Proteasome regulatory subunit C-terminal family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

proteasome regulatory non-ATP-ase subunit 3, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IEE7_LEIDO

TriTrypDb:

LdBPK_271370.1 , LdCL_270020500 , LDHU3_27.2110

Length:

334

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000502	proteasome complex	3	11
GO:0032991	protein-containing complex	1	12
GO:0140535	intracellular protein-containing complex	2	11
GO:1902494	catalytic complex	2	11
GO:1905368	peptidase complex	3	11
GO:1905369	endopeptidase complex	4	11
GO:0005737	cytoplasm	2	1
GO:0008541	proteasome regulatory particle, lid subcomplex	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IEE7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEE7

Function

Biological processes
Term	Name	Level	Count
GO:0009894	regulation of catabolic process	4	12
GO:0019222	regulation of metabolic process	3	12
GO:0042176	regulation of protein catabolic process	5	12
GO:0050789	regulation of biological process	2	12
GO:0051171	regulation of nitrogen compound metabolic process	4	12
GO:0051246	regulation of protein metabolic process	5	12
GO:0060255	regulation of macromolecule metabolic process	4	12
GO:0065007	biological regulation	1	12
GO:0080090	regulation of primary metabolic process	4	12
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0030234	enzyme regulator activity	2	12
GO:0098772	molecular function regulator activity	1	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	148	152	PF00656	0.604
CLV_C14_Caspase3-7	282	286	PF00656	0.423
CLV_C14_Caspase3-7	323	327	PF00656	0.702
CLV_C14_Caspase3-7	98	102	PF00656	0.450
CLV_NRD_NRD_1	110	112	PF00675	0.441
CLV_NRD_NRD_1	204	206	PF00675	0.317
CLV_NRD_NRD_1	274	276	PF00675	0.354
CLV_NRD_NRD_1	303	305	PF00675	0.355
CLV_PCSK_KEX2_1	17	19	PF00082	0.673
CLV_PCSK_KEX2_1	204	206	PF00082	0.317
CLV_PCSK_KEX2_1	274	276	PF00082	0.354
CLV_PCSK_KEX2_1	287	289	PF00082	0.354
CLV_PCSK_KEX2_1	303	305	PF00082	0.354
CLV_PCSK_PC1ET2_1	17	19	PF00082	0.666
CLV_PCSK_PC1ET2_1	287	289	PF00082	0.354
CLV_PCSK_SKI1_1	170	174	PF00082	0.356
CLV_PCSK_SKI1_1	26	30	PF00082	0.493
CLV_PCSK_SKI1_1	305	309	PF00082	0.472
DEG_ODPH_VHL_1	153	165	PF01847	0.431
DEG_SPOP_SBC_1	262	266	PF00917	0.369
DOC_CYCLIN_RxL_1	90	101	PF00134	0.444
DOC_MAPK_gen_1	274	281	PF00069	0.389
DOC_MAPK_MEF2A_6	126	135	PF00069	0.383
DOC_MAPK_MEF2A_6	150	159	PF00069	0.421
DOC_MAPK_MEF2A_6	186	194	PF00069	0.517
DOC_PP1_RVXF_1	272	279	PF00149	0.369
DOC_WW_Pin1_4	5	10	PF00397	0.708
LIG_14-3-3_CanoR_1	170	175	PF00244	0.599
LIG_14-3-3_CanoR_1	186	191	PF00244	0.454
LIG_14-3-3_CanoR_1	212	222	PF00244	0.571
LIG_14-3-3_CanoR_1	26	31	PF00244	0.547
LIG_Actin_WH2_2	191	206	PF00022	0.517
LIG_FHA_1	185	191	PF00498	0.528
LIG_FHA_1	67	73	PF00498	0.508
LIG_FHA_1	90	96	PF00498	0.410
LIG_FHA_2	280	286	PF00498	0.373
LIG_FHA_2	293	299	PF00498	0.395
LIG_FHA_2	321	327	PF00498	0.727
LIG_LIR_Gen_1	169	175	PF02991	0.611
LIG_LIR_LC3C_4	128	131	PF02991	0.434
LIG_LIR_Nem_3	169	174	PF02991	0.627
LIG_LIR_Nem_3	29	34	PF02991	0.513
LIG_PDZ_Class_3	329	334	PF00595	0.671
LIG_PTB_Apo_2	324	331	PF02174	0.742
LIG_SH2_CRK	210	214	PF00017	0.517
LIG_SH2_CRK	31	35	PF00017	0.445
LIG_SH2_NCK_1	210	214	PF00017	0.517
LIG_SH2_PTP2	88	91	PF00017	0.400
LIG_SH2_SRC	99	102	PF00017	0.415
LIG_SH2_STAT5	156	159	PF00017	0.517
LIG_SH2_STAT5	232	235	PF00017	0.517
LIG_SH2_STAT5	85	88	PF00017	0.402
LIG_SH2_STAT5	99	102	PF00017	0.410
LIG_SH3_3	291	297	PF00018	0.501
LIG_SUMO_SIM_anti_2	125	131	PF11976	0.377
LIG_TYR_ITSM	27	34	PF00017	0.471
LIG_WW_3	138	142	PF00397	0.451
MOD_CK1_1	211	217	PF00069	0.542
MOD_CK1_1	256	262	PF00069	0.519
MOD_CK2_1	261	267	PF00069	0.393
MOD_CK2_1	292	298	PF00069	0.450
MOD_GSK3_1	213	220	PF00069	0.603
MOD_GSK3_1	22	29	PF00069	0.616
MOD_GSK3_1	66	73	PF00069	0.510
MOD_LATS_1	184	190	PF00433	0.517
MOD_N-GLC_1	10	15	PF02516	0.701
MOD_N-GLC_1	279	284	PF02516	0.354
MOD_N-GLC_1	70	75	PF02516	0.661
MOD_NEK2_1	149	154	PF00069	0.468
MOD_NEK2_1	222	227	PF00069	0.610
MOD_NEK2_1	279	284	PF00069	0.389
MOD_NEK2_1	53	58	PF00069	0.453
MOD_NEK2_1	66	71	PF00069	0.464
MOD_PKA_2	149	155	PF00069	0.510
MOD_PKA_2	211	217	PF00069	0.520
MOD_Plk_1	70	76	PF00069	0.523
MOD_Plk_4	125	131	PF00069	0.413
MOD_Plk_4	170	176	PF00069	0.532
MOD_Plk_4	186	192	PF00069	0.517
MOD_Plk_4	26	32	PF00069	0.571
MOD_ProDKin_1	5	11	PF00069	0.707
MOD_SUMO_for_1	307	310	PF00179	0.497
MOD_SUMO_rev_2	301	309	PF00179	0.491
TRG_DiLeu_BaEn_1	250	255	PF01217	0.528
TRG_ENDOCYTIC_2	156	159	PF00928	0.529
TRG_ENDOCYTIC_2	210	213	PF00928	0.517
TRG_ENDOCYTIC_2	31	34	PF00928	0.446
TRG_ENDOCYTIC_2	88	91	PF00928	0.400
TRG_ER_diArg_1	203	205	PF00400	0.566
TRG_ER_diArg_1	274	276	PF00400	0.369
TRG_Pf-PMV_PEXEL_1	204	208	PF00026	0.342
TRG_Pf-PMV_PEXEL_1	316	320	PF00026	0.408
TRG_Pf-PMV_PEXEL_1	93	98	PF00026	0.452

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I651	Leptomonas seymouri	92%	100%
A0A0S4JNS0	Bodo saltans	63%	95%
A0A1X0P493	Trypanosomatidae	72%	100%
A0A3R7N9B6	Trypanosoma rangeli	72%	100%
A4HFS3	Leishmania braziliensis	97%	100%
A4I372	Leishmania infantum	100%	100%
D0A615	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	71%	84%
E9ADC7	Leishmania major	99%	100%
E9AZ51	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
O42897	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	39%	67%
O61470	Anopheles gambiae	44%	67%
P25161	Drosophila melanogaster	43%	68%
P93768	Nicotiana tabacum	44%	68%
Q04908	Caenorhabditis elegans	42%	66%
Q06364	Daucus carota	44%	68%
Q1ZXD3	Dictyostelium discoideum	40%	66%
Q7ZTN8	Xenopus laevis	21%	79%
Q8SRT7	Encephalitozoon cuniculi (strain GB-M1)	25%	89%
Q9LNU4	Arabidopsis thaliana	42%	68%
Q9LQR8	Arabidopsis thaliana	44%	69%
Q9U5Z8	Anopheles stephensi	44%	67%
V5B0Y8	Trypanosoma cruzi	73%	100%