Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IEG5_LEIDO

TriTrypDb:

LdBPK_280480.1 , LdCL_280008300 , LDHU3_28.0430

Length:

1153

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IEG5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEG5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	841	845	PF00656	0.445
CLV_NRD_NRD_1	10	12	PF00675	0.462
CLV_NRD_NRD_1	1011	1013	PF00675	0.388
CLV_NRD_NRD_1	239	241	PF00675	0.467
CLV_NRD_NRD_1	468	470	PF00675	0.426
CLV_NRD_NRD_1	60	62	PF00675	0.521
CLV_NRD_NRD_1	902	904	PF00675	0.457
CLV_NRD_NRD_1	969	971	PF00675	0.489
CLV_PCSK_KEX2_1	10	12	PF00082	0.485
CLV_PCSK_KEX2_1	1011	1013	PF00082	0.438
CLV_PCSK_KEX2_1	239	241	PF00082	0.537
CLV_PCSK_KEX2_1	468	470	PF00082	0.426
CLV_PCSK_KEX2_1	60	62	PF00082	0.467
CLV_PCSK_KEX2_1	902	904	PF00082	0.333
CLV_PCSK_SKI1_1	10	14	PF00082	0.472
CLV_PCSK_SKI1_1	1105	1109	PF00082	0.385
CLV_PCSK_SKI1_1	111	115	PF00082	0.637
CLV_PCSK_SKI1_1	220	224	PF00082	0.592
CLV_PCSK_SKI1_1	240	244	PF00082	0.276
CLV_PCSK_SKI1_1	407	411	PF00082	0.503
CLV_PCSK_SKI1_1	469	473	PF00082	0.461
CLV_PCSK_SKI1_1	757	761	PF00082	0.367
CLV_PCSK_SKI1_1	786	790	PF00082	0.434
DEG_APCC_DBOX_1	1104	1112	PF00400	0.376
DEG_APCC_DBOX_1	1121	1129	PF00400	0.389
DEG_APCC_DBOX_1	122	130	PF00400	0.418
DEG_APCC_DBOX_1	468	476	PF00400	0.457
DEG_APCC_DBOX_1	59	67	PF00400	0.514
DEG_SPOP_SBC_1	160	164	PF00917	0.404
DOC_CYCLIN_RxL_1	234	245	PF00134	0.581
DOC_CYCLIN_RxL_1	754	765	PF00134	0.352
DOC_CYCLIN_yCln2_LP_2	12	18	PF00134	0.507
DOC_CYCLIN_yCln2_LP_2	901	907	PF00134	0.384
DOC_MAPK_gen_1	123	132	PF00069	0.486
DOC_MAPK_gen_1	294	304	PF00069	0.453
DOC_MAPK_gen_1	465	474	PF00069	0.382
DOC_MAPK_MEF2A_6	23	30	PF00069	0.375
DOC_MAPK_MEF2A_6	468	476	PF00069	0.382
DOC_MAPK_MEF2A_6	708	717	PF00069	0.412
DOC_MAPK_NFAT4_5	23	31	PF00069	0.353
DOC_PP2B_LxvP_1	12	15	PF13499	0.415
DOC_PP2B_LxvP_1	491	494	PF13499	0.534
DOC_PP2B_LxvP_1	693	696	PF13499	0.427
DOC_PP2B_LxvP_1	789	792	PF13499	0.420
DOC_PP2B_LxvP_1	946	949	PF13499	0.424
DOC_PP4_FxxP_1	378	381	PF00568	0.488
DOC_PP4_FxxP_1	87	90	PF00568	0.510
DOC_USP7_MATH_1	1021	1025	PF00917	0.478
DOC_USP7_MATH_1	202	206	PF00917	0.565
DOC_USP7_MATH_1	402	406	PF00917	0.476
DOC_USP7_MATH_1	566	570	PF00917	0.491
DOC_USP7_MATH_1	59	63	PF00917	0.518
DOC_USP7_MATH_1	593	597	PF00917	0.356
DOC_USP7_MATH_1	680	684	PF00917	0.457
DOC_USP7_MATH_1	745	749	PF00917	0.515
DOC_USP7_MATH_1	770	774	PF00917	0.466
DOC_USP7_MATH_1	920	924	PF00917	0.420
DOC_USP7_UBL2_3	496	500	PF12436	0.355
DOC_USP7_UBL2_3	971	975	PF12436	0.388
DOC_WW_Pin1_4	204	209	PF00397	0.559
DOC_WW_Pin1_4	245	250	PF00397	0.549
DOC_WW_Pin1_4	262	267	PF00397	0.566
DOC_WW_Pin1_4	323	328	PF00397	0.453
DOC_WW_Pin1_4	359	364	PF00397	0.555
DOC_WW_Pin1_4	48	53	PF00397	0.625
DOC_WW_Pin1_4	577	582	PF00397	0.469
DOC_WW_Pin1_4	643	648	PF00397	0.424
DOC_WW_Pin1_4	748	753	PF00397	0.495
DOC_WW_Pin1_4	768	773	PF00397	0.378
LIG_14-3-3_CanoR_1	10	15	PF00244	0.515
LIG_14-3-3_CanoR_1	100	109	PF00244	0.538
LIG_14-3-3_CanoR_1	1055	1063	PF00244	0.387
LIG_14-3-3_CanoR_1	1122	1132	PF00244	0.522
LIG_14-3-3_CanoR_1	123	133	PF00244	0.512
LIG_14-3-3_CanoR_1	294	300	PF00244	0.453
LIG_14-3-3_CanoR_1	387	391	PF00244	0.404
LIG_14-3-3_CanoR_1	511	515	PF00244	0.562
LIG_14-3-3_CanoR_1	60	64	PF00244	0.440
LIG_14-3-3_CanoR_1	708	715	PF00244	0.422
LIG_14-3-3_CanoR_1	757	762	PF00244	0.398
LIG_14-3-3_CanoR_1	764	772	PF00244	0.539
LIG_14-3-3_CanoR_1	848	854	PF00244	0.428
LIG_14-3-3_CanoR_1	890	896	PF00244	0.468
LIG_14-3-3_CanoR_1	912	917	PF00244	0.416
LIG_14-3-3_CanoR_1	960	964	PF00244	0.384
LIG_Actin_WH2_2	210	225	PF00022	0.476
LIG_Actin_WH2_2	309	325	PF00022	0.553
LIG_APCC_ABBA_1	939	944	PF00400	0.318
LIG_BIR_III_2	666	670	PF00653	0.360
LIG_BRCT_BRCA1_1	914	918	PF00533	0.446
LIG_BRCT_BRCA1_1	922	926	PF00533	0.295
LIG_Clathr_ClatBox_1	678	682	PF01394	0.460
LIG_deltaCOP1_diTrp_1	226	235	PF00928	0.455
LIG_EVH1_2	792	796	PF00568	0.465
LIG_FHA_1	102	108	PF00498	0.457
LIG_FHA_1	1025	1031	PF00498	0.452
LIG_FHA_1	1086	1092	PF00498	0.365
LIG_FHA_1	1134	1140	PF00498	0.575
LIG_FHA_1	119	125	PF00498	0.544
LIG_FHA_1	144	150	PF00498	0.360
LIG_FHA_1	4	10	PF00498	0.546
LIG_FHA_1	411	417	PF00498	0.464
LIG_FHA_1	437	443	PF00498	0.524
LIG_FHA_1	493	499	PF00498	0.529
LIG_FHA_1	517	523	PF00498	0.481
LIG_FHA_1	53	59	PF00498	0.418
LIG_FHA_1	637	643	PF00498	0.511
LIG_FHA_1	712	718	PF00498	0.461
LIG_FHA_1	734	740	PF00498	0.519
LIG_FHA_1	853	859	PF00498	0.496
LIG_FHA_1	896	902	PF00498	0.526
LIG_FHA_1	93	99	PF00498	0.465
LIG_FHA_1	936	942	PF00498	0.430
LIG_FHA_1	972	978	PF00498	0.320
LIG_FHA_2	1039	1045	PF00498	0.570
LIG_FHA_2	1046	1052	PF00498	0.336
LIG_FHA_2	1059	1065	PF00498	0.273
LIG_FHA_2	283	289	PF00498	0.588
LIG_FHA_2	40	46	PF00498	0.679
LIG_FHA_2	689	695	PF00498	0.511
LIG_GBD_Chelix_1	717	725	PF00786	0.516
LIG_GBD_Chelix_1	812	820	PF00786	0.385
LIG_IRF3_LxIS_1	618	625	PF10401	0.393
LIG_LIR_Apic_2	226	231	PF02991	0.511
LIG_LIR_Apic_2	376	381	PF02991	0.491
LIG_LIR_Apic_2	510	515	PF02991	0.524
LIG_LIR_Gen_1	171	181	PF02991	0.427
LIG_LIR_Gen_1	373	382	PF02991	0.494
LIG_LIR_Gen_1	428	438	PF02991	0.339
LIG_LIR_Gen_1	439	445	PF02991	0.527
LIG_LIR_Gen_1	779	789	PF02991	0.445
LIG_LIR_Gen_1	794	804	PF02991	0.260
LIG_LIR_Nem_3	171	176	PF02991	0.377
LIG_LIR_Nem_3	373	378	PF02991	0.680
LIG_LIR_Nem_3	428	434	PF02991	0.326
LIG_LIR_Nem_3	779	784	PF02991	0.453
LIG_LIR_Nem_3	794	799	PF02991	0.257
LIG_LIR_Nem_3	908	914	PF02991	0.506
LIG_LIR_Nem_3	915	921	PF02991	0.471
LIG_NRBOX	630	636	PF00104	0.397
LIG_NRBOX	720	726	PF00104	0.374
LIG_NRBOX	754	760	PF00104	0.260
LIG_NRBOX	811	817	PF00104	0.390
LIG_PCNA_yPIPBox_3	884	896	PF02747	0.281
LIG_Pex14_1	228	232	PF04695	0.505
LIG_PTB_Apo_2	336	343	PF02174	0.470
LIG_PTB_Apo_2	962	969	PF02174	0.483
LIG_PTB_Phospho_1	336	342	PF10480	0.462
LIG_SH2_CRK	781	785	PF00017	0.475
LIG_SH2_CRK	969	973	PF00017	0.437
LIG_SH2_GRB2like	337	340	PF00017	0.461
LIG_SH2_NCK_1	342	346	PF00017	0.564
LIG_SH2_NCK_1	781	785	PF00017	0.490
LIG_SH2_STAP1	103	107	PF00017	0.448
LIG_SH2_STAP1	232	236	PF00017	0.433
LIG_SH2_STAP1	337	341	PF00017	0.454
LIG_SH2_STAT5	103	106	PF00017	0.504
LIG_SH2_STAT5	1052	1055	PF00017	0.421
LIG_SH2_STAT5	142	145	PF00017	0.474
LIG_SH2_STAT5	429	432	PF00017	0.468
LIG_SH3_3	321	327	PF00018	0.517
LIG_SH3_3	576	582	PF00018	0.419
LIG_SH3_3	87	93	PF00018	0.441
LIG_SUMO_SIM_anti_2	127	134	PF11976	0.454
LIG_SUMO_SIM_anti_2	171	178	PF11976	0.394
LIG_SUMO_SIM_anti_2	913	918	PF11976	0.367
LIG_SUMO_SIM_par_1	1135	1140	PF11976	0.573
LIG_SUMO_SIM_par_1	309	315	PF11976	0.410
LIG_TRAF2_1	1140	1143	PF00917	0.492
LIG_TRAF2_1	285	288	PF00917	0.484
LIG_TRAF2_1	70	73	PF00917	0.379
LIG_TRAF2_1	997	1000	PF00917	0.524
LIG_WRC_WIRS_1	375	380	PF05994	0.501
MOD_CK1_1	1019	1025	PF00069	0.466
MOD_CK1_1	1058	1064	PF00069	0.480
MOD_CK1_1	1133	1139	PF00069	0.566
MOD_CK1_1	164	170	PF00069	0.431
MOD_CK1_1	374	380	PF00069	0.637
MOD_CK1_1	41	47	PF00069	0.659
MOD_CK1_1	440	446	PF00069	0.372
MOD_CK1_1	492	498	PF00069	0.524
MOD_CK1_1	51	57	PF00069	0.472
MOD_CK1_1	510	516	PF00069	0.629
MOD_CK1_1	688	694	PF00069	0.561
MOD_CK1_1	711	717	PF00069	0.558
MOD_CK1_1	748	754	PF00069	0.531
MOD_CK1_1	88	94	PF00069	0.523
MOD_CK1_1	894	900	PF00069	0.338
MOD_CK1_1	959	965	PF00069	0.423
MOD_CK2_1	1038	1044	PF00069	0.401
MOD_CK2_1	1137	1143	PF00069	0.505
MOD_CK2_1	282	288	PF00069	0.519
MOD_CK2_1	417	423	PF00069	0.457
MOD_CK2_1	688	694	PF00069	0.525
MOD_DYRK1A_RPxSP_1	323	327	PF00069	0.445
MOD_GlcNHglycan	111	114	PF01048	0.522
MOD_GlcNHglycan	1139	1142	PF01048	0.572
MOD_GlcNHglycan	200	203	PF01048	0.614
MOD_GlcNHglycan	419	422	PF01048	0.433
MOD_GlcNHglycan	482	485	PF01048	0.544
MOD_GlcNHglycan	491	494	PF01048	0.549
MOD_GlcNHglycan	595	598	PF01048	0.380
MOD_GlcNHglycan	624	627	PF01048	0.533
MOD_GlcNHglycan	688	691	PF01048	0.581
MOD_GlcNHglycan	747	750	PF01048	0.490
MOD_GlcNHglycan	772	775	PF01048	0.690
MOD_GlcNHglycan	81	84	PF01048	0.399
MOD_GlcNHglycan	827	830	PF01048	0.403
MOD_GlcNHglycan	87	90	PF01048	0.477
MOD_GlcNHglycan	870	873	PF01048	0.356
MOD_GSK3_1	111	118	PF00069	0.587
MOD_GSK3_1	1133	1140	PF00069	0.563
MOD_GSK3_1	159	166	PF00069	0.502
MOD_GSK3_1	198	205	PF00069	0.642
MOD_GSK3_1	370	377	PF00069	0.626
MOD_GSK3_1	41	48	PF00069	0.654
MOD_GSK3_1	411	418	PF00069	0.535
MOD_GSK3_1	436	443	PF00069	0.393
MOD_GSK3_1	446	453	PF00069	0.344
MOD_GSK3_1	681	688	PF00069	0.523
MOD_GSK3_1	707	714	PF00069	0.433
MOD_GSK3_1	764	771	PF00069	0.658
MOD_GSK3_1	852	859	PF00069	0.486
MOD_GSK3_1	88	95	PF00069	0.456
MOD_GSK3_1	891	898	PF00069	0.394
MOD_N-GLC_1	1038	1043	PF02516	0.385
MOD_N-GLC_1	109	114	PF02516	0.497
MOD_N-GLC_1	38	43	PF02516	0.488
MOD_NEK2_1	1005	1010	PF00069	0.460
MOD_NEK2_1	1128	1133	PF00069	0.417
MOD_NEK2_1	143	148	PF00069	0.445
MOD_NEK2_1	149	154	PF00069	0.373
MOD_NEK2_1	197	202	PF00069	0.553
MOD_NEK2_1	242	247	PF00069	0.546
MOD_NEK2_1	410	415	PF00069	0.515
MOD_NEK2_1	480	485	PF00069	0.541
MOD_NEK2_1	620	625	PF00069	0.469
MOD_NEK2_1	681	686	PF00069	0.579
MOD_NEK2_1	868	873	PF00069	0.460
MOD_NEK2_1	885	890	PF00069	0.302
MOD_NEK2_1	935	940	PF00069	0.378
MOD_NEK2_1	98	103	PF00069	0.436
MOD_NEK2_2	103	108	PF00069	0.501
MOD_NEK2_2	59	64	PF00069	0.524
MOD_NEK2_2	920	925	PF00069	0.448
MOD_PIKK_1	1110	1116	PF00454	0.485
MOD_PIKK_1	1123	1129	PF00454	0.508
MOD_PIKK_1	149	155	PF00454	0.398
MOD_PIKK_1	3	9	PF00454	0.489
MOD_PIKK_1	733	739	PF00454	0.533
MOD_PIKK_1	830	836	PF00454	0.331
MOD_PIKK_1	895	901	PF00454	0.387
MOD_PK_1	1067	1073	PF00069	0.483
MOD_PK_1	708	714	PF00069	0.375
MOD_PKA_1	10	16	PF00069	0.521
MOD_PKA_2	10	16	PF00069	0.439
MOD_PKA_2	1123	1129	PF00069	0.374
MOD_PKA_2	124	130	PF00069	0.437
MOD_PKA_2	386	392	PF00069	0.519
MOD_PKA_2	480	486	PF00069	0.537
MOD_PKA_2	510	516	PF00069	0.529
MOD_PKA_2	59	65	PF00069	0.428
MOD_PKA_2	707	713	PF00069	0.482
MOD_PKA_2	763	769	PF00069	0.506
MOD_PKA_2	847	853	PF00069	0.465
MOD_PKA_2	959	965	PF00069	0.373
MOD_PKB_1	762	770	PF00069	0.421
MOD_Plk_1	1038	1044	PF00069	0.391
MOD_Plk_1	143	149	PF00069	0.335
MOD_Plk_1	681	687	PF00069	0.518
MOD_Plk_4	1029	1035	PF00069	0.333
MOD_Plk_4	1045	1051	PF00069	0.367
MOD_Plk_4	1133	1139	PF00069	0.664
MOD_Plk_4	143	149	PF00069	0.472
MOD_Plk_4	17	23	PF00069	0.456
MOD_Plk_4	328	334	PF00069	0.544
MOD_Plk_4	386	392	PF00069	0.540
MOD_Plk_4	411	417	PF00069	0.599
MOD_Plk_4	425	431	PF00069	0.265
MOD_Plk_4	437	443	PF00069	0.575
MOD_Plk_4	470	476	PF00069	0.425
MOD_Plk_4	545	551	PF00069	0.460
MOD_Plk_4	682	688	PF00069	0.602
MOD_Plk_4	708	714	PF00069	0.592
MOD_Plk_4	891	897	PF00069	0.460
MOD_Plk_4	959	965	PF00069	0.497
MOD_ProDKin_1	204	210	PF00069	0.551
MOD_ProDKin_1	245	251	PF00069	0.560
MOD_ProDKin_1	262	268	PF00069	0.555
MOD_ProDKin_1	323	329	PF00069	0.447
MOD_ProDKin_1	359	365	PF00069	0.564
MOD_ProDKin_1	48	54	PF00069	0.614
MOD_ProDKin_1	577	583	PF00069	0.466
MOD_ProDKin_1	643	649	PF00069	0.420
MOD_ProDKin_1	748	754	PF00069	0.490
MOD_ProDKin_1	768	774	PF00069	0.373
MOD_SUMO_for_1	22	25	PF00179	0.458
TRG_DiLeu_BaEn_1	1145	1150	PF01217	0.604
TRG_DiLeu_BaEn_4	1142	1148	PF01217	0.544
TRG_DiLeu_BaLyEn_6	600	605	PF01217	0.371
TRG_DiLeu_BaLyEn_6	615	620	PF01217	0.359
TRG_DiLeu_BaLyEn_6	754	759	PF01217	0.500
TRG_ENDOCYTIC_2	781	784	PF00928	0.441
TRG_ENDOCYTIC_2	893	896	PF00928	0.333
TRG_ENDOCYTIC_2	969	972	PF00928	0.368
TRG_ENDOCYTIC_2	995	998	PF00928	0.461
TRG_ER_diArg_1	1011	1013	PF00400	0.388
TRG_ER_diArg_1	1122	1125	PF00400	0.375
TRG_ER_diArg_1	123	126	PF00400	0.447
TRG_ER_diArg_1	217	220	PF00400	0.462
TRG_ER_diArg_1	761	764	PF00400	0.546
TRG_ER_diArg_1	9	11	PF00400	0.482
TRG_ER_diArg_1	901	903	PF00400	0.441
TRG_NES_CRM1_1	293	308	PF08389	0.520
TRG_NES_CRM1_1	930	944	PF08389	0.358
TRG_Pf-PMV_PEXEL_1	240	244	PF00026	0.550

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD59	Leptomonas seymouri	47%	97%
A0A1X0NVE5	Trypanosomatidae	27%	100%
A0A422N6R4	Trypanosoma rangeli	28%	100%
A4HG75	Leishmania braziliensis	79%	100%
A4I3B8	Leishmania infantum	100%	100%
D0A7T7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AZJ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q8N6	Leishmania major	95%	100%
V5B9X1	Trypanosoma cruzi	23%	100%