Pentamidine resistance protein 1

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ABC-thiol transporter (fragment)

Species:

Leishmania donovani

UniProt:

A0A3Q8IEG0_LEIDO

TriTrypDb:

LdBPK_230290.1 , LdBPK_340690.1 , LdCL_230008300 , LDHU3_23.0440

Length:

1569

Annotations

LeishMANIAdb annotations

Multidrug resistance transporters, involved in active transport of various unidentified small-molecule substrates.. ABC transporters belonging to subfamily C.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 63

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 36
NetGPI	no	yes: 0, no: 36

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	37
GO:0043226	organelle	2	1
GO:0043229	intracellular organelle	3	1
GO:0110165	cellular anatomical entity	1	37

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Expansion

Sequence features

A0A3Q8IEG0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	7
GO:0009987	cellular process	1	7
GO:0010035	response to inorganic substance	3	1
GO:0010038	response to metal ion	4	1
GO:0042221	response to chemical	2	1
GO:0050896	response to stimulus	1	1
GO:0051179	localization	1	7
GO:0051234	establishment of localization	2	7
GO:0055085	transmembrane transport	2	7

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	37
GO:0003824	catalytic activity	1	12
GO:0005215	transporter activity	1	37
GO:0005488	binding	1	37
GO:0005524	ATP binding	5	37
GO:0015399	primary active transmembrane transporter activity	4	37
GO:0016787	hydrolase activity	2	12
GO:0017076	purine nucleotide binding	4	37
GO:0022804	active transmembrane transporter activity	3	37
GO:0022857	transmembrane transporter activity	2	37

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1080	1084	PF00656	0.486
CLV_C14_Caspase3-7	1443	1447	PF00656	0.456
CLV_C14_Caspase3-7	625	629	PF00656	0.509
CLV_C14_Caspase3-7	743	747	PF00656	0.508
CLV_C14_Caspase3-7	818	822	PF00656	0.522
CLV_C14_Caspase3-7	890	894	PF00656	0.659
CLV_C14_Caspase3-7	899	903	PF00656	0.680
CLV_NRD_NRD_1	1135	1137	PF00675	0.247
CLV_NRD_NRD_1	1174	1176	PF00675	0.303
CLV_NRD_NRD_1	127	129	PF00675	0.373

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGL0	Leptomonas seymouri	70%	100%
A0A0S4IYC2	Bodo saltans	42%	96%
A0A0S4JM70	Bodo saltans	40%	88%
A0A179H0T5	Purpureocillium lilacinum	24%	100%
A0A1U8QTJ9	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	32%	100%
A0A1X0NHR8	Trypanosomatidae	46%	94%
A0A1X0NPP4	Trypanosomatidae	40%	90%
A0A3Q8IAV7	Leishmania donovani	99%	100%
A0A3Q8IFB0	Leishmania donovani	39%	100%
A0A3Q8III5	Leishmania donovani	39%	100%

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