LeishMANIAdb
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SAM-dependent methyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
SAM-dependent methyltransferase
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3Q8IEE9_LEIDO
TriTrypDb:
LdBPK_280010.1 * , LdCL_280005000 , LDHU3_28.0030
Length:
550

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IEE9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEE9

Function

Biological processes
Term Name Level Count
GO:0006793 phosphorus metabolic process 3 3
GO:0006796 phosphate-containing compound metabolic process 4 3
GO:0008152 metabolic process 1 3
GO:0009987 cellular process 1 3
GO:0016310 phosphorylation 5 3
GO:0044237 cellular metabolic process 2 3
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 3
GO:0016301 kinase activity 4 3
GO:0016740 transferase activity 2 3
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 113 117 PF00656 0.500
CLV_C14_Caspase3-7 41 45 PF00656 0.433
CLV_NRD_NRD_1 105 107 PF00675 0.380
CLV_NRD_NRD_1 141 143 PF00675 0.505
CLV_NRD_NRD_1 15 17 PF00675 0.496
CLV_NRD_NRD_1 2 4 PF00675 0.707
CLV_NRD_NRD_1 261 263 PF00675 0.409
CLV_NRD_NRD_1 293 295 PF00675 0.523
CLV_NRD_NRD_1 376 378 PF00675 0.404
CLV_NRD_NRD_1 410 412 PF00675 0.521
CLV_NRD_NRD_1 512 514 PF00675 0.617
CLV_NRD_NRD_1 545 547 PF00675 0.687
CLV_PCSK_KEX2_1 105 107 PF00082 0.380
CLV_PCSK_KEX2_1 141 143 PF00082 0.400
CLV_PCSK_KEX2_1 15 17 PF00082 0.491
CLV_PCSK_KEX2_1 2 4 PF00082 0.571
CLV_PCSK_KEX2_1 376 378 PF00082 0.404
CLV_PCSK_KEX2_1 410 412 PF00082 0.567
CLV_PCSK_KEX2_1 51 53 PF00082 0.514
CLV_PCSK_KEX2_1 544 546 PF00082 0.651
CLV_PCSK_PC1ET2_1 410 412 PF00082 0.609
CLV_PCSK_PC1ET2_1 51 53 PF00082 0.514
CLV_PCSK_PC7_1 101 107 PF00082 0.372
CLV_PCSK_PC7_1 540 546 PF00082 0.651
CLV_PCSK_SKI1_1 15 19 PF00082 0.441
CLV_PCSK_SKI1_1 181 185 PF00082 0.517
CLV_PCSK_SKI1_1 457 461 PF00082 0.543
CLV_PCSK_SKI1_1 540 544 PF00082 0.520
CLV_PCSK_SKI1_1 96 100 PF00082 0.489
DEG_APCC_DBOX_1 2 10 PF00400 0.655
DEG_APCC_DBOX_1 28 36 PF00400 0.434
DEG_APCC_DBOX_1 413 421 PF00400 0.369
DEG_Nend_UBRbox_1 1 4 PF02207 0.598
DOC_CKS1_1 384 389 PF01111 0.504
DOC_CYCLIN_RxL_1 10 23 PF00134 0.551
DOC_CYCLIN_RxL_1 222 233 PF00134 0.436
DOC_CYCLIN_yCln2_LP_2 179 185 PF00134 0.536
DOC_CYCLIN_yCln2_LP_2 190 196 PF00134 0.479
DOC_MAPK_gen_1 267 276 PF00069 0.440
DOC_MAPK_gen_1 294 303 PF00069 0.393
DOC_MAPK_gen_1 373 381 PF00069 0.406
DOC_MAPK_gen_1 410 419 PF00069 0.404
DOC_MAPK_gen_1 445 453 PF00069 0.648
DOC_MAPK_gen_1 457 465 PF00069 0.533
DOC_MAPK_MEF2A_6 201 210 PF00069 0.462
DOC_PP2B_LxvP_1 190 193 PF13499 0.498
DOC_PP4_FxxP_1 217 220 PF00568 0.390
DOC_PP4_FxxP_1 398 401 PF00568 0.517
DOC_PP4_FxxP_1 55 58 PF00568 0.349
DOC_SPAK_OSR1_1 377 381 PF12202 0.504
DOC_USP7_MATH_1 81 85 PF00917 0.499
DOC_USP7_UBL2_3 445 449 PF12436 0.594
DOC_WW_Pin1_4 265 270 PF00397 0.577
DOC_WW_Pin1_4 337 342 PF00397 0.471
DOC_WW_Pin1_4 383 388 PF00397 0.471
DOC_WW_Pin1_4 535 540 PF00397 0.481
LIG_14-3-3_CanoR_1 15 20 PF00244 0.537
LIG_14-3-3_CanoR_1 169 175 PF00244 0.458
LIG_14-3-3_CanoR_1 411 420 PF00244 0.560
LIG_14-3-3_CanoR_1 497 501 PF00244 0.613
LIG_14-3-3_CterR_2 545 550 PF00244 0.701
LIG_deltaCOP1_diTrp_1 107 114 PF00928 0.409
LIG_EVH1_2 198 202 PF00568 0.440
LIG_FHA_1 155 161 PF00498 0.465
LIG_FHA_1 394 400 PF00498 0.537
LIG_FHA_1 421 427 PF00498 0.558
LIG_FHA_1 88 94 PF00498 0.521
LIG_FHA_2 108 114 PF00498 0.494
LIG_LIR_Apic_2 363 367 PF02991 0.596
LIG_LIR_Apic_2 382 387 PF02991 0.297
LIG_LIR_Apic_2 396 401 PF02991 0.454
LIG_LIR_Gen_1 162 171 PF02991 0.370
LIG_LIR_Gen_1 333 343 PF02991 0.485
LIG_LIR_Gen_1 44 55 PF02991 0.395
LIG_LIR_Nem_3 107 111 PF02991 0.359
LIG_LIR_Nem_3 148 153 PF02991 0.382
LIG_LIR_Nem_3 162 167 PF02991 0.350
LIG_LIR_Nem_3 170 174 PF02991 0.375
LIG_LIR_Nem_3 280 285 PF02991 0.589
LIG_LIR_Nem_3 333 339 PF02991 0.489
LIG_LIR_Nem_3 44 50 PF02991 0.391
LIG_LIR_Nem_3 469 473 PF02991 0.503
LIG_LIR_Nem_3 501 507 PF02991 0.612
LIG_LIR_Nem_3 78 83 PF02991 0.424
LIG_LYPXL_yS_3 504 507 PF13949 0.599
LIG_LYPXL_yS_3 80 83 PF13949 0.434
LIG_Pex14_1 213 217 PF04695 0.386
LIG_PTB_Apo_2 124 131 PF02174 0.385
LIG_PTB_Apo_2 270 277 PF02174 0.554
LIG_REV1ctd_RIR_1 333 340 PF16727 0.510
LIG_SH2_CRK 194 198 PF00017 0.514
LIG_SH2_CRK 298 302 PF00017 0.393
LIG_SH2_CRK 384 388 PF00017 0.409
LIG_SH2_CRK 47 51 PF00017 0.487
LIG_SH2_NCK_1 384 388 PF00017 0.514
LIG_SH2_PTP2 164 167 PF00017 0.472
LIG_SH2_PTP2 34 37 PF00017 0.357
LIG_SH2_SRC 34 37 PF00017 0.489
LIG_SH2_STAP1 161 165 PF00017 0.330
LIG_SH2_STAP1 298 302 PF00017 0.393
LIG_SH2_STAP1 370 374 PF00017 0.447
LIG_SH2_STAT5 129 132 PF00017 0.408
LIG_SH2_STAT5 146 149 PF00017 0.300
LIG_SH2_STAT5 150 153 PF00017 0.368
LIG_SH2_STAT5 164 167 PF00017 0.246
LIG_SH2_STAT5 34 37 PF00017 0.380
LIG_SH2_STAT5 534 537 PF00017 0.590
LIG_SH3_3 179 185 PF00018 0.410
LIG_SH3_3 359 365 PF00018 0.441
LIG_SH3_3 499 505 PF00018 0.501
LIG_SUMO_SIM_anti_2 205 211 PF11976 0.485
LIG_TRAF2_1 305 308 PF00917 0.517
LIG_TYR_ITIM 192 197 PF00017 0.462
LIG_TYR_ITIM 32 37 PF00017 0.385
LIG_UBA3_1 207 211 PF00899 0.484
LIG_WRC_WIRS_1 168 173 PF05994 0.374
MOD_CDK_SPK_2 265 270 PF00069 0.577
MOD_CDK_SPK_2 535 540 PF00069 0.481
MOD_CDK_SPxK_1 383 389 PF00069 0.500
MOD_CK1_1 154 160 PF00069 0.431
MOD_CK1_1 170 176 PF00069 0.494
MOD_CK1_1 200 206 PF00069 0.467
MOD_CK1_1 272 278 PF00069 0.517
MOD_CK1_1 42 48 PF00069 0.448
MOD_CK2_1 169 175 PF00069 0.440
MOD_CK2_1 535 541 PF00069 0.538
MOD_GlcNHglycan 232 235 PF01048 0.397
MOD_GlcNHglycan 310 313 PF01048 0.601
MOD_GlcNHglycan 390 393 PF01048 0.586
MOD_GlcNHglycan 83 86 PF01048 0.503
MOD_GSK3_1 265 272 PF00069 0.517
MOD_GSK3_1 337 344 PF00069 0.464
MOD_GSK3_1 496 503 PF00069 0.614
MOD_N-GLC_1 119 124 PF02516 0.399
MOD_N-GLC_1 272 277 PF02516 0.554
MOD_NEK2_1 119 124 PF00069 0.394
MOD_NEK2_1 167 172 PF00069 0.380
MOD_NEK2_1 526 531 PF00069 0.529
MOD_NEK2_2 5 10 PF00069 0.578
MOD_PIKK_1 133 139 PF00454 0.387
MOD_PIKK_1 200 206 PF00454 0.529
MOD_PK_1 422 428 PF00069 0.505
MOD_PKA_1 15 21 PF00069 0.382
MOD_PKA_2 15 21 PF00069 0.499
MOD_PKA_2 388 394 PF00069 0.575
MOD_PKA_2 496 502 PF00069 0.618
MOD_Plk_1 119 125 PF00069 0.391
MOD_Plk_1 154 160 PF00069 0.372
MOD_Plk_1 21 27 PF00069 0.513
MOD_Plk_1 272 278 PF00069 0.556
MOD_Plk_2-3 107 113 PF00069 0.498
MOD_Plk_4 175 181 PF00069 0.464
MOD_Plk_4 42 48 PF00069 0.394
MOD_ProDKin_1 265 271 PF00069 0.567
MOD_ProDKin_1 337 343 PF00069 0.465
MOD_ProDKin_1 383 389 PF00069 0.480
MOD_ProDKin_1 535 541 PF00069 0.481
MOD_SUMO_rev_2 369 374 PF00179 0.418
MOD_SUMO_rev_2 469 475 PF00179 0.627
TRG_DiLeu_BaEn_1 155 160 PF01217 0.389
TRG_DiLeu_BaEn_1 163 168 PF01217 0.326
TRG_DiLeu_BaEn_1 175 180 PF01217 0.303
TRG_DiLeu_BaEn_1 205 210 PF01217 0.483
TRG_DiLeu_BaLyEn_6 473 478 PF01217 0.614
TRG_ENDOCYTIC_2 150 153 PF00928 0.374
TRG_ENDOCYTIC_2 164 167 PF00928 0.323
TRG_ENDOCYTIC_2 194 197 PF00928 0.512
TRG_ENDOCYTIC_2 298 301 PF00928 0.384
TRG_ENDOCYTIC_2 34 37 PF00928 0.369
TRG_ENDOCYTIC_2 47 50 PF00928 0.363
TRG_ENDOCYTIC_2 504 507 PF00928 0.599
TRG_ENDOCYTIC_2 80 83 PF00928 0.434
TRG_ER_diArg_1 1 3 PF00400 0.633
TRG_ER_diArg_1 104 106 PF00400 0.365
TRG_ER_diArg_1 140 142 PF00400 0.516
TRG_ER_diArg_1 15 17 PF00400 0.543
TRG_ER_diArg_1 254 257 PF00400 0.539
TRG_ER_diArg_1 376 378 PF00400 0.404
TRG_ER_diArg_1 543 546 PF00400 0.670
TRG_NLS_MonoExtC_3 293 299 PF00514 0.549
TRG_NLS_MonoExtC_3 409 414 PF00514 0.515
TRG_NLS_MonoExtN_4 407 414 PF00514 0.514
TRG_Pf-PMV_PEXEL_1 411 416 PF00026 0.450
TRG_Pf-PMV_PEXEL_1 479 483 PF00026 0.653

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I7B7 Leptomonas seymouri 75% 100%
A0A0S4IYT6 Bodo saltans 49% 90%
A0A1X0NV91 Trypanosomatidae 55% 99%
A0A422NKU0 Trypanosoma rangeli 55% 99%
A4I374 Leishmania infantum 100% 100%
D0A7Q0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 53% 99%
E9AIS9 Leishmania braziliensis 85% 100%
E9AZG2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
Q4Q8R9 Leishmania major 96% 100%
V5AS03 Trypanosoma cruzi 54% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS