LeishMANIAdb
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Rab GDP dissociation inhibitor

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Rab GDP dissociation inhibitor
Gene product:
rab-GDP dissociation inhibitor, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8IEG2_LEIDO
TriTrypDb:
LdBPK_292270.1 , LdCL_290028800 , LDHU3_29.3360
Length:
445

Annotations

Annotations by Jardim et al.

Intracellular protein trafficking, rab-GDP dissociation inhibitor

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 4
Forrest at al. (procyclic) yes yes: 4
Silverman et al. no yes: 0
Pissara et al. yes yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 10
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A0A3Q8IEG2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEG2

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 12
GO:0007165 signal transduction 2 12
GO:0007264 small GTPase mediated signal transduction 4 12
GO:0008104 protein localization 4 12
GO:0009987 cellular process 1 12
GO:0015031 protein transport 4 12
GO:0033036 macromolecule localization 2 12
GO:0035556 intracellular signal transduction 3 12
GO:0045184 establishment of protein localization 3 12
GO:0050789 regulation of biological process 2 12
GO:0050794 regulation of cellular process 3 12
GO:0051179 localization 1 12
GO:0051234 establishment of localization 2 12
GO:0051641 cellular localization 2 12
GO:0065007 biological regulation 1 12
GO:0070727 cellular macromolecule localization 3 12
GO:0071702 organic substance transport 4 12
GO:0071705 nitrogen compound transport 4 12
GO:0016192 vesicle-mediated transport 4 1
Molecular functions
Term Name Level Count
GO:0005092 GDP-dissociation inhibitor activity 3 12
GO:0005093 Rab GDP-dissociation inhibitor activity 4 12
GO:0030234 enzyme regulator activity 2 12
GO:0030695 GTPase regulator activity 4 12
GO:0060589 nucleoside-triphosphatase regulator activity 3 12
GO:0098772 molecular function regulator activity 1 12
GO:0140677 molecular function activator activity 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 137 139 PF00675 0.260
CLV_NRD_NRD_1 329 331 PF00675 0.255
CLV_PCSK_KEX2_1 136 138 PF00082 0.250
CLV_PCSK_KEX2_1 328 330 PF00082 0.230
CLV_PCSK_KEX2_1 437 439 PF00082 0.615
CLV_PCSK_PC1ET2_1 136 138 PF00082 0.250
CLV_PCSK_PC1ET2_1 437 439 PF00082 0.611
CLV_PCSK_SKI1_1 114 118 PF00082 0.273
CLV_PCSK_SKI1_1 140 144 PF00082 0.278
CLV_PCSK_SKI1_1 273 277 PF00082 0.296
CLV_PCSK_SKI1_1 278 282 PF00082 0.282
DEG_APCC_DBOX_1 139 147 PF00400 0.537
DEG_APCC_DBOX_1 65 73 PF00400 0.446
DEG_Nend_UBRbox_2 1 3 PF02207 0.446
DEG_SPOP_SBC_1 125 129 PF00917 0.531
DOC_CKS1_1 250 255 PF01111 0.446
DOC_MAPK_gen_1 273 281 PF00069 0.455
DOC_MAPK_gen_1 328 335 PF00069 0.438
DOC_PP1_RVXF_1 254 260 PF00149 0.451
DOC_USP7_MATH_1 125 129 PF00917 0.533
DOC_USP7_MATH_1 264 268 PF00917 0.531
DOC_USP7_MATH_2 391 397 PF00917 0.489
DOC_USP7_UBL2_3 274 278 PF12436 0.470
DOC_WW_Pin1_4 218 223 PF00397 0.452
DOC_WW_Pin1_4 249 254 PF00397 0.446
DOC_WW_Pin1_4 56 61 PF00397 0.456
LIG_14-3-3_CanoR_1 290 298 PF00244 0.489
LIG_14-3-3_CanoR_1 90 94 PF00244 0.454
LIG_Actin_WH2_2 297 314 PF00022 0.542
LIG_BIR_III_4 260 264 PF00653 0.531
LIG_BRCT_BRCA1_1 397 401 PF00533 0.458
LIG_eIF4E_1 211 217 PF01652 0.489
LIG_FHA_1 10 16 PF00498 0.463
LIG_FHA_1 245 251 PF00498 0.446
LIG_FHA_2 119 125 PF00498 0.454
LIG_FHA_2 250 256 PF00498 0.512
LIG_FHA_2 354 360 PF00498 0.446
LIG_FHA_2 408 414 PF00498 0.458
LIG_FHA_2 90 96 PF00498 0.446
LIG_LIR_Apic_2 221 226 PF02991 0.448
LIG_LIR_Gen_1 100 109 PF02991 0.447
LIG_LIR_Gen_1 2 9 PF02991 0.446
LIG_LIR_Gen_1 347 358 PF02991 0.461
LIG_LIR_Gen_1 380 389 PF02991 0.458
LIG_LIR_Gen_1 432 439 PF02991 0.458
LIG_LIR_Gen_1 49 60 PF02991 0.458
LIG_LIR_Nem_3 100 104 PF02991 0.447
LIG_LIR_Nem_3 154 160 PF02991 0.516
LIG_LIR_Nem_3 2 8 PF02991 0.446
LIG_LIR_Nem_3 212 218 PF02991 0.447
LIG_LIR_Nem_3 380 385 PF02991 0.450
LIG_LIR_Nem_3 386 392 PF02991 0.442
LIG_LIR_Nem_3 432 436 PF02991 0.501
LIG_LIR_Nem_3 49 55 PF02991 0.446
LIG_NRBOX 18 24 PF00104 0.446
LIG_PDZ_Class_2 440 445 PF00595 0.665
LIG_REV1ctd_RIR_1 131 142 PF16727 0.446
LIG_SH2_CRK 28 32 PF00017 0.446
LIG_SH2_CRK 5 9 PF00017 0.446
LIG_SH2_GRB2like 211 214 PF00017 0.489
LIG_SH2_NCK_1 406 410 PF00017 0.482
LIG_SH2_PTP2 223 226 PF00017 0.446
LIG_SH2_SRC 211 214 PF00017 0.512
LIG_SH2_SRC 223 226 PF00017 0.446
LIG_SH2_STAP1 211 215 PF00017 0.458
LIG_SH2_STAP1 431 435 PF00017 0.537
LIG_SH2_STAP1 5 9 PF00017 0.446
LIG_SH2_STAT3 160 163 PF00017 0.514
LIG_SH2_STAT3 248 251 PF00017 0.446
LIG_SH2_STAT3 334 337 PF00017 0.446
LIG_SH2_STAT5 145 148 PF00017 0.542
LIG_SH2_STAT5 196 199 PF00017 0.472
LIG_SH2_STAT5 223 226 PF00017 0.443
LIG_SH2_STAT5 286 289 PF00017 0.456
LIG_SH2_STAT5 334 337 PF00017 0.446
LIG_SH3_3 355 361 PF00018 0.572
LIG_SUMO_SIM_par_1 350 356 PF11976 0.512
LIG_TRAF2_1 439 442 PF00917 0.636
LIG_UBA3_1 335 343 PF00899 0.446
LIG_UBA3_1 422 429 PF00899 0.476
LIG_WRC_WIRS_1 379 384 PF05994 0.458
MOD_CDK_SPxxK_3 249 256 PF00069 0.446
MOD_CK1_1 238 244 PF00069 0.542
MOD_CK1_1 267 273 PF00069 0.446
MOD_CK2_1 118 124 PF00069 0.454
MOD_CK2_1 353 359 PF00069 0.446
MOD_CK2_1 407 413 PF00069 0.458
MOD_Cter_Amidation 271 274 PF01082 0.255
MOD_GlcNHglycan 146 149 PF01048 0.324
MOD_GlcNHglycan 19 22 PF01048 0.252
MOD_GlcNHglycan 229 232 PF01048 0.267
MOD_GlcNHglycan 240 243 PF01048 0.345
MOD_GlcNHglycan 269 272 PF01048 0.312
MOD_GlcNHglycan 413 416 PF01048 0.233
MOD_GlcNHglycan 42 45 PF01048 0.275
MOD_GSK3_1 17 24 PF00069 0.451
MOD_GSK3_1 175 182 PF00069 0.520
MOD_GSK3_1 407 414 PF00069 0.438
MOD_GSK3_1 56 63 PF00069 0.460
MOD_LATS_1 427 433 PF00433 0.537
MOD_N-GLC_1 218 223 PF02516 0.331
MOD_N-GLC_2 316 318 PF02516 0.258
MOD_NEK2_1 104 109 PF00069 0.446
MOD_NEK2_1 126 131 PF00069 0.536
MOD_NEK2_1 353 358 PF00069 0.579
MOD_NEK2_1 64 69 PF00069 0.458
MOD_NEK2_1 89 94 PF00069 0.446
MOD_PKA_2 238 244 PF00069 0.542
MOD_PKA_2 89 95 PF00069 0.454
MOD_Plk_1 1 7 PF00069 0.430
MOD_Plk_1 104 110 PF00069 0.446
MOD_Plk_1 211 217 PF00069 0.458
MOD_Plk_4 104 110 PF00069 0.446
MOD_Plk_4 126 132 PF00069 0.534
MOD_Plk_4 201 207 PF00069 0.448
MOD_Plk_4 211 217 PF00069 0.497
MOD_Plk_4 244 250 PF00069 0.446
MOD_Plk_4 282 288 PF00069 0.446
MOD_Plk_4 353 359 PF00069 0.497
MOD_Plk_4 378 384 PF00069 0.458
MOD_Plk_4 89 95 PF00069 0.446
MOD_ProDKin_1 218 224 PF00069 0.452
MOD_ProDKin_1 249 255 PF00069 0.446
MOD_ProDKin_1 56 62 PF00069 0.456
MOD_SUMO_rev_2 107 116 PF00179 0.472
MOD_SUMO_rev_2 340 344 PF00179 0.542
TRG_DiLeu_BaEn_1 212 217 PF01217 0.489
TRG_ENDOCYTIC_2 28 31 PF00928 0.446
TRG_ENDOCYTIC_2 389 392 PF00928 0.446
TRG_ENDOCYTIC_2 5 8 PF00928 0.446
TRG_ENDOCYTIC_2 52 55 PF00928 0.458
TRG_ER_diArg_1 137 140 PF00400 0.542
TRG_ER_diArg_1 327 330 PF00400 0.489
TRG_NES_CRM1_1 179 194 PF08389 0.458

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5R8 Leptomonas seymouri 86% 100%
A0A0S4JSB4 Bodo saltans 69% 100%
A0A1X0P0G2 Trypanosomatidae 77% 100%
A0A3R7MJZ3 Trypanosoma rangeli 74% 100%
A4HHL6 Leishmania braziliensis 91% 100%
A4I4S5 Leishmania infantum 100% 100%
C9ZLH0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 74% 100%
E9AE78 Leishmania major 99% 100%
E9ALK7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 98% 100%
G4MT60 Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) 45% 96%
O24653 Arabidopsis thaliana 50% 100%
O93831 Candida albicans 25% 70%
O97555 Canis lupus familiaris 51% 100%
O97556 Canis lupus familiaris 49% 100%
P21856 Bos taurus 51% 100%
P24386 Homo sapiens 26% 68%
P26374 Homo sapiens 26% 68%
P31150 Homo sapiens 51% 100%
P32864 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 26% 74%
P37727 Rattus norvegicus 25% 68%
P39958 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 47% 99%
P50395 Homo sapiens 50% 100%
P50396 Mus musculus 51% 100%
P50397 Bos taurus 50% 100%
P50398 Rattus norvegicus 51% 100%
P50399 Rattus norvegicus 50% 100%
P60028 Pan troglodytes 51% 100%
Q10305 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 51% 100%
Q5RCE1 Pongo abelii 50% 100%
Q61598 Mus musculus 50% 100%
Q6Q7J2 Sus scrofa 50% 100%
Q7YQM0 Pongo pygmaeus 51% 100%
Q8HXX7 Macaca fascicularis 51% 100%
Q8LLD4 Arabidopsis thaliana 28% 79%
Q96254 Arabidopsis thaliana 51% 100%
Q9BKQ5 Caenorhabditis elegans 24% 87%
Q9LXC0 Arabidopsis thaliana 50% 100%
Q9QXG2 Mus musculus 26% 67%
Q9QZD5 Mus musculus 25% 72%
Q9V8W3 Drosophila melanogaster 26% 87%
V5BGJ6 Trypanosoma cruzi 75% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS