Small_nuclear_ribonucleoprotein_protein_putative/ GeneDB:LmjF.27.1970

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

small nuclear ribonucleoprotein protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IEE4_LEIDO

TriTrypDb:

LdBPK_271890.1 , LdCL_270026100 , LDHU3_27.2870

Length:

111

Annotations

Annotations by Jardim et al.

Nucleic acid binding, small nuclear ribonucleo

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	11
GO:1990904	ribonucleoprotein complex	2	11
GO:0005634	nucleus	5	1
GO:0005681	spliceosomal complex	3	1
GO:0005682	U5 snRNP	5	1
GO:0005684	U2-type spliceosomal complex	4	1
GO:0005685	U1 snRNP	5	1
GO:0005686	U2 snRNP	5	1
GO:0005687	U4 snRNP	5	1
GO:0005737	cytoplasm	2	1
GO:0030532	small nuclear ribonucleoprotein complex	3	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0046540	U4/U6 x U5 tri-snRNP complex	6	1
GO:0071004	U2-type prespliceosome	5	1
GO:0071010	prespliceosome	4	1
GO:0071013	catalytic step 2 spliceosome	3	1
GO:0097525	spliceosomal snRNP complex	4	1
GO:0097526	spliceosomal tri-snRNP complex	5	1
GO:0110165	cellular anatomical entity	1	1
GO:0120114	Sm-like protein family complex	2	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

A0A3Q8IEE4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEE4

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	1
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	1
GO:0000398	mRNA splicing, via spliceosome	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006397	mRNA processing	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008380	RNA splicing	7	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	106	108	PF00675	0.728
CLV_PCSK_KEX2_1	106	108	PF00082	0.656
CLV_PCSK_KEX2_1	60	62	PF00082	0.419
CLV_PCSK_PC1ET2_1	106	108	PF00082	0.656
CLV_PCSK_PC1ET2_1	60	62	PF00082	0.419
CLV_PCSK_SKI1_1	22	26	PF00082	0.344
CLV_PCSK_SKI1_1	98	102	PF00082	0.747
DOC_CYCLIN_RxL_1	22	32	PF00134	0.574
DOC_MAPK_gen_1	60	68	PF00069	0.576
DOC_MAPK_HePTP_8	66	78	PF00069	0.558
DOC_MAPK_MEF2A_6	60	67	PF00069	0.581
DOC_MAPK_MEF2A_6	69	78	PF00069	0.528
DOC_MAPK_NFAT4_5	60	68	PF00069	0.624
DOC_PP1_RVXF_1	25	32	PF00149	0.574
DOC_WW_Pin1_4	55	60	PF00397	0.512
LIG_Clathr_ClatBox_1	28	32	PF01394	0.596
LIG_FHA_1	23	29	PF00498	0.570
LIG_SH2_CRK	4	8	PF00017	0.588
LIG_SH2_STAT5	4	7	PF00017	0.563
LIG_SUMO_SIM_anti_2	75	80	PF11976	0.692
LIG_SUMO_SIM_par_1	71	77	PF11976	0.550
LIG_TRAF2_1	42	45	PF00917	0.624
LIG_UBA3_1	6	12	PF00899	0.582
MOD_CDC14_SPxK_1	58	61	PF00782	0.536
MOD_CDK_SPK_2	55	60	PF00069	0.578
MOD_CDK_SPxK_1	55	61	PF00069	0.536
MOD_GlcNHglycan	86	89	PF01048	0.700
MOD_GlcNHglycan	98	101	PF01048	0.541
MOD_GSK3_1	96	103	PF00069	0.787
MOD_Plk_4	2	8	PF00069	0.551
MOD_Plk_4	74	80	PF00069	0.565
MOD_ProDKin_1	55	61	PF00069	0.512
TRG_ENDOCYTIC_2	4	7	PF00928	0.593
TRG_ER_diLys_1	106	111	PF00400	0.728
TRG_NLS_MonoCore_2	105	110	PF00514	0.794
TRG_NLS_MonoExtN_4	106	111	PF00514	0.721

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Y3	Leptomonas seymouri	80%	100%
A0A0S4J6U1	Bodo saltans	49%	100%
A0A1X0NSU4	Trypanosomatidae	59%	100%
A0A3R7MNH5	Trypanosoma rangeli	58%	97%
A4HFX2	Leishmania braziliensis	91%	100%
A4I304	Leishmania infantum	100%	100%
C9ZJF6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9ADH7	Leishmania major	97%	100%
E9AZA1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
P91918	Caenorhabditis elegans	43%	69%
Q10163	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	44%	76%
Q9D2U5	Mus musculus	38%	89%