PF00069	0.378
MOD_NEK2_1	19	24	PF00069	0.644
MOD_NEK2_1	296	301	PF00069	0.397
MOD_NEK2_1	315	320	PF00069	0.372
MOD_NEK2_1	340	345	PF00069	0.312
MOD_NEK2_1	478	483	PF00069	0.634
MOD_NEK2_1	548	553	PF00069	0.530
MOD_NEK2_1	560	565	PF00069	0.646
MOD_NEK2_1	70	75	PF00069	0.414
MOD_NEK2_1	9	14	PF00069	0.718
MOD_NEK2_1	94	99	PF00069	0.409
MOD_NEK2_2	431	436	PF00069	0.474
MOD_PIKK_1	14	20	PF00454	0.604
MOD_PIKK_1	256	262	PF00454	0.359
MOD_PIKK_1	323	329	PF00454	0.296
MOD_PIKK_1	476	482	PF00454	0.569
MOD_PKA_1	3	9	PF00069	0.707
MOD_PKA_2	124	130	PF00069	0.636
MOD_PKA_2	210	216	PF00069	0.412
MOD_PKA_2	3	9	PF00069	0.707
MOD_PKA_2	405	411	PF00069	0.631
MOD_PKA_2	538	544	PF00069	0.524
MOD_PKA_2	94	100	PF00069	0.384
MOD_PKB_1	263	271	PF00069	0.540
MOD_Plk_1	123	129	PF00069	0.623
MOD_Plk_1	249	255	PF00069	0.410
MOD_Plk_1	289	295	PF00069	0.478
MOD_Plk_1	318	324	PF00069	0.391
MOD_Plk_1	345	351	PF00069	0.281
MOD_Plk_1	381	387	PF00069	0.367
MOD_Plk_1	95	101	PF00069	0.498
MOD_Plk_4	331	337	PF00069	0.338
MOD_Plk_4	381	387	PF00069	0.325
MOD_Plk_4	431	437	PF00069	0.525
MOD_Plk_4	461	467	PF00069	0.476
MOD_Plk_4	539	545	PF00069	0.416
MOD_Plk_4	62	68	PF00069	0.516
MOD_Plk_4	87	93	PF00069	0.447
MOD_ProDKin_1	114	120	PF00069	0.533
MOD_ProDKin_1	300	306	PF00069	0.533
MOD_ProDKin_1	388	394	PF00069	0.307
MOD_ProDKin_1	446	452	PF00069	0.461
MOD_SUMO_rev_2	268	275	PF00179	0.459
TRG_DiLeu_BaEn_1	222	227	PF01217	0.349
TRG_DiLeu_BaLyEn_6	311	316	PF01217	0.584
TRG_DiLeu_BaLyEn_6	447	452	PF01217	0.506
TRG_ENDOCYTIC_2	100	103	PF00928	0.353
TRG_ENDOCYTIC_2	261	264	PF00928	0.523
TRG_ENDOCYTIC_2	305	308	PF00928	0.580
TRG_ENDOCYTIC_2	386	389	PF00928	0.410
TRG_ENDOCYTIC_2	432	435	PF00928	0.393
TRG_ENDOCYTIC_2	436	439	PF00928	0.387
TRG_ER_diArg_1	262	265	PF00400	0.395
TRG_ER_diArg_1	3	5	PF00400	0.652
TRG_ER_diArg_1	505	507	PF00400	0.429
TRG_Pf-PMV_PEXEL_1	137	141	PF00026	0.536

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8E5	Leptomonas seymouri	77%	100%
A0A1X0P3V6	Trypanosomatidae	47%	100%
A0A3R7M8R7	Trypanosoma rangeli	48%	100%
A4HFU9	Leishmania braziliensis	85%	100%
A4I2W6	Leishmania infantum	100%	100%
D0A651	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9ADF3	Leishmania major	97%	100%
E9AZ76	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	99%
V5BYH8	Trypanosoma cruzi	48%	100%