Lipase_3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IEE2_LEIDO

TriTrypDb:

LdBPK_291980.1 , LdCL_290025700 , LDHU3_29.2830

Length:

554

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005777	peroxisome	6	1
GO:0020015	glycosome	7	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IEE2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEE2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	430	434	PF00656	0.515
CLV_NRD_NRD_1	445	447	PF00675	0.499
CLV_NRD_NRD_1	454	456	PF00675	0.477
CLV_NRD_NRD_1	481	483	PF00675	0.459
CLV_PCSK_KEX2_1	445	447	PF00082	0.455
CLV_PCSK_KEX2_1	453	455	PF00082	0.381
CLV_PCSK_SKI1_1	375	379	PF00082	0.531
CLV_PCSK_SKI1_1	466	470	PF00082	0.425
DEG_APCC_DBOX_1	136	144	PF00400	0.428
DEG_SPOP_SBC_1	272	276	PF00917	0.753
DOC_MAPK_gen_1	134	142	PF00069	0.460
DOC_MAPK_gen_1	263	273	PF00069	0.651
DOC_MAPK_gen_1	482	489	PF00069	0.466
DOC_MAPK_JIP1_4	15	21	PF00069	0.575
DOC_PP2B_LxvP_1	206	209	PF13499	0.386
DOC_PP4_FxxP_1	119	122	PF00568	0.420
DOC_PP4_FxxP_1	179	182	PF00568	0.361
DOC_PP4_FxxP_1	238	241	PF00568	0.651
DOC_USP7_MATH_1	194	198	PF00917	0.399
DOC_USP7_MATH_1	272	276	PF00917	0.764
DOC_USP7_MATH_1	318	322	PF00917	0.638
DOC_USP7_MATH_1	329	333	PF00917	0.557
DOC_USP7_MATH_1	549	553	PF00917	0.656
DOC_WW_Pin1_4	178	183	PF00397	0.358
DOC_WW_Pin1_4	252	257	PF00397	0.684
DOC_WW_Pin1_4	307	312	PF00397	0.707
DOC_WW_Pin1_4	545	550	PF00397	0.677
LIG_14-3-3_CanoR_1	103	111	PF00244	0.456
LIG_14-3-3_CanoR_1	446	452	PF00244	0.429
LIG_14-3-3_CanoR_1	472	478	PF00244	0.392
LIG_14-3-3_CanoR_1	503	509	PF00244	0.371
LIG_APCC_ABBA_1	115	120	PF00400	0.415
LIG_eIF4E_1	347	353	PF01652	0.586
LIG_FHA_1	103	109	PF00498	0.430
LIG_FHA_1	172	178	PF00498	0.365
LIG_FHA_1	225	231	PF00498	0.532
LIG_FHA_1	234	240	PF00498	0.635
LIG_FHA_1	379	385	PF00498	0.503
LIG_FHA_1	421	427	PF00498	0.523
LIG_FHA_1	458	464	PF00498	0.438
LIG_Integrin_RGD_1	10	12	PF01839	0.491
LIG_LIR_Apic_2	178	182	PF02991	0.357
LIG_LIR_Apic_2	236	241	PF02991	0.642
LIG_LIR_Gen_1	67	73	PF02991	0.383
LIG_LIR_Nem_3	150	155	PF02991	0.414
LIG_LIR_Nem_3	282	287	PF02991	0.547
LIG_LIR_Nem_3	438	443	PF02991	0.503
LIG_LIR_Nem_3	67	72	PF02991	0.388
LIG_LIR_Nem_3	83	88	PF02991	0.273
LIG_MYND_1	26	30	PF01753	0.436
LIG_PDZ_Class_1	549	554	PF00595	0.626
LIG_Pex14_1	151	155	PF04695	0.387
LIG_SH2_CRK	284	288	PF00017	0.552
LIG_SH2_CRK	44	48	PF00017	0.321
LIG_SH2_SRC	462	465	PF00017	0.449
LIG_SH2_STAP1	44	48	PF00017	0.392
LIG_SH2_STAP1	508	512	PF00017	0.297
LIG_SH2_STAT3	118	121	PF00017	0.490
LIG_SH2_STAT5	118	121	PF00017	0.431
LIG_SH2_STAT5	155	158	PF00017	0.373
LIG_SH2_STAT5	205	208	PF00017	0.389
LIG_SH2_STAT5	221	224	PF00017	0.365
LIG_SH2_STAT5	347	350	PF00017	0.529
LIG_SH2_STAT5	351	354	PF00017	0.523
LIG_SH2_STAT5	366	369	PF00017	0.536
LIG_SH2_STAT5	440	443	PF00017	0.455
LIG_SH2_STAT5	449	452	PF00017	0.389
LIG_SH2_STAT5	462	465	PF00017	0.377
LIG_SH2_STAT5	504	507	PF00017	0.363
LIG_SH2_STAT5	518	521	PF00017	0.319
LIG_SH2_STAT5	52	55	PF00017	0.402
LIG_SH2_STAT5	85	88	PF00017	0.326
LIG_SH2_STAT5	90	93	PF00017	0.345
LIG_SH3_3	227	233	PF00018	0.527
LIG_SH3_3	238	244	PF00018	0.640
LIG_SH3_3	285	291	PF00018	0.543
LIG_SH3_3	308	314	PF00018	0.696
LIG_SH3_3	520	526	PF00018	0.451
LIG_SH3_3	60	66	PF00018	0.472
LIG_SUMO_SIM_anti_2	18	24	PF11976	0.588
LIG_SUMO_SIM_anti_2	32	37	PF11976	0.447
LIG_SUMO_SIM_par_1	15	20	PF11976	0.610
LIG_SUMO_SIM_par_1	171	178	PF11976	0.421
LIG_SUMO_SIM_par_1	221	227	PF11976	0.472
LIG_SUMO_SIM_par_1	485	491	PF11976	0.451
LIG_TRAF2_1	169	172	PF00917	0.393
LIG_WRC_WIRS_1	339	344	PF05994	0.617
MOD_CDC14_SPxK_1	548	551	PF00782	0.684
MOD_CDK_SPK_2	252	257	PF00069	0.702
MOD_CDK_SPxK_1	545	551	PF00069	0.679
MOD_CDK_SPxxK_3	178	185	PF00069	0.342
MOD_CK1_1	255	261	PF00069	0.650
MOD_CK1_1	262	268	PF00069	0.598
MOD_CK1_1	274	280	PF00069	0.754
MOD_CK1_1	297	303	PF00069	0.717
MOD_CK1_1	321	327	PF00069	0.648
MOD_CK1_1	386	392	PF00069	0.491
MOD_CK2_1	194	200	PF00069	0.424
MOD_DYRK1A_RPxSP_1	309	313	PF00069	0.645
MOD_GlcNHglycan	147	150	PF01048	0.449
MOD_GlcNHglycan	233	236	PF01048	0.617
MOD_GlcNHglycan	257	260	PF01048	0.691
MOD_GlcNHglycan	281	284	PF01048	0.622
MOD_GlcNHglycan	323	326	PF01048	0.640
MOD_GlcNHglycan	331	334	PF01048	0.581
MOD_GSK3_1	147	154	PF00069	0.508
MOD_GSK3_1	171	178	PF00069	0.392
MOD_GSK3_1	188	195	PF00069	0.466
MOD_GSK3_1	255	262	PF00069	0.647
MOD_GSK3_1	271	278	PF00069	0.716
MOD_GSK3_1	290	297	PF00069	0.745
MOD_GSK3_1	298	305	PF00069	0.755
MOD_GSK3_1	312	319	PF00069	0.582
MOD_GSK3_1	504	511	PF00069	0.347
MOD_GSK3_1	537	544	PF00069	0.584
MOD_GSK3_1	545	552	PF00069	0.604
MOD_GSK3_1	98	105	PF00069	0.432
MOD_N-GLC_1	321	326	PF02516	0.749
MOD_N-GLC_1	420	425	PF02516	0.496
MOD_NEK2_1	192	197	PF00069	0.534
MOD_NEK2_1	273	278	PF00069	0.636
MOD_NEK2_1	3	8	PF00069	0.593
MOD_NEK2_1	36	41	PF00069	0.380
MOD_NEK2_1	378	383	PF00069	0.500
MOD_NEK2_1	419	424	PF00069	0.489
MOD_NEK2_1	73	78	PF00069	0.421
MOD_NEK2_2	211	216	PF00069	0.435
MOD_NEK2_2	233	238	PF00069	0.625
MOD_NMyristoyl	1	7	PF02799	0.553
MOD_PIKK_1	224	230	PF00454	0.508
MOD_PIKK_1	378	384	PF00454	0.503
MOD_PKA_2	102	108	PF00069	0.377
MOD_PKA_2	262	268	PF00069	0.819
MOD_PKA_2	92	98	PF00069	0.373
MOD_PKB_1	336	344	PF00069	0.608
MOD_Plk_1	188	194	PF00069	0.462
MOD_Plk_1	31	37	PF00069	0.425
MOD_Plk_4	147	153	PF00069	0.483
MOD_Plk_4	233	239	PF00069	0.629
MOD_Plk_4	31	37	PF00069	0.402
MOD_Plk_4	485	491	PF00069	0.476
MOD_ProDKin_1	178	184	PF00069	0.358
MOD_ProDKin_1	252	258	PF00069	0.685
MOD_ProDKin_1	307	313	PF00069	0.700
MOD_ProDKin_1	545	551	PF00069	0.679
MOD_SUMO_rev_2	12	17	PF00179	0.580
MOD_SUMO_rev_2	488	495	PF00179	0.430
TRG_ENDOCYTIC_2	221	224	PF00928	0.425
TRG_ENDOCYTIC_2	284	287	PF00928	0.551
TRG_ENDOCYTIC_2	44	47	PF00928	0.321
TRG_ENDOCYTIC_2	440	443	PF00928	0.471
TRG_ENDOCYTIC_2	85	88	PF00928	0.385
TRG_ER_diArg_1	25	28	PF00400	0.395
TRG_ER_diArg_1	444	446	PF00400	0.486
TRG_ER_diArg_1	452	455	PF00400	0.473
TRG_NES_CRM1_1	346	362	PF08389	0.589
TRG_Pf-PMV_PEXEL_1	424	428	PF00026	0.509

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HS69	Leptomonas seymouri	62%	94%
A0A0S4KE41	Bodo saltans	44%	100%
A4HIZ0	Leishmania braziliensis	84%	100%
A4I4P4	Leishmania infantum	100%	100%
E9AE47	Leishmania major	95%	100%
E9ALN8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%