Phosphatidylinositol 3- and 4-kinase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphatidylinositol 3- and 4-kinase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IEF4_LEIDO

TriTrypDb:

LdBPK_272060.1 , LdCL_270027900 , LDHU3_27.3160

Length:

1008

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IEF4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEF4

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016310	phosphorylation	5	2
GO:0044237	cellular metabolic process	2	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	205	209	PF00656	0.583
CLV_C14_Caspase3-7	311	315	PF00656	0.687
CLV_C14_Caspase3-7	410	414	PF00656	0.419
CLV_C14_Caspase3-7	538	542	PF00656	0.391
CLV_C14_Caspase3-7	840	844	PF00656	0.743
CLV_C14_Caspase3-7	870	874	PF00656	0.672
CLV_NRD_NRD_1	240	242	PF00675	0.726
CLV_NRD_NRD_1	248	250	PF00675	0.664
CLV_NRD_NRD_1	258	260	PF00675	0.771
CLV_NRD_NRD_1	324	326	PF00675	0.810
CLV_NRD_NRD_1	454	456	PF00675	0.411
CLV_NRD_NRD_1	47	49	PF00675	0.714
CLV_NRD_NRD_1	612	614	PF00675	0.358
CLV_NRD_NRD_1	619	621	PF00675	0.359
CLV_NRD_NRD_1	962	964	PF00675	0.516
CLV_PCSK_FUR_1	322	326	PF00082	0.731
CLV_PCSK_FUR_1	45	49	PF00082	0.772
CLV_PCSK_KEX2_1	240	242	PF00082	0.739
CLV_PCSK_KEX2_1	248	250	PF00082	0.643
CLV_PCSK_KEX2_1	324	326	PF00082	0.810
CLV_PCSK_KEX2_1	45	47	PF00082	0.760
CLV_PCSK_KEX2_1	454	456	PF00082	0.411
CLV_PCSK_KEX2_1	619	621	PF00082	0.374
CLV_PCSK_KEX2_1	815	817	PF00082	0.622
CLV_PCSK_KEX2_1	962	964	PF00082	0.516
CLV_PCSK_PC1ET2_1	815	817	PF00082	0.604
CLV_PCSK_PC7_1	320	326	PF00082	0.733
CLV_PCSK_PC7_1	41	47	PF00082	0.624
CLV_PCSK_SKI1_1	455	459	PF00082	0.411
CLV_PCSK_SKI1_1	699	703	PF00082	0.224
CLV_PCSK_SKI1_1	717	721	PF00082	0.367
CLV_PCSK_SKI1_1	788	792	PF00082	0.663
CLV_Separin_Metazoa	245	249	PF03568	0.744
CLV_Separin_Metazoa	714	718	PF03568	0.411
DEG_APCC_DBOX_1	454	462	PF00400	0.430
DEG_APCC_DBOX_1	996	1004	PF00400	0.527
DEG_SCF_FBW7_1	219	224	PF00400	0.734
DEG_SCF_FBW7_1	731	737	PF00400	0.557
DEG_SCF_FBW7_2	132	139	PF00400	0.745
DEG_SCF_TRCP1_1	271	276	PF00400	0.681
DEG_SPOP_SBC_1	124	128	PF00917	0.565
DEG_SPOP_SBC_1	280	284	PF00917	0.701
DEG_SPOP_SBC_1	32	36	PF00917	0.727
DEG_SPOP_SBC_1	398	402	PF00917	0.600
DEG_SPOP_SBC_1	819	823	PF00917	0.726
DEG_SPOP_SBC_1	898	902	PF00917	0.774
DOC_CDC14_PxL_1	803	811	PF14671	0.575
DOC_CKS1_1	69	74	PF01111	0.689
DOC_CKS1_1	731	736	PF01111	0.594
DOC_CYCLIN_yCln2_LP_2	70	76	PF00134	0.737
DOC_MAPK_gen_1	78	85	PF00069	0.590
DOC_MAPK_MEF2A_6	554	562	PF00069	0.430
DOC_PP2B_LxvP_1	560	563	PF13499	0.512
DOC_PP2B_LxvP_1	70	73	PF13499	0.773
DOC_PP4_FxxP_1	158	161	PF00568	0.567
DOC_PP4_MxPP_1	219	222	PF00568	0.777
DOC_USP7_MATH_1	124	128	PF00917	0.738
DOC_USP7_MATH_1	235	239	PF00917	0.614
DOC_USP7_MATH_1	33	37	PF00917	0.786
DOC_USP7_MATH_1	355	359	PF00917	0.677
DOC_USP7_MATH_1	396	400	PF00917	0.690
DOC_USP7_MATH_1	409	413	PF00917	0.410
DOC_USP7_MATH_1	498	502	PF00917	0.389
DOC_USP7_MATH_1	517	521	PF00917	0.385
DOC_USP7_MATH_1	629	633	PF00917	0.479
DOC_USP7_MATH_1	639	643	PF00917	0.443
DOC_USP7_MATH_1	734	738	PF00917	0.662
DOC_USP7_MATH_1	753	757	PF00917	0.735
DOC_USP7_MATH_1	780	784	PF00917	0.707
DOC_USP7_MATH_1	796	800	PF00917	0.679
DOC_USP7_MATH_1	8	12	PF00917	0.690
DOC_USP7_MATH_1	810	814	PF00917	0.661
DOC_USP7_MATH_1	820	824	PF00917	0.673
DOC_USP7_MATH_1	826	830	PF00917	0.570
DOC_USP7_MATH_1	836	840	PF00917	0.515
DOC_USP7_MATH_1	853	857	PF00917	0.670
DOC_USP7_MATH_1	898	902	PF00917	0.765
DOC_USP7_MATH_1	906	910	PF00917	0.652
DOC_USP7_MATH_1	918	922	PF00917	0.469
DOC_WW_Pin1_4	120	125	PF00397	0.740
DOC_WW_Pin1_4	132	137	PF00397	0.586
DOC_WW_Pin1_4	20	25	PF00397	0.729
DOC_WW_Pin1_4	203	208	PF00397	0.698
DOC_WW_Pin1_4	217	222	PF00397	0.707
DOC_WW_Pin1_4	240	245	PF00397	0.780
DOC_WW_Pin1_4	281	286	PF00397	0.807
DOC_WW_Pin1_4	635	640	PF00397	0.512
DOC_WW_Pin1_4	646	651	PF00397	0.199
DOC_WW_Pin1_4	65	70	PF00397	0.739
DOC_WW_Pin1_4	730	735	PF00397	0.533
DOC_WW_Pin1_4	901	906	PF00397	0.723
LIG_14-3-3_CanoR_1	167	172	PF00244	0.629
LIG_14-3-3_CanoR_1	240	244	PF00244	0.767
LIG_14-3-3_CanoR_1	281	285	PF00244	0.700
LIG_14-3-3_CanoR_1	397	407	PF00244	0.586
LIG_14-3-3_CanoR_1	546	555	PF00244	0.405
LIG_14-3-3_CanoR_1	61	66	PF00244	0.745
LIG_14-3-3_CanoR_1	699	704	PF00244	0.224
LIG_14-3-3_CanoR_1	735	743	PF00244	0.683
LIG_14-3-3_CanoR_1	963	972	PF00244	0.542
LIG_Actin_WH2_2	540	556	PF00022	0.430
LIG_APCC_ABBA_1	134	139	PF00400	0.745
LIG_Clathr_ClatBox_1	377	381	PF01394	0.629
LIG_Clathr_ClatBox_1	666	670	PF01394	0.411
LIG_deltaCOP1_diTrp_1	683	689	PF00928	0.411
LIG_deltaCOP1_diTrp_1	981	990	PF00928	0.560
LIG_EVH1_1	806	810	PF00568	0.568
LIG_FHA_1	104	110	PF00498	0.746
LIG_FHA_1	163	169	PF00498	0.732
LIG_FHA_1	172	178	PF00498	0.671
LIG_FHA_1	209	215	PF00498	0.591
LIG_FHA_1	252	258	PF00498	0.626
LIG_FHA_1	274	280	PF00498	0.729
LIG_FHA_1	289	295	PF00498	0.644
LIG_FHA_1	388	394	PF00498	0.522
LIG_FHA_1	4	10	PF00498	0.689
LIG_FHA_1	471	477	PF00498	0.411
LIG_FHA_1	497	503	PF00498	0.286
LIG_FHA_1	65	71	PF00498	0.768
LIG_FHA_1	726	732	PF00498	0.644
LIG_FHA_1	734	740	PF00498	0.623
LIG_FHA_1	902	908	PF00498	0.736
LIG_FHA_1	937	943	PF00498	0.431
LIG_FHA_2	171	177	PF00498	0.741
LIG_FHA_2	408	414	PF00498	0.384
LIG_FHA_2	656	662	PF00498	0.327
LIG_FHA_2	756	762	PF00498	0.718
LIG_FHA_2	929	935	PF00498	0.496
LIG_FHA_2	951	957	PF00498	0.467
LIG_HCF-1_HBM_1	670	673	PF13415	0.411
LIG_Integrin_RGD_1	871	873	PF01839	0.720
LIG_IRF3_LxIS_1	163	169	PF10401	0.728
LIG_LIR_Apic_2	155	161	PF02991	0.569
LIG_LIR_Apic_2	670	676	PF02991	0.411
LIG_LIR_Apic_2	677	682	PF02991	0.411
LIG_LIR_Gen_1	189	198	PF02991	0.676
LIG_LIR_Gen_1	681	690	PF02991	0.380
LIG_LIR_Nem_3	189	195	PF02991	0.677
LIG_LIR_Nem_3	478	484	PF02991	0.409
LIG_LIR_Nem_3	530	535	PF02991	0.327
LIG_LIR_Nem_3	681	687	PF02991	0.380
LIG_LIR_Nem_3	982	988	PF02991	0.563
LIG_MYND_1	664	668	PF01753	0.411
LIG_NRBOX	457	463	PF00104	0.430
LIG_REV1ctd_RIR_1	788	797	PF16727	0.566
LIG_SH2_NCK_1	679	683	PF00017	0.411
LIG_SH2_NCK_1	764	768	PF00017	0.564
LIG_SH2_PTP2	673	676	PF00017	0.352
LIG_SH2_SRC	679	682	PF00017	0.411
LIG_SH2_SRC	955	958	PF00017	0.468
LIG_SH2_STAP1	764	768	PF00017	0.564
LIG_SH2_STAP1	924	928	PF00017	0.658
LIG_SH2_STAT5	192	195	PF00017	0.601
LIG_SH2_STAT5	298	301	PF00017	0.649
LIG_SH2_STAT5	460	463	PF00017	0.430
LIG_SH2_STAT5	673	676	PF00017	0.352
LIG_SH2_STAT5	703	706	PF00017	0.411
LIG_SH2_STAT5	854	857	PF00017	0.570
LIG_SH2_STAT5	88	91	PF00017	0.743
LIG_SH3_1	647	653	PF00018	0.368
LIG_SH3_3	21	27	PF00018	0.726
LIG_SH3_3	418	424	PF00018	0.411
LIG_SH3_3	63	69	PF00018	0.807
LIG_SH3_3	647	653	PF00018	0.366
LIG_SH3_3	728	734	PF00018	0.524
LIG_SH3_3	804	810	PF00018	0.718
LIG_SUMO_SIM_anti_2	6	11	PF11976	0.618
LIG_SUMO_SIM_par_1	126	135	PF11976	0.715
LIG_SUMO_SIM_par_1	3	11	PF11976	0.660
LIG_SUMO_SIM_par_1	472	479	PF11976	0.411
LIG_TRAF2_1	198	201	PF00917	0.736
LIG_WW_2	807	810	PF00397	0.562
MOD_CDK_SPK_2	730	735	PF00069	0.533
MOD_CK1_1	100	106	PF00069	0.735
MOD_CK1_1	107	113	PF00069	0.745
MOD_CK1_1	126	132	PF00069	0.621
MOD_CK1_1	185	191	PF00069	0.813
MOD_CK1_1	226	232	PF00069	0.711
MOD_CK1_1	25	31	PF00069	0.730
MOD_CK1_1	3	9	PF00069	0.776
MOD_CK1_1	331	337	PF00069	0.740
MOD_CK1_1	399	405	PF00069	0.740
MOD_CK1_1	441	447	PF00069	0.341
MOD_CK1_1	501	507	PF00069	0.405
MOD_CK1_1	524	530	PF00069	0.373
MOD_CK1_1	632	638	PF00069	0.338
MOD_CK1_1	64	70	PF00069	0.726
MOD_CK1_1	640	646	PF00069	0.478
MOD_CK1_1	874	880	PF00069	0.683
MOD_CK1_1	897	903	PF00069	0.744
MOD_CK2_1	239	245	PF00069	0.733
MOD_CK2_1	33	39	PF00069	0.731
MOD_CK2_1	450	456	PF00069	0.411
MOD_CK2_1	655	661	PF00069	0.306
MOD_CK2_1	8	14	PF00069	0.749
MOD_CK2_1	928	934	PF00069	0.502
MOD_CK2_1	950	956	PF00069	0.471
MOD_CK2_1	967	973	PF00069	0.511
MOD_CMANNOS	686	689	PF00535	0.411
MOD_Cter_Amidation	611	614	PF01082	0.512
MOD_GlcNHglycan	1005	1008	PF01048	0.616
MOD_GlcNHglycan	120	123	PF01048	0.717
MOD_GlcNHglycan	139	142	PF01048	0.642
MOD_GlcNHglycan	266	269	PF01048	0.635
MOD_GlcNHglycan	271	274	PF01048	0.686
MOD_GlcNHglycan	344	347	PF01048	0.548
MOD_GlcNHglycan	353	356	PF01048	0.617
MOD_GlcNHglycan	357	360	PF01048	0.495
MOD_GlcNHglycan	385	388	PF01048	0.539
MOD_GlcNHglycan	401	404	PF01048	0.698
MOD_GlcNHglycan	450	453	PF01048	0.407
MOD_GlcNHglycan	519	522	PF01048	0.397
MOD_GlcNHglycan	639	642	PF01048	0.343
MOD_GlcNHglycan	676	679	PF01048	0.411
MOD_GlcNHglycan	717	720	PF01048	0.411
MOD_GlcNHglycan	723	726	PF01048	0.572
MOD_GlcNHglycan	736	739	PF01048	0.508
MOD_GlcNHglycan	777	780	PF01048	0.732
MOD_GlcNHglycan	822	825	PF01048	0.678
MOD_GlcNHglycan	828	831	PF01048	0.663
MOD_GlcNHglycan	849	852	PF01048	0.642
MOD_GlcNHglycan	896	899	PF01048	0.648
MOD_GSK3_1	103	110	PF00069	0.698
MOD_GSK3_1	120	127	PF00069	0.705
MOD_GSK3_1	162	169	PF00069	0.743
MOD_GSK3_1	171	178	PF00069	0.609
MOD_GSK3_1	182	189	PF00069	0.542
MOD_GSK3_1	213	220	PF00069	0.747
MOD_GSK3_1	22	29	PF00069	0.808
MOD_GSK3_1	221	228	PF00069	0.769
MOD_GSK3_1	235	242	PF00069	0.671
MOD_GSK3_1	251	258	PF00069	0.532
MOD_GSK3_1	269	276	PF00069	0.703
MOD_GSK3_1	279	286	PF00069	0.795
MOD_GSK3_1	288	295	PF00069	0.698
MOD_GSK3_1	327	334	PF00069	0.675
MOD_GSK3_1	351	358	PF00069	0.524
MOD_GSK3_1	383	390	PF00069	0.536
MOD_GSK3_1	397	404	PF00069	0.658
MOD_GSK3_1	407	414	PF00069	0.408
MOD_GSK3_1	484	491	PF00069	0.394
MOD_GSK3_1	496	503	PF00069	0.419
MOD_GSK3_1	517	524	PF00069	0.419
MOD_GSK3_1	60	67	PF00069	0.740
MOD_GSK3_1	635	642	PF00069	0.391
MOD_GSK3_1	685	692	PF00069	0.417
MOD_GSK3_1	721	728	PF00069	0.623
MOD_GSK3_1	729	736	PF00069	0.631
MOD_GSK3_1	828	835	PF00069	0.685
MOD_GSK3_1	890	897	PF00069	0.688
MOD_GSK3_1	93	100	PF00069	0.798
MOD_LATS_1	552	558	PF00433	0.430
MOD_N-GLC_1	107	112	PF02516	0.738
MOD_N-GLC_1	186	191	PF02516	0.630
MOD_N-GLC_1	250	255	PF02516	0.689
MOD_N-GLC_1	699	704	PF02516	0.224
MOD_N-GLC_1	86	91	PF02516	0.753
MOD_NEK2_1	1003	1008	PF00069	0.612
MOD_NEK2_1	166	171	PF00069	0.723
MOD_NEK2_1	223	228	PF00069	0.573
MOD_NEK2_1	293	298	PF00069	0.683
MOD_NEK2_1	351	356	PF00069	0.539
MOD_NEK2_1	373	378	PF00069	0.597
MOD_NEK2_1	522	527	PF00069	0.430
MOD_NEK2_1	715	720	PF00069	0.524
MOD_NEK2_1	721	726	PF00069	0.467
MOD_NEK2_1	936	941	PF00069	0.439
MOD_NEK2_1	950	955	PF00069	0.499
MOD_NEK2_2	235	240	PF00069	0.559
MOD_NEK2_2	315	320	PF00069	0.733
MOD_NEK2_2	906	911	PF00069	0.680
MOD_OFUCOSY	326	332	PF10250	0.711
MOD_PIKK_1	964	970	PF00454	0.554
MOD_PK_1	61	67	PF00069	0.794
MOD_PKA_1	837	843	PF00069	0.742
MOD_PKA_2	147	153	PF00069	0.814
MOD_PKA_2	166	172	PF00069	0.502
MOD_PKA_2	182	188	PF00069	0.590
MOD_PKA_2	239	245	PF00069	0.733
MOD_PKA_2	273	279	PF00069	0.777
MOD_PKA_2	280	286	PF00069	0.706
MOD_PKA_2	342	348	PF00069	0.576
MOD_PKA_2	396	402	PF00069	0.550
MOD_PKA_2	438	444	PF00069	0.512
MOD_PKA_2	522	528	PF00069	0.401
MOD_PKA_2	60	66	PF00069	0.718
MOD_PKA_2	734	740	PF00069	0.677
MOD_PKA_2	964	970	PF00069	0.554
MOD_PKB_1	325	333	PF00069	0.711
MOD_PKB_1	888	896	PF00069	0.644
MOD_Plk_1	3	9	PF00069	0.586
MOD_Plk_1	315	321	PF00069	0.817
MOD_Plk_1	669	675	PF00069	0.401
MOD_Plk_1	699	705	PF00069	0.224
MOD_Plk_1	981	987	PF00069	0.564
MOD_Plk_2-3	981	987	PF00069	0.564
MOD_Plk_4	188	194	PF00069	0.532
MOD_Plk_4	294	300	PF00069	0.677
MOD_Plk_4	373	379	PF00069	0.633
MOD_Plk_4	387	393	PF00069	0.524
MOD_Plk_4	476	482	PF00069	0.340
MOD_Plk_4	669	675	PF00069	0.401
MOD_Plk_4	699	705	PF00069	0.276
MOD_Plk_4	967	973	PF00069	0.511
MOD_ProDKin_1	120	126	PF00069	0.738
MOD_ProDKin_1	132	138	PF00069	0.584
MOD_ProDKin_1	20	26	PF00069	0.728
MOD_ProDKin_1	203	209	PF00069	0.695
MOD_ProDKin_1	217	223	PF00069	0.710
MOD_ProDKin_1	240	246	PF00069	0.778
MOD_ProDKin_1	281	287	PF00069	0.807
MOD_ProDKin_1	635	641	PF00069	0.512
MOD_ProDKin_1	646	652	PF00069	0.199
MOD_ProDKin_1	65	71	PF00069	0.741
MOD_ProDKin_1	730	736	PF00069	0.541
MOD_ProDKin_1	901	907	PF00069	0.727
TRG_DiLeu_BaLyEn_6	70	75	PF01217	0.735
TRG_DiLeu_BaLyEn_6	938	943	PF01217	0.443
TRG_ENDOCYTIC_2	192	195	PF00928	0.683
TRG_ENDOCYTIC_2	684	687	PF00928	0.396
TRG_ER_diArg_1	239	241	PF00400	0.784
TRG_ER_diArg_1	247	249	PF00400	0.735
TRG_ER_diArg_1	319	322	PF00400	0.806
TRG_ER_diArg_1	323	325	PF00400	0.826
TRG_ER_diArg_1	44	47	PF00400	0.726
TRG_ER_diArg_1	619	622	PF00400	0.368
TRG_ER_diArg_1	887	890	PF00400	0.607
TRG_ER_diArg_1	962	965	PF00400	0.468
TRG_ER_diArg_1	996	999	PF00400	0.488
TRG_Pf-PMV_PEXEL_1	590	595	PF00026	0.411
TRG_Pf-PMV_PEXEL_1	784	789	PF00026	0.606

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD91	Leptomonas seymouri	45%	100%
A4HFZ1	Leishmania braziliensis	61%	100%
A4I310	Leishmania infantum	98%	100%
E9ADJ4	Leishmania major	85%	100%
E9AZC0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%