Tryparedoxin_1_putative/GeneDB:LmjF.29.1160

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tryparedoxin 1, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IED6_LEIDO

TriTrypDb:

LdBPK_291250.1 , LdCL_290017600 , LDHU3_29.1730

Length:

145

Annotations

LeishMANIAdb annotations

A large family of kinetoplastid-specific oxidoreductases. Only expanded in the Leptomonas genus. Localization: ER (by feature) / Mitochondial outer membrane (by feature)

Annotations by Jardim et al.

Redox homeostasis, Tryparedoxin TXN1

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 4
Forrest at al. (procyclic)	yes	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 33

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 29
NetGPI	no	yes: 0, no: 29

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	10
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0005634	nucleus	5	2
GO:0032473	cytoplasmic side of mitochondrial outer membrane	4	1
GO:0098552	side of membrane	2	1
GO:0098562	cytoplasmic side of membrane	3	1
GO:0005829	cytosol	2	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3Q8IED6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IED6

PDB structure(s): 3s9f_A

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009987	cellular process	1	2
GO:0042743	hydrogen peroxide metabolic process	4	2
GO:0042744	hydrogen peroxide catabolic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0072593	reactive oxygen species metabolic process	3	2
GO:0009892	negative regulation of metabolic process	4	2
GO:0009966	regulation of signal transduction	4	2
GO:0009968	negative regulation of signal transduction	5	2
GO:0010605	negative regulation of macromolecule metabolic process	5	2
GO:0010646	regulation of cell communication	4	2
GO:0010648	negative regulation of cell communication	5	2
GO:0019222	regulation of metabolic process	3	2
GO:0023051	regulation of signaling	3	2
GO:0023057	negative regulation of signaling	4	2
GO:0030111	regulation of Wnt signaling pathway	5	2
GO:0030178	negative regulation of Wnt signaling pathway	6	2
GO:0031396	regulation of protein ubiquitination	8	2
GO:0031397	negative regulation of protein ubiquitination	9	2
GO:0031399	regulation of protein modification process	6	2
GO:0031400	negative regulation of protein modification process	7	2
GO:0048519	negative regulation of biological process	3	2
GO:0048523	negative regulation of cellular process	4	2
GO:0048583	regulation of response to stimulus	3	2
GO:0048585	negative regulation of response to stimulus	4	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0051172	negative regulation of nitrogen compound metabolic process	5	2
GO:0051246	regulation of protein metabolic process	5	2
GO:0051248	negative regulation of protein metabolic process	6	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2
GO:0080090	regulation of primary metabolic process	4	2
GO:1903320	regulation of protein modification by small protein conjugation or removal	7	2
GO:1903321	negative regulation of protein modification by small protein conjugation or removal	8	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	20
GO:0004791	thioredoxin-disulfide reductase activity	2	20
GO:0015035	protein-disulfide reductase activity	3	20
GO:0015036	disulfide oxidoreductase activity	4	20
GO:0016209	antioxidant activity	1	20
GO:0016491	oxidoreductase activity	2	20
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	3	20
GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	4	20
GO:0047134	protein-disulfide reductase (NAD(P)) activity	4	20
GO:0140096	catalytic activity, acting on a protein	2	20

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	93	95	PF00082	0.181
CLV_PCSK_PC1ET2_1	93	95	PF00082	0.181
CLV_PCSK_SKI1_1	128	132	PF00082	0.543
CLV_PCSK_SKI1_1	29	33	PF00082	0.251
CLV_PCSK_SKI1_1	44	48	PF00082	0.274
DOC_MAPK_MEF2A_6	83	91	PF00069	0.459
DOC_PP1_RVXF_1	47	54	PF00149	0.549
DOC_PP2B_LxvP_1	87	90	PF13499	0.456
DOC_WW_Pin1_4	44	49	PF00397	0.464
LIG_BIR_II_1	1	5	PF00653	0.440
LIG_BRCT_BRCA1_1	59	63	PF00533	0.484
LIG_BRCT_BRCA1_1	87	91	PF00533	0.543
LIG_BRCT_BRCA1_2	87	93	PF00533	0.374
LIG_FHA_1	28	34	PF00498	0.419
LIG_FHA_1	45	51	PF00498	0.469
LIG_LIR_Apic_2	36	42	PF02991	0.459
LIG_LIR_Gen_1	30	37	PF02991	0.478
LIG_LIR_Gen_1	60	68	PF02991	0.443
LIG_LIR_Nem_3	30	35	PF02991	0.471
LIG_LIR_Nem_3	60	66	PF02991	0.427
LIG_LIR_Nem_3	74	80	PF02991	0.458
LIG_PCNA_PIPBox_1	1	10	PF02747	0.494
LIG_Pex14_2	35	39	PF04695	0.461
LIG_SH2_STAT5	34	37	PF00017	0.457
MOD_CDK_SPK_2	44	49	PF00069	0.410
MOD_CK1_1	108	114	PF00069	0.478
MOD_CK1_1	2	8	PF00069	0.400
MOD_CK1_1	24	30	PF00069	0.388
MOD_CK2_1	66	72	PF00069	0.477
MOD_GlcNHglycan	1	4	PF01048	0.435
MOD_GlcNHglycan	26	29	PF01048	0.372
MOD_GlcNHglycan	35	38	PF01048	0.235
MOD_NEK2_1	33	38	PF00069	0.468
MOD_PIKK_1	129	135	PF00454	0.542
MOD_PK_1	105	111	PF00069	0.422
MOD_Plk_1	21	27	PF00069	0.472
MOD_Plk_4	108	114	PF00069	0.486
MOD_Plk_4	27	33	PF00069	0.269
MOD_ProDKin_1	44	50	PF00069	0.464
TRG_ENDOCYTIC_2	81	84	PF00928	0.462

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HT51	Leptomonas seymouri	40%	79%
A0A0N1HZM3	Leptomonas seymouri	54%	95%
A0A0N1I697	Leptomonas seymouri	64%	99%
A0A1X0P005	Trypanosomatidae	61%	100%
A0A1X0P190	Trypanosomatidae	35%	73%
A0A3Q8IG90	Leishmania donovani	40%	78%
A0A3S7X2H1	Leishmania donovani	60%	97%
A0A422MZX1	Trypanosoma rangeli	37%	75%
A0A422MZX8	Trypanosoma rangeli	63%	100%
A0A6L0XIW2	Leishmania infantum	60%	100%
A0A6L0XKX4	Leishmania infantum	100%	100%
A4HHC6	Leishmania braziliensis	61%	100%
A4HHC7	Leishmania braziliensis	76%	100%
A4HHC8	Leishmania braziliensis	75%	100%
A4HJH8	Leishmania braziliensis	42%	78%
A4I6X1	Leishmania infantum	40%	78%
B6DTG3	Bodo saltans	46%	83%
B6DTG4	Bodo saltans	57%	100%
C9ZKL4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	73%
C9ZL57	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9ADX3	Leishmania major	60%	100%
E9ADX4	Leishmania major	86%	100%
E9ALV7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
E9ALV8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	59%	100%
E9B1Z5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	76%
E9B1Z6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
O77404	Trypanosoma brucei brucei	60%	100%
Q4Q665	Leishmania major	38%	100%
Q4Q666	Leishmania major	39%	78%
Q5VZ03	Homo sapiens	30%	93%
Q96CM4	Homo sapiens	31%	68%
Q9D531	Mus musculus	29%	93%