C2 domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Coiled-coil and C2 domain-containing protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IEG3_LEIDO

TriTrypDb:

LdBPK_342370.1 , LdCL_340031300 , LDHU3_34.3920

Length:

870

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0044297	cell body	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IEG3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEG3

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0030030	cell projection organization	4	1
GO:0030031	cell projection assembly	5	1
GO:0044782	cilium organization	5	1
GO:0060271	cilium assembly	6	1
GO:0070925	organelle assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0120031	plasma membrane bounded cell projection assembly	6	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	266	270	PF00656	0.670
CLV_C14_Caspase3-7	342	346	PF00656	0.509
CLV_C14_Caspase3-7	486	490	PF00656	0.591
CLV_C14_Caspase3-7	570	574	PF00656	0.588
CLV_NRD_NRD_1	104	106	PF00675	0.625
CLV_NRD_NRD_1	134	136	PF00675	0.593
CLV_NRD_NRD_1	149	151	PF00675	0.557
CLV_NRD_NRD_1	294	296	PF00675	0.536
CLV_NRD_NRD_1	524	526	PF00675	0.491
CLV_NRD_NRD_1	578	580	PF00675	0.659
CLV_NRD_NRD_1	582	584	PF00675	0.622
CLV_NRD_NRD_1	592	594	PF00675	0.486
CLV_NRD_NRD_1	619	621	PF00675	0.650
CLV_NRD_NRD_1	638	640	PF00675	0.458
CLV_NRD_NRD_1	668	670	PF00675	0.594
CLV_NRD_NRD_1	688	690	PF00675	0.530
CLV_NRD_NRD_1	810	812	PF00675	0.396
CLV_PCSK_KEX2_1	104	106	PF00082	0.584
CLV_PCSK_KEX2_1	122	124	PF00082	0.360
CLV_PCSK_KEX2_1	149	151	PF00082	0.459
CLV_PCSK_KEX2_1	157	159	PF00082	0.507
CLV_PCSK_KEX2_1	192	194	PF00082	0.578
CLV_PCSK_KEX2_1	294	296	PF00082	0.559
CLV_PCSK_KEX2_1	498	500	PF00082	0.616
CLV_PCSK_KEX2_1	524	526	PF00082	0.466
CLV_PCSK_KEX2_1	563	565	PF00082	0.424
CLV_PCSK_KEX2_1	582	584	PF00082	0.674
CLV_PCSK_KEX2_1	618	620	PF00082	0.549
CLV_PCSK_KEX2_1	667	669	PF00082	0.622
CLV_PCSK_KEX2_1	688	690	PF00082	0.607
CLV_PCSK_KEX2_1	810	812	PF00082	0.443
CLV_PCSK_PC1ET2_1	122	124	PF00082	0.488
CLV_PCSK_PC1ET2_1	157	159	PF00082	0.519
CLV_PCSK_PC1ET2_1	192	194	PF00082	0.578
CLV_PCSK_PC1ET2_1	498	500	PF00082	0.616
CLV_PCSK_PC1ET2_1	563	565	PF00082	0.420
CLV_PCSK_PC1ET2_1	618	620	PF00082	0.549
CLV_PCSK_PC7_1	559	565	PF00082	0.407
CLV_PCSK_PC7_1	663	669	PF00082	0.623
CLV_PCSK_SKI1_1	11	15	PF00082	0.530
CLV_PCSK_SKI1_1	167	171	PF00082	0.465
CLV_PCSK_SKI1_1	228	232	PF00082	0.553
CLV_PCSK_SKI1_1	32	36	PF00082	0.445
CLV_PCSK_SKI1_1	524	528	PF00082	0.525
CLV_PCSK_SKI1_1	583	587	PF00082	0.674
CLV_PCSK_SKI1_1	713	717	PF00082	0.429
CLV_PCSK_SKI1_1	726	730	PF00082	0.331
CLV_Separin_Metazoa	460	464	PF03568	0.479
CLV_Separin_Metazoa	504	508	PF03568	0.519
CLV_Separin_Metazoa	605	609	PF03568	0.605
DOC_CYCLIN_RxL_1	422	432	PF00134	0.426
DOC_CYCLIN_RxL_1	504	515	PF00134	0.563
DOC_MAPK_gen_1	452	461	PF00069	0.361
DOC_MAPK_gen_1	729	738	PF00069	0.428
DOC_MAPK_gen_1	807	817	PF00069	0.389
DOC_MAPK_gen_1	837	845	PF00069	0.349
DOC_MAPK_MEF2A_6	810	819	PF00069	0.356
DOC_PP4_FxxP_1	766	769	PF00568	0.358
DOC_USP7_MATH_1	304	308	PF00917	0.683
DOC_USP7_MATH_1	317	321	PF00917	0.579
DOC_USP7_MATH_1	380	384	PF00917	0.571
DOC_USP7_MATH_1	512	516	PF00917	0.529
DOC_USP7_MATH_1	662	666	PF00917	0.628
DOC_USP7_UBL2_3	236	240	PF12436	0.561
DOC_USP7_UBL2_3	452	456	PF12436	0.551
DOC_USP7_UBL2_3	591	595	PF12436	0.471
DOC_USP7_UBL2_3	67	71	PF12436	0.603
DOC_USP7_UBL2_3	729	733	PF12436	0.350
DOC_USP7_UBL2_3	83	87	PF12436	0.571
DOC_WW_Pin1_4	312	317	PF00397	0.698
DOC_WW_Pin1_4	644	649	PF00397	0.682
DOC_WW_Pin1_4	651	656	PF00397	0.519
DOC_WW_Pin1_4	658	663	PF00397	0.602
DOC_WW_Pin1_4	667	672	PF00397	0.528
DOC_WW_Pin1_4	800	805	PF00397	0.393
DOC_WW_Pin1_4	850	855	PF00397	0.388
LIG_14-3-3_CanoR_1	295	305	PF00244	0.625
LIG_14-3-3_CanoR_1	379	388	PF00244	0.646
LIG_14-3-3_CanoR_1	395	402	PF00244	0.679
LIG_14-3-3_CanoR_1	582	592	PF00244	0.629
LIG_14-3-3_CanoR_1	649	657	PF00244	0.766
LIG_14-3-3_CanoR_1	713	722	PF00244	0.441
LIG_14-3-3_CanoR_1	96	106	PF00244	0.469
LIG_Actin_WH2_2	152	169	PF00022	0.536
LIG_Actin_WH2_2	216	233	PF00022	0.505
LIG_Actin_WH2_2	355	373	PF00022	0.615
LIG_Actin_WH2_2	454	471	PF00022	0.516
LIG_Actin_WH2_2	695	712	PF00022	0.487
LIG_Actin_WH2_2	82	98	PF00022	0.529
LIG_BIR_II_1	1	5	PF00653	0.581
LIG_BIR_III_4	573	577	PF00653	0.487
LIG_BRCT_BRCA1_1	772	776	PF00533	0.495
LIG_FHA_1	146	152	PF00498	0.417
LIG_FHA_1	313	319	PF00498	0.662
LIG_FHA_1	630	636	PF00498	0.527
LIG_FHA_1	704	710	PF00498	0.370
LIG_FHA_1	760	766	PF00498	0.327
LIG_FHA_2	227	233	PF00498	0.634
LIG_FHA_2	245	251	PF00498	0.454
LIG_FHA_2	481	487	PF00498	0.534
LIG_FHA_2	624	630	PF00498	0.602
LIG_FHA_2	699	705	PF00498	0.305
LIG_FHA_2	829	835	PF00498	0.456
LIG_FHA_2	98	104	PF00498	0.471
LIG_Integrin_isoDGR_2	711	713	PF01839	0.490
LIG_LIR_Nem_3	141	145	PF02991	0.426
LIG_LIR_Nem_3	746	752	PF02991	0.383
LIG_LIR_Nem_3	787	792	PF02991	0.409
LIG_PCNA_yPIPBox_3	177	188	PF02747	0.530
LIG_Pex14_1	326	330	PF04695	0.577
LIG_Pex14_2	745	749	PF04695	0.325
LIG_SH2_CRK	789	793	PF00017	0.449
LIG_SH2_GRB2like	528	531	PF00017	0.479
LIG_SH2_NCK_1	330	334	PF00017	0.494
LIG_SH2_SRC	528	531	PF00017	0.479
LIG_SH2_STAP1	402	406	PF00017	0.519
LIG_SH2_STAT3	454	457	PF00017	0.548
LIG_SH2_STAT3	752	755	PF00017	0.350
LIG_SH2_STAT5	752	755	PF00017	0.354
LIG_SH3_3	385	391	PF00018	0.696
LIG_SH3_3	642	648	PF00018	0.781
LIG_SH3_3	798	804	PF00018	0.490
LIG_SUMO_SIM_anti_2	550	556	PF11976	0.356
LIG_SUMO_SIM_par_1	425	430	PF11976	0.416
LIG_SUMO_SIM_par_1	701	707	PF11976	0.374
LIG_TRAF2_1	501	504	PF00917	0.539
LIG_TRAF2_1	602	605	PF00917	0.407
LIG_TRAF2_1	831	834	PF00917	0.577
LIG_UBA3_1	272	277	PF00899	0.575
LIG_UBA3_1	491	498	PF00899	0.441
LIG_UBA3_1	78	83	PF00899	0.600
MOD_CDK_SPK_2	644	649	PF00069	0.763
MOD_CDK_SPK_2	658	663	PF00069	0.612
MOD_CDK_SPxxK_3	312	319	PF00069	0.571
MOD_CDK_SPxxK_3	800	807	PF00069	0.405
MOD_CK1_1	261	267	PF00069	0.538
MOD_CK1_1	306	312	PF00069	0.787
MOD_CK1_1	393	399	PF00069	0.633
MOD_CK1_1	401	407	PF00069	0.684
MOD_CK1_1	6	12	PF00069	0.407
MOD_CK1_1	651	657	PF00069	0.646
MOD_CK1_1	677	683	PF00069	0.582
MOD_CK1_1	784	790	PF00069	0.464
MOD_CK1_1	803	809	PF00069	0.536
MOD_CK2_1	107	113	PF00069	0.557
MOD_CK2_1	126	132	PF00069	0.332
MOD_CK2_1	15	21	PF00069	0.622
MOD_CK2_1	165	171	PF00069	0.601
MOD_CK2_1	226	232	PF00069	0.634
MOD_CK2_1	244	250	PF00069	0.419
MOD_CK2_1	393	399	PF00069	0.609
MOD_CK2_1	435	441	PF00069	0.543
MOD_CK2_1	498	504	PF00069	0.576
MOD_CK2_1	512	518	PF00069	0.421
MOD_CK2_1	549	555	PF00069	0.455
MOD_CK2_1	680	686	PF00069	0.697
MOD_CK2_1	698	704	PF00069	0.306
MOD_CK2_1	724	730	PF00069	0.394
MOD_CK2_1	828	834	PF00069	0.467
MOD_CK2_1	95	101	PF00069	0.540
MOD_DYRK1A_RPxSP_1	644	648	PF00069	0.563
MOD_GlcNHglycan	108	112	PF01048	0.441
MOD_GlcNHglycan	167	170	PF01048	0.466
MOD_GlcNHglycan	260	263	PF01048	0.609
MOD_GlcNHglycan	298	301	PF01048	0.705
MOD_GlcNHglycan	319	322	PF01048	0.514
MOD_GlcNHglycan	437	440	PF01048	0.607
MOD_GlcNHglycan	5	8	PF01048	0.669
MOD_GlcNHglycan	610	613	PF01048	0.548
MOD_GlcNHglycan	664	667	PF01048	0.635
MOD_GlcNHglycan	689	692	PF01048	0.687
MOD_GSK3_1	240	247	PF00069	0.448
MOD_GSK3_1	303	310	PF00069	0.715
MOD_GSK3_1	389	396	PF00069	0.680
MOD_GSK3_1	549	556	PF00069	0.486
MOD_GSK3_1	640	647	PF00069	0.658
MOD_GSK3_1	658	665	PF00069	0.621
MOD_GSK3_1	677	684	PF00069	0.509
MOD_GSK3_1	824	831	PF00069	0.565
MOD_NEK2_1	145	150	PF00069	0.478
MOD_NEK2_1	226	231	PF00069	0.593
MOD_NEK2_1	258	263	PF00069	0.533
MOD_NEK2_1	308	313	PF00069	0.662
MOD_NEK2_1	547	552	PF00069	0.436
MOD_NEK2_1	698	703	PF00069	0.307
MOD_NEK2_1	738	743	PF00069	0.375
MOD_NEK2_1	745	750	PF00069	0.312
MOD_NEK2_1	824	829	PF00069	0.452
MOD_NEK2_1	95	100	PF00069	0.482
MOD_NEK2_2	732	737	PF00069	0.351
MOD_PIKK_1	380	386	PF00454	0.518
MOD_PIKK_1	409	415	PF00454	0.650
MOD_PIKK_1	828	834	PF00454	0.446
MOD_PK_1	329	335	PF00069	0.497
MOD_PK_1	390	396	PF00069	0.687
MOD_PK_1	498	504	PF00069	0.595
MOD_PK_1	549	555	PF00069	0.357
MOD_PK_1	724	730	PF00069	0.361
MOD_PKA_1	294	300	PF00069	0.579
MOD_PKA_1	498	504	PF00069	0.595
MOD_PKA_2	113	119	PF00069	0.361
MOD_PKA_2	294	300	PF00069	0.590
MOD_PKA_2	389	395	PF00069	0.693
MOD_PKA_2	404	410	PF00069	0.622
MOD_PKA_2	492	498	PF00069	0.582
MOD_PKA_2	648	654	PF00069	0.610
MOD_PKA_2	662	668	PF00069	0.574
MOD_PKA_2	681	687	PF00069	0.497
MOD_PKA_2	95	101	PF00069	0.480
MOD_PKB_1	105	113	PF00069	0.445
MOD_Plk_1	162	168	PF00069	0.579
MOD_Plk_1	226	232	PF00069	0.442
MOD_Plk_1	240	246	PF00069	0.439
MOD_Plk_1	398	404	PF00069	0.593
MOD_Plk_1	469	475	PF00069	0.631
MOD_Plk_1	745	751	PF00069	0.334
MOD_Plk_2-3	113	119	PF00069	0.467
MOD_Plk_2-3	126	132	PF00069	0.384
MOD_Plk_2-3	623	629	PF00069	0.377
MOD_Plk_4	240	246	PF00069	0.449
MOD_Plk_4	480	486	PF00069	0.602
MOD_Plk_4	549	555	PF00069	0.357
MOD_Plk_4	738	744	PF00069	0.398
MOD_Plk_4	745	751	PF00069	0.377
MOD_Plk_4	784	790	PF00069	0.374
MOD_Plk_4	824	830	PF00069	0.430
MOD_ProDKin_1	312	318	PF00069	0.695
MOD_ProDKin_1	644	650	PF00069	0.684
MOD_ProDKin_1	651	657	PF00069	0.515
MOD_ProDKin_1	658	664	PF00069	0.600
MOD_ProDKin_1	667	673	PF00069	0.527
MOD_ProDKin_1	800	806	PF00069	0.397
MOD_ProDKin_1	850	856	PF00069	0.386
MOD_SUMO_for_1	219	222	PF00179	0.494
MOD_SUMO_for_1	602	605	PF00179	0.462
MOD_SUMO_rev_2	137	145	PF00179	0.542
MOD_SUMO_rev_2	33	41	PF00179	0.442
MOD_SUMO_rev_2	353	363	PF00179	0.465
MOD_SUMO_rev_2	438	445	PF00179	0.544
MOD_SUMO_rev_2	550	558	PF00179	0.475
MOD_SUMO_rev_2	567	574	PF00179	0.515
TRG_DiLeu_BaEn_1	353	358	PF01217	0.523
TRG_DiLeu_BaEn_1	504	509	PF01217	0.571
TRG_DiLeu_BaEn_1	84	89	PF01217	0.431
TRG_DiLeu_BaEn_2	837	843	PF01217	0.351
TRG_DiLeu_BaEn_4	221	227	PF01217	0.490
TRG_DiLeu_LyEn_5	504	509	PF01217	0.571
TRG_ENDOCYTIC_2	142	145	PF00928	0.426
TRG_ENDOCYTIC_2	330	333	PF00928	0.566
TRG_ENDOCYTIC_2	789	792	PF00928	0.445
TRG_ER_diArg_1	104	107	PF00400	0.441
TRG_ER_diArg_1	149	151	PF00400	0.377
TRG_ER_diArg_1	422	425	PF00400	0.538
TRG_ER_diArg_1	523	525	PF00400	0.514
TRG_ER_diArg_1	619	621	PF00400	0.650
TRG_ER_diArg_1	667	669	PF00400	0.668
TRG_ER_diArg_1	793	796	PF00400	0.381
TRG_NES_CRM1_1	542	555	PF08389	0.388
TRG_NLS_Bipartite_1	563	583	PF00514	0.442
TRG_NLS_MonoExtC_3	578	583	PF00514	0.655
TRG_NLS_MonoExtC_3	592	598	PF00514	0.511
TRG_NLS_MonoExtN_4	591	597	PF00514	0.507
TRG_Pf-PMV_PEXEL_1	125	130	PF00026	0.481
TRG_Pf-PMV_PEXEL_1	149	154	PF00026	0.586
TRG_Pf-PMV_PEXEL_1	228	232	PF00026	0.540
TRG_Pf-PMV_PEXEL_1	281	285	PF00026	0.566
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.548
TRG_Pf-PMV_PEXEL_1	425	430	PF00026	0.507
TRG_Pf-PMV_PEXEL_1	53	57	PF00026	0.329
TRG_Pf-PMV_PEXEL_1	583	587	PF00026	0.671
TRG_Pf-PMV_PEXEL_1	619	623	PF00026	0.511
TRG_Pf-PMV_PEXEL_1	713	717	PF00026	0.483
TRG_Pf-PMV_PEXEL_1	790	795	PF00026	0.394

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I241	Leptomonas seymouri	57%	100%
A0A1X0P9P4	Trypanosomatidae	35%	95%
A0A3R7KUQ1	Trypanosoma rangeli	35%	93%
A4HAX2	Leishmania braziliensis	80%	100%
A4IA30	Leishmania infantum	100%	100%
C9ZMJ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	96%
E9B545	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q2U1	Leishmania major	93%	100%
V5B4V3	Trypanosoma cruzi	33%	93%